Aggregate (Hoboken, N.J.)最新文献

{"title":"Circularly Polarized Luminescence Inversion in AIE-Active Crystal Enabled by Solvent-Induced Transition Dipole Moment Regulation","authors":"Xiaofei Niu,&nbsp;Xinwen Ou,&nbsp;Shizhe Ren,&nbsp;Ke Wang,&nbsp;Fengyan Song,&nbsp;Xiaobin Dong,&nbsp;Wu-Jie Guo,&nbsp;Hui-Qing Peng,&nbsp;Zujin Zhao,&nbsp;Jacky W. Y. Lam,&nbsp;Yong Sheng Zhao,&nbsp;Fei Li,&nbsp;Shu-Yan Yu,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.70003","DOIUrl":"https://doi.org/10.1002/agt2.70003","url":null,"abstract":"<p>Control of the dissymmetry of circularly polarized luminescence (CPL) is intriguing and has great potential for applications in the field of optics. The traditional control strategy involves using the opposite enantiomers to achieve reversal of CPL signs. However, regulating CPL reversal by controlling only the transition dipole moments without changing molecular or supramolecular chirality remains a challenge. Herein, we developed a couple of crystal materials based on axially chiral aggregation-induced emission luminogens (AIEgens). These materials exhibit achiral solvent-induced CPL sign inversion with identical helical structures and molecular chirality in their crystalline states. (<i>R</i>)-BPAuCz^T displays (+)-CPL with a dissymmetry factor of luminescence (<i>g</i>_lum) value of +9.81 × 10⁻⁴ (560 nm), while (<i>R</i>)-BPAuCz^C exhibits (−)-CPL with a <i>g</i>_lum value of −1.02 × 10⁻³ (560 nm). Time-dependent density functional theory calculations show that the magnetic and electric transition dipole moments at S₁ → S₀ of the (<i>R</i>)-BPAuCz^C unit cell are considerably influenced by the cocrystallized solvent molecules, revealing a solvent-induced CPL inversion mechanism. The nonbonding interactions between the solvent molecules (i.e., tetrahydrofuran or CDCl₃) and AIEgens in the crystal play a crucial role in the manipulation of the transition dipole moment of these crystal materials. Moreover, microrods of (<i>R</i>)-BPAuCz^T, (<i>R</i>)-BPAuCz^C, and (<i>R</i>)-BPAuCz^DCE exhibit optical waveguide properties with relatively low optical-loss coefficients of 187.3, 567.4, and 65.2 dB/cm, respectively. These findings can help in developing a new strategy toward controlling CPL signals and providing a potential application for future integrated photonic circuits.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggregation Induced Emissive Liquid Crystals-Polymer Composite Membrane for Dual-Channel Analysis of Parathyroid Hormone","authors":"Yingping Tong,&nbsp;Birong Wang,&nbsp;Dongyu Zhao,&nbsp;Min Li,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.70000","DOIUrl":"https://doi.org/10.1002/agt2.70000","url":null,"abstract":"<p>Parathyroid hormone (PTH) is an important factor in maintaining blood calcium levels in the human body. Therefore, monitoring PTH levels is essential for assessing the various diseases progression and managing overall health. In this study, a fluorescence and optical sensor based on an aggregation-induced emissive liquid crystal photopolymer (AIE-LC-Poly) film was established for the qualitative and quantitative detection of PTH. The specific interaction between PTH and anti-PTH on the substrate surface was utilized, and variations in orientation and aggregation state of the fluorescent LCs were evaluated by both optic and fluorescent means. The detection limit for PTH using optical image was above 10 µg/mL, while fluorescence detection achieved a much lower limit of 1 ng/mL. Additionally, the photopolymer further amplified the detection signals by strengthening the AIE effect of the fluorescent LCs in initiate state, and enhancing the disturbance of LCs ordered orientation upon PTH addition. Ultimately, the detection limits for PTH were reduced to 0.01 µg/mL for optical detection and 50 pg/mL for fluorescence detection. The quantitative and sensitive AIE-LC-Poly biosensing technology presented here sets the stage to develop LC-based sensor for biomedical applications without labeling.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable Emissions in Zero-Dimensional (C6H5CH2NH3)3InBr6 Enabled by Controlled Structural Amorphization","authors":"Qian Li,&nbsp;Bin Xu,&nbsp;Xiaofan Xu,&nbsp;Yayun Wang,&nbsp;Zewei Quan","doi":"10.1002/agt2.70004","DOIUrl":"https://doi.org/10.1002/agt2.70004","url":null,"abstract":"<p>Zero-dimensional (0D) hybrid metal halides (HMHs) hold great promise as multifunctional emitters. However, precise functionalization of organic moieties and controlled modulation of self-trapped exciton (STE) emission from inorganic polyhedra remain challenging. This study introduces 0D (PMA)₃InBr₆ (PMA⁺ = C₆H₅CH₂NH₃⁺) as a multifunctional emitter, leveraging pressure-induced structural regulation to control photoluminescence properties. Increasing pressure leads to simultaneous contraction and distortion of InBr₆³⁻ octahedra, shifting the STE emission color from orange to green. At high compression, structural amorphization quenches STE emission, but upon pressure release, a bright cyan emission from the PMA⁺ cation emerges, with intensity approximately 21 times stronger than that of the initial STE emission. The enhanced emission is attributed to altered molecular configurations, disrupted intermolecular contacts, and reduced lattice vibrations, collectively suppressing excimeric coupling and minimizing nonradiative losses in the recovered amorphous phase. Furthermore, emission conversion is also achieved via laser-induced structural amorphization, expanding the potential of (PMA)₃InBr₆ for direct laser writing and sensitive laser detection applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrin-Targeted, Activatable Nanophototherapeutics for Immune Modulation: Enhancing Photoimmunotherapy Efficacy in Prostate Cancer Through Macrophage Reprogramming","authors":"Cheng Zhang,&nbsp;Xiaolan Yin,&nbsp;Lei Hao,&nbsp;Yumei Wang,&nbsp;Linqiang Dou,&nbsp;Qixian Chen,&nbsp;Jun-Seok Lee,&nbsp;Jingyun Wang,&nbsp;Xiaojun Peng,&nbsp;Juyoung Yoon,&nbsp;Haidong Li","doi":"10.1002/agt2.70001","DOIUrl":"https://doi.org/10.1002/agt2.70001","url":null,"abstract":"<p>Prostate cancer is an epithelial malignancy with a high incidence among elderly men. Photochemistry-based dye photodrugs (known as photosensitizers) offer a promising clinical approach for treating tumors. These agents work by inducing immunogenic cell death (ICD), which activates antitumor immune response. This approach is favored owing to its minimal invasiveness, low toxicity, and high efficiency. However, the immunosuppressive microenvironment of characteristics of “cold” tumors significantly restricts the clinical efficacy of photodrugs. Developing an advanced nanocarrier system to deliver photodrugs and immune agonists for efficient drug delivery to tumor lesion sites and to reshape the immunosuppressive microenvironment is crucial in clinical practice. Therefore, in this study, we designed an integrin-targeted, activatable nano photodrug co-assembly with an immune agonist (RPST@IMQ) for enhancing photoimmunotherapy in prostate cancer via the reprogramming of tumor-associated macrophages. The active-targeted nanosystem enhanced the dosage of photodrug at the lesion site through systemic administration. High doses of glutathione at the tumor site cleaved the disulfide bonds of RPST@IMQ, releasing the photodrug and the immune agonist imiquimod (IMQ). Under photoirradiation, the photodrug generated significant doses of singlet oxygen to eliminate tumor cells, thereby inducing ICD to activate antitumor immune responses. Simultaneously, the released IMQ reprograms immunosuppressive M2-type tumor-associated macrophages (TAMs) in the tumor microenvironment into M1-type TAMs with tumor-killing capabilities, thereby converting “cold” tumors into “hot” tumors. This conversion enhances the therapeutic efficacy against primary and distant tumors in vivo. This study offers new insights into the development of innovative, smart, activatable nano photodrugs to enhance anticancer therapeutic outcomes.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Diagnosis and Therapy of Dental Caries by Oral Microbiome-Selective Aggregation-Induced Photosensitivity","authors":"Yandi Zhang,&nbsp;Wenjun Wang,&nbsp;Xiaoru Yang,&nbsp;Xuanmeng An,&nbsp;Xiaoyi Liu,&nbsp;Weiwei Zhao,&nbsp;Lina Zhu,&nbsp;Ting Wang,&nbsp;Ying Wang,&nbsp;Yi Chen,&nbsp;Junkun Feng,&nbsp;Jinlong Shao,&nbsp;Xuedong Zhou,&nbsp;Ben Zhong Tang,&nbsp;Shaohua Ge,&nbsp;Jianhua Li","doi":"10.1002/agt2.733","DOIUrl":"https://doi.org/10.1002/agt2.733","url":null,"abstract":"<p>Dental caries represents one of the most widespread oral bacterial infections, affecting billions of individuals worldwide and presenting significant public health challenges. Effective diagnosis and treatment are hindered by the limitations of traditional clinical treatment methodologies, which often involve laborious examinations and invasive procedures. In this study, we employ an aggregation-induced emission probe, MeOTpy, for instant molecular detection and photodynamic treatment of dental caries. MeOTpy interacts specifically with cariogenic bacteria, exhibiting bright fluorescence upon binding to bacteria and generating reactive oxygen species under white light irradiation. This aggregation-induced photosensitivity enables rapid assessment of carious disease through fluorescent detection in dental plaque samples, facilitating easy identification of lesion sites in decayed teeth treated with MeOTpy. Furthermore, photodynamic inhibition of cariogenic biofilms is achieved by culturing ex vivo biofilms isolated from children with severe early childhood caries. MeOTpy also effectively prevents dental caries while preserving oral microbial diversity in a cariogenic infection model on rat pups. This study presents an integrated strategy for the precise diagnosis and treatment of dental caries at the point of care.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential","authors":"Chiara Bellini,&nbsp;Unai Atxabal,&nbsp;Szilvia Bősze,&nbsp;Orsolya Dobay,&nbsp;Andrea Horváth,&nbsp;Imola Cs. Szigyártó,&nbsp;Tamás Beke-Somfai,&nbsp;Jesús Jiménez-Barbero,&nbsp;István Puskás,&nbsp;Kata Horváti","doi":"10.1002/agt2.741","DOIUrl":"https://doi.org/10.1002/agt2.741","url":null,"abstract":"<p>In the last decade, the rise of antibiotic resistance has heightened interest in antimicrobial peptides and lipopeptides as promising alternatives to conventional antibiotics because of their lower propensity to develop resistance. However, lipopeptides often show undesired cytotoxicity due to their non-selective membrane disruptive effect, and their limited aqueous solubility represents a matter of concern from a pharmaceutical point of view. This study demonstrates a panel of ultrashort cationic lipopeptides (USCLs) consisting of a tetrapeptide (L1), originated from buforin II, coupled with saturated fatty acids of different lengths. Our results highlight that the 16-carbon fatty acid lipopeptide (Pal-L1) exhibits relevant antibacterial activity against multiresistant <i>Staphylococcus aureus</i> strain. However, the formation of heterogenic aggregates in cell culture medium and toxic effects on human cells were also observed. Pal-L1 formulation with the randomly methylated α-cyclodextrin (RAMEA) and the sulfobutylether-β-cyclodextrin (SBECD) has resulted in a production of ultralow-sized molecular dispersion systems and reduced lipopeptide toxicity without compromising its antimicrobial activity. With titration ¹H-NMR, 2D NMR experiments, together with molecular dynamics simulations, we described the size, structure, stoichiometry, and dissociation constant of the supramolecular complexes. Interactions of neutral and negatively charged model liposomes with Pal-L1 lipopeptide in the presence or absence of cyclodextrins serve an explanation for the membrane selectivity, and based on the results, we proposed a potential mechanism of action for the Pal-L1+cyclodextrin complexes on different biological membranes. Overall, our model characterization points out that cyclodextrin formulation improves the therapeutical applicability of lipopeptides.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.741","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New AIE Emitters from the Unexpected Boron Tribromide/Boron Trichloride-mediated Cyclization Reaction and Application for Fluorescence Imaging of Lipid Droplets","authors":"Yichen Hu,&nbsp;Xin Gao,&nbsp;Junlong Ma,&nbsp;Zhichun Shangguan,&nbsp;Liangliang Chen,&nbsp;Guanxin Zhang,&nbsp;Xi-Sha Zhang,&nbsp;Cheng Li,&nbsp;Yanbang Li,&nbsp;Deqing Zhang","doi":"10.1002/agt2.735","DOIUrl":"https://doi.org/10.1002/agt2.735","url":null,"abstract":"<p>The aberrant behavior of lipid droplets (LDs) is often indicative of cellular dysfunction, which may contribute to the development of a range of diseases, particularly metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis (AS). Consequently, there is an urgent need to develop fluorescence probes targeting LDs to monitor the progression of disease. In this study, an unanticipated one-pot boron tribromide (BBr₃)/boron trichloride (BCl₃)-promoted cyclization reaction was discovered, yielding a bromo-/chloro-substituted triphenylamine (TPA) derivative (<b>TPA-Br</b>/<b>TPA-Cl</b>). <b>TPA-Br</b> was successfully transformed into new TPA-containing donor-acceptor (D–A) molecules which show typical aggregation induced emission (AIE) property. Among these new AIE emitters, <b>TPA-N</b> shows the most promising LDs targeting specificity, lowest toxicity and best photo-stability. Ex vivo studies further demonstrate that <b>TPA-N</b> can be used to fluorescence image fatty liver and AS plaque quickly and effectively.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel [3+2+1] Coordinated Iridium (III) Complexes for Hyperefficient Photodynamic Therapy","authors":"Siwei Zhang,&nbsp;Ming Shao,&nbsp;Yuan Wu,&nbsp;Yun-Ran Gao,&nbsp;Fulong Ma,&nbsp;Jinhui Jiang,&nbsp;Chao Chen,&nbsp;Zun-Yun Wang,&nbsp;Jacky W. Y. Lam,&nbsp;Xi-Ling Xu,&nbsp;Chen Yang,&nbsp;Juan Du,&nbsp;Zheng Zhao,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.710","DOIUrl":"https://doi.org/10.1002/agt2.710","url":null,"abstract":"<p>Efficient photosensitizers are crucial for the success of photodynamic therapy (PDT). Herein, we reported two [3+2+1] coordinated organometallic Iridium (III) complexes (labeled as <b>Ir-C1</b> and <b>Ir-C4</b>). <b>Ir-C1</b>/<b>C4</b> can generate both type I and type II reactive oxygen species (ROS). In vitro experiments, <b>Ir-C1</b>/<b>C4</b> show low biotoxicity and high phototoxicity of half-maximal inhibitory concentration values of 14 nM and 33 nM on rectal cancer cell line HCT116, respectively. Western blot analysis revealed that the <b>Ir-C1</b>/<b>C4</b> activated ferroptosis, apoptosis, and inhibiting autophagy simultaneously. Proteomics analysis demonstrated that the photosensitizers destroyed the endoplasmic reticulum (ER), blocking the signal transmission and material transfer between the ER and other tissues of the cell, especially the ER to Golgi vesicle-mediated transport. <b>Ir-C1</b>/<b>C4</b> can achieve better antitumor performance than commercial photosensitizer Chlorin e6 and the ferroptosis activator RSL3 at lower concentrations. The low biotoxicity and high phototoxicity make them ideal candidates for PDT. The findings provide new insights into the design of photosensitizers for metal complexes and have significant implications for the development of PDT and related drugs.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 4","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Fluorescence imaging-guided lipid droplets-localized photodynamic therapy","authors":"Shan Wang,&nbsp;Qiang Wang,&nbsp;Yang Lv,&nbsp;Zhe Liu,&nbsp;Kippeum Lee,&nbsp;Dongeun Kim,&nbsp;Miae Won,&nbsp;Jianliang Shen,&nbsp;Jong Seung Kim","doi":"10.1002/agt2.737","DOIUrl":"https://doi.org/10.1002/agt2.737","url":null,"abstract":"<p>This review focuses on the lipid droplets (LDs)-localized chemical chromophores for photodynamic therapy. It highlights the design principles, performance, and biomedical applications of these photosensitizers (PSs). Especially, the cell death pathways induced by these tools are introduced. These targetable PSs guard our health by destroying the LDs of cancer cells, just as soldiers protect our cities from alien invasion by destroying the energy cores of alien airships (e665).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Near-room-temperature π-conjugated nematic liquid crystals in molecules with a flexible seven-membered ring structure","authors":"Riki Iwai,&nbsp;Hiroyuki Yoshida,&nbsp;Yuki Arakawa,&nbsp;Shunsuke Sasaki,&nbsp;Yuuto Iida,&nbsp;Kazunobu Igawa,&nbsp;Tsuneaki Sakurai,&nbsp;Satoshi Suzuki,&nbsp;Masatoshi Tokita,&nbsp;Junji Watanabe,&nbsp;Gen-ichi Konishi","doi":"10.1002/agt2.736","DOIUrl":"https://doi.org/10.1002/agt2.736","url":null,"abstract":"<p>This study provides a novel molecular design methodology that dramatically decreases the isotropization temperature of π-conjugated nematic liquid crystals (NLC). In addition, a large-area electric-field-responsive fluorescent switch device with a sub-millisecond response time is demonstrated using a luminescent NLC and a liquid crystal display cell. The era of alignment of liquid crystalline organic semiconductors as desired has begun (e660).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}