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On the thermodynamics of aggregation toward phosphorescent metallomesogens: From electronic tuning to supramolecular design 磷光金属诱导体聚集的热力学:从电子调谐到超分子设计
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-22 DOI: 10.1002/agt2.473
Matias E. Gutierrez Suburu, Meik Blanke, Leon Geerkens, Alexander Hepp, Iván Maisuls, Jutta Kösters, Thorben Neumann, Jens Voskuhl, Michael Giese, Cristian A. Strassert
{"title":"On the thermodynamics of aggregation toward phosphorescent metallomesogens: From electronic tuning to supramolecular design","authors":"Matias E. Gutierrez Suburu,&nbsp;Meik Blanke,&nbsp;Leon Geerkens,&nbsp;Alexander Hepp,&nbsp;Iván Maisuls,&nbsp;Jutta Kösters,&nbsp;Thorben Neumann,&nbsp;Jens Voskuhl,&nbsp;Michael Giese,&nbsp;Cristian A. Strassert","doi":"10.1002/agt2.473","DOIUrl":"10.1002/agt2.473","url":null,"abstract":"<p>Two series with three Pt(II) complexes each (<b>PtL<sub>Ph</sub>-n</b>, <b>PtL<sub>Fpy</sub>-n</b>) bearing asymmetric tetradentate ligands as dianionic luminophores with variable alkyl chain lengths were synthesized. Hence, each ligand series is distinguished by one of its cyclometallating rings (phenyl vs. 2,6-difluoropyrid-3-yl). Steady-state and time-resolved photoluminescence spectroscopic studies in diluted solutions at room temperature and in glassy matrices at 77 K show that the emissive state is mainly centered on the invariantly electron-rich cyclometalated side while the second ring regulates the admixture of ligand-centered and metal-to-ligand charge-transfer character. Hence, the radiative rates can be controlled, as indicated by quantum-mechanical calculations, which also explain the temperature-dependent trend in the phosphorescence rate constants. Studies in condensed phases (single-crystal X-ray diffractometry, polarized optical microscopy, differential scanning calorimetry, steady-state and time-resolved photoluminescence micro(spectro)scopy) showed the development of a smectic A mesophase for the fluorinated species bearing the two longest alkyl chains. Nuclear magnetic resonance-based studies on the thermodynamics of aggregation in solution confirm the marked enthalpic stabilization of aggregates mediated by the polar 2,6-difluoropyrid-3-yl moiety (and to a lesser extent by dispersive forces between the alkyl chains). On the other hand, the negative entropy of aggregation is dominated by the restriction of degrees of freedom involving the peripheral alkyl moieties upon stacking, which becomes increasingly relevant for longer chains. All these factors control Pt···Pt coupling, a crucial interaction for the design of photofunctional mesogens based on Pt(II) complexes.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activated aggregation-induced emission therapeutics agents for triggering regulated cell death 活化聚集诱导发射治疗剂,用于触发调节性细胞死亡
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-22 DOI: 10.1002/agt2.503
Yu-Qiang Zhao, Le Yu, Lanyun Zhang, Huan Liu, Ying Zhou, Jong Seung Kim
{"title":"Activated aggregation-induced emission therapeutics agents for triggering regulated cell death","authors":"Yu-Qiang Zhao,&nbsp;Le Yu,&nbsp;Lanyun Zhang,&nbsp;Huan Liu,&nbsp;Ying Zhou,&nbsp;Jong Seung Kim","doi":"10.1002/agt2.503","DOIUrl":"10.1002/agt2.503","url":null,"abstract":"<p>The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation-induced emission (AIE) therapeutic agents generate reactive oxygen species through photo/ultrasound activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting in the death of tumor cells. The presented comprehensive review delves into recent advancements in AIE therapeutic agents designed to trigger RCD or synergize with RCD inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic cell death, autophagy, ferroptosis, and cuproptosis. Additionally, the intricate regulatory mechanisms through which activatory-AIE therapeutics influence distinct RCD pathways are examined. A forward-looking perspective on future developments and pertinent challenges within this exciting realm is presented, anticipating the continued evolution of activatable AIE therapeutics as a transformative approach to enhance tumor therapy.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139559291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggregation of titanium-oxo clusters 钛-氧簇的聚集
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-22 DOI: 10.1002/agt2.506
Yu-Long Xie, Wei-Hui Fang, Jian Zhang
{"title":"Aggregation of titanium-oxo clusters","authors":"Yu-Long Xie,&nbsp;Wei-Hui Fang,&nbsp;Jian Zhang","doi":"10.1002/agt2.506","DOIUrl":"10.1002/agt2.506","url":null,"abstract":"<p>Compared with nanoparticle-aspect relatives titanium dioxide (TiO<sub>2</sub>), titanium-oxo clusters (TOCs) are atomically structural-determined and can be further precisely modified through coordination and supramolecular chemistry. Another parallel research direction is titanium-based metal-organic frameworks, and those based on TOC have attracted particular attention because of their high optical performances resulting from the cluster aggregation effect. Though challenging, assembling macro-materials from specific clusters helps establish the assembly chemistry of clusters and incorporates porous and flexible characteristics into a single bulk material. Although separate reviews are reported in these two branches, no comprehensive review is available to highlight the bridges between them. Herein, we review and summarize the development and progress of new aggregation of TOCs, from intramolecular unique cluster aggregation to hierarchical intermolecular aggregation via covalent forces, coordination bonds, and non-covalent forces using the specific clusters as precursors. We hope this review fills the gap in the methodology of assembling particular-aggregated TOCs and their derived frameworks, providing general guidance to researchers interested in this area.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139559131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control over the aggregated structure of donor–acceptor conjugated polymer films for high-mobility organic field-effect transistors 控制用于高迁移率有机场效应晶体管的供体-受体共轭聚合物薄膜的聚集结构
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-15 DOI: 10.1002/agt2.501
Xinxiu Cao, Yanchun Han
{"title":"Control over the aggregated structure of donor–acceptor conjugated polymer films for high-mobility organic field-effect transistors","authors":"Xinxiu Cao,&nbsp;Yanchun Han","doi":"10.1002/agt2.501","DOIUrl":"10.1002/agt2.501","url":null,"abstract":"<p>Donor–acceptor (D-A) conjugated polymers have demonstrated great potential in organic field-effect transistors application, and their aggregated structure is a crucial factor for high charge mobility. However, the aggregated structure of D-A conjugated polymer films is complex and the structure–property relationship is difficult to understand. This review provides an overview of recent progress in controlling the aggregated structure of D-A conjugated polymer films for higher mobility, including the mechanisms, methods, and properties. We first discuss the multilevel microstructures of D-A conjugated polymer films, and then summarize the current understanding of the relationship between film microstructures and charge transport properties. Subsequently, we review the theory of D-A conjugated polymer crystallization. After that, we summarize the common methods to control the aggregated structure of semi-crystalline and near-amorphous D-A conjugated polymer films, such as crystallites and aggregates, tie chains, film alignment, and attempt to understand them from the basic theory of polymer crystallization. Finally, we provide the current challenges in controlling the aggregated structure of D-A conjugated polymer films and in understanding the structure–property relationship.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139470590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A tumor-targeting nano-adjuvant for in situ vaccine based on ultrasound therapy 基于超声波疗法的原位疫苗肿瘤靶向纳米辅助剂
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-15 DOI: 10.1002/agt2.504
Linjie Cui, Haochen Yao, Fuxin Xue, Jiali Sun, Xitong Ren, Mengfei Zheng, Zhilin Liu, Zhaohui Tang
{"title":"A tumor-targeting nano-adjuvant for in situ vaccine based on ultrasound therapy","authors":"Linjie Cui,&nbsp;Haochen Yao,&nbsp;Fuxin Xue,&nbsp;Jiali Sun,&nbsp;Xitong Ren,&nbsp;Mengfei Zheng,&nbsp;Zhilin Liu,&nbsp;Zhaohui Tang","doi":"10.1002/agt2.504","DOIUrl":"10.1002/agt2.504","url":null,"abstract":"<p>Ultrasound-generated antigens combined with TLR7/8 agonists as adjuvants have demonstrated significant anti-tumor efficacy as an in-situ vaccine. However, the use of TLR7/8 agonists can cause severe inflammatory responses. In this study, we present a novel tumor-targeting nano-adjuvant termed aPDL1-PLG/R848 NPs, which are composed of aPDL1 antibody, Fc-III-4C peptide linker (Fc-linker) and poly(<i><sub>L</sub></i>-glutamic acid)-<i>grafted</i>-R848. Under ultrasound irradiation, antigen-presenting cells activate immune mechanisms in vivo under dual stimulation of in situ antigens and immune adjuvants. The strategy inhibits primary tumor growth and induces a strong antigen-specific immune memory effect to prevent tumor recurrence in vivo. This work offers a safe and potent platform for an in situ cancer vaccine based on ultrasound therapy.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139470588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA nanostructures prevent the formation of and convert toxic amyloid proteospecies into cytocompatible and biodegradable spherical complexes DNA 纳米结构可防止有毒淀粉样蛋白形成,并将其转化为细胞兼容、可生物降解的球形复合物
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-15 DOI: 10.1002/agt2.502
Nadjib Kihal, Phuong Trang Nguyen, Ali Nazemi, Andrea A. Greschner, Marc A. Gauthier, Steve Bourgault
{"title":"DNA nanostructures prevent the formation of and convert toxic amyloid proteospecies into cytocompatible and biodegradable spherical complexes","authors":"Nadjib Kihal,&nbsp;Phuong Trang Nguyen,&nbsp;Ali Nazemi,&nbsp;Andrea A. Greschner,&nbsp;Marc A. Gauthier,&nbsp;Steve Bourgault","doi":"10.1002/agt2.502","DOIUrl":"10.1002/agt2.502","url":null,"abstract":"<p>The deposition of insoluble proteinaceous aggregates in the form of amyloid fibrils within the extracellular space of tissues is associated with numerous diseases. The development of molecular approaches to arrest amyloid formation and prevent cellular degeneration remains very challenging due to the complexity of the process of protein aggregation, which encompasses an infinite array of conformations and quaternary structures. Polyanionic biopolymers, such as glycosaminoglycans and RNAs, have been shown to modulate the self-assembly of amyloidogenic polypeptides and to reduce the toxicity induced by the formation of oligomeric and/or pre-fibrillar proteospecies. This study evaluates the effects of double-stranded DNA (dsDNA) nanostructures (1D, 2D, and 3D) on amyloid self-assembly, fibril disaggregation, and the cytotoxicity associated with amyloidogenesis. Using the islet amyloid polypeptide (IAPP) whose pancreatic accumulation is the hallmark of type 2 diabetes, it was observed that dsDNA nanostructures inhibit amyloid formation by inducing the formation of spherical complexes in which the peptide adopts a random coil conformation. Interestingly, the DNA nanostructures showed a persistent ability to disassemble enzymatically and thermodynamically stable amyloid fibrils into nanoscale DNA/IAPP entities that are fully compatible with β-pancreatic cells and are biodegradable by proteolysis. Notably, dsDNA nanostructures avidly trapped highly toxic soluble oligomeric species in complete cell culture media and converted them into non-toxic binary complexes. Overall, these results expose the potent modulatory effects of dsDNA on amyloidogenic pathways, and these DNA nanoscaffolds could be used as a source of inspiration for the design of molecules to fight amyloid-related disorders.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139470594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicene-type β-isoindigo-based boron-dipyrromethene analogs with strong near-infrared chiroptical activity 具有较强近红外光致变色活性的螺旋烯型 β-isoindigo 硼基二吡咯烷类似物
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-05 DOI: 10.1002/agt2.498
Ziwei Chen, Zhigang Ni, Xing-Yu Chen, Yongqiang Xu, Chunyan Yu, SiSi Wang, Xiao-Ye Wang, Hua Lu
{"title":"Helicene-type β-isoindigo-based boron-dipyrromethene analogs with strong near-infrared chiroptical activity","authors":"Ziwei Chen,&nbsp;Zhigang Ni,&nbsp;Xing-Yu Chen,&nbsp;Yongqiang Xu,&nbsp;Chunyan Yu,&nbsp;SiSi Wang,&nbsp;Xiao-Ye Wang,&nbsp;Hua Lu","doi":"10.1002/agt2.498","DOIUrl":"10.1002/agt2.498","url":null,"abstract":"<p>Near-infrared (NIR) chiroptical response has been less explored because it is challenging to achieve both chirality and NIR absorption/emission. Herein, we describe the design of heterohelicene-type β-isoindigo-based boron-dipyrromethene (BODIPY) analogs (β-IBs), which shift the absorption peak to 800 nm and produce significant Cotton effects (127.8 M<sup>−1</sup> cm<sup>−1</sup>) and absorbance dissymmetry factors (|<i>g</i><sub>abs</sub>| = 3.5 × 10<sup>−3</sup>). The luminescence dissymmetry factor (<i>g</i><sub>lum</sub>) and circularly polarized luminescence (CPL) brightness (<i>B</i><sub>CPL</sub>) of up to 1.24 × 10<sup>−3</sup> and 1.78 M<sup>−1</sup> cm<sup>−1</sup> were realized beyond 800 nm. These β-IBs are the first examples of helicene-type compounds with the highest <i>g</i><sub>abs</sub> in the NIR region and CPL beyond 800 nm. Theoretical calculations demonstrate that the strong chiroptical activities are triggered by their large transition magnetic dipole moments. This study not only provides a new approach to the synthesis of a larger variety of unprecedented helicene-type BODIPY analogs but also demonstrates excellent NIR chiroptical properties.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139103422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circularly polarized luminescence from a common alkoxy pillar[5]arene and its co-aggregates with π-conjugated rods 普通烷氧基柱[5]炔及其与π共轭棒共聚物的圆偏振发光
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-04 DOI: 10.1002/agt2.482
Kenichi Kato, Ryo Iwano, Shun Tokuda, Kiichi Yasuzawa, Masayuki Gon, Shunsuke Ohtani, Shuhei Furukawa, Kazuo Tanaka, Tomoki Ogoshi
{"title":"Circularly polarized luminescence from a common alkoxy pillar[5]arene and its co-aggregates with π-conjugated rods","authors":"Kenichi Kato,&nbsp;Ryo Iwano,&nbsp;Shun Tokuda,&nbsp;Kiichi Yasuzawa,&nbsp;Masayuki Gon,&nbsp;Shunsuke Ohtani,&nbsp;Shuhei Furukawa,&nbsp;Kazuo Tanaka,&nbsp;Tomoki Ogoshi","doi":"10.1002/agt2.482","DOIUrl":"10.1002/agt2.482","url":null,"abstract":"<p>Cylinder-shaped macrocycles composed of π-panels have attracted special attention as one of the best platforms for the development of organic molecule-based chiroptical materials. Pillar[<i>n</i>]arenes are a class of macrocycles with the advantage of easy preparation but have not been extensively investigated from the perspective of luminescent molecules. However, common alkoxy pillar[<i>n</i>]arenes are fluorescent in non-haloalkane solvents, showing potential to be used for molecule-based chiroptical materials. In this work, circularly polarized luminescence (CPL) spectra are reported for a pillar[5]arene with stable planar chirality using tetrahydrofuran (THF) and cyclohexane as solvents, which has been missing for many years. The pillar[5]arene also forms co-aggregates with 1,4-bis(phenylethynyl)benzene and 1,4-bis[(pentafluorophenyl)ethynyl]benzene in THF/H<sub>2</sub>O mixtures, owing to a hydrophobic effect. The co-aggregates with the fluorinated π-rod display a new low-energy absorption peak and broad emission band as well as intense circular dichroism and CPL signals. Chiral information from the enantiopure pillar[5]arene core is efficiently transmitted to the co-aggregates with the π-conjugated rod, leading to the highest dissymmetry factor for CPL (2.9 × 10<sup>−2</sup> at 472 nm) among pillar[<i>n</i>]arene-based CPL materials.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139096199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrogen-bonded organic framework core–shell composite for synergistic antimicrobial therapy 用于协同抗菌治疗的氢键有机框架核壳复合材料
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-04 DOI: 10.1002/agt2.481
Jian Xiao, Acharya Ramachandra Mahammed Shaheer, Chen Liu, Tian-Fu Liu, Rong Cao
{"title":"Hydrogen-bonded organic framework core–shell composite for synergistic antimicrobial therapy","authors":"Jian Xiao,&nbsp;Acharya Ramachandra Mahammed Shaheer,&nbsp;Chen Liu,&nbsp;Tian-Fu Liu,&nbsp;Rong Cao","doi":"10.1002/agt2.481","DOIUrl":"10.1002/agt2.481","url":null,"abstract":"<p>Hydrogen-bonded organic frameworks (HOFs) are crystalline porous materials with permanent voids formed via self-assembly of organic molecules through hydrogen bonding and intermolecular forces. Further combination of HOFs with functional material would broaden their application horizon but were less explored in existing literature. Herein, a highly porous and photosensitive HOF was successfully coated onto upconversion nanoparticles (UCNPs) to construct a core–shell structure named UNCPs@PFC-73-Ni. To enhance spectral overlap and maximize energy conversion efficiency, this study utilized the Er and Tm co-doped UCNPs, which can effectively convert infrared light into visible light emission thereby exciting the porphyrin shell. Subsequent investigation reveals that the composite exhibits significant photodynamic and photothermal effects under infrared light. Encouraged by its noticeable photoactivity, UCNPs@PFC-73-Ni was evaluated as an antibacterial agent against <i>Escherichia coli</i>. Notably, significant antibacterial efficacy was observed, highlighting the potential of UCNPs@PFC-73-Ni as an effective antibacterial agent under infrared light irradiation.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139103253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extrusion bioprinting of elastin-containing bioactive double-network tough hydrogels for complex elastic tissue regeneration 挤压生物打印含弹性蛋白的生物活性双网韧性水凝胶,用于复杂弹性组织再生
Aggregate (Hoboken, N.J.) Pub Date : 2024-01-04 DOI: 10.1002/agt2.477
Di Wang, Jinshi Zeng, Hailin Zhu, Siyu Liu, Litao Jia, Wenshuai Liu, Qian Wang, Senmao Wang, Wei Liu, Jiayu Zhou, Huimin Chen, Xia Liu, Haiyue Jiang
{"title":"Extrusion bioprinting of elastin-containing bioactive double-network tough hydrogels for complex elastic tissue regeneration","authors":"Di Wang,&nbsp;Jinshi Zeng,&nbsp;Hailin Zhu,&nbsp;Siyu Liu,&nbsp;Litao Jia,&nbsp;Wenshuai Liu,&nbsp;Qian Wang,&nbsp;Senmao Wang,&nbsp;Wei Liu,&nbsp;Jiayu Zhou,&nbsp;Huimin Chen,&nbsp;Xia Liu,&nbsp;Haiyue Jiang","doi":"10.1002/agt2.477","DOIUrl":"10.1002/agt2.477","url":null,"abstract":"<p>Despite recent advances in extrusion bioprinting of cell-laden hydrogels, using naturally derived bioinks to biofabricate complex elastic tissues with both satisfying biological functionalities and superior mechanical properties is hitherto an unmet challenge. Here, we address this challenge with precisely designed biological tough hydrogel bioinks featuring a double-network structure. The tough hydrogels consisted of energy-dissipative dynamically crosslinked glycosaminoglycan hyaluronic acid (o-nitrobenzyl-grafted hyaluronic acid) and elastin through Schiff's base reaction, and free-radically polymerized gelatin methacryloyl. The incorporation of elastin further improved the elasticity, stretchability (∼170% strain), and toughness (∼45 kJ m<sup>−3</sup>) of the hydrogels due to the random coiling structure. We used this novel class of hydrogel bioinks to bioprint several complex elastic tissues with good shape retention. Furthermore, in vitro and in vivo experiments also demonstrated that the existence of elastin in the biocompatible bioinks facilitated improved cell behaviors and biological functions of bioprinted tissues, such as cell spreading and phenotype maintenance as well as tissue regeneration. The results confirmed the potential of the elastin-containing tough hydrogel bioinks for bioprinting of 3D complex elastic tissues with biological functionalities, which may find widespread applications in elastic tissue regeneration.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139096194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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