Aggregate (Hoboken, N.J.)最新文献_第8页

Incorporation of an Extended Electron-Deficient Central Block Into Small-Molecule Acceptors Toward Enhanced-Performance Organic Solar Cells 在小分子受体中加入扩展的缺电子中心块以增强有机太阳能电池的性能

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-06-07 DOI: 10.1002/agt2.70355

Lan Xie, Yizhi Jiang, Lu Chen, Dingding Qiu, Jicheng Yi, Han Yu, Jianqi Zhang, Zhixiang Wei, Joshua Yuk Lin Lai, Shengjian Liu, He Yan

{"title":"Incorporation of an Extended Electron-Deficient Central Block Into Small-Molecule Acceptors Toward Enhanced-Performance Organic Solar Cells","authors":"Lan Xie, Yizhi Jiang, Lu Chen, Dingding Qiu, Jicheng Yi, Han Yu, Jianqi Zhang, Zhixiang Wei, Joshua Yuk Lin Lai, Shengjian Liu, He Yan","doi":"10.1002/agt2.70355","DOIUrl":"https://doi.org/10.1002/agt2.70355","url":null,"abstract":"Almost all high-performance acceptors currently rely on a single electron-withdrawing core or a core modified with electron-withdrawing groups, which significantly limits structural innovation. In this study, we introduced two novel extended electron-deficient units, [1, 2, 5]thiadiazolo[3,4-b]pyrazine (Tz-Qx) and [1, 2, 5]oxadiazolo[3,4-b]pyrazine (Dz-Qx), into the acceptor central cores. Coupled with fluorine and chlorine-substituted terminal groups, the performance of the acceptors can be synergistically optimized. A systematic investigation elucidates the impact of the central core and terminal groups on the intrinsic photoelectronic properties of the acceptors. Among the four acceptors—Tz-Qx-4F, Tz-Qx-4Cl, Dz-Qx-4F, and Dz-Qx-4Cl—Tz-Qx-4F demonstrated significant near-infrared absorption, excellent crystallinity, and enhanced aggregation capabilities. When blended with the polymer donor D18, the binary device achieved a remarkable power conversion efficiency (PCE) of 19.50%, accompanied by a record short-circuit current density (JSC) of 29.3 mA cm−2. This performance is attributed to the balanced charge transport properties and reduced non-radiative energy losses in the blend films. In stark contrast, Dz-Qx-based counterparts yielded substantially lower PCEs (∼9%), underscoring the profound influence of core heteroatom identity. This work highlights the critical influence of extended electron-deficient units and terminal groups on the molecular photovoltaic properties, providing valuable insights for the design of enhanced-performance organic solar cell acceptors.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Challenges in Machine Learning-based Image Analysis for Monitoring and Predicting Organic Crystal Formation 基于机器学习的图像分析用于监测和预测有机晶体形成的进展与挑战

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-06-07 DOI: 10.1002/agt2.70372

Tianqi Ma, Yating Qu, Chenxian Guan, Hang Yin, Wenmian Yang, Shing Fung Chow, Henry Hoi Yee Tong, Defang Ouyang, Zhuyifan Ye

{"title":"Advances and Challenges in Machine Learning-based Image Analysis for Monitoring and Predicting Organic Crystal Formation","authors":"Tianqi Ma, Yating Qu, Chenxian Guan, Hang Yin, Wenmian Yang, Shing Fung Chow, Henry Hoi Yee Tong, Defang Ouyang, Zhuyifan Ye","doi":"10.1002/agt2.70372","DOIUrl":"https://doi.org/10.1002/agt2.70372","url":null,"abstract":"Manual crystallization experiments have always been challenging, requiring extensive process development expertise and often resulting in unpredictable results. The crystallization process plays a critical role in the development of high-quality organic materials, which are essential for various industries such as pharmaceuticals, materials science, and electronics. Therefore, crystallization experiments are in urgent need of innovative methods to ensure consistency, efficiency, and scalability. Recent studies have shown that machine learning can effectively assist crystal detection and segmentation, thus providing a new way to optimize organic crystallization processes, improving both the speed and precision of crystal formation. However, a comprehensive review of machine learning-based approaches for organic crystallization process monitoring remains elusive. It is therefore necessary to review the machine learning technologies involved, their current applications, technical challenges, and development blueprints. In this work, we focus on the application scenarios, basic principles, and common tools of machine learning methods based on image detection and segmentation in effectively monitoring the crystallization process of organic crystals, especially the research on artificial intelligence technology in the detection of crystal size and morphology, monitoring, and optimization of crystallization processes. Through this work, we aim to provide the oretical references and practical guidance for researchers in related fields.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AIEgen Targets the STAT3‒SUCLG2 Axis to Regulate Metabolism for Colorectal Cancer Theranostics AIEgen靶向STAT3-SUCLG2轴调节结直肠癌治疗的代谢

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-06-07 DOI: 10.1002/agt2.70383

Shaomin Zou, Dan Zhong, Song Xiang, Jieping Zhang, Ruijia Zhang, Ziqing Yang, Manqi Meng, Kuiheng Chen, Ling Fang, Bart Ghesquiere, Hai-Tao Feng, Ben Zhong Tang, Lekun Fang

{"title":"AIEgen Targets the STAT3‒SUCLG2 Axis to Regulate Metabolism for Colorectal Cancer Theranostics","authors":"Shaomin Zou, Dan Zhong, Song Xiang, Jieping Zhang, Ruijia Zhang, Ziqing Yang, Manqi Meng, Kuiheng Chen, Ling Fang, Bart Ghesquiere, Hai-Tao Feng, Ben Zhong Tang, Lekun Fang","doi":"10.1002/agt2.70383","DOIUrl":"https://doi.org/10.1002/agt2.70383","url":null,"abstract":"The integration of precise diagnosis with mechanism-based therapy remains a pivotal challenge in colorectal oncology. Here, building on the triphenylamine (TPA) core, we employed a donor‒acceptor (D‒A) molecular design strategy by integrating a pyridinium acceptor to engineer TPA-FB, a derivative exhibiting aggregation-induced emission (AIE) characteristic. Both in vitro and in vivo experiments demonstrated that TPA-FB functioned as an effective theranostic agent against colorectal cancer (CRC). Prompted by its molecular structure and notable biological activity, we sought to identify its specific cellular target. We discovered that TPA-FB directly binds to and inhibits the phosphorylation of STAT3, leading to downregulation of SUCLG2. Suppression of SUCLG2 thereby disrupts the tricarboxylic acid (TCA) cycle, reducing succinate and its downstream metabolites, which also disrupts critical protein succinylation modifications. By employing our designed AIEgen to selectively disrupt the STAT3‒SUCLG2 axis, we offer a transformative perspective for the development of CRC therapeutics.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Polaronic Exciton in A-Type 2D van der Waals Bulk Material CrSBr a型二维范德华块状材料CrSBr中的磁极化子

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-06-04 DOI: 10.1002/agt2.70371

Xiaodong Shen, Jiajun Cao, Weizheng Liang, Borong Cong, Bao Ke, Jialong Zhao, Bingsuo Zou

{"title":"Magnetic Polaronic Exciton in A-Type 2D van der Waals Bulk Material CrSBr","authors":"Xiaodong Shen, Jiajun Cao, Weizheng Liang, Borong Cong, Bao Ke, Jialong Zhao, Bingsuo Zou","doi":"10.1002/agt2.70371","DOIUrl":"https://doi.org/10.1002/agt2.70371","url":null,"abstract":"Two-dimensional van der Waals magnetic semiconductors offer unprecedented opportunities to explore coupled magnetic and excitonic phenomena. Through femtosecond transient absorption spectroscopy and density functional theory calculations, we identify the charge-transfer band edge in CrSBr near 500 nm (2.48 eV) and correlate distinct photoluminescence (PL) channels with Cr3+ coordination environments. Temperature-dependent measurements reveal that 720 nm emission (PL1) persists across all temperatures, consistent with isolated Cr3+ centers; ∼920 nm emission (PL2) intensifies near the ferromagnetic (FM) transition (140 K); and 990 nm emission (PL3) appears only in thick samples below the antiferromagnetic (AFM) transition (132 K). Under strong perpendicular magnetic fields with 488 nm excitation, we observe a dark-state exciton at ∼850 nm, with anticorrelated intensity variations between PL1/dark-state and PL2/PL3, demonstrating field-tuned energy redistribution. These findings establish magnetic polaronic excitons in van der Waals semiconductors and enable manipulation of excitonic properties through magnetic order control.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphagnum-Inspired Multi-Chamber Layered Aerogel Scaffolds for Portable Photothermal Energy Storage With Tunable Heat Dissipation 用于可调散热便携式光热储能的sphagus - inspired多层气凝胶支架

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-06-03 DOI: 10.1002/agt2.70369

ZhuCheng Jiang, Fei Zhang, LingHang Wang, FuLai Zhao, YanZhao Yang, Wei Feng

{"title":"Sphagnum-Inspired Multi-Chamber Layered Aerogel Scaffolds for Portable Photothermal Energy Storage With Tunable Heat Dissipation","authors":"ZhuCheng Jiang, Fei Zhang, LingHang Wang, FuLai Zhao, YanZhao Yang, Wei Feng","doi":"10.1002/agt2.70369","DOIUrl":"https://doi.org/10.1002/agt2.70369","url":null,"abstract":"Portable phase-change composite (PCC) materials with rapid heat storage and leakage suppression capabilities are crucial for heating supply and temperature regulation under complex environmental conditions; however, their development remains challenging. Inspired by the serial multi-chamber water-retention architecture of Sphagnum, a polyimide/MXene/etched zeolitic imidazolate framework-8 phase-change energy storage composite platform (sPMZ) was designed. The biomimetic hierarchical porous architecture, featuring aligned microcavities and nanopores, generated multiscale capillary forces that effectively suppress phase-change material leakage, enabling a paraffin loading of 85.3% while maintaining structural integrity over repeated thermal charging–discharging cycles. The incorporation of the biomimetic architecture increased the specific surface area of the sPMZ platform by 1198%, enhanced the thermal conductivity of the resulting PCC prepared by paraffin impregnation into sPMZ by 43.7%, and delivered a melting enthalpy of 119.5 J·g−1 with a relative enthalpy efficiency of 94.6%. In addition, the photothermal conversion efficiency attained 90.7%. Through photothermal conversion measurements, practical irradiation assessments, and integrated control of energy storage and heat dissipation, the feasibility and tunability of the Sphagnum-inspired strategy were validated, paving the way for developing portable thermal storage devices with rapid heat charging and suppressed leakage.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148173988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Efficient Short-Wavelength Infrared OLEDs at 1000 nm via Phosphorescent-Host Engineering 通过磷光主机工程实现的1000纳米高效短波长红外oled

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-06-03 DOI: 10.1002/agt2.70381

Zi-Qi Feng, You-Jun Yu, Zi-Yu Song, Dong-Ying Zhou, Zuo-Quan Jiang, Liang-Sheng Liao

{"title":"Highly Efficient Short-Wavelength Infrared OLEDs at 1000 nm via Phosphorescent-Host Engineering","authors":"Zi-Qi Feng, You-Jun Yu, Zi-Yu Song, Dong-Ying Zhou, Zuo-Quan Jiang, Liang-Sheng Liao","doi":"10.1002/agt2.70381","DOIUrl":"https://doi.org/10.1002/agt2.70381","url":null,"abstract":"Short-wavelength infrared (SWIR) organic light-emitting diodes (OLEDs) are highly attractive for applications in night vision, bio-imaging, and optical communication, yet achieving efficient emission beyond 900 nm remains challenging due to severe non-radiative losses and limited exciton utilization. Here, we introduce a phosphorescent-host-based exciton management strategy, in which phosphorescent materials function as hosts rather than conventional sensitizers. By simultaneously harvesting singlet and triplet excitons, this approach enables highly efficient SWIR OLEDs with an emission peak at 1000 nm. The resulting devices deliver a record external quantum efficiency (EQE) exceeding 0.22% and a radiance of 1805 mW sr−1 m−2, representing record performance for SWIR OLEDs. Photophysical studies reveal that host-mediated exciton management and triplet energy confinement are critical to suppressing energy-loss pathways. This work establishes a general host-engineering strategy for extending OLED emission into the SWIR region.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148173989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy 整合溶瘤病毒工程和增强癌症病毒治疗的递送策略

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-06-03 DOI: 10.1002/agt2.70380

Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding

{"title":"Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy","authors":"Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding","doi":"10.1002/agt2.70380","DOIUrl":"https://doi.org/10.1002/agt2.70380","url":null,"abstract":"Oncolytic virotherapy represents a compelling strategy for cancer immunotherapy, integrating direct tumor cell lysis with the activation of systemic antitumor immunity. Despite its therapeutic promise, clinical translation remains fundamentally limited by inefficient viral delivery, rapid immune clearance, and the highly immunosuppressive tumor microenvironment (TME). These barriers have shifted the field from virus-centric optimization alone toward integrated engineering strategies that jointly modulate viral design, delivery platforms (e.g., cell-based, microbial, or engineered systems), and host immunity. This review examines how genetic engineering has improved the potency and selectivity of oncolytic viruses (OVs) under local administration, and how delivery platforms have expanded these capabilities by enabling viral protection, controlled release, and microenvironmental modulation. In addition, emerging strategies for systemic delivery, including molecular camouflage, carrier-mediated transport, and biomimetic nanosystems designed to overcome immune neutralization and enhance tumor targeting, are discussed. Finally, we outline key design principles for the next generation of oncolytic virotherapy, emphasizing the need for spatiotemporally controlled, immune-integrated delivery systems that can support safe and effective systemic treatment.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregation of Ag6-Derived Clusters in Dialdehyde Hydroxypropyl Methylcellulose for Fluorescent Security Ink 荧光安全油墨用二醛羟丙基甲基纤维素中ag6衍生团簇的聚集

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-05-29 DOI: 10.1002/agt2.70378

Zijun Zhang, Jinpeng Li, Kefu Chen

{"title":"Aggregation of Ag6-Derived Clusters in Dialdehyde Hydroxypropyl Methylcellulose for Fluorescent Security Ink","authors":"Zijun Zhang, Jinpeng Li, Kefu Chen","doi":"10.1002/agt2.70378","DOIUrl":"https://doi.org/10.1002/agt2.70378","url":null,"abstract":"Aggregation-induced emission (AIE) is a powerful route to amplify weakly emissive metal nanoclusters, yet simultaneously achieving AIE, structural precision, and ink compatibility remains challenging. Here, we demonstrate an aldehyde-functional cellulose ether as a soft, switchable template that regulates aggregation and emission of Ag6-derived cluster species. Periodate oxidation converts hydroxypropyl methylcellulose (HPMC) into dialdehyde HPMC (DHPMC), which forms swollen, homogeneous domains in water but collapses into confining microenvironments in ethanol-rich media. In the presence of 2-mercaptonicotinic acid (H2mna), DHPMC promotes the formation of Ag6-derived cluster species; the corresponding Ag6(H2mna)6 crystalline core is established in the crystalline state by single-crystal X-ray diffraction, while negative-mode ESI-MS supports the presence of Ag6-derived species in solution. Notably, DHPMC converts inefficient aggregation into emissive aggregation. In 85 vol% ethanol, DHPMC/H2mna@AgNCs shows a dominant emission at 578 nm (λex = 385 nm), a quantum yield of 1.70%, and an average lifetime of 63.64 ns, reflecting suppressed non-radiative decay in a microenvironment-sensitive excited state. Structural and microscopic analyses further indicate that, in the presence of H2mna, the DHPMC-containing formulations favor cluster-derived Ag-containing domains rather than plasmonic Ag nanoparticles. Coupled with printing-adapted rheology and antibacterial performance, this platform enables fluorescent patterns and latent fingerprint visualization, providing a practical polymer-cluster co-design strategy for multifunctional security inks.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Plasmonic Group 4 Transition Metal Carbide Interfaces for Solar-Driven Desalination 撤回：等离子体群4过渡金属碳化物界面用于太阳能驱动的海水淡化

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-05-29 DOI: 10.1002/agt2.70373

{"title":"RETRACTION: Plasmonic Group 4 Transition Metal Carbide Interfaces for Solar-Driven Desalination","authors":"","doi":"10.1002/agt2.70373","DOIUrl":"https://doi.org/10.1002/agt2.70373","url":null,"abstract":"<div>\u0000 \u0000 M.J. Margeson, M. Atwood, Y.E. Monfared, and M. Dasog, “Plasmonic Group 4 Transition Metal Carbide Interfaces for Solar-Driven Desalination,” Aggregate 5, no. 4 (2024): e531, https://doi.org/10.1002/agt2.531.\u0000 The above article, published online on 5 March 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor-in-Chief, Ben Zhong Tang; and John Wiley & Sons Australia, Ltd. The corresponding author notified the journal that when performing post-publication work intended to extend this study, discrepancies were identified between newly collected microscopy data and several images reported in this article. The authors undertook a thorough internal review of the underlying data. As a result of this review, they determined that multiple microscopy images in Figure 4 were not original to the study, and that the lead author had taken these images from an earlier article by a different author (Bercea 2022: https://doi.org/10.3390/polym14122365). The corresponding author has requested a retraction on behalf of the authors. Due to the falsified data, the editor agrees that the article must be retracted.\u0000 </div>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70373","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isomer Engineering of NIR-II Aggregation-Induced Emission for the Theranostics of MRSA-Induced Abscess NIR-II聚集诱导发射异构体工程治疗mrsa诱导脓肿

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2026-05-29 DOI: 10.1002/agt2.70376

Wentian Zhang, Haifei Wen, Ximing Chen, Tianxing Liu, Yuanyuan Li, Zhiliang Yu, Linjie Tan, Shichuang Xu, Parvej Alam, Zheng Zhao, Ying Li, Junfeng Dong, Ben Zhong Tang

{"title":"Isomer Engineering of NIR-II Aggregation-Induced Emission for the Theranostics of MRSA-Induced Abscess","authors":"Wentian Zhang, Haifei Wen, Ximing Chen, Tianxing Liu, Yuanyuan Li, Zhiliang Yu, Linjie Tan, Shichuang Xu, Parvej Alam, Zheng Zhao, Ying Li, Junfeng Dong, Ben Zhong Tang","doi":"10.1002/agt2.70376","DOIUrl":"https://doi.org/10.1002/agt2.70376","url":null,"abstract":"The escalating crisis of antimicrobial resistance poses an urgent threat to global public health. Conventional photodynamic therapy (PDT) is limited by oxygen dependence and restricted light penetration, which can compromise its therapeutic efficacy in the hypoxic microenvironment of deep abscesses. Herein, we report a positional isomer engineering strategy that transforms a thioxanthene (THX) scaffold into aggregation-induced emission luminogens (AIEgens) with fluorescence extending into the second near-infrared (NIR-II) window and dual-modal therapeutic capability. Theoretical and photophysical studies revealed that the para-configured isomer (Ph-p-THX) exhibited a smaller energy gap and higher oscillator strength than its meta-counterpart (Ph-m-THX). These electronic features provide more favorable singlet-triplet energy alignment, thereby supporting triplet-involved Type-I-dominant mixed reactive oxygen species (ROS) generation under hypoxic-relevant conditions associated with abscess microenvironments. In parallel, the narrowed energy gap and enhanced light-harvesting capability contribute to efficient photothermal conversion. As a result, Ph-p-THX enabled NIR-II imaging-guided treatment and exhibited superior antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) abscesses in vivo. Overall, this study highlights positional isomerization as an effective strategy for optimizing THX-based AIE photosensitizers for antimicrobial theranostic applications.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"7 6","pages":""},"PeriodicalIF":13.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0