Aggregate (Hoboken, N.J.)最新文献_第8页

Immunostimulatory DNA Tetrahedron-Based Nanovaccine Combined With Immune Checkpoint PD-1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma 免疫刺激DNA四面体纳米疫苗联合免疫检查点PD-1阻断剂增强口腔鳞状细胞癌的全身免疫应答

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-13 DOI: 10.1002/agt2.70061

Xueting Yang, Yun Wang, Yan Yang, Sicheng Zhang, Dianri Wang, Yi Luo, Chunyan Shui, Yongcong Cai, Ruoyi Yang, Shuang Dong, Mu Yang, Yunfeng Lin, Chao Li

{"title":"Immunostimulatory DNA Tetrahedron-Based Nanovaccine Combined With Immune Checkpoint PD-1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma","authors":"Xueting Yang, Yun Wang, Yan Yang, Sicheng Zhang, Dianri Wang, Yi Luo, Chunyan Shui, Yongcong Cai, Ruoyi Yang, Shuang Dong, Mu Yang, Yunfeng Lin, Chao Li","doi":"10.1002/agt2.70061","DOIUrl":"https://doi.org/10.1002/agt2.70061","url":null,"abstract":"Despite advancements in immune checkpoint blockade (ICB) therapies for treating various tumors, the immunosuppressive environment in oral squamous cell carcinoma (OSCC) significantly limits therapeutic efficacy. Tumor vaccines, which offer great potential for cancer immunotherapy, still face challenges like potential mutation risks, rapid elimination, and low in vivo delivery efficiency. In this study, we fabricate an immunostimulatory nanovaccine using tetrahedral framework nucleic acids (tFNAs) as a carrier for stable and efficient delivery of CpG oligonucleotide. Then an intensive tumor immunotherapeutic strategy by combining tFNA-CpG nanovaccine with PD-1 inhibitor is used in OSCC tumor-bearing mice. Intravenous administration of the tFNA-CpG nanovaccine effectively activates the antigen-presenting cells (APCs), resulting in an increased proportion of M1-like macrophages and mature dendritic cells, accompanied by heightened production of inflammatory cytokines IL-1β, IL-12, and IL-6. When combined with ICB therapy, the anti-PD-1 drug inhibits the PD-1/PD-L1 interaction within tumor microenvironment. Subsequently, the APCs activated by tFNA-CpG facilitate the phenotypic differentiation of T cells, resulting in a substantial boost in infiltration of cytotoxic T cells (expressing IFN-γ and Granzyme B) in both lymph nodes and tumor tissues, thereby executing a potent antitumor effect and inhibiting the progression of OSCC tumors in C3H mouse. Therefore, this study presents an attractive approach to overcoming current ICB limitations in OSCC immunotherapy and provides new avenues for future clinical practice.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the Gap Between Traditional and Nontraditional Luminogens With Strong Non-Aromatic Through-Bond Conjugation and Through-Space Conjugation 用强非芳香的全键共轭和全空间共轭来弥合传统和非传统发光物质之间的差距

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-12 DOI: 10.1002/agt2.70063

Xiaomi Zhang, Yunhao Bai, Junwen Deng, Xuanshu Zhong, Jinsheng Xiao, Wendi Xie, Huiliang Wang

{"title":"Bridging the Gap Between Traditional and Nontraditional Luminogens With Strong Non-Aromatic Through-Bond Conjugation and Through-Space Conjugation","authors":"Xiaomi Zhang, Yunhao Bai, Junwen Deng, Xuanshu Zhong, Jinsheng Xiao, Wendi Xie, Huiliang Wang","doi":"10.1002/agt2.70063","DOIUrl":"https://doi.org/10.1002/agt2.70063","url":null,"abstract":"The development of nontraditional luminogens (NTLs) with superior photoluminescence (PL) properties is of great scientific and practical significance and has drawn rapidly growing interest in recent years. An extremely important but unresolved question is that if there are any distinct differences in the structures and PL mechanisms between traditional luminogens (TLs) and NTLs. In this work, four dihydropyridine derivatives with strong non-aromatic through-bond conjugation (TBC) were designed and synthesized, and the influence of strong non-aromatic TBC and through-space conjugation (TSC) effects on their PL behaviors was studied. These compounds in solutions show significant concentration-dependent emission (CDE) and excitation-dependent emission (EDE), which are typical PL behaviors of NTLs. In solid state, the compounds show wide excitation spectra while narrow emission spectra, with high quantum yields up to 57.4%, but they do not show significant EDE, similar to TLs. And very impressively, two kinds of crystals also exhibit optical waveguide property, which is the first report in NTLs. The UV–vis spectra, crystal structures, and theoretical calculations prove the presence of large non-aromatic TBC interactions in these NTLs, and strong non-aromatic TSC can be formed among the molecules that are in a planar conformation and stacked into layers through intermolecular hydrogen bonding and π⋅⋅⋅π interactions. The combined effect of strong non-aromatic TBC and TSC endows the compounds unique PL behaviors that are between those of TLs and NTLs, thus bridging the gap between TLs and NTLs.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral Amplification and Regulation: Design and Applications of Circularly Polarized Luminescence-Active Materials Derived From Macrocyclic Compounds 手性放大与调控：大环化合物衍生圆偏振发光活性材料的设计与应用

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-09 DOI: 10.1002/agt2.70039

Wei Zhang, Mao-Qin Liu, Yang Luo

{"title":"Chiral Amplification and Regulation: Design and Applications of Circularly Polarized Luminescence-Active Materials Derived From Macrocyclic Compounds","authors":"Wei Zhang, Mao-Qin Liu, Yang Luo","doi":"10.1002/agt2.70039","DOIUrl":"https://doi.org/10.1002/agt2.70039","url":null,"abstract":"Chirality is a fundamental property in molecules and biological systems, characterized by asymmetric configurational features. Circularly polarized luminescence (CPL) materials have gained significant attention due to their unique optical activities, with applications in 3D displays, chiral sensors, asymmetric catalysis, and more. Chiral transfer and amplification typically involve the generation of chirality in the excited state, facilitated by interactions like energy transfer, electron transfer, or chiral induction. Supramolecular self-assembly strategies, particularly macrocyclic compounds, enable chiral amplification by linking chiral and achiral luminescent units through intermolecular interactions. Macrocyclic hosts—cyclodextrins, calix[n]arenes, pillar[n]arenes, chiral cyclophanes, and cucurbit[n]urils—are especially promising due to their stable structures and adjustable cavities for guest encapsulation. These compounds induce unique photophysical properties through host–guest complexation, making them ideal for constructing chiral transfer, amplification, and CPL-active materials. This review summarizes their advancements in multicolor CPL materials, chiral sensing, induction, asymmetric catalysis, and separation, highlighting their potential in supramolecular chiral material design. The challenges and future directions of this field are also discussed, aiming to guide further research and application in supramolecular chiral systems.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of Active Sites-Accessible Au8 Clusters for Intensive Tumor Pyroptosis 构建活性位点可达的Au8细胞簇用于恶性肿瘤焦亡

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-08 DOI: 10.1002/agt2.70046

Qiu-Xu Zang, Wei-Tong Chen, Wenjing Zhang, Zhao-Yang Wang, Xi-Yan Dong, Runping Han, Yanjuan Sang, Xiaoyuan Chen, Shuang-Quan Zang

{"title":"Construction of Active Sites-Accessible Au8 Clusters for Intensive Tumor Pyroptosis","authors":"Qiu-Xu Zang, Wei-Tong Chen, Wenjing Zhang, Zhao-Yang Wang, Xi-Yan Dong, Runping Han, Yanjuan Sang, Xiaoyuan Chen, Shuang-Quan Zang","doi":"10.1002/agt2.70046","DOIUrl":"https://doi.org/10.1002/agt2.70046","url":null,"abstract":"Atomically precise gold nanoclusters (NCs), possessing characteristics of molecules and nanoparticles, offer a promising solution to the challenges faced by existing pyroptosis inducers. Their abilities to catalyze the generation of reactive oxygen species and enhance radiosensitization position them as effective agents for activating pyroptosis. However, their catalytic efficiency is often compromised by limited geometrically accessible spaces around the active sites and the lack of suitable ligands. Leveraging the exposed metal centers in mononuclear organometallic catalysts and the tunable ligand of NCs, herein, ethynylferrocene (EFc) was utilized to amplify the peroxidase (POD)-like activity of gold NCs by establishing the unshielded catalytic center and electron donor-acceptor interaction between EFc and Au core. The resulting Au8Fe2 NCs with excellent POD-mimicking activity could efficiently trigger pyroptosis by inducing intracellular oxidative stress. Moreover, the Au8Fe2 NCs, with their potential to deplete glutathione and enable magnetic resonance imaging, could also induce ferroptosis and serve as a diagnostic tool for tumors. All of these processes can be further potentiated by X-ray radiation, taking advantage of the high atomic number of gold. This work opens new avenues for engineering the catalytic properties of NCs and broadens their potential applications in biomedicine.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation of the Most Iodine-Rich Polyiodide [I13]− in Pore-Partitioned Metal-Organic Frameworks for Efficient Iodine Capture 多孔金属-有机骨架中最富碘多碘化物[I13]−的形成及高效碘捕获

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-08 DOI: 10.1002/agt2.70051

Feng-Yu Chen, Xin-Xin Lu, Yu-Hui Luo, Jie Li, Dong-En Zhang, Yong Yan

{"title":"Formation of the Most Iodine-Rich Polyiodide [I13]− in Pore-Partitioned Metal-Organic Frameworks for Efficient Iodine Capture","authors":"Feng-Yu Chen, Xin-Xin Lu, Yu-Hui Luo, Jie Li, Dong-En Zhang, Yong Yan","doi":"10.1002/agt2.70051","DOIUrl":"https://doi.org/10.1002/agt2.70051","url":null,"abstract":"Radioactive iodine produced from nuclear fission in power plants presents substantial environmental risks and requires effective remediation measures. Metal-organic frameworks (MOFs) containing specifically designed pore geometries with stable skeletons that allow dense packing of guest molecules are sought after for iodine capture. Here, 14 new MOFs were developed through reticular chemistry for a comprehensive study of the iodine capture behavior. Remarkably, one of this family of materials, JOU-20(FeCo2), exhibited an exceptional static vapor iodine uptake capacity of 3.08 g/g at 80°C and a high iodine storage density of 4.69 g/cm3. Significantly, single-crystal X-ray diffraction revealed the adsorbed iodine in JOU-20(FeCo2) forming an unusual aggregation of the giant trigonal antiprismatic polyiodide anion [I13]−. To the best of our knowledge, this is the first time that the polyiodide [I13]− was structurally resolved in a crystalline framework, and it represents the most iodine-rich polyiodide species ever discovered experimentally. Combined spectroscopy and theoretical calculation methods demonstrated that nitrogen/sulfur sites and metal nodes play critical roles in stabilizing [I13]−. This work introduces a pore partition strategy to create a confined space with specific pore geometry for the formation of unusual polyiodide [I13]−, and multiple binding sites for stabilizing it, which significantly enhances the iodine adsorption performance of MOFs.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Engineering-Boosted High-Performance AIE Sonosensitizer for Cancer Sonodynamic-Augmented Immunotherapy 分子工程-增强高性能AIE声敏剂用于癌症声动力增强免疫治疗

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-07 DOI: 10.1002/agt2.70058

Chao Fu, Wei Zhao, Xionglei Wang, Xia He, Yuting Yin, Jiayi Li, Qiyun Deng, Caihong Yan, Yuli Yin, Zhiming Wang, Rong Hu

{"title":"Molecular Engineering-Boosted High-Performance AIE Sonosensitizer for Cancer Sonodynamic-Augmented Immunotherapy","authors":"Chao Fu, Wei Zhao, Xionglei Wang, Xia He, Yuting Yin, Jiayi Li, Qiyun Deng, Caihong Yan, Yuli Yin, Zhiming Wang, Rong Hu","doi":"10.1002/agt2.70058","DOIUrl":"https://doi.org/10.1002/agt2.70058","url":null,"abstract":"Immunogenic cell death (ICD) has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity. However, the trigger of ICD on the basis of chemotherapy and phototherapy meets the obstacles of serious side effect and poor penetration ability, which seriously impedes the therapeutic effect. The development of sonodynamic immunotherapy with the evoking of ICD presents high promise for cancer treatment with high efficacy. Herein, high performance aggregation-induced emission (AIE) sonosensitizer is constructed on the basis of the engineering structure modulation for sonodynamic-augmented immunotherapy. By regulating the intermolecular interaction and pull-push electronic effect, sonosensitizer bearing AIE feature and amplified sono-sensitizing effect is developed. In addition, in vitro observation demonstrated that thiolate-substituted segment incorporation endows the molecules with enhanced cellular uptake efficiency and improved tumor cell eradication ability. More importantly, the developed sonosensitizer could efficiently evoke ICD upon the trigger of ultrasound, which allows for the efficient tumor eradication both at cellular level and in solid tumor. The inhibition of primary tumor and further boost systemic immunity response with the complete elimination toward the distant tumor is achieved. The investigation highlights the promise of utilizing AIE sonosensitizers in sonodynamic immunotherapy to conquer the current limitation of immunotherapy in solid tumor treatment.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Membrane-Coated Lipid Nanoparticles for Drug Delivery 用于药物递送的细胞膜包被脂质纳米颗粒

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-05 DOI: 10.1002/agt2.70054

Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun-Xia Zhao, Yun Liu

{"title":"Cell Membrane-Coated Lipid Nanoparticles for Drug Delivery","authors":"Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun-Xia Zhao, Yun Liu","doi":"10.1002/agt2.70054","DOIUrl":"https://doi.org/10.1002/agt2.70054","url":null,"abstract":"Cell membrane coating (CMC) of nanoparticles (NPs) has emerged as a prominent strategy that has gained significant attention and achieved notable progress across various therapeutic sectors. Coating NPs with natural cell membranes endows them with various functions and addresses various challenges in drug delivery, such as prolonging circulation time, reducing immunogenicity, and improving targeting efficiency and cellular communication. Among the different NPs, lipid nanoparticles (LNPs) have revolutionized the field of nanomedicine by providing various advantageous features for drug delivery. The versatile characteristics of LNPs synergize well with cell membranes’ biomimetic properties, creating hybrid structures with enhanced functionalities for diverse biomedical applications. A more advanced form of LNPs with significantly enhanced capabilities can be achieved through CMC. However, significant opportunities remain for further advancements, with ongoing efforts focused on discovering innovative applications and fully harnessing the potential of this promising combination. This article provides a critical review of recent progress in cell membrane coated-LNPs (CMC-LNPs). First, different LNP types, their preparation methods, and coating strategies are summarized. The development, properties, functions, and applications of CMC-LNPs are then discussed. Last, their advantages, limitations, challenges, and future perspectives are presented.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “[Droplets Cas13a-RPA Measurement Delineates Potential Role For Plasma CircWDR37 in Colorectal Cancer]” 更正“[液滴Cas13a-RPA测量描述血浆CircWDR37在结直肠癌中的潜在作用]”

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-01 DOI: 10.1002/agt2.70056

引用次数: 0

An NIR-III 3P Excitable AIE Nanoprobe for High-Quality Intravital Deep-Brain Angiography 用于高质量活体脑深部血管造影的NIR-III 3P可激发AIE纳米探针

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-05-01 DOI: 10.1002/agt2.70055

Zhijun Zhang, Hui Cheng, Zengming Yang, Xiangquan Deng, Miaomiao Kang, Ping Qiu, Ke Wang, Dong Wang, Ben Zhong Tang

{"title":"An NIR-III 3P Excitable AIE Nanoprobe for High-Quality Intravital Deep-Brain Angiography","authors":"Zhijun Zhang, Hui Cheng, Zengming Yang, Xiangquan Deng, Miaomiao Kang, Ping Qiu, Ke Wang, Dong Wang, Ben Zhong Tang","doi":"10.1002/agt2.70055","DOIUrl":"https://doi.org/10.1002/agt2.70055","url":null,"abstract":"Three-photon (3P) fluorescence imaging (FLI) utilizing excitation wavelengths within the near-infrared-III (NIR-III, 1600–1870 nm) window has emerged as a transformative modality for intravital imaging, owing to its combined advantages of excellent spatiotemporal resolution and remarkable tissue penetration. High-performance fluorescent probes are the cornerstone of high-quality NIR-III 3P FLI. However, the construction of such probes is often hindered by inherent trade-offs in molecular design principles, posing significant challenges for their performance optimization and practical application. Here, we propose a straightforward and effective strategy based on π-bridge manipulation to reconcile those competing molecular design parameters and substantially enhance 3P fluorescence properties. Leveraging this approach, a robust AIE-active small molecule, named TSSID, was developed, which exhibits bright NIR-I (700–950 nm) emission under 1665 nm NIR-III 3P excitation when formulated into nanoparticles (NPs). Remarkably, upon retro-orbital injection into mice following craniotomy, TSSID NPs achieved the best performance in deep-brain angiography among all reported organic 3P materials in terms of vascular imaging depth, signal-to-background ratio, spatial resolution, and hemodynamic imaging depth. Additionally, TSSID NPs demonstrated outstanding biocompatibility through systematic biosafety evaluations. This study provides an excellent imaging agent and useful molecular design philosophy, facilitating the development of advanced organic 3P FLI probes.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 7","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exactly Restricting the Phenyl Ring Rotation in Metal-Organic Framework for Ultra-Sensitive and Specific Ratiometric Fluorescent Sensing of Sarin 精确限制金属-有机骨架中苯环旋转的超灵敏比荧光检测沙林

IF 13.7

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-30 DOI: 10.1002/agt2.70053

Cong Lyu, Chuanfang Zhao, Meimei Wang, Jiawen Li, Zhenzhen Cai, Xincun Dou, Baiyi Zu

{"title":"Exactly Restricting the Phenyl Ring Rotation in Metal-Organic Framework for Ultra-Sensitive and Specific Ratiometric Fluorescent Sensing of Sarin","authors":"Cong Lyu, Chuanfang Zhao, Meimei Wang, Jiawen Li, Zhenzhen Cai, Xincun Dou, Baiyi Zu","doi":"10.1002/agt2.70053","DOIUrl":"https://doi.org/10.1002/agt2.70053","url":null,"abstract":"To realize highly sensitive and specific sensing toward sarin, an Eu(III) based metal-organic framework (Eu-CTTB-MOF), encompassing a π-conjugated organic ligand H4CTTB (4,4′,4″,4‴-(9H-carbazole-1,3,6,8-tetrayl)tetrabenzoic acid) was explored for ratiometric fluorescent sensing. An unprecedented specific recognition of nerve-agent sarin mimic diethyl chlorophosphate (DCP) in the presence of HCl interferent and a low limit of detection (LOD, 20.97 nM) were achieved. This excellent detection performance is driven by the dual hydrogen bonding and hydrophobic interaction between the CTTB organic ligand and DCP, which would cause a dramatic change in the molecular configuration of the CTTB ligand. Density functional theory (DFT) calculations further verify the recognition of DCP by Eu-CTTB-MOF could suppress the rotations of the aromatic rings in CTTB ligand, significantly reducing the nonradiative decay pathways and subsequently enhancing the fluorescent intensity of the CTTB ligand. Especially, the Eu-CTTB-MOF enables the immediate response to DCP vapor and excellent specificity towards DCP even in the presence of 18 types of interferents, including HCl vapor, structural analogs, and volatile organic solvent, and a gas detector with accurate detection of DCP in simulated scenarios, positioning the designed MOF as a promising sensing material for practical scenarios. We expect that the present sensing strategy will shine a light on the development of brand-new sensing materials for on-site detection applications.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 8","pages":""},"PeriodicalIF":13.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0