Aggregate (Hoboken, N.J.)最新文献

{"title":"Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects","authors":"Nadezhda A. Pechnikova,&nbsp;Kalliopi Domvri,&nbsp;Konstantinos Porpodis,&nbsp;Maria S. Istomina,&nbsp;Aleksandra V. Iaremenko,&nbsp;Alexey V. Yaremenko","doi":"10.1002/agt2.707","DOIUrl":"https://doi.org/10.1002/agt2.707","url":null,"abstract":"<p>Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress in utilizing CQDs for drug delivery, bioimaging, biosensing, and cancer therapy. With their unique optical properties, such as tunable fluorescence, high quantum yield, and photostability, CQDs enable precise bioimaging and sensitive biosensing. Their small size, biocompatibility, and ease of surface functionalization allow for the development of targeted drug delivery systems, enhancing therapeutic precision and minimizing side effects. In cancer therapy, CQDs have shown potential in photodynamic and photothermal treatments by generating reactive oxygen species under light exposure, selectively targeting cancer cells while sparing healthy tissues. Furthermore, CQDs’ ability to penetrate biological barriers including the blood–brain barrier opens new possibilities for delivering therapeutic agents to hard-to-reach areas, such as tumors or diseased tissues. However, challenges such as optimizing synthesis, ensuring long-term stability, and addressing safety concerns in biological environments remain critical hurdles. This review discusses current efforts to overcome these barriers and improve CQD performance in clinical settings, including scalable production methods and enhanced biocompatibility. As research progresses, CQDs are expected to play an important role in improving healthcare by offering more targeted treatment options and contributing to advancements in personalized medicine.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.707","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gram-Negative Bacteria Targeting AIE Photosensitizer for Selective Photodynamic Killing of Vibrio vulnificus","authors":"Hao-Tian Xin,&nbsp;Qiao-Wen Lin,&nbsp;Simin Sun,&nbsp;Yu-Ying Wang,&nbsp;Bing Liu,&nbsp;Wen-Jin Wang,&nbsp;Zong-Wan Mao,&nbsp;Kang-Nan Wang","doi":"10.1002/agt2.709","DOIUrl":"https://doi.org/10.1002/agt2.709","url":null,"abstract":"<p><i>Vibrio vulnificus</i> is a highly virulent Gram-negative bacterium exhibiting extensive resistance to various antibiotics, presenting significant challenges for efficient and selective eradication. Recently, photosensitizer (PS)-based photodynamic therapy has emerged as an effective strategy against bacteria and biofilms. However, traditional PS struggles to penetrate the unique membrane structure of Gram-negative bacteria such as <i>V. vulnificus</i>, while avoiding traversal of the membrane barrier of eukaryotic cells. To address this issue, herein, a PS named BDTP with aggregation-induced emission properties was developed. BDTP can specifically target the DNA of <i>V. vulnificus</i>, but integrate into the cell membrane, preventing damage to the contents in eukaryotic cells due to its hydrophilic/lipophilic “Y-shaped” structural characteristics. In dark conditions, BDTP functions as an antibiotic, inhibiting bacterial proliferation. Upon white light stimulation, BDTP can induce phototoxic damage to the DNA of <i>V. vulnificus</i> and effectively inhibit/clear <i>V. vulnificus</i> biofilms. Additionally, the eukaryotic cell membrane barrier significantly reduces PS-induced damage to its nucleic acids. This strategy significantly promotes the healing of infected wounds in <i>V. vulnificus</i>-infected mice. Our work introduces the first PS targeting <i>V. vulnificus</i>-associated infections, demonstrating efficacy both in vitro and in vivo.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term In Vivo Fluorescence Analyses and Imaging-Guided Tumor Surgery in the Second Near-Infrared Window Using a Supramolecular Metallacage","authors":"Yi Qin,&nbsp;Niu Niu,&nbsp;Xue Li,&nbsp;Xueke Yan,&nbsp;Shuai Lu,&nbsp;Zhikai Li,&nbsp;Yixiong Gui,&nbsp;Jun-Long Zhu,&nbsp;Lin Xu,&nbsp;Xiaopeng Li,&nbsp;Dong Wang,&nbsp;Ben Zhong Tang","doi":"10.1002/agt2.708","DOIUrl":"https://doi.org/10.1002/agt2.708","url":null,"abstract":"<p>Long-term in vivo fluorescence analysis is growing into a sparkling frontier in gaining deep insights into various biological processes. Exploration of such fluorophores with high performance still remains an appealing yet significantly challenging task. In this study, we have elaborately integrated a second near-infrared (NIR-II) emissive fluorophore with the metal Pt into a self-assembled prism-like metallacage M-DBTP, which enables the intravital long-term tracking of the metal Pt through NIR-II fluorescence imaging technologies. In addition, the intravital bioimaging of the metallacage-loaded nanoparticles (NPs) indicated an extraordinary photographic performance on the mice blood vessels and the rapid clearance of M-DBTP NPs from the blood within 7 h. The subsequent transfer to the bones and the retention of NPs in the bone marrow region for up to 35 days was revealed by long-term fluorescence analysis, which was confirmed by the distribution and metabolism of Pt through an inductively coupled plasma optical emission spectrometer. Moreover, the bright emission of M-DBTP NPs in the NIR-II region enables them to well perform on fluorescence imaging-guided tumor surgery.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.708","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring toward a Broader Space: The Upcoming New Voyage of Aggregate","authors":"Ben Zhong Tang","doi":"10.1002/agt2.714","DOIUrl":"https://doi.org/10.1002/agt2.714","url":null,"abstract":"&lt;p&gt;Developing a top-notch journal is a great yet challenging voyage. To sail steadily and speedily toward the ultimate destination, the ship of &lt;i&gt;Aggregate&lt;/i&gt; needs a compass and an engine. The compass is the original aspiration of publishing high-quality research accomplishments on aggregate science, and the engine is the enthusiastic support from the scientific community, including the authors, reviewers, readers, and editorial board members.&lt;/p&gt;&lt;p&gt;In the past four years, &lt;i&gt;Aggregate&lt;/i&gt; enjoyed a successful takeoff followed by high-speed sailing. Now it has arrived at the transition point of the next-stage shipping line, where we should summarize the previous performance and envision the upcoming new voyage toward a broader space.&lt;/p&gt;&lt;p&gt;In 2024, &lt;i&gt;Aggregate&lt;/i&gt; received the 2nd Journal Impact Factor (JIF) of 13.9, maintaining a Q1 ranking in three categories: “Chemistry, Multidisciplinary”, “Chemistry, Physical”, and “Materials Science, Multidisciplinary” based on the Journal Citation Reports (JCR) 2024 published by Clarivate Analytics. For the first time, &lt;i&gt;Aggregate&lt;/i&gt; received a CiteScore&lt;sup&gt;TM&lt;/sup&gt; of 17.4, ranking top 5% and 6% in the categories of “Chemistry: Chemistry (Miscellaneous)” and “Materials Science, Materials Chemistry,” respectively.&lt;/p&gt;&lt;p&gt;Besides the impressive journal metrics mentioned above, 2024 is a year of rapid expansion for &lt;i&gt;Aggregate&lt;/i&gt; in terms of a significant increase in the numbers of manuscript submissions and paper publications, a broader scope of the journal, a stronger editorial board team, and a wider range of authors and reviewers (Figure 1). So proud to say that the “compass” is upgraded, and the “engine” is further empowered!&lt;/p&gt;&lt;p&gt;To date, &lt;i&gt;Aggregate&lt;/i&gt; has received manuscript submissions from international authors in 38 countries/regions. In 2024, &lt;i&gt;Aggregate&lt;/i&gt; has published 185 papers until November 13, 2024 (Figure 1A). Considering the continuous increase in the number of published papers, we have decided to shift &lt;i&gt;Aggregate&lt;/i&gt; from the current bimonthly journal to a monthly journal from 2025. To maintain high quality with increased quantity, we will set a higher standard for prescreening, while keeping our tradition of fast and fair peer review. In the past 12 months, the acceptance rate has gradually dropped and the average times from the submission to the first and final decisions have been shortened to 12 and 25 days, respectively.&lt;/p&gt;&lt;p&gt;&lt;i&gt;Aggregate&lt;/i&gt; aims to grow into a comprehensive and multidisciplinary journal in the area of aggregate science, covering significant advancements and innovative breakthroughs in a wide range of research fields, including chemistry, materials science, physics, engineering, nanotechnology, biology, life science, and so on. &lt;i&gt;Aggregate&lt;/i&gt; encourages paradigm shift in research philosophy and promotes the study of complex systems and processes at higher structural hierarchy across disciplinary boundaries. We emphasize that all the studies beyond","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"5 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.714","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulose-Based Switchable Circularly Polarized Light Emitter: Photo-Actuated Chiral Assemblies With Azobenzene Polymers","authors":"Wenye Sun,&nbsp;Bing Tian,&nbsp;Bang An,&nbsp;Rui Teng,&nbsp;Mingcong Xu,&nbsp;Chunhui Ma,&nbsp;Zhijun Chen,&nbsp;Haipeng Yu,&nbsp;Jian Li,&nbsp;Wei Li,&nbsp;Siqi Huan,&nbsp;Shouxin Liu,&nbsp;Orlando J. Rojas","doi":"10.1002/agt2.712","DOIUrl":"https://doi.org/10.1002/agt2.712","url":null,"abstract":"<p>Circularly polarized luminescent materials find extensive applications in 3D displays, information encryption, and photoinduced supramolecular chirality. However, controlling the handedness of circularly polarized luminescence remains a significant challenge in advancing optical technologies. In this study, we present a Janus circularly polarized light emitter comprising a fluorescent film combined with chiral nematic cellulose with switchable chirality. The emitter achieves maximum luminescence dissymmetry factors (0.28 and −0.65) through mode switching. In addition, we show the emitter's versatility in inducing chiral helices in azobenzene polymers with varying polar groups, resulting in significant chiral signals. Importantly, the chirality of these polymers can be switched by altering the luminescence mode of the emitter. These results are expected to facilitate the efficient design of chiral luminescent materials and photoinduction devices.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAFT Copolymerization of Pt(II) Pincer Complexes With Water-Soluble Polymer as an Efficient Way to Obtain Micellar-Type Nanoparticles With Aggregation-Induced NIR Emission","authors":"Roman A. Shilov,&nbsp;Vadim A. Baigildin,&nbsp;Kristina S. Kisel,&nbsp;Ekaterina E. Galenko,&nbsp;Alexander S. Gubarev,&nbsp;Mariya E. Mikhailova,&nbsp;Olga S. Vezo,&nbsp;Nikolai V. Tsvetkov,&nbsp;Andrey A. Shtyrov,&nbsp;Mikhail N. Ryazantsev,&nbsp;Julia R. Shakirova,&nbsp;Sergey P. Tunik","doi":"10.1002/agt2.713","DOIUrl":"https://doi.org/10.1002/agt2.713","url":null,"abstract":"<p>The idea of preparation a water-soluble Pt-containing AIEgen was successfully realized by direct reversible addition-fragmentation transfer copolymerization of a Pt(II) complex (<b>LPtPV</b>) containing a vinyl group and polyvinylpyrrolidone (<b>p(VP)</b>). The resulting block-copolymer <b>p(VP-<i>b</i>-LPtPV)</b> containing 5–8 Pt(II) chromophores exhibits intriguing photophysical properties—strong solvent and concentration dependence of absorption and emission characteristics. Various physicochemical and analytical methods (NMR spectroscopy, XRD analysis, ESI-MS, AUC, DLS, ICP-OES, GPC, viscometry, TEM) were used to characterize the initial complex, its binuclear analogs, <b>p(VP)</b> and <b>p(VP-<i>b</i>-LPtPV)</b>. The obtained data indicate that the photophysical properties of the latter are dictated by the type of aggregation process rather than solvatochromic effects. It is shown that at low concentration in organic solvents, the platinum chromophores aggregation is either absent (dimethylformamide) or occurs predominantly at intramolecular level (MeCN), whereas in aqueous media, <b>p(VP-<i>b</i>-LPtPV)</b> readily aggregates into micellar-type nanoparticles with a hydrophilic p(VP) corona and a hydrophobic Pt-containing core, in which strong intra- and intermolecular Pt···Pt and/or π···π interactions result in a significant red shift of absorption and emission down to 600 and 816 nm, respectively. Despite of emission shift into NIR area where emission is commonly quenched by nonradiative vibrational relaxation, an increase in the emission quantum yield occurs in complete agreement with the typical aggregation-induced emission (AIE) emitters’ behavior. Quantum mechanics/molecular mechanics simulations of aggregation processes also confirm the trends in the relationship between aggregation mode and photophysical behavior, particularly, in the variations of energy gaps between the ground state of the AIEgens and their excited singlet and triplet states.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.713","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy","authors":"Haiqiao Huang,&nbsp;Qiang Liu,&nbsp;Jing-Hui Zhu,&nbsp;Yunkang Tong,&nbsp;Daipeng Huang,&nbsp;Danhong Zhou,&nbsp;Saran Long,&nbsp;Lei Wang,&nbsp;Mingle Li,&nbsp;Xiaoqiang Chen,&nbsp;Xiaojun Peng","doi":"10.1002/agt2.706","DOIUrl":"https://doi.org/10.1002/agt2.706","url":null,"abstract":"<p>Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged promising applications in both fundamental research and clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integrate high photostability, large near-infrared absorptivity, and efficient therapeutic capabilities. Herein, we reported a sample engineering strategy to afford a benzene-fused Cy5 dimer (<b>Cy-D-5</b>) for synergistically boosting PDT/PTT applications. Intriguingly, <b>Cy-D-5</b> exhibits a tendency to form both <i>J</i>-aggregates and <i>H</i>-aggregates in phosphate-buffered saline, which show a long-wavelength absorption band bathochromically shifted to 810 nm and a short-wavelength absorption band hypsochromically shifted to 745 nm, respectively, when compared to its behavior in ethanol (778 nm). Density-functional theory calculations combined with time-resolved transient optical spectroscopy analysis reveal that the fused dimer <b>Cy-D-5</b> exhibits a low Δ<i>E</i>_ST (0.51 eV) and efficient non-radiative transition rates (12.6 times greater than that of the clinically approved PS-indocyanine green [PS-<b>ICG</b>]). Furthermore, the <b>Cy-D-5</b> demonstrates a higher photosensitizing ability to produce ¹O₂, stronger photothermal conversion efficiency (<i>η</i> = 64.4%), and higher photostability compared with <b>ICG</b>. These combined properties enable <b>Cy-D-5</b> to achieve complete tumor ablation upon 808 nm laser irradiation, highlighting its potential as a powerful and dual-function phototherapeutic agent. This work may offer a practical strategy for engineering other existing dyes to a red-shifted spectral range for various phototherapy applications.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.706","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Platelets for Cancer Therapy","authors":"Kai Zhang,&nbsp;Hongyang Li,&nbsp;Zhaoyu Ma,&nbsp;Wenbin Zhong,&nbsp;Yongkang Yu,&nbsp;Yanli Zhao","doi":"10.1002/agt2.704","DOIUrl":"https://doi.org/10.1002/agt2.704","url":null,"abstract":"<p>While nanomedicine research shows a great progress in the treatment of cancer, it still faces challenges of tumor recurrence and metastasis. Numerous studies have demonstrated intricate crosstalk between platelets and tumor cells. The re-education of platelets by tumor cells enables these platelets to provide critical assistance for tumor proliferation, recurrence, and metastasis. Engineered platelets have shown promising potential in the treatment of tumors, postoperative tumor recurrence, and tumor metastasis. Different engineering technologies such as surface modification, gene editing, membrane coating, and loading into hydrogels can produce multifunctional and customized engineered platelets. These engineered platelets inherit the key properties of platelets, including long blood circulation, tumor targeting, and thrombus targeting, and can be stimulated to generate derivatized particles. In this review, we elucidate the critical role of platelets in the complex processes of tumorigenesis and tumor progression and summarize the emerging paradigm of engineered platelets in tumor therapy. The purpose of this review is to comprehensively explore the potential value of engineered platelets toward the clinical treatment of cancer, providing a valuable reference for the further development of engineered platelets and their broader applications in the field of cancer therapy.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.704","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrafast Excitonic Transitions in Enantiopure and Racemic Squaraine Thin Films","authors":"Robin Bernhardt,&nbsp;Lukas Rieland,&nbsp;Tianyi Wang,&nbsp;Marvin F. Schumacher,&nbsp;Arne Lützen,&nbsp;Manuela Schiek,&nbsp;Paul H. M. van Loosdrecht","doi":"10.1002/agt2.698","DOIUrl":"https://doi.org/10.1002/agt2.698","url":null,"abstract":"<p>While chirality is a prevalent character of numerous biological and synthetic organic molecules, its selective absorption of circularly polarized light, known as circular dichroism (CD), is typically small due to intrinsically weak coupling between magnetic and electric dipoles. However, thin films of aggregated, enantiopure prolinol-derived squaraine molecules (ProSQ-C16) exhibit an unusually large excitonic CD signal, although the underlying mechanism is not yet known. In this study, we employ steady-state and ultrafast transient absorption spectroscopy to investigate the nature and dynamics of excitons in aggregates of enantiopure and racemic ProSQ-C16 thin films. Highly resembling transient responses of enantiopure thin films under excitations at different photon energies strongly indicate that a single type of aggregate dominates the linear optical response, that is, a strong red-shifted (J-like) and weak blue-shifted (H-like) absorption band. On the other hand, the transient properties of the racemic thin film deviate from this pattern and remain largely ambiguous. The short lifetime of excited states and coherent oscillations present in the dynamics of the transient absorption signal indicate that the early time dynamics are governed by a transition towards a dark intermediate state, which might arise from intermolecular charge transfer with potential contributions from the coupling of excitons to the vibrations. This non-radiative relaxation pathway explains the unusually weak fluorescence of the predominately J-like behaving aggregate. Our findings conclusively show that the chiral aggregate structure has a strong impact on the optical and dynamic response of the excitons and underline the significance of non-Frenkel exciton states for the optical properties of anilino squaraine dyes.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous/exogenous stimuli-responsive smart hydrogels for diabetic wound healing","authors":"Saadullah Khattak,&nbsp;Ihsan Ullah,&nbsp;Mohammad Sohail,&nbsp;Muhammad Usman Akbar,&nbsp;Mohd Ahmar Rauf,&nbsp;Salim Ullah,&nbsp;Jianliang Shen,&nbsp;Hong-Tao Xu","doi":"10.1002/agt2.688","DOIUrl":"https://doi.org/10.1002/agt2.688","url":null,"abstract":"<p>Diabetes significantly impairs the body's wound-healing capabilities, leading to chronic, infection-prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. These complex conditions complicate effective wound management, prompting the development of advanced diabetic wound care strategies that exploit specific wound characteristics such as acidic pH, high glucose levels, and oxidative stress to trigger controlled drug release, thereby enhancing the therapeutic effects of the dressings. Among the solutions, hydrogels emerge as promising due to their stimuli-responsive nature, making them highly effective for managing these wounds. The latest advancements in mono/multi-stimuli-responsive smart hydrogels showcase their superiority and potential as healthcare materials, as highlighted by relevant case studies. However, traditional wound dressings fall short of meeting the nuanced needs of these wounds, such as adjustable adhesion, easy removal, real-time wound status monitoring, and dynamic drug release adjustment according to the wound's specific conditions. Responsive hydrogels represent a significant leap forward as advanced dressings proficient in sensing and responding to the wound environment, offering a more targeted approach to diabetic wound treatment. This review highlights recent advancements in smart hydrogels for wound dressing, monitoring, and drug delivery, emphasizing their role in improving diabetic wound healing. It addresses ongoing challenges and future directions, aiming to guide their clinical adoption.</p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.688","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}