Aggregate (Hoboken, N.J.)最新文献_第7页

Wide-Spectrum Nano-Antibiotics Based on TPA-Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug-Resistant Bacteria and Wound Infections 基于TPA-Py@AuNCs的广谱纳米抗生素（BSA）多模态协同治疗耐药细菌和伤口感染

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-11-04 DOI: 10.1002/agt2.699

Feng-Rui Xu, Guo-Ling Zhang, Kai Zhang, Pu Chen, Qianqian Wang, Yuezhe Pan, Ben Zhong Tang, Hai-Tao Feng

{"title":"Wide-Spectrum Nano-Antibiotics Based on TPA-Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug-Resistant Bacteria and Wound Infections","authors":"Feng-Rui Xu, Guo-Ling Zhang, Kai Zhang, Pu Chen, Qianqian Wang, Yuezhe Pan, Ben Zhong Tang, Hai-Tao Feng","doi":"10.1002/agt2.699","DOIUrl":"https://doi.org/10.1002/agt2.699","url":null,"abstract":"To meet the high requirements of biomedical applications in antimicrobial agents, it is crucial to explore efficient nano-antimicrobial agents with no resistance and good biocompatibility for treating infected wounds. In this study, composite nano-antibiotic TPA-Py@AuNCs⊂BSA nanoparticles (TAB NPs) are prepared using hollow mesoporous Au nanocages (AuNCs) loaded with a photosensitizer (namely TPA-Py) with D-π-A structure showing aggregation-induced emission properties. When TPA-Py is encapsulated in the cavity of AuNCs, its fluorescence is suppressed. In the presence of photothermal induction, TPA-Py can be released from the AuNCs, allowing for the restoration of fluorescence illumination and the specific imaging of Gram-positive bacteria. TAB NPs demonstrate outstanding antimicrobial activity against a variety of bacteria, and this multimodal antimicrobial property does not lead to the development of bacterial resistance. In vitro experiments show that TAB NPs could eliminate bacteria and ablate bacterial biofilm. In vivo experiments show that the synergistic antimicrobial effect of TAB NPs has a significant positive impact on the treatment of infected wounds, including rapid antibacterial action, promotion of M2 macrophage polarization, and enhancement of chronic wound healing. This study provides an effective strategy for developing wide-spectrum nano-antibiotics for the ablation of bacterial biofilms and the treatment of infected wounds.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apical-out Tubuloids for Accurate Kidney Toxicity Studies 尖向外小管精确的肾毒性研究

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-11-01 DOI: 10.1002/agt2.697

Yugyeong Lee, Ji Su Hwang, Ziliang Zhai, Kyungwon Park, Ye Seul Son, Dae-Soo Kim, Seok Chung, Sejoong Kim, Mi-Young Son, Gwang Lee, Sungsu Park

{"title":"Apical-out Tubuloids for Accurate Kidney Toxicity Studies","authors":"Yugyeong Lee, Ji Su Hwang, Ziliang Zhai, Kyungwon Park, Ye Seul Son, Dae-Soo Kim, Seok Chung, Sejoong Kim, Mi-Young Son, Gwang Lee, Sungsu Park","doi":"10.1002/agt2.697","DOIUrl":"https://doi.org/10.1002/agt2.697","url":null,"abstract":"In kidney organoids, typically only the basal membrane is exposed, limiting toxicity assessments of apically transported drugs. Although the reversion of basal-out organoids has successfully created apical-out organoids of the intestine and airway, this method has not yet been applied to kidney organoids. Here, a technique to reverse tubuloid polarity is reported, enabling the apical surface to evert and face the medium by dissolving extracellular matrix proteins in the culture system. The resulting apical-out tubuloids maintain high viability, exhibit proper morphological characteristics, and express cell adhesion proteins and biomarkers appropriately. Further analyses, including RNA sequencing and scanning electron microscopy, confirm the presence of primary cilia on the outer surface, along with albumin receptors and Na+/K+-ATPase on the outer and inner surfaces, respectively, and apical proteins such as zonula occludens-1 on the lateral membrane, verifying the apical-out orientation. These apical-out tubuloids demonstrate selective albumin internalization, greater sensitivity to apically transported colistin, and reduced sensitivity to basally transported tenofovir, effectively mimicking drug transport mechanisms. This approach for generating apical-out tubuloids is a valuable tool for assessing drug efficacy and toxicity in physiologically relevant, tissue-like microenvironments, significantly advancing the field of nephrotoxicity research.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Triplet Messenger RNA Formulation in MXene Hydrogel Microneedles for Wound Healing 用于伤口愈合的MXene水凝胶微针仿生三联体信使RNA配方

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-31 DOI: 10.1002/agt2.700

Ji Wang, Yu Wang, Minhui Lu, Xinyue Cao, Ming Xia, Miaoqing Zhao, Yuanjin Zhao

{"title":"Biomimetic Triplet Messenger RNA Formulation in MXene Hydrogel Microneedles for Wound Healing","authors":"Ji Wang, Yu Wang, Minhui Lu, Xinyue Cao, Ming Xia, Miaoqing Zhao, Yuanjin Zhao","doi":"10.1002/agt2.700","DOIUrl":"https://doi.org/10.1002/agt2.700","url":null,"abstract":"Messenger RNA (mRNA) has demonstrated immense potential in disease therapeutic applications. The current direction is focused on imparting mRNA with competitive synthetic functions and delicate carrier systems. Here, inspired by the collaborative regulation of growth factors by the cellular microenvironment, we present novel transition metal carbide/nitride (MXene) hydrogel microneedles loaded with a biomimetic triplet mRNA formulation (TM) for diabetic wound treatment. Such microneedles were composed of TM, MXene, and hyaluronic acid hydrogel. The presence of MXene imparted the microneedles with great photo-thermal responsiveness properties, thus realizing controlled active release by the shrinkage/swelling of hydrogel. With the effective release of TM, the microneedles were proven to enhance endothelial cell migration, growth, and angiogenesis. Through in vivo animal experiments, we have confirmed that TM-microneedles (TM-MNs) can promote tissue regeneration and collagen deposition more effectively than intravenous and intradermal administration. Thus, we believe that the proposed TM-MN platform with precise delivery and controllable release of TM will show great potential for promoting the healing of clinic diabetic wounds.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assembled small molecule spherulites under mild conditions: High solid-state quantum yield and unique interconnected structural and fluorescent colors 温和条件下的自组装小分子球粒：高固子产率，独特的互联结构和荧光颜色

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-24 DOI: 10.1002/agt2.695

Cheng Li, Oriol Arteaga, Florian Ehlers, Marcel Krüsmann, Bianjing Sun, Jade Poisson, Matthias Karg, Philipp Vana, Kai Zhang

{"title":"Self-assembled small molecule spherulites under mild conditions: High solid-state quantum yield and unique interconnected structural and fluorescent colors","authors":"Cheng Li, Oriol Arteaga, Florian Ehlers, Marcel Krüsmann, Bianjing Sun, Jade Poisson, Matthias Karg, Philipp Vana, Kai Zhang","doi":"10.1002/agt2.695","DOIUrl":"https://doi.org/10.1002/agt2.695","url":null,"abstract":"Spherulites are generally fabricated from cooling polymer melts, while their fabrication under mild conditions or from small molecule materials has been barely reported. Besides, organic luminescent molecules typically suffer from low quantum yields in a solid state. Moreover, preparing material with interconnected and simultaneous changes in structural and fluorescent colors is challenging. Here, we present the first solution-derived spherulites with unique interconnected structural and fluorescent colors, self-assembled from stearoylated monosaccharides at room temperature. D-galactose stearoyl ester self-assembled into banded spherulites, containing twisted nanoplates and interconnected simultaneously changing structural and fluorescent colors. In comparison, D-mannose stearoyl ester can only form non-banded spherulites, which contain oriented nanoplates and uniform structural and fluorescent colors. Such materials revealed a novel negative correlation between fluorescence and birefringence, termed alignment-promoted quenching propensity. Remarkably, the solid-state fluorescence quantum yields of galactose and mannose-derived spherulites are as high as 49 ± 2% and 51 ± 2% respectively, approximately ten times higher than those of unmodified monosaccharides. These quantum yield values are among the highest of reported organic nonconventional fluorophores and even comparable to those of conventional aromatic chromophores. Moreover, these spherulites manifested an unexpected excitation-dependent multicolor photoluminescence with a broad-spectrum emission (410−620 nm). They show multiple peaks in the photoluminescent emission spectra and broad fluorescence lifetime distributions, which should be attributed to the clustering of a variety of oxygen-containing functional groups as emissive moieties.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.695","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous achieving color-tuning long persistent luminescence and phosphorescent quantum yield of 81.05% in 2D organic metal halide perovskite 同时在二维有机金属卤化物钙钛矿中实现了可调色长持续发光和81.05%的磷光量子产率

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-24 DOI: 10.1002/agt2.696

Zheng Wang, Chen-Qi Li, Jun-Ting Mo, Mei Pan

{"title":"Simultaneous achieving color-tuning long persistent luminescence and phosphorescent quantum yield of 81.05% in 2D organic metal halide perovskite","authors":"Zheng Wang, Chen-Qi Li, Jun-Ting Mo, Mei Pan","doi":"10.1002/agt2.696","DOIUrl":"https://doi.org/10.1002/agt2.696","url":null,"abstract":"Ionically bonded organic metal halide perovskite-like luminescent materials, which incorporate organic cations and metal halides, have emerged as a versatile multicomponent material system. However, these materials still face challenges in terms of low phosphorescence quantum yields and limited long persistent luminescence (LPL) colors. Herein, we present the design and synthesis of an intraligand charge-transfer organic-based metal halide perovskite-like material, in which organic cations form a compact supramolecular hydrogen-bonded organic framework (HOF) structure, exhibiting crystallization-induced phosphorescence emission of ligand, while metal halides form a unique two-dimensional (2D) structure that displays intrinsic self-trapped excitons (STE) emission under the radiation of UV light. Notably, the metal halide hybrid is found to exhibit enhanced phosphorescent photoluminescence efficiency of up to 81.05% and tunable LPL from cyan to orange compared to the pristine organic phosphor, due to the structural distortion and scaffolding effects of 2D metal halides as well as a well-packed HOF structure. Optical characterizations and theoretical calculations reveal that charge transfer from organic cations and halogen to ligand as well as STE from inorganic layers are responsible for the tunable LPL. Meanwhile, the high-efficiency phosphorescent quantum yield is attributed to stronger hydrogen bond stacking as well as structural distortion of metal halogen bands. Thus, the obtained LPL provides potentials in anti-counterfeiting, security systems, and so on.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.696","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A combination of covalent and noncovalent restricted-intramolecular-rotation strategy for supramolecular AIE-type photosensitizer toward photodynamic therapy 超分子aie型光敏剂用于光动力治疗的共价和非共价限制分子内旋转组合策略

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-21 DOI: 10.1002/agt2.676

Qingfang Li, Peijuan Zhang, Pingxia Wang, Chaochao Yan, Kaige Wang, Wanni Yang, Dongfeng Dang, Liping Cao

{"title":"A combination of covalent and noncovalent restricted-intramolecular-rotation strategy for supramolecular AIE-type photosensitizer toward photodynamic therapy","authors":"Qingfang Li, Peijuan Zhang, Pingxia Wang, Chaochao Yan, Kaige Wang, Wanni Yang, Dongfeng Dang, Liping Cao","doi":"10.1002/agt2.676","DOIUrl":"https://doi.org/10.1002/agt2.676","url":null,"abstract":"Photodynamic therapy (PDT) is a promising noninvasive method for targeted cancer cell destruction. Still, its effectiveness is often hindered by the aggregation-caused quenching effect of organic photosensitizer (PS) in aqueous environments. Here, we have employed a combination of covalent and noncovalent restricted-intramolecular-rotation strategies to develop supramolecular PSs with aggregation-induced emission (AIE) characteristics. Firstly, a water-soluble octacationic molecular cage (1) with a bilayer tetraphenylethene (TPE) structure has been designed and synthesized, which minimizes intramolecular rotation of TPE moieties and achieves the single-molecule-level aggregation by the covalent restriction of intramolecular rotation (RIR) via molecular engineering synthesis. Compared with its single-layer TPE analog, 1 exhibits superior efficiency in generating reactive oxygen species (ROS) including superoxide radical (O2−•) and singlet oxygen (1O2) upon white-light irradiation. Subsequently, by forming a 1:4 host–guest complex (1@CB[8]4) between 1 and cucurbit[8]uril (CB[8]), O2−• generation can be further enhanced by the noncovalent RIR via the host–guest assembly. Additionally, 1@CB[8]4 as a photocatalyst promotes rapid oxidation of nicotinamide adenine dinucleotide (NADH) in water. Given its Type-I ROS generation and catalytic activity for NADH oxidation, 1@CB[8]4 acts as a supramolecular AIE-type PS to exhibit strong photo-induced cytotoxicity upon white-light irradiation under hypoxic conditions, showcasing its potential for synergistic PDT.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Steric hindrance induced low exciton binding energy enables low-driving-force organic solar cells 封面：立体阻碍诱导的低激子结合能可实现低驱动力有机太阳能电池

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-20 DOI: 10.1002/agt2.681

Tianyu Hu, Xufan Zheng, Ting Wang, Aziz Saparbaev, Bowen Gao, Jingnan Wu, Jingyi Xiong, Ming Wan, Tingting Cong, Yuda Li, Ergang Wang, Xunchang Wang, Renqiang Yang

引用次数: 0

Back Cover: Lysine aggregates-based nanostructured antimicrobial peptides for cariogenic biofilm microenvironment-activated caries treatment 封底：基于赖氨酸聚合体的纳米结构抗菌肽用于致龋生物膜微环境激活型龋病治疗

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-20 DOI: 10.1002/agt2.684

Siyuan Li, Feng Wang, Yang Chen, Wanrui Shi, Dashuai Liu, Mingyang Lv, Bin Zhao, Yi Liu, Hao Zhang

引用次数: 0

Inside Front Cover: Stimuli-responsive photoluminescent copper(I) halides for scintillation, anticounterfeiting, and light-emitting diode applications 封面内页：用于闪烁、防伪和发光二极管的刺激响应型光致发光铜（I）卤化物

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-20 DOI: 10.1002/agt2.682

Dilruba A. Popy, Yashpal Singh, Yauhen Tratsiak, Abby M. Cardoza, John M. Lane, Luis Stand, Mariya Zhuravleva, Neeraj Rai, Bayram Saparov

引用次数: 0

Inside Back Cover: Supramolecular self-assembled nanoparticles for targeted therapy of myocardial infarction by enhancing cardiomyocyte mitophagy 封底内页超分子自组装纳米粒子通过增强心肌细胞有丝分裂靶向治疗心肌梗死