Aggregate (Hoboken, N.J.)最新文献_第6页

Near-Infrared Organic Room Temperature Phosphorescent Probes Targeting Fibroblast Activation Protein for Surgical Navigation of Liver Cancer 靶向成纤维细胞激活蛋白的近红外室温磷光探针在肝癌手术导航中的应用

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-06 DOI: 10.1002/agt2.70031

Jinghua Li, Juqing Gu, Liangxuan Ding, Xiaomian Li, Peng Xia, Fusheng Liu, Xi Chen, Weijie Ma, Yong He, Qianqian Li, Zhen Li, Yufeng Yuan

{"title":"Near-Infrared Organic Room Temperature Phosphorescent Probes Targeting Fibroblast Activation Protein for Surgical Navigation of Liver Cancer","authors":"Jinghua Li, Juqing Gu, Liangxuan Ding, Xiaomian Li, Peng Xia, Fusheng Liu, Xi Chen, Weijie Ma, Yong He, Qianqian Li, Zhen Li, Yufeng Yuan","doi":"10.1002/agt2.70031","DOIUrl":"https://doi.org/10.1002/agt2.70031","url":null,"abstract":"Hepatectomy is a critical treatment for liver cancer, but achieving complete tumor removal remains challenging. The development of tumor-targeting probes capable of accurately identifying tumor locations and providing real-time intraoperative navigation is of significant clinical importance. We synthesize a tumor-targeted probe by conjugating a fibroblast activation protein inhibitor (FAPI) with near-infrared organic room temperature phosphorescence (RTP) material. We then analyze its surgical navigation performance in the liver cancer model and its imaging performance in fresh patient-derived samples. In vivo validation reveals that the probe exhibits optimal phosphorescence intensity within 48 h (8.53 × 105 p s−1 cm−2 sr−1) and an average signal-to-noise ratio of 16. The probe could effectively identify FAP-positive samples from liver cancer patients. The successful application of phosphorescence-guided surgery suggests that the near-infrared RTP probe holds significant clinical translational value and could serve as an auxiliary tool for the surgical treatment of liver cancer.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence Color Gradient Immunochromatographic Assay for Highly-Sensitive, Quantitative, and Simultaneous Detection of Small-Molecule Pollutants 荧光色梯度免疫层析法用于高灵敏度、定量和同时检测小分子污染物

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-04-03 DOI: 10.1002/agt2.70033

Shu Wang, Changyue Xu, Xiaosong Wu, Tao Zhang, Jiahuan Zhang, Wenlong Bai, Shuai Zheng, Bing Gu, Chongwen Wang

{"title":"Fluorescence Color Gradient Immunochromatographic Assay for Highly-Sensitive, Quantitative, and Simultaneous Detection of Small-Molecule Pollutants","authors":"Shu Wang, Changyue Xu, Xiaosong Wu, Tao Zhang, Jiahuan Zhang, Wenlong Bai, Shuai Zheng, Bing Gu, Chongwen Wang","doi":"10.1002/agt2.70033","DOIUrl":"https://doi.org/10.1002/agt2.70033","url":null,"abstract":"Rapid on-site screening of small-molecule pollutants in complex samples is essential but remains unachieved. In this study, we introduce a universal fluorescence color gradient immunochromatographic assay (FCGICA) utilizing dual-signal superposition to enable ultra-sensitive, wide-range, and simultaneous quantitative detection of multiple small molecules. A red fluorescent nanomembrane (GTQD@Si) is synthesized by the continuous self-assembly of multilayer quantum dots and a SiO2 shell on a graphene oxide surface. This nanomembrane exhibits high stability in complex environments and provides superior fluorescence along with a larger reactive interface for sensing. The integration of GTQD@Si with green fluorescent microspheres embedded in the test line generates a broad fluorescence color gradient based on variations in target molecule concentrations, thereby significantly enhancing the sensitivity, stability, and quantitative range of the immunochromatographic assay (ICA). By directly reading the ratio of red and green image signals, the proposed FCGICA enables simultaneous, high-sensitivity, and quantitative detection of three different types of small-molecule pollutants including fumonisin B1, imidacloprid, and clenbuterol within 15 min, with a detection range improved by 2–3 orders of magnitude compared with traditional methods. Moreover, the powerful practicality of FCGICA has been verified through comprehensive testing on various real samples, demonstrating its great potential in on-site detection of small molecules.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Host–Emitter Interactions on Light Amplification in Laser Dyes 宿主-发射器相互作用对激光染料光放大的影响

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-27 DOI: 10.1002/agt2.70030

Masashi Mamada, Ayano Abe, Takashi Fujihara, Tatsuya Yoshida, Kenichi Goushi, Kiyoshi Miyata, Ken Onda, Chihaya Adachi

{"title":"Impact of Host–Emitter Interactions on Light Amplification in Laser Dyes","authors":"Masashi Mamada, Ayano Abe, Takashi Fujihara, Tatsuya Yoshida, Kenichi Goushi, Kiyoshi Miyata, Ken Onda, Chihaya Adachi","doi":"10.1002/agt2.70030","DOIUrl":"https://doi.org/10.1002/agt2.70030","url":null,"abstract":"Organic lasers hold great promise for enabling a new class of future optoelectronics. Consequently, the development of new organic semiconductors as gain media has recently been the subject of significant interest. The molecular design principle based on Einstein coefficients has been validated for achieving high gain, with para-phenylene-vinylene scaffolds recognized as one of the most crucial frameworks. In this study, we develop a stilbene tetramer derivative, QSBCz, which has significantly increased conjugation compared to the highly efficient laser material, BSBCz, resulting in a remarkably high radiative decay rate and a large gain cross-section. However, we find that the optical losses play a significant role in the light amplification of QSBCz. Indeed, a comprehensive understanding and suppression of detrimental optical loss pathways throughout the lasing process are essential, whereas the losses intrinsically associated with molecules have not been well considered. Although host–guest systems are helpful in preventing concentration quenching in aggregated states, this study reveals notable losses when using common host molecules such as 4,4′-bis(9H-carbazol-9-yl)biphenyl (CBP) and mCBP. In contrast, a BSBCz derivative is successfully employed as the host, leading to improved stimulated emission amplification. These findings indicate the importance of host–emitter interactions in lasing properties and highlight the necessity to optimize host materials for developing new laser dyes.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen-Derived Extracellular Vesicles 整合聚合材料和机器学习算法：推进病原体来源的细胞外囊泡的检测

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-27 DOI: 10.1002/agt2.70018

Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu

引用次数: 0

Size-dependent Stability and Luminescence Property in Organic Aggregates 有机聚集体的尺寸依赖性稳定性和发光特性

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-27 DOI: 10.1002/agt2.70029

Junfang Yang, Jikai Lv, Yuan Jiao, Xiaoyan Zheng, Qian Peng

{"title":"Size-dependent Stability and Luminescence Property in Organic Aggregates","authors":"Junfang Yang, Jikai Lv, Yuan Jiao, Xiaoyan Zheng, Qian Peng","doi":"10.1002/agt2.70029","DOIUrl":"https://doi.org/10.1002/agt2.70029","url":null,"abstract":"Unveiling the dependence of stability and luminescence properties on the size of organic aggregates is crucial for biomedical and optoelectronic applications. Taking the helical hexaphenylsilole (HPS) and planar 3-(2-cyano-2-phenylethenyl-Z)-NH-indole (CPEI) aggregates of different sizes as examples, their stability and luminescent properties are investigated using multiscale modeling and thermal vibration correlation function approach. The size of stable aggregates formed depends on the molecular shape, with the critical aggregate sizes of 2.62 nm (2 molecules) and 2.87 nm (10 molecules) for helical HPS and planar CPEI, respectively. Their critical sizes for luminescence are 2.99 nm (6 molecules) and 2.87 nm (10 molecules), respectively. For HPS aggregates, as the size increases the luminescence is blue-shifted and enhanced owing to denser molecular packing until the size is large enough (4.66 nm, 20 molecules) the luminescence tends to remain unchanged; and thermal annealing makes these changes more pronounced. In contrast, the luminescent properties of CPEI aggregates are insensitive to aggregate size and thermal annealing treatment. These findings provide dynamic insights into the AIE mechanism and invaluable guidance for optimizing the size of AIE-based nanoparticles in practical applications.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 6","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside Front Cover: Apical-out Tubuloids for Accurate Kidney Toxicity Studies 内封面：尖向外的小管精确肾毒性研究

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70026

Yugyeong Lee, Ji Su Hwang, Ziliang Zhai, Kyungwon Park, Ye Seul Son, Dae-Soo Kim, Seok Chung, Sejoong Kim, Mi-Young Son, Gwang Lee, Sungsu Park

引用次数: 0

Inside Back Cover: Ultrafast Excitonic Transitions in Enantiopure and Racemic Squaraine Thin Films 封底内页对映体和外消旋水杨酸薄膜中的超快激子跃迁

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70027

Robin Bernhardt, Lukas Rieland, Tianyi Wang, Marvin F. Schumacher, Arne Lützen, Manuela Schiek, Paul H. M. van Loosdrecht

引用次数: 0

Back Cover: Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects 封底：碳量子点在生物医学上的应用：进展、挑战和未来前景

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70028

Nadezhda A. Pechnikova, Kalliopi Domvri, Konstantinos Porpodis, Maria S. Istomina, Aleksandra V. Iaremenko, Alexey V. Yaremenko

引用次数: 0

Front Cover: Long-Term In Vivo Fluorescence Analyses and Imaging-Guided Tumor Surgery in the Second Near-Infrared Window Using a Supramolecular Metallacage 封面：利用超分子金属骨架在第二近红外窗口进行长期体内荧光分析和成像引导的肿瘤手术

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-24 DOI: 10.1002/agt2.70025

Yi Qin, Niu Niu, Xue Li, Xueke Yan, Shuai Lu, Zhikai Li, Yixiong Gui, Jun-Long Zhu, Lin Xu, Xiaopeng Li, Dong Wang, Ben Zhong Tang

引用次数: 0

Bridging Mechanical Properties with Atomic Structures of Polymorphic α-Synuclein Fibrils by Single-Molecule Analysis and Molecular Dynamics Simulations 多晶α-突触核蛋白原纤维与原子结构的桥接力学性能的单分子分析和分子动力学模拟

IF 13.9

Aggregate (Hoboken, N.J.) Pub Date : 2025-03-13 DOI: 10.1002/agt2.70023

Lulu Bi, Linge Li, Xiang Li, Shaojuan Wu, Xia Zhang, Yilin Zhao, Dan Li, Cong Liu, Zhonghuai Hou, Bo Sun

{"title":"Bridging Mechanical Properties with Atomic Structures of Polymorphic α-Synuclein Fibrils by Single-Molecule Analysis and Molecular Dynamics Simulations","authors":"Lulu Bi, Linge Li, Xiang Li, Shaojuan Wu, Xia Zhang, Yilin Zhao, Dan Li, Cong Liu, Zhonghuai Hou, Bo Sun","doi":"10.1002/agt2.70023","DOIUrl":"https://doi.org/10.1002/agt2.70023","url":null,"abstract":"α-Synuclein (α-syn) forms structurally distinct fibril polymorphs with various pathological activities in different subtypes of synucleinopathies, such as Parkinson's disease (PD). As a unique proteinaceous polymer, the mechanical property of α-syn fibril is a primary determinant of its neurotoxicity, immunogenicity, and seeding and transmission capacity. Nevertheless, how genetic mutations in α-syn fibrils cause varied polymer behaviors remains largely unknown. Using optical tweezers, we quantitatively characterize the mechanical properties of three α-syn fibril variants at the single-molecule level. We find that wild-type α-syn fibrils are generally more sustainable to an axial disruption force than those formed by the disease-causing E46K and A53T α-syn mutants, whereas their heterogeneous elastic properties manifest similarity. Based on the molecular dynamics simulations, the β-sheet motif and the interface between the two protofilaments dominate in stabilizing the fibril structure. Additionally, single-molecule and simulation analysis consistently reveal the force-driven α-syn protein unfolding without a fibril break. Due to the flexible periphery, these subtle structural changes become more pronounced with the E46K fibril. The structure–mechanics relationship of α-syn fibrils built in this work sheds new light on the fibril assembly and disassembly mechanism and the mutant-associated pathogenesis in PD.","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":"6 5","pages":""},"PeriodicalIF":13.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0