3D printing in medicine最新文献

{"title":"The novel technique for surgical simulation training of patient-specific silicone models of pediatric congenital choledochal cysts.","authors":"Shijiao Lu, Yiming Gong, Shengqian Pan, Jun Liu, Jianfeng Wang, Peng Wang","doi":"10.1186/s41205-025-00252-3","DOIUrl":"https://doi.org/10.1186/s41205-025-00252-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study was aimed to design a patient-specific models of pediatric congenital choledochal cysts(CCC) for surgical simulation training.</p><p><strong>Methods: </strong>Seventeen children suffering from CCC were included in this study. Liver and hepatic hilum structures were generated as standard parts by traditional silicone casting after 3D printing via digital imaging. Moreover, the choledochal cyst was produced as an individualized part by the silicone shaking technique and soft resin printing. Afterwards, the two model parts were assembled for laparoscopic surgical simulation. Surgical excision and suturing, and usability were evaluated. P < 0.05 was considered to indicate a significant difference.</p><p><strong>Results: </strong>Compared with those of the digital models, the liver well and hepatic hilum structures produced were more aesthetically pleasing. Moreover, cyst models were produced accordingly. In addition, silicone models have good mechanical properties and lower costs than resins and TPU powder, and silicone models are recommended as useful tools for presurgical simulated planning. The results also showed good feedback of cutting and suturing with good face validity and usability after the simulation was complete.</p><p><strong>Conclusions: </strong>It is feasible that the application of the silicone shaking technique can produce a hollow individualized model of CCC for surgical simulation and medical training.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"37"},"PeriodicalIF":3.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of a large distal femoral giant cell tumor using a 3D-printed condylar support lattice metal implant and fibular grafts: a novel biomechanical and surgical approach.","authors":"Aashish Chaudhry, Abhishek Kumar Sambharia, Bharat Bahre, Mani Pandey, Tanvi Chawla","doi":"10.1186/s41205-025-00282-x","DOIUrl":"https://doi.org/10.1186/s41205-025-00282-x","url":null,"abstract":"","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"38"},"PeriodicalIF":3.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-assisted finite element modeling of additively manufactured meta-materials.","authors":"Alexander Meynen, Hma Kolken, Michiel Mulier, Amir A Zadpoor, Lennart Scheys","doi":"10.1186/s41205-025-00286-7","DOIUrl":"10.1186/s41205-025-00286-7","url":null,"abstract":"<p><p>Mechanical characterization of three-dimensional (3D) printed meta-biomaterials is rapidly becoming a crucial step in the development of novel medical device concepts, including those used in functionally graded implants for orthopedic applications. Finite element simulations are a valid, FDA-acknowledged alternative to experimental tests, which are time-consuming, expensive, and labor-intensive. However, when applied to 3D-printed meta-biomaterials, state-of-the-art finite element modeling approaches are becoming increasingly complex, while their accuracy remains limited. A critical condition for accurate simulation results is the identification of correct modelling parameters. This study proposes a machine learning-based strategy for identifying model parameters, including material properties and model boundary conditions, to enable accurate simulations of macro-scale mechanical behavior. To achieve this goal, a physics-informed artificial neural network model (PIANN) was developed and trained using data generated through a fully automated finite element modeling workflow. Subsequently, the PIANN model was then tested using real experimental force-displacement data as its input. The experimental data from 3D-printed structures were used to predict the associated parameters for finite element modeling. Finally, the workflow was validated by qualitatively and quantitatively comparing simulation results to the experimental data. Based on these results, we concluded that the proposed workflow could identify model parameters such that the predictions of associated finite element simulations are in agreement with experimental observations. Furthermore, resulting finite element models were found to outperform state-of-the-art models in terms of both quantitative and qualitative accuracy. Therefore, the proposed strategy has the potential to facilitate the broader application of finite element simulations in evaluating 3D-printed parts, in general, and 3D-printed meta-biomaterials, in particular.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"36"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic evaluation of the manufacturing of 3D-printed wrist orthoses vs low temperature thermoplastic wrist orthoses.","authors":"Marianne von Haller, Louise Couchman, Philipp Honigmann","doi":"10.1186/s41205-025-00287-6","DOIUrl":"10.1186/s41205-025-00287-6","url":null,"abstract":"","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"35"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed polymers that mimic the mechanical properties of atherosclerotic blood vessels for training models: the advantageous degradation induced by UV radiation and hydrolysis.","authors":"Joana Filipa Henriques, Lino Gonçalves, Ana Martins Amaro, Ana Paula Piedade","doi":"10.1186/s41205-025-00288-5","DOIUrl":"10.1186/s41205-025-00288-5","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerosis is a chronic disease characterized by the narrowing and hardening of arteries that may induce serious complications and even sudden death. Percutaneous angioplasty is performed as the main treatment of atherosclerotic-based cardiovascular diseases, which are the leading cause of mortality worldwide. Patient-specific physical models of these vascular conditions would greatly assist percutaneous angioplasty medical training and planning. Such models must be composed of materials that accurately replicate the properties of tissues. However, this mimicking can be challenging due to the complexity and composition of atherosclerotic vasculature. As additive manufacturing allows the production of complex and personalized structures, it provides great potential for manufacturing those models. The application of additive manufacturing in this context is often associated with high production costs, mainly related to material synthesis. Commercial materials could break this limitation, but they are still misaddressed.</p><p><strong>Methods: </strong>Therefore, this work intends to explore the use of three different commercial UV-curable resins to mimic the several types of atherosclerotic vessels. They were manufactured by vat photopolymerisation process, specifically the stereolithography (SLA) technology to mimic atherosclerotic vessels. The mechanical performance of materials and the influence of immersion in phosphate buffered saline (PBS) solution and irradiation with UV light, during different times, were evaluated. Dynamic tensile tests were conducted to study the fatigue resistance of materials under physiological loads.</p><p><strong>Results: </strong>The results showed that immersion in PBS solution enhanced the dynamic mechano-stability. Likewise, irradiation with UV-C light was pointed out as an interesting strategy to adjust the hardness of materials, with the advantage of being a fast and low-cost approach.</p><p><strong>Conclusion: </strong>Comparisons with the literature supported that all used materials are suitable for mimicking the mechanical properties of atherosclerotic vessels, specifically when previously immersed in physiological-simulated fluids, such as PBS.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"34"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A personalized 3D printed cranial shield using mirror-image modeling: design and clinical assessment.","authors":"Zhongjie Shi, Zhengbo Yuan, Jie Chen, Hongwei Zhu, Hualing Huang, Zhanxiang Wang, Zirui Su","doi":"10.1186/s41205-025-00289-4","DOIUrl":"10.1186/s41205-025-00289-4","url":null,"abstract":"<p><strong>Background: </strong>Patients who undergo decompressive craniectomy (DC) are at increased risk of head trauma due to postoperative cranial defects, which not only raise concerns about physical vulnerability but also negatively impact psychological well-being. Conventional protective strategies remain insufficient. This study aimed to develop a personalized, low-cost, three-dimensional (3D) printed external head protection device using mirror-image modeling, and to evaluate its performance in providing physical protection and improving patient-reported outcomes during the post-discharge period.</p><p><strong>Method: </strong>A prospective study was conducted involving 58 patients treated with DC between August 2023 and February 2025 across two neurosurgical centers. Participants were randomly assigned to an observation group (n = 28), who wore a custom-designed 3D printed protective device based on postoperative CT scans, or to a control group (n = 30) without special protective measures. A custom questionnaire was used to assess satisfaction with appearance, willingness to engage in social activities, and fear of accidental impact at weeks 1, 4, and 8 post-discharge. Objective indicators such as fall events, adverse reactions, and device integrity were also recorded.</p><p><strong>Results: </strong>The 3D printed models demonstrated good anatomical fit and structural reliability. At weeks 4 and 8, the observation group showed significantly higher Visual Analog Scale (VAS) scores compared to the control group (P = 0.014 and P = 0.002, respectively), with continuous improvement over time (P < 0.05). The average daily usage time of the device was 4.4 ± 1.2 h. No cases of skin irritation or pressure injuries were reported. One patient in the observation group experienced a fall that caused a minor device crack but no head injury (fall rate: 3.6%). In the control group, two patients fell without head trauma (fall rate: 6.7%).</p><p><strong>Conclusions: </strong>Our findings introduce a personalized, 3D printed external helmet as a new option for cranial protection after decompressive craniectomy. The prototype provided reliable mechanical shielding, conformed closely to each patient's skull contour, and was well tolerated. By reducing physical risk, boosting confidence in appearance, and alleviating anxiety during the interval before cranioplasty, the device may bridge a critical safety and psycho-social gap in early rehabilitation.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"32"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandibular reconstruction outcomes for in-house patient-specific solutions.","authors":"Matthew D Marquardt, Erin Cowen, Rachel Fenberg, Natalia von Windheim, Margaret Lashutka, Abigail E Reid, Amit Agarwal, Enver K Ozer, Ricardo L Carrau, James W Rocco, Catherine T Haring, Stephen Y Kang, Nolan B Seim, Matthew O Old, Kyle K VanKoevering","doi":"10.1186/s41205-025-00280-z","DOIUrl":"10.1186/s41205-025-00280-z","url":null,"abstract":"<p><strong>Background: </strong>Segmental mandibulectomy and mandibular reconstruction are often performed for various benign and malignant head and neck conditions. Standard of care reconstruction involves titanium plate fixation with tissue transfer. The advent of computer-aided design and manufacturing (CAD/CAM) has enhanced aesthetic and functional outcomes in mandibular reconstruction by enabling patient-specific solutions like 3D-printed anatomic models. At an increasing number of institutions, these solutions can be produced in-house via point-of-care manufacturing. Since little has been published on the accuracy and outcomes of this approach, this study sought to evaluate the reconstructive accuracy and clinical outcomes of patients who received in-house patient-specific mandible models.</p><p><strong>Methods: </strong>A retrospective chart review was conducted of 44 patients from a large midwestern academic medical center who received point-of-care patient-specific 3D printed models to assist in segmental mandibulectomy and reconstruction from December 2020 to June 2022. CAD/CAM models were produced from pre- and post-operative CT scans. Pre- and post-operative scans were aligned using a novel reference landmark-the maxilla. Measurements were taken by two different researchers at the mandibular condyles, coronoids, angles as well as a plane from the maxilla to the mandibular pogonion to determine reconstructive accuracy. Inter-rater reliability was assessed via intraclass correlation coefficient. Demographic, clinical, surgical, and radiographic variables were also collected to profile cohort characteristics and outcomes.</p><p><strong>Results: </strong>After exclusions due to poor or no post-operative imaging, 25 patients were included in the final analysis. Squamous cell carcinoma (n = 19) was the most common pathology, and males (n = 18) were represented more than females (n = 7). 96% (24/25) of patients had good plate adaptation and 96% (24/25) had good osteotomy adaptation. Reconstruction accuracy measured by comparing preoperative to postoperative anatomic alignment was very good, with an average absolute difference across all patients of only 3.10 mm. Inter-rater reliability between measurements was high with an average 0.98 intraclass correlation coefficient.</p><p><strong>Conclusions: </strong>We present a novel method for measuring mandibular reconstruction accuracy through the use of the maxilla as the anatomic landmark. Furthermore, our profile of patients who underwent segmental mandibulectomy and reconstruction with the assistance of in-house produced 3D printed patient-specific models appears to result in suitable anatomic alignment of the reconstructed mandible and produce good clinical outcomes.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"31"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printing and acute maxillofacial trauma: an overview of the literature.","authors":"E Bertin, C Coussens, E Brumpt, C Meyer, A Louvrier","doi":"10.1186/s41205-025-00285-8","DOIUrl":"10.1186/s41205-025-00285-8","url":null,"abstract":"","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"33"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early stage prediction of bone regeneration using FEA and cell differentiation algorithms with 3D-printed PLA and PCL scaffolds: modeling and application to dorsal double-plating in distal radius fractures.","authors":"Hsuan Chih Liu, Ya-Han Chan, Shao-Fu Huang, Wei-Che Tsai, Yen Cheng, Chun-Li Lin","doi":"10.1186/s41205-025-00278-7","DOIUrl":"10.1186/s41205-025-00278-7","url":null,"abstract":"<p><p>This study introduces an advanced framework that integrates biphasic cell differentiation bone remodeling theory with finite element (FE) analysis and multi-remodeling simulation to evaluate the performance of 3D-printed biodegradable scaffolds for bone defect repair. The program incorporates a time-dependent cell differentiation stimulus (S), accounting for fluid-phase shear stress and solid-phase shear strain, to dynamically predict bone cell behavior. The study focuses on polylactic acid (PLA) and polycaprolactone (PCL) scaffolds with diamond (DU) and random (YM) lattice designs, applied to a dorsal double-plating (DDP) fixation model for distal radius fractures. Material testing reveals that PLA provides higher rigidity and strength, while PCL offers superior ductility. Mechanical strength tests confirm the superior performance of DU lattice structures under compression, shear, and torsion forces. The bone remodeling program, applied to 36 model combinations of fracture gaps, materials, and lattice designs, computes the total percentage of cell differentiation (TPCD), identifying scaffold material as the key factor, with PLA significantly enhancing TPCD values. Biomechanical analysis after 50 remodeling iterations in a 5.4 mm fracture gap shows that the PLA + DU scaffold reduces displacement by 35%/39%/75%, bone stress by 19%/16%/67%, and fixation plate stress by 77%/66%/93% under axial/bending/torsion loads, respectively, compared to the PCL + YM scaffold. This study highlights the critical role of dynamic remodeling programs in optimizing scaffold material properties and lattice architectures, establishing a robust platform for patient-specific bone repair solutions in regenerative medicine.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"30"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study between CT angiography and flow parameters in hemodynamic phantom of carotid stenosis evaluated by duplex sonography.","authors":"Anna Seidlová, Norbert Svoboda, Richard Voldřich, Petra Kešnerová, Roman Matějka, David Pakizer, David Školoudík, David Netuka","doi":"10.1186/s41205-025-00271-0","DOIUrl":"10.1186/s41205-025-00271-0","url":null,"abstract":"<p><strong>Background: </strong>The use of 3D-printed hemodynamic phantom of a stenotic carotid artery has not been extensively investigated. Our study aims to address this gap by exploring the correlation between CTA and flow parameters in hemodynamic phantom.</p><p><strong>Methods: </strong>Patients with carotid stenosis were included in a prospective study. A realistic phantoms of carotid artery stenoses were 3D-printed based on CT angiography. Stenosis severity and hemodynamic flow parameters in the phantom evaluated using duplex sonography were correlated with CTA. The primary outcome was to compare the evaluation of the percentage of stenosis based on the measurement of diameter reduction and area reduction of the carotid artery among CTA, a 3D model constructed from CTA data, and ultrasound measurement of stenosis percentage within the 3D printed phantom. The secondary outcome was to determine whether the percentage of stenosis measured by ultrasound in B-mode or ultrasound-measured flow velocities (PSV, EDV) better correlates with the stenosis percentage derived from CTA and the phantom.</p><p><strong>Results: </strong>The study included 95 subjects (average age 71 years, 75% male) with carotid stenosis, 39% were symptomatic. Significant correlations were found between ultrasound B-Mode findings on the phantom and CTA, with the strongest correlations for area reduction (Spearman r = 0.615, p < 0.0001) and diameter reduction (Spearman r = 0.465, p < 0.0001). The most robust correlation between PSV and EDV in stenosis and the percentage of stenosis was identified between PSV in stenosis and the percentage of stenosis by diameter reduction, as evaluated through ultrasound. The Spearman correlation coefficient revealed a relatively strong correlation, with a value of r = 0.444 (p < 0.0001), and the Kendall Tau correlation coefficient also demonstrated significance, with a value of r = 0.302 (p < 0.0001).</p><p><strong>Conclusions: </strong>A significant correlation between CTA and duplex sonography measurements on the carotid phantom was demostrated, suggesting the potential utilization of the phantom in testing hemodynamic parameters of carotid stenosis.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"29"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}