3D printing in medicine最新文献

{"title":"Use of 3-dimensional printing at the point-of-care to manage a complex wound in hemifacial necrotizing fasciitis: a case report.","authors":"Sarah C Nyirjesy,&nbsp;Ryan T Judd,&nbsp;Yazen Alfayez,&nbsp;Peter Lancione,&nbsp;Brian Swendseid,&nbsp;Natalia von Windheim,&nbsp;Stephen Nogan,&nbsp;Nolan B Seim,&nbsp;Kyle K VanKoevering","doi":"10.1186/s41205-022-00166-4","DOIUrl":"https://doi.org/10.1186/s41205-022-00166-4","url":null,"abstract":"<p><strong>Background: </strong>Complex facial wounds can be difficult to stabilize due to proximity of vital structures. We present a case in which a patient-specific wound splint was manufactured using computer assisted design and three-dimensional printing at the point-of-care to allow for wound stabilization in the setting of hemifacial necrotizing fasciitis. We also describe the process and implementation of the United States Food and Drug Administration Expanded Access for Medical Devices Emergency Use mechanism.</p><p><strong>Case presentation: </strong>A 58-year-old female presented with necrotizing fasciitis of the neck and hemiface. After multiple debridements, she remained critically ill with poor vascularity of tissue in the wound bed and no evidence of healthy granulation tissue and concern for additional breakdown towards the right orbit, mediastinum, and pretracheal soft tissues, precluding tracheostomy placement despite prolonged intubation. A negative pressure wound vacuum was considered for improved healing, but proximity to the eye raised concern for vision loss due to traction injury. As a solution, under the Food and Drug Administration's Expanded Access for Medical Devices Emergency Use mechanism, we designed a three-dimensional printed, patient-specific silicone wound splint from a CT scan, allowing the wound vacuum to be secured to the splint rather than the eyelid. After 5 days of splint-assisted vacuum therapy, the wound bed stabilized with no residual purulence and developed healthy granulation tissue, without injury to the eye or lower lid. With continued vacuum therapy, the wound contracted to allow for safe tracheostomy placement, ventilator liberation, oral intake, and hemifacial reconstruction with a myofascial pectoralis muscle flap and a paramedian forehead flap 1 month later. She was eventually decannulated and at six-month follow-up has excellent wound healing and periorbital function.</p><p><strong>Conclusions: </strong>Patient-specific, three-dimensional printing is an innovative solution that can facilitate safe placement of negative pressure wound therapy adjacent to delicate structures. This report also demonstrates feasibility of point-of-care manufacturing of customized devices for optimizing complex wound management in the head and neck, and describes successful use of the United States Food and Drug Administration's Expanded Access for Medical Devices Emergency Use mechanism.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10760813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of a facile mesh-to-surface tool for customised wheelchair cushions.","authors":"Susan Nace,&nbsp;John Tiernan,&nbsp;Aisling Ní Annaidh,&nbsp;Donal Holland","doi":"10.1186/s41205-022-00165-5","DOIUrl":"https://doi.org/10.1186/s41205-022-00165-5","url":null,"abstract":"<p><strong>Background: </strong>Custom orthoses are becoming more commonly prescribed for upper and lower limbs. They require some form of shape-capture of the body parts they will be in contact with, which generates an STL file that designers prepare for manufacturing. For larger devices such as custom-contoured wheelchair cushions, the STL created during shape-capture can contain hundreds of thousands of tessellations, making them difficult to alter and prepare for manufacturing using mesh-editing software. This study covers the development and testing of a mesh-to-surface workflow in a parametric computer-aided design software using its visual programming language such that STL files of custom wheelchair cushions can be efficiently converted into a parametric single surface.</p><p><strong>Methods: </strong>A volunteer in the clinical space with expertise in computer-aided design aided was interviewed to understand and document the current workflow for creating a single surface from an STL file of a custom wheelchair cushion. To understand the user needs of typical clinical workers with little computer-aided design experience, potential end-users of the process were tasked with completing the workflow and providing feedback during the experience. This feedback was used to automate part of the computer-aided design process using a visual programming tool, creating a new semi-automated workflow for mesh-to-surface translation. Both the original and semi-automated process were then evaluated by nine volunteers with varying levels of computer-aided design experience.</p><p><strong>Results: </strong>The semi-automated process showed a 37% reduction in the total number of steps required to convert an STL model to a parametric surface. Regardless of previous computer-aided design experience, volunteers completed the semi-automated workflow 31% faster on average than the manual workflow.</p><p><strong>Conclusions: </strong>The creation of a semi-automated process for creating a single parametric surface of a custom wheelchair cushion from an STL mesh makes mesh-to-surface conversion more efficient and more user-friendly to all, regardless of computer-aided design experience levels. The steps followed in this study may guide others in the development of their own mesh-to-surface tools in the wheelchair sector, as well as those creating other large custom prosthetic devices.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of virtual reality (VR) vs 3D printed models of congenital heart disease in resident and nurse practitioner educational experience.","authors":"Jonathan Awori,&nbsp;Seth D Friedman,&nbsp;Christopher Howard,&nbsp;Richard Kronmal,&nbsp;Sujatha Buddhe","doi":"10.1186/s41205-022-00164-6","DOIUrl":"https://doi.org/10.1186/s41205-022-00164-6","url":null,"abstract":"<p><strong>Background: </strong>Medical trainees frequently note that cardiac anatomy is difficult to conceive within a two dimensional framework. The specific anatomic defects and the subsequent pathophysiology in flow dynamics may become more apparent when framed in three dimensional models. Given the evidence of improved comprehension using such modeling, this study aimed to contribute further to that understanding by comparing Virtual Reality (VR) and 3D printed models (3DP) in medical education.</p><p><strong>Objectives: </strong>We sought to systematically compare the perceived subjective effectiveness of Virtual Reality (VR) and 3D printed models (3DP) in the educational experience of residents and nurse practitioners.</p><p><strong>Methods: </strong>Trainees and practitioners underwent individual 15-minute teaching sessions in which features of a developmentally typical heart as well as a congenitally diseased heart were demonstrated using both Virtual Reality (VR) and 3D printed models (3DP). Participants then briefly explored each modality before filling out a short survey in which they identified which model (3DP or VR) they felt was more effective in enhancing their understanding of cardiac anatomy and associated pathophysiology. The survey included a binary summative assessment and a series of Likert scale questions addressing usefulness of each model type and degree of comfort with each modality.</p><p><strong>Results: </strong>Twenty-seven pediatric residents and 3 nurse practitioners explored models of a developmentally typical heart and tetralogy of Fallot pathology. Most participants had minimal prior exposure to VR (1.1 ± 0.4) or 3D printed models (2.1 ± 1.5). Participants endorsed a greater degree of understanding with VR models (8.5 ± 1) compared with 3D Printed models (6.3 ± 1.8) or traditional models of instruction (5.5 ± 1.5) p < 0.001. Most participants felt comfortable with modern technology (7.6 ± 2.1). 87% of participants preferred VR over 3DP.</p><p><strong>Conclusions: </strong>Our study shows that, overall, VR was preferred over 3DP models by pediatric residents and nurse practitioners for understanding cardiac anatomy and pathophysiology.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2023-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Image Segmentation and Modeling - A Review of the 2021-2022 Thematic Series.","authors":"Prashanth Ravi","doi":"10.1186/s41205-022-00163-7","DOIUrl":"https://doi.org/10.1186/s41205-022-00163-7","url":null,"abstract":"<p><p>Medical 3D printing is a form of manufacturing that benefits patient care, particularly when the 3D printed part is patient-specific and either enables or facilitates an intervention for a specific condition. Most of the patient-specific medical 3D printing begins with volume based medical images of the patient. Several digital manipulations are typically performed to prescribe a final anatomic representation that is then 3D printed. Among these are image segmentation where a volume of interest such as an organ or a set of tissues is digitally extracted from the volumetric imaging data. Image segmentation requires medical expertise, training, software, and effort. The theme of image segmentation has a broad intersection with medical 3D printing. The purpose of this editorial is to highlight different points of that intersection in a recent thematic series within 3D Printing in Medicine.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9172166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric analysis of patient-specific 3D-printed acetabular cups: a comparative study of commercially available implants from 6 manufacturers.","authors":"Harry Hothi,&nbsp;Johann Henckel,&nbsp;Sean Bergiers,&nbsp;Anna Di Laura,&nbsp;Klaus Schlueter-Brust,&nbsp;Alister Hart","doi":"10.1186/s41205-022-00160-w","DOIUrl":"https://doi.org/10.1186/s41205-022-00160-w","url":null,"abstract":"<p><strong>Background: </strong>3D printed patient-specific titanium acetabular cups are used to treat patients with massive acetabular defects. These have highly porous surfaces, with the design intent of enhancing bony fixation. Our aim was to characterise these porous structures in commercially available designs.</p><p><strong>Methods: </strong>We obtained 12 final-production, patient-specific 3D printed acetabular cups that had been produced by 6 manufacturers. High resolution micro-CT imaging was used to characterise morphometric features of their porous structures: (1) strut thickness, 2) the depth of the porous layer, (3) pore size and (4) the level of porosity. Additionally, we computed the surface area of each component to quantify how much titanium may be in contact with patient tissue. Statistical comparisons were made between the designs.</p><p><strong>Results: </strong>We found a variability between designs in relation to the thickness of the struts (0.28 to 0.65 mm), how deep the porous layers are (0.57 to 11.51 mm), the pore size (0.74 to 1.87 mm) and the level of porosity (34 to 85%). One manufacturer printed structures with different porosities between the body and flange; another manufacturer had two differing porous regions within the body of the cups. The cups had a median (range) surface area of 756.5 mm² (348 - 1724).</p><p><strong>Conclusions: </strong>There is a wide variability between manufacturers in the porous titanium structures they 3D print. We do not currently know whether there is an optimal porosity and how this variability will impact clinically on the integrity of bony fixation; this will become clearer as post market surveillance data is generated.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":" ","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40452618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed model for triple negative inflammatory breast cancer.","authors":"Yu-Hui Huang,&nbsp;Todd M Tuttle,&nbsp;Noelle Hoven","doi":"10.1186/s41205-022-00158-4","DOIUrl":"https://doi.org/10.1186/s41205-022-00158-4","url":null,"abstract":"<p><strong>Background: </strong>Access to imaging reports and review of the breast imaging directly with a patient with breast cancer helps improve the understanding of disease extent and severity. A 3D printed breast model can further enhance a patient's understanding and communication with the healthcare team resulting in improved patient comprehension and patient input with reduced treatment decision conflict. Furthermore, 3D printed models can facilitate training of residents and fellows involved in the diagnosis and treatment management of breast cancer.</p><p><strong>Case presentation: </strong>We present a 3D printed breast tumor model segmented from positron electron tomography/computed tomography and fabricated via desktop vat polymerization as proof of concept for treatment planning for a patient diagnosed with triple negative inflammatory breast carcinoma.</p><p><strong>Conclusion: </strong>We illustrate benefits and indications for 3D printing in the management of breast cancer and specifically inflammatory breast cancer in this case. Fabrication and implementation of 3D printed models enhances patient's understanding and communication with the healthcare team regarding their condition, treatment options and anticipated outcomes. It provides personalized treatment planning by examining patient-specific pathology and the anatomic spatial relationships. Furthermore, 3D printed models facilitate medical education for trainees across disciplines involved in the patient's care.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":" ","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40452258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting a simple surgical manual tool to a 3D printed implantology protocol: the use of a universal screwdriver for fixation of custom-made laser sintered titanium subperiosteal implants.","authors":"Mustafa Ayna,&nbsp;Aydin Gülses","doi":"10.1186/s41205-022-00159-3","DOIUrl":"https://doi.org/10.1186/s41205-022-00159-3","url":null,"abstract":"<p><strong>Purpose: </strong>Current paper aims to describe a simple technique used for the fixation of the screws of a customized implant via a universal screw driver (BoneTrust® Easy Screw according to Dr. Bayer, Medical Instinct®, GmbH, Germany) to simplify the surgical placement of the customized implants.</p><p><strong>Methods: </strong>The insertion of the drilling screws for the retention of the implant with angulated handpiece into the palatinal region or zygomatic buttress were performed with universal screw driver.</p><p><strong>Results: </strong>The retention screws could be inserted with a proper angulation without interfering with the surrounding tissues. The technique described herein has significantly simplified the surgical intervention.</p><p><strong>Conclusion: </strong>The insertion of the drilling screws for the retention of the implant with angulated handpiece into the palatinal region or zygomatic buttress could be challenging, thus the anatomical structures and the insufficient length of the handpiece could interfere with the placement of the screw with a proper angulation. This problem could be easily managed with the use of universal screw driver.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":" ","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40651796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional bioprinting of mucoadhesive scaffolds for the treatment of oral mucosal lesions; an in vitro study.","authors":"Maryam Koopaie,&nbsp;Duha Hayder Mohammad Ali Nassar,&nbsp;Mahvash Shokrolahi","doi":"10.1186/s41205-022-00157-5","DOIUrl":"https://doi.org/10.1186/s41205-022-00157-5","url":null,"abstract":"<p><strong>Background: </strong>Chronic oral lesions could be a part of some diseases, including mucocutaneous diseases, immunobullous diseases, gastrointestinal diseases, and graft versus host diseases. Systemic steroids are an effective treatment, but they cause unfavorable and even severe systemic side effects. Discontinuation of systemic corticosteroids or other immunosuppressive drugs leads to relapse, confirming the importance of long-term corticosteroid use. The present study aims to fabricate a mucoadhesive scaffold using three-dimensional (3D) bioprinting for sustained drug delivery in oral mucosal lesions to address the clinical need for alternative treatment, especially for those who do not respond to routine therapy.</p><p><strong>Methods: </strong>3D bioprinting method was used for the fabrication of the scaffolds. Scaffolds were fabricated in three layers; adhesive/drug-containing, backing, and middle layers. For evaluation of the release profile of the drug, artificial saliva was used as the release medium. Mucoadhesive scaffolds were analyzed using a scanning electron microscope (SEM) and SEM surface reconstruction. The pH of mucoadhesive scaffolds and swelling efficacy were measured using a pH meter and Enslin dipositive, respectively. A microprocessor force gauge was used for the measurement of tensile strength. For the evaluation of the cytotoxicity, oral keratinocyte cells' survival rate was evaluated by the MTT method. Folding endurance tests were performed using a stable microsystem texture analyzer and analytic probe mini tensile grips.</p><p><strong>Results: </strong>All scaffolds had the same drug release trend; An initial rapid explosive release during the first 12 h, followed by a gradual release. The scaffolds showed sustained drug release and continued until the fourth day. The pH of the surface of the scaffolds was 5.3-6.3, and the rate of swelling after 5 h was 28 ± 3.2%. The tensile strength of the scaffolds containing the drug was 7.8 ± 0.12 MPa. The scaffolds were non-irritant to the mucosa, and the folding endurance of the scaffolds was over three hundred times.</p><p><strong>Conclusion: </strong>The scaffold fabricated using the 3D bioprinting method could be suitable for treating oral mucosal lesions.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":" ","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40380024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating surface coatings to reduce bone cement adhesion to point of care 3D printed molds in the intraoperative setting.","authors":"Brian Beitler,&nbsp;Gregory R Roytman,&nbsp;Grace Parmer,&nbsp;Steven M Tommasini,&nbsp;Daniel H Wiznia","doi":"10.1186/s41205-022-00156-6","DOIUrl":"https://doi.org/10.1186/s41205-022-00156-6","url":null,"abstract":"<p><strong>Background: </strong>Polymethyl methacrylate, or \"bone cement,\" can be used intraoperatively to replace damaged or diseased bone and to deliver local antibiotics. 3D printed molds allow surgeons to form personalized and custom shapes with bone cement. One factor hindering the clinical utility of anatomically accurate 3D printed molds is that cured bone cement can be difficult to remove due to the strong adhesion between the mold and the bone cement. One way to reduce the adhesion between the 3D printed mold and the cured bone cement is with the use of a surface coating, such as a lubricant. This study sought to determine the optimal surface coating to prevent bone cement adhesion to 3D printed molds that could be utilized within a sterile operating room environment.</p><p><strong>Methods: </strong>Hemispheric molds were 3D printed using a stereolithography printer. The molds were coated with four sterile surface coatings available in most operating theatres (light mineral oil, bacitracin ointment, lubricating jelly, and ultrasound transmission gel). Polymethyl methacrylate with tobramycin antibiotic was mixed and poured into the molds. The amount of force needed to \"push out\" the cured bone cement from the molds was measured to determine the efficacy of each surface coating. Tukey's multiple comparison test was performed to compare the results of the pushout test.</p><p><strong>Results: </strong>The average pushout force for the surface coatings, in increasing order, were as follows (mean ± standard deviation) --- bacitracin ointment: 9.10 ± 6.68 N, mineral oil: 104.93 ± 69.92 N, lubricating jelly: 147.76 ± 63.77 N, control group: 339.31 ± 305.20 N, ultrasound transmission gel 474.11 ± 94.77 N. Only the bacitracin ointment required significantly less pushout force than the control (p = 0.0123).</p><p><strong>Conclusions: </strong>The bacitracin ointment was the most effective surface coating, allowing the bone cement to be pushed out of the mold using the least amount of force. In addition, the low standard deviation speaks to the reliability of the bacitracin ointment to reduce mold adhesion compared to the other surface coatings. Given its efficacy as well as its ubiquitous presence in the hospital operating room setting, bacitracin ointment is an excellent choice to prevent adhesion between bone cement and 3D printed molds intraoperatively.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"8 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9169897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed mouthpiece adapter for sampling exhaled breath in medical applications.","authors":"Y Lan Pham,&nbsp;Jonathan Beauchamp,&nbsp;Alexander Clement,&nbsp;Felix Wiegandt,&nbsp;Olaf Holz","doi":"10.1186/s41205-022-00150-y","DOIUrl":"https://doi.org/10.1186/s41205-022-00150-y","url":null,"abstract":"<p><p>The growing use of 3D printing in the biomedical sciences demonstrates its utility for a wide range of research and healthcare applications, including its potential implementation in the discipline of breath analysis to overcome current limitations and substantial costs of commercial breath sampling interfaces. This technical note reports on the design and construction of a 3D-printed mouthpiece adapter for sampling exhaled breath using the commercial respiration collector for in-vitro analysis (ReCIVA) device. The paper presents the design and digital workflow transition of the adapter and its fabrication from three commercial resins (Surgical Guide, Tough v5, and BioMed Clear) using a Formlabs Form 3B stereolithography (SLA) printer. The use of the mouthpiece adapter in conjunction with a pulmonary function filter is appraised in comparison to the conventional commercial silicon facemask sampling interface. Besides its lower cost - investment cost of the printing equipment notwithstanding - the 3D-printed adapter has several benefits, including ensuring breath sampling via the mouth, reducing the likelihood of direct contact of the patient with the breath sampling tubes, and being autoclaveable to enable the repeated use of a single adapter, thereby reducing waste and associated environmental burden compared to current one-way disposable facemasks. The novel adapter for breath sampling presented in this technical note represents an additional field of application for 3D printing that further demonstrates its widespread applicability in biomedicine.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":" ","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40596621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}