3D printing in medicine最新文献

{"title":"Assessment of Staphylococcus Aureus growth on biocompatible 3D printed materials.","authors":"Nicole Senderovich,&nbsp;Sharan Shah,&nbsp;Thomas J Ow,&nbsp;Stephanie Rand,&nbsp;Joshua Nosanchuk,&nbsp;Nicole Wake","doi":"10.1186/s41205-023-00195-7","DOIUrl":"10.1186/s41205-023-00195-7","url":null,"abstract":"<p><p>The customizability of 3D printing allows for the manufacturing of personalized medical devices such as laryngectomy tubes, but it is vital to establish the biocompatibility of printing materials to ensure that they are safe and durable. The goal of this study was to assess the presence of S. aureus biofilms on a variety of 3D printed materials (two surgical guide resins, a photopolymer, an elastomer, and a thermoplastic elastomer filament) as compared to standard, commercially available laryngectomy tubes.C-shaped discs (15 mm in height, 20 mm in diameter, and 3 mm in thickness) were printed with five different biocompatible 3D printing materials and S. aureus growth was compared to Shiley™ laryngectomy tubes made from polyvinyl chloride. Discs of each material were inoculated with S. aureus cultures and incubated overnight. All materials were then removed from solution, washed in phosphate-buffered saline to remove planktonic bacteria, and sonicated to detach biofilms. Some solution from each disc was plated and colony-forming units were manually counted the following day. The resulting data was analyzed using a Kruskal-Wallis and Wilcoxon Rank Sum test to determine pairwise significance between the laryngectomy tube material and the 3D printed materials.The Shiley™ tube grew a median of 320 colonies (IQR 140-520), one surgical guide resin grew a median of 640 colonies (IQR 356-920), the photopolymer grew a median of 340 colonies (IQR 95.5-739), the other surgical guide resin grew a median of 431 colonies (IQR 266.5-735), the thermoplastic elastomer filament grew a median of 188 colonies (IQR 113.5-335), and the elastomer grew a median of 478 colonies (IQR 271-630). Using the Wilcoxon Rank Sum test, manual quantification showed a significant difference between biofilm formation only between the Shiley™ tube and a surgical guide resin (p = 0.018).This preliminary study demonstrates that bacterial colonization was comparable among most 3D printed materials as compared to the conventionally manufactured device. Continuation of this work with increased replicates will be necessary to determine which 3D printing materials optimally resist biofilm formation.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a 3D-printed, patient-specific stereotactic system for bihemispheric deep brain stimulation.","authors":"Patrick Knorr, Dirk Winkler, Fabian Kropla, Robert Möbius, Marcel Müller, Sebastian Scholz, Ronny Grunert","doi":"10.1186/s41205-023-00193-9","DOIUrl":"10.1186/s41205-023-00193-9","url":null,"abstract":"<p><p>The aim of the project was to develop a patient-specific stereotactic system that allows simultaneous and thus time-saving treatment of both cerebral hemispheres and that contains all spatial axes and can be used as a disposable product. Furthermore, the goal was to reduce the size and weight of the stereotactic system compared to conventional systems to keep the strain on the patient, who is awake during the operation, to a minimum. In addition, the currently mandatory computed tomography should be avoided in order not to expose the patient to harmful X-ray radiation as well as to eliminate errors in the fusion of CT and MRI data.3D printing best meets the requirements in terms of size and weight: on the one hand, the use of plastic has considerable potential for weight reduction. On the other hand, the free choice of the individual components offers the possibility to optimize the size and shape of the stereotactic system and to adapt it to the individual circumstances while maintaining the same precision. The all-in-one stereotactic system was produced by means of the Multi Jet Fusion process. As a result, the components are highly precise, stable in use, lightweight and sterilizable. The number of individual components and interfaces, which in their interaction are potential sources of error, was significantly reduced. In addition, on-site manufacturing leads to faster availability of the system.Within the project, a patient-specific stereotaxy system was developed, printed, and assembled, which enables the execution of deep brain stimulation via only three bone anchors located on the skull. Pre-developed MRI markers, which can be screwed directly onto the bone anchors via the sleeves, eliminate the need for a CT scan completely. The fusion of the data, which is no longer required, suggests an improvement in target accuracy.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41221520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printing of the elbow in complex posttraumatic elbow-stiffness for preoperative planning, surgery-simulation and postoperative control.","authors":"Ronny Grunert, Dirk Winkler, Franziska Frank, Robert Moebius, Fabian Kropla, Juergen Meixensberger, Pierre Hepp, Maria Elze","doi":"10.1186/s41205-023-00191-x","DOIUrl":"10.1186/s41205-023-00191-x","url":null,"abstract":"<p><strong>Background: </strong>Restoration of mobility of the elbow after post-traumatic elbow stiffening due to osteophytes is often a problem.</p><p><strong>Methods: </strong>The anatomical structures were segmented within the CT-scan. Afterwards, the Multi Jet Fusion 3D-printing was applied to create the model made of biocompatible and steam-sterilizable plastic. Preoperative simulation of osteophyte resection at the 3D-model was performed as well as the direct comparison with the patient anatomy intraoperatively.</p><p><strong>Results: </strong>The patient-specific was very helpful for the preoperative simulation of the resection of elbow osteophytes. The 3D anatomical representation improved the preoperative plan its implementation. A high degree of fidelity was found between the 3D Printed Anatomical representation and the actual joint pathology.</p><p><strong>Conclusions: </strong>Arthrolysis of complex post-traumatic bony changes is an important indication for the use of 3D models for preoperative planning. Due to the use of 3D printing and software simulation, accurate resection planning is feasible and residual bony stiffening can be avoided. 3D printing models can lead to an improvement in surgical quality.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical 3D printing with polyjet technology: effect of material type and printing orientation on printability, surface structure and cytotoxicity.","authors":"Karl H Schneider, Gunpreet Oberoi, Ewald Unger, Klara Janjic, Sabrina Rohringer, Stefan Heber, Hermann Agis, Andreas Schedle, Herbert Kiss, Bruno K Podesser, Reinhard Windhager, Stefan Toegel, Francesco Moscato","doi":"10.1186/s41205-023-00190-y","DOIUrl":"10.1186/s41205-023-00190-y","url":null,"abstract":"<p><p>Due to its high printing resolution and ability to print multiple materials simultaneously, inkjet technology has found wide application in medicine. However, the biological safety of 3D-printed objects is not always guaranteed due to residues of uncured resins or support materials and must therefore be verified. The aim of this study was to evaluate the quality of standard assessment methods for determining the quality and properties of polyjet-printed scaffolds in terms of their dimensional accuracy, surface topography, and cytotoxic potential.Standardized 3D-printed samples were produced in two printing orientations (horizontal or vertical). Printing accuracy and surface roughness was assessed by size measurements, VR-5200 3D optical profilometer dimensional analysis, and scanning electron microscopy. Cytotoxicity tests were performed with a representative cell line (L929) in a comparative laboratory study. Individual experiments were performed with primary cells from clinically relevant tissues and with a Toxdent cytotoxicity assay.Dimensional measurements of printed discs indicated high print accuracy and reproducibility. Print accuracy was highest when specimens were printed in horizontal direction. In all cytotoxicity tests, the estimated mean cell viability was well above 70% (p < 0.0001) regardless of material and printing direction, confirming the low cytotoxicity of the final 3D-printed objects.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid modeling techniques for 3D printed deep inferior epigastric perforator flap models.","authors":"Nicholas M Jacobson, Erik Carerra, Aaron Treat, Megan McDonnell, David Mathes, Christodoulous Kaoutzanis","doi":"10.1186/s41205-023-00181-z","DOIUrl":"10.1186/s41205-023-00181-z","url":null,"abstract":"<p><strong>Background: </strong>Deep Inferior Epigastric Perforator Flap (DIEP) surgical procedures have benefited in recent years from the introduction of 3D printed models, yet new technologies are expanding design opportunities which promise to improve patient specific care. Numerous studies, utilizing 3D printed models for DIEP, have shown a reduction of surgical time and complications when used in addition to the review of standard CT imaging. A DIEP free flap procedure requires locating the inferior epigastric perforator vessels traversing and perforating the rectus abdominis muscle, perfusing the abdominal skin and fatty tissue. The goal of dissecting the inferior epigastric perforator vessels is complicated by the opacity of the fatty tissue and muscle. Previous attempts to 3D print patient specific models for DIEP free flap cases from CT imaging has shown a wide range of designs which only show variations of perforator arteries, fatty tissue, and the abdominis rectus muscle.</p><p><strong>Methods: </strong>To remedy this limitation, we have leveraged a voxel-based modeling environment to composite complex modeling elements and incorporate a ruled grid upon the muscle providing effortless 'booleaning' and measured guidance.</p><p><strong>Results: </strong>A limitation of digital surface-based modeling tools has led to existing models lacking the ability to composite critical anatomical features, such as differentiation of vessels through different tissues, coherently into one model, providing information more akin to the surgical challenge.</p><p><strong>Conclusion: </strong>With new technology, highly detailed multi-material 3D printed models are allowing more of the information from medical imaging to be expressed in 3D printed models. This additional data, coupled with advanced digital modeling tools harnessing both voxel- and mesh-based modeling environments, is allowing for an expanded library of modeling techniques which create a wealth of concepts surgeons can use to assemble a presurgical planning model tailored to their setting, equipment, and needs.</p><p><strong>Trial registration: </strong>COMIRB 21-3135, ClinicalTrials.gov ID: NCT05144620.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10498601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10294503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical improvements in preparing 3D printed anatomical models for comminuted fracture preoperative planning.","authors":"Naomi C Paxton, Brandon G Wilkinson, Daniel Fitzpatrick, Erin C Owen, Simon Luposchainsky, Paul D Dalton","doi":"10.1186/s41205-023-00189-5","DOIUrl":"10.1186/s41205-023-00189-5","url":null,"abstract":"<p><p>Preoperative planning of comminuted fracture repair using 3D printed anatomical models is enabling surgeons to visualize and simulate the fracture reduction processes before surgery. However, the preparation of such models can be challenging due to the complexity of certain fractures, particularly in preserving fine detail in bone fragments, maintaining the positioning of displaced fragments, and accurate positioning of multiple bones. This study described several key technical considerations for preparing 3D printed anatomical models for comminuted fracture preoperative planning. An optimized segmentation protocol was developed that preserves fine detail in bone fragments, resulting in a more accurate representation of the fracture. Additionally, struts were manually added to the digital model to maintain the positioning of displaced fragments after fabrication, reducing the likelihood of errors during printing or misrepresentation of fragment positioning. Magnets were also used to enable separation and visualization of accurate positioning of multiple bones, making it easier to visualize fracture components otherwise obscured by the anatomy. Finally, the infill for non-target structures was adjusted to minimize print time and material wastage. These technical optimizations improved the accuracy and efficiency of preparing 3D printed anatomical models for comminuted fracture preoperative planning, improving opportunities for surgeons to better plan surgical treatment in advance, reducing the likelihood of errors, with the goal of improving surgical outcomes.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of patient-specific guides and 3D model in scapula osteotomy for symptomatic malunion.","authors":"Stefano Cattaneo, Marco Domenicucci, Claudio Galante, Elena Biancardi, Alessandro Casiraghi, Giuseppe Milano","doi":"10.1186/s41205-023-00184-w","DOIUrl":"10.1186/s41205-023-00184-w","url":null,"abstract":"<p><strong>Background: </strong>Scapular osteotomy for malunion can lead to resolution of pain and functional improvement in scapula fracture sequelae. Understanding three-dimensional bone morphology and analysing post-traumatic deformity is the main step of planning and the key to success of the procedure. 3D models and patient-specific guides are a growing technology to enhance accuracy of planning and to assist during surgery.</p><p><strong>Case presentation: </strong>We report the case of a 50 years old male, complaining of pain and limited function after a malunited scapular body fracture. Clinical assessment showed a severe impairment of shoulder function with active and passive forward flexion limited to 80°, absent external rotation, and internal rotation limited to the buttock. X-rays and CT scan showed an excessive lateral border offset of 53 mm and complete displacement of the glenoid segment anteriorly and medially to the scapular body, with impingement between the lateral most prominent scapular bone spur and humeral shaft. Glenopolar angle was 19°, scapular body angulation on the sagittal plane was 12°. Corrective osteotomy was planned on a virtual interactive rendering and on 3D printed models. Patient-specific guides were developed to perform a body-spine osteotomy with removal of a bone wedge, and a glenoid-spine osteotomy; a patient-specific wedge spacer was used to hold the reduction during plate fixation. Follow-up up to 12 months after surgery demonstrated improvement in scapula anatomy, shoulder girdle function, and patient-reported outcomes.</p><p><strong>Conclusions: </strong>For the first time in scapula malunion surgery, patient-specific osteotomy guides were succesfully used during surgery to perform osteotomies and to assist in reduction maneuvers.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10550148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Design, printing optimization, and material testing of a 3D-printed nasal osteotomy task trainer.","authors":"Lauren Schlegel, Eric Malani, Sara Belko, Ayan Kumar, Eric Barbarite, Howard Krein, Ryan Hefelfnger, Morgan Hutchinson, Robert Pugliese","doi":"10.1186/s41205-023-00188-6","DOIUrl":"10.1186/s41205-023-00188-6","url":null,"abstract":"","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10406729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an individual helmet orthosis for infants based on a 3D scan.","authors":"Fabian Kropla, Martin Hoffmann, Dirk Winkler, Matthias Krause, Sebastian Scholz, Ronny Grunert","doi":"10.1186/s41205-023-00187-7","DOIUrl":"10.1186/s41205-023-00187-7","url":null,"abstract":"<p><p>An early childhood skull deformity can have long-term health and aesthetic consequences for the growing toddler. Individual helmet therapy aims at a healthy growth of the skull shape, although not every helmet shape guarantees an optimal result. To ensure an optimal fit, a scanning procedure based on a hand-held surface scanner was evaluated.The new helmet orthosis has an inner layer adapted to the shape of the head, which can be exchanged depending on the growth stage without changing the outer layer.In collaboration with surgeons and engineers, a new helmet orthosis concept was developed that is intended to offer improvements in wearing comfort, overall weight, fit and user-friendliness compared to conventional systems. In the course of the development process and in constant exchange with parents, a multi-layer helmet system with generous perforations was created using additive manufacturing processes. The new helmet shape promises easier handling, especially through the closure system.The helmet shape developed in this study is of high quality, especially in terms of fitting accuracy. Unpleasant perspiration is significantly reduced. The integration of the closure as a direct component of the helmet represents a secure closure option.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10045529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative AI for medical 3D printing: a comparison of ChatGPT outputs to reference standard education.","authors":"Aakanksha Sriwastwa,&nbsp;Prashanth Ravi,&nbsp;Andrew Emmert,&nbsp;Shivum Chokshi,&nbsp;Shayne Kondor,&nbsp;Kashish Dhal,&nbsp;Parimal Patel,&nbsp;Leonid L Chepelev,&nbsp;Frank J Rybicki,&nbsp;Rajul Gupta","doi":"10.1186/s41205-023-00186-8","DOIUrl":"https://doi.org/10.1186/s41205-023-00186-8","url":null,"abstract":"","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"9 1","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}