3D printing in medicine最新文献

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A novel algorithm for streamlined surgeon-dominated patient-specific implant design in computer-assisted jaw reconstruction. 计算机辅助颌骨重建中以外科医生为主导的患者特异性种植体设计的新算法。
IF 3.2
3D printing in medicine Pub Date : 2025-03-11 DOI: 10.1186/s41205-025-00260-3
Ankit Nayak, Jane Jingya Pu, Xingna Yu, Yu-Xiong Su
{"title":"A novel algorithm for streamlined surgeon-dominated patient-specific implant design in computer-assisted jaw reconstruction.","authors":"Ankit Nayak, Jane Jingya Pu, Xingna Yu, Yu-Xiong Su","doi":"10.1186/s41205-025-00260-3","DOIUrl":"10.1186/s41205-025-00260-3","url":null,"abstract":"<p><strong>Background: </strong>Computer-assisted surgery has transformed the approach to jaw resection and reconstruction in recent years. However, the extensive time and technical expertise needed for the planning and creation of patient-specific implants and guides have posed significant challenges for many surgeons in the field. This study introduces a novel algorithm designed to streamline the traditionally intricate and time-consuming Computer-Aided Design (CAD) process for developing patient-specific implants (PSIs).</p><p><strong>Methods: </strong>The algorithm requires a three-dimensional (3D) model of the reconstructed part. A set of points is selected along the planned location of the plate by the surgeon, defining both the geometry and the positions of the screw holes. These points are then connected to create trace lines, followed by smoothing using cubic-spline data interpolation. Subsequently, a rectangle is swept along the trace line to form the skeleton of the PSI's surface model. Screw holes are incorporated into the surface model, which is then converted into 3D printable file format. Finite element analysis is conducted to evaluate the functionality of the designed PSI.</p><p><strong>Results: </strong>Implant design time exhibits significant reductions with the proposed algorithm, which optimizes the model files for printing. Finite Element Analysis is successfully applied to demonstrate the stress levels in the implant plate, which are within safe limits for titanium 3D-printed implants.</p><p><strong>Conclusions: </strong>This algorithm offers a faster, more efficient, and accurate alternative to traditional CAD methods, with the potential to revolutionize the field of patient-specific implant design. Furthermore, the study demonstrates the utility of a mechanistic model for correlating patient bite force with muscle forces in the literature.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"12"},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generalizable deep learning framework for 3D medical image segmentation using limited training data. 基于有限训练数据的三维医学图像分割的可推广深度学习框架。
IF 3.2
3D printing in medicine Pub Date : 2025-03-06 DOI: 10.1186/s41205-025-00254-1
Tobias Ekman, Arthur Barakat, Einar Heiberg
{"title":"Generalizable deep learning framework for 3D medical image segmentation using limited training data.","authors":"Tobias Ekman, Arthur Barakat, Einar Heiberg","doi":"10.1186/s41205-025-00254-1","DOIUrl":"10.1186/s41205-025-00254-1","url":null,"abstract":"<p><p>Medical image segmentation is a critical component in a wide range of clinical applications, enabling the identification and delineation of anatomical structures. This study focuses on segmentation of anatomical structures for 3D printing, virtual surgery planning, and advanced visualization such as virtual or augmented reality. Manual segmentation methods are labor-intensive and can be subjective, leading to inter-observer variability. Machine learning algorithms, particularly deep learning models, have gained traction for automating the process and are now considered state-of-the-art. However, deep-learning methods typically demand large datasets for fine-tuning and powerful graphics cards, limiting their applicability in resource-constrained settings. In this paper we introduce a robust deep learning framework for 3D medical segmentation that achieves high performance across a range of medical segmentation tasks, even when trained on a small number of subjects. This approach overcomes the need for extensive data and heavy GPU resources, facilitating adoption within healthcare systems. The potential is exemplified through six different clinical applications involving orthopedics, orbital segmentation, mandible CT, cardiac CT, fetal MRI and lung CT. Notably, a small set of hyper-parameters and augmentation settings produced segmentations with an average Dice score of 92% (SD = ±0.06) across a diverse range of organs and tissues.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"9"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-Site evaluation of a novel point-of-care 3D printing quality assurance protocol for a material jetting 3D printer. 一种新型点护理3D打印质量保证方案的多站点评估,用于材料喷射3D打印机。
IF 3.2
3D printing in medicine Pub Date : 2025-03-06 DOI: 10.1186/s41205-025-00259-w
Matthew D Marquardt, Nicholas Beemster, William Corcuera, Dylan T Beckler, Kyle VanKoevering, Megan Malara, Teri Snyder, Zachary C Thumser
{"title":"Multi-Site evaluation of a novel point-of-care 3D printing quality assurance protocol for a material jetting 3D printer.","authors":"Matthew D Marquardt, Nicholas Beemster, William Corcuera, Dylan T Beckler, Kyle VanKoevering, Megan Malara, Teri Snyder, Zachary C Thumser","doi":"10.1186/s41205-025-00259-w","DOIUrl":"10.1186/s41205-025-00259-w","url":null,"abstract":"<p><strong>Background: </strong>The maturation of 3D printing technologies has opened up a new space for patient advancements in healthcare from trainee education to patient specific medical devices. Point-of-care (POC) manufacturing, where model production is done on-site, includes multiple benefits such as enhanced communication, reduced lead time, and lower costs. However, the small scale of many POC manufacturing operations complicates their ability to establish quality assurance practices. This study presents a novel low-cost quality assurance protocol for POC 3D printing.</p><p><strong>Methods: </strong>Four hundred specially designed quality assurance cubes were printed across four material jetting printers (J5 Medijet, Stratasys, Eden Prairie, Minnesota, USA) at two large medical centers. Three inner dimension and three outer dimension measurements as well as edge angles were measured for every cube by trained research personnel. The delta and absolute error was calculated for each cube and then compared across variables (axis, material, inner vs. outer dimension, swath and machine/site/personnel) using ANOVA analysis.</p><p><strong>Results: </strong>Print axis and inner vs. outer dimension of the model produced statistically significant differences in error while there was no statistically significant difference in the error for material, print swath, or machine/site/personnel. For the print axes, the printers produced an average error of 26, 53, and 57 μm and the error at three sigma was found to be 100, 158, and 198 μm for the Z, R, and Theta axes, respectively.</p><p><strong>Conclusion: </strong>This study demonstrates that this novel protocol is both feasible and reliable for quality assurance in POC 3D printing across multiple sites. This protocol offers an adaptable framework that allows users to tailor the QA process to their specific needs. Through the comprehensive method, users can measure and identify all relevant factors that might introduce error into their printed product and then follow the most critical aspects for their situation across every print. The QA cubes produced via this protocol can provide guidance on print quality and alert users to unsatisfactory machine operation which could cause prints to fall outside of engineering and clinical tolerances.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"10"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical application of three-dimensional printing technology in laparoscopic right hemicolectomy for colon cancer: a pilot study and video demonstration. 三维打印技术在腹腔镜结肠癌右半结肠切除术中的临床应用:初步研究及视频演示。
IF 3.2
3D printing in medicine Pub Date : 2025-02-28 DOI: 10.1186/s41205-025-00258-x
Zongxian Zhao, Rundong Yao, Yuan Yao, Zongju Hu, Shu Zhu, Fusheng Wang
{"title":"Clinical application of three-dimensional printing technology in laparoscopic right hemicolectomy for colon cancer: a pilot study and video demonstration.","authors":"Zongxian Zhao, Rundong Yao, Yuan Yao, Zongju Hu, Shu Zhu, Fusheng Wang","doi":"10.1186/s41205-025-00258-x","DOIUrl":"10.1186/s41205-025-00258-x","url":null,"abstract":"<p><strong>Background: </strong>Patients who undergo laparoscopic right hemicolectomy often have vascular anomalies, creating challenges for surgeons. Preoperative identification of vascular anomalies and intraoperative precise navigation can enhance surgical safety and reduce the difficulty of the procedure. Accordingly, this study aimed to explore and evaluate the application of three-dimensional (3D) reconstruction and printing technology in laparoscopic right hemicolectomy and its assistance in preoperative planning and intraoperative navigation.</p><p><strong>Method: </strong>11 3D-reconstructed images and printed models of right hemicolectomy vasculature were preoperatively created to assist in developing individualized surgical plans. Intraoperatively, essential vessels (gastrocolic trunk of Henle, GTH) were identified and located with the help of the 3D printed models. Additionally, 36 cases without the assistance of 3D printing were retrospectively collected for the control group. Statistical analysis was performed to evaluate the impact of the 3D printed models on surgery-related characteristics.</p><p><strong>Results: </strong>The 3D-printed models accurately depicted anatomical structures, particularly the positions and adjacent relationships of essential vessels, including the superior mesenteric artery (SMA), superior mesenteric vein (SMV), GTH and related arterial/venous branches. The operation time was significantly lower in the 3D printing group (198.6 ± 8.8 min in 3D printing group vs. 230.7 ± 47.5 min in control group, P = 0.025).</p><p><strong>Conclusions: </strong>In conclusion, this study represents a novel vascular 3D printed modelfor surgical planning and intraoperative navigation in laparoscopic right hemicolectomy. It underscores the potential clinical applications of 3D printing in this context. Preoperative identification of vascular anomalies and precise intraoperative navigation can feasibly reduce surgical difficulty and enhance safety.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"8"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D reconstructed models based on real cervical cancer cases for undergraduate gynecological oncology education: a pre- and post-test study. 基于真实宫颈癌病例的三维重建模型用于本科妇科肿瘤学教育的前后试验研究。
IF 3.2
3D printing in medicine Pub Date : 2025-02-26 DOI: 10.1186/s41205-025-00256-z
Jingjing Zhang, Xiuying Liu, Yinye Huang, Liangyi Kong, Min Su, Zheng Hu
{"title":"3D reconstructed models based on real cervical cancer cases for undergraduate gynecological oncology education: a pre- and post-test study.","authors":"Jingjing Zhang, Xiuying Liu, Yinye Huang, Liangyi Kong, Min Su, Zheng Hu","doi":"10.1186/s41205-025-00256-z","DOIUrl":"10.1186/s41205-025-00256-z","url":null,"abstract":"<p><strong>Background: </strong>The landscape of medical education is rapidly evolving, driven by advancements in technology. This evolution has ushered in a new era characterized by digitization, connectivity, and intelligence. In this era, traditional teaching methods are being augmented with innovative technologies such as virtual learning, artificial intelligence platforms, and access to cloud-based health platforms. One notable advancement is the integration of three-dimensional (3D) reconstructed models into medical education, particularly in fields like gynecological oncology.</p><p><strong>Methods: </strong>This study introduces 3D reconstructed models based on real cervical cancer cases as a teaching tool for undergraduate gynecological oncology education. Participants were fourth-year Clinical Medicine students of Wuhan University, China. Using student identity document numbers for grouping, half were assigned to the control group (odd numbers) and the other half to the 3D reconstructed model teaching group (even numbers). All the students completed the pre-tests before receiving traditional teaching on cervical intraepithelial lesions and cervical cancer. The control group completed the post-tests after traditional teaching alone, while the 3D reconstructed model teaching group completed the post-tests after receiving the additional 3D reconstructed model teaching. Feedback on this innovative teaching tool was collected. The pre-tests and post-tests covered cervical intraepithelial lesions, cervical cancer and staging system, and female pelvic anatomy.</p><p><strong>Results: </strong>This study includes 267 students, with 134 in the control group and 133 in the 3D reconstructed model teaching group. The pre-test scores of the three tests between the control group and the 3D reconstructed model teaching group showed no statistical difference (p > 0.05). Compared to the control group, the post-test scores of the 3D reconstructed model teaching group in theoretical knowledge of cervical intraepithelial lesions and cervical cancer, female pelvic anatomy and 2018 International Federation of Gynecology and Obstetrics staging system for cervical cancer increased significantly (p < 0.05). Feedback from students underscored the visual benefits and engaging nature of the models, with many expressing that the 3D models provided a clearer representation of cervical cancer and enhanced their learning experience.</p><p><strong>Conclusion: </strong>The integration of 3D reconstructed models into medical education represents a promising approach to address the complexities of teaching intricate subjects in anatomy such as gynecological oncology. These models offer a more intuitive and thorough visualization of anatomical structures and pathological processes, fostering a hands-on and exploratory learning experience for students.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"7"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACL tunnel placement using 3D printed surgical guides - a porcine feasibility study. 使用3D打印手术指南放置ACL隧道-猪的可行性研究。
IF 3.2
3D printing in medicine Pub Date : 2025-02-19 DOI: 10.1186/s41205-024-00215-0
Sophie C Eberlein, Silvan Hess, Samuel F Schaible, Frank M Klenke, Andreas Hecker
{"title":"ACL tunnel placement using 3D printed surgical guides - a porcine feasibility study.","authors":"Sophie C Eberlein, Silvan Hess, Samuel F Schaible, Frank M Klenke, Andreas Hecker","doi":"10.1186/s41205-024-00215-0","DOIUrl":"10.1186/s41205-024-00215-0","url":null,"abstract":"<p><strong>Background: </strong>Anterior cruciate ligament reconstruction (ACLR) failures are associated with misplacement of the bone tunnels in up to 88%. The aim of this study is to evaluate the feasibility and accuracy of ACL tunnel placement performed with 3D printed guides.</p><p><strong>Methods: </strong>3D models of the femur and tibia from ten porcine specimens were reconstructed using CT scans. ACL tunnel aiming guides were created and fitted to the proximal tibial and distal femoral metaphyseal cortices. Each guide comprised two sleeves to secure the guide to the bone using Kirschner wires and one sleeve for inserting the ACL tunnel guide wire. Guides were printed using a biomedically certified resin on the in-house 3D printer. They were fixed to the antero-medial tibia/distal-lateral femur with Kirschner wires and the ACL guide wire was inserted, then the guides were removed and the ACL guide wire was drilled over. Post-operative CT scans were obtained in order to compare the actual positions of the tunnel to the planned positions. Results are presented as medians and ranges since normal distribution could not be confirmed.</p><p><strong>Result: </strong>Median deviations between preoperative plan and actual postoperative positon were 1.15 mm (0.7-3 mm) and 0.75 mm (0.3-2.8 mm) for femoral and tibial tunnels, respectively.</p><p><strong>Conclusion: </strong>Good accuracy of ACL tunnel placement can be achieved using 3D printed guides. Applied to a clinical setting, this technique has the potential to significantly reduce complications due to misplacement of bone tunnels.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"6"},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the landscape of clinical and observational trials involving bioprinting: a scoping review. 评估涉及生物打印的临床和观察性试验的前景:范围综述。
IF 3.2
3D printing in medicine Pub Date : 2025-02-17 DOI: 10.1186/s41205-025-00253-2
Yumi Briones, Beatrice Pascua, Narra Tiangco, Isabel Crisostomo, Samantha Casiguran, Roland Remenyi
{"title":"Assessing the landscape of clinical and observational trials involving bioprinting: a scoping review.","authors":"Yumi Briones, Beatrice Pascua, Narra Tiangco, Isabel Crisostomo, Samantha Casiguran, Roland Remenyi","doi":"10.1186/s41205-025-00253-2","DOIUrl":"10.1186/s41205-025-00253-2","url":null,"abstract":"<p><strong>Objective: </strong>Bioprinting is a tissue engineering technique that is rapidly evolving to include complex clinical applications. However, there is limited evidence describing how far bioprinting has progressed past the pre-clinical stage. Thus, we conducted a scoping review to assess the landscape of clinical studies, including interventional and observational trials, involving bioprinting by charting trends in general characteristics, bioprinting application, and trial design.</p><p><strong>Methods: </strong>The term \"bioprint\" and its variants were searched in five trial databases (ICTRP, ScanMedicine, CENTRAL, NIHCC, HCCTD) and two registries (ClinicalTrials.gov, PHRR) on 22 February 2024. This was followed by duplicate removal and dual independent review to finalize the inclusion list. We included trials published in or translated to English mentioning \"bioprint\" in their design, while we excluded those that did not adhere to our definition of bioprinting. Finally, data were charted and synthesized narratively.</p><p><strong>Results: </strong>Of 36 total search records, 11 trials met the inclusion criteria. Registration dates ranged from 2016 to 2023, with China conducting the most trials globally. Four trials had published results, while the remaining were still in progress. Four interventional trials aimed to implant bioprinted tissues made with autologous cells, including blood vessels, trachea, external ear, and wound dressings. The other seven studies were interventional and observational trials aiming to bioprint autologous cell-laden in vitro models to study conditions such as cancer.</p><p><strong>Conclusion: </strong>Bioprinting is still in the early stages of clinical research, with a focus on producing patient-specific tissues for cancer precision medicine and regenerative purposes. More standardized reporting of bioprinting-related information is needed to improve research transparency and replicability. As the body of evidence grows, our review may be used as a framework to monitor the clinical translation of bioprinting over the years.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"5"},"PeriodicalIF":3.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual 3D reconstruction of complex congenital cardiac anatomy from 3D rotational angiography. 从三维旋转血管造影虚拟三维重建复杂的先天性心脏解剖结构。
IF 3.2
3D printing in medicine Pub Date : 2025-01-27 DOI: 10.1186/s41205-024-00247-6
Ernesto Mejia, Shannon Sweeney, Jenny E Zablah
{"title":"Virtual 3D reconstruction of complex congenital cardiac anatomy from 3D rotational angiography.","authors":"Ernesto Mejia, Shannon Sweeney, Jenny E Zablah","doi":"10.1186/s41205-024-00247-6","DOIUrl":"10.1186/s41205-024-00247-6","url":null,"abstract":"<p><strong>Background: </strong>Despite advancements in imaging technologies, including CT scans and MRI, these modalities may still fail to capture intricate details of congenital heart defects accurately. Virtual 3D models have revolutionized the field of pediatric interventional cardiology by providing clinicians with tangible representations of complex anatomical structures. We examined the feasibility and accuracy of utilizing an automated, Artificial Intelligence (AI) driven, cloud-based platform for virtual 3D visualization of complex congenital heart disease obtained from 3D rotational angiography DICOM images.</p><p><strong>Methods: </strong>Five patients selected at random with 3DRA performed in the pediatric cardiac catheterization suite were selected. 3DRA's were performed following published institutional protocols and segmentations performed by primary operators. The 3DRA DICOM images were anonymized as per protocol and exported. Images when then processed by Axial3D Artificial Intelligence (AI) driven cloud-based platform for virtual segmentation. Two separate expert operators were selected to subjectively analyze the segmentations and compare them to the operator reconstructions for anatomic accuracy.</p><p><strong>Results: </strong>Comparing results with local reconstructions by expert operators, five different patient anatomies were analyzed, showcasing Axial3D's ability to produce highly detailed reconstructions with improved visual appeal, including color-coded segments for implanted materials like stents. The reconstructions exhibited superior segmentation of different intrathoracic structures when compared to local models, offering valuable insights for medical professionals and patients.</p><p><strong>Conclusions: </strong>The use of the AI driven, cloud-based platform for 3D visualization of complex congenital heart lesions presents a promising advancement in pediatric interventional cardiology, facilitating enhanced patient care, procedural planning, and educational opportunities for trainees and patients alike.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"4"},"PeriodicalIF":3.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and biomechanical evaluation of a 3D printed analogue of the human lumbar spine. 人类腰椎3D打印模拟物的开发和生物力学评估。
IF 3.2
3D printing in medicine Pub Date : 2025-01-23 DOI: 10.1186/s41205-025-00249-y
Siril Teja Dukkipati, Mark Driscoll
{"title":"Development and biomechanical evaluation of a 3D printed analogue of the human lumbar spine.","authors":"Siril Teja Dukkipati, Mark Driscoll","doi":"10.1186/s41205-025-00249-y","DOIUrl":"10.1186/s41205-025-00249-y","url":null,"abstract":"<p><strong>Background: </strong>There exists a need for validated lumbar spine models in spine biomechanics research. Although cadaveric testing is the current gold standard for spinal implant development, it poses significant issues related to reliability and repeatability due to the wide variability in cadaveric physiologies. Moreover, there are increasing ethical concerns with human dissection practices. Analogue models can act as cost saving alternatives to human tissue with better repeatability. The current study proposes a new methodology of spinal biomechanics testing using 3D printable surrogates and characterized its multi-dimensional stiffness in displacement-controlled loading scenarios.</p><p><strong>Methods: </strong>The model consisted of L1 to S1 vertebrae, intervertebral discs (IVD), intertransverse, interspinous, anterior and posterior longitudinal ligaments. The vertebrae and the IVDs were derived from an open-source 3D MRI anatomography database, while the ligaments were modeled based on literature incorporating mounting points on the spinous and transverse processes. Stereolithography 3D printing along with a combination of stiff and soft photopolymer resins were used to manufacture the vertebrae and the soft tissues in the model. Thereafter, displacement-controlled pure moments were applied in the range of ± 15° at 0.5°/sec in all bending modes using a torsion testing machine and a custom pure bending jig. Model rotation and resisting moment under loading were recorded to quantify the rotational stiffness and hysteresis in the model.</p><p><strong>Results: </strong>The model reached a maximum of 5.66Nm and 3.53Nm at 15° flexion-extension, 3.84Nm and 3.93Nm at 15° right and left lateral bending, and 2.45Nm and 2.59Nm at 15° right and left axial rotation respectively. Model RMS error against ex vivo human response was estimated to be 1.57°, 1.64°, 0.82° in flexion-extension, lateral bending and axial rotation respectively. Bilateral symmetry in model stiffness was observed in lateral bending and axial rotation directions.</p><p><strong>Conclusions: </strong>This study presents a reproducible 3D printable L1-S1 lumbar spine and validated it in all three orthogonal bending modes in the range of ± 15° against ex vivo and in silico data. The 3D printed analogue spine model described herein shows promising results, suggesting this model, with further validation, could have potential as a human cadaveric tissue substitute within the explored contexts of use.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the value of 3D-printed bone models with fracture fragments connected by flexible rods for training and preoperative planning. 评估用柔性棒连接骨折碎片的3d打印骨模型在训练和术前规划中的价值。
IF 3.2
3D printing in medicine Pub Date : 2025-01-15 DOI: 10.1186/s41205-025-00250-5
Monica Ghidinelli, Dankward Höntzsch, Bedran Atici, Stefano Crespan
{"title":"Evaluating the value of 3D-printed bone models with fracture fragments connected by flexible rods for training and preoperative planning.","authors":"Monica Ghidinelli, Dankward Höntzsch, Bedran Atici, Stefano Crespan","doi":"10.1186/s41205-025-00250-5","DOIUrl":"10.1186/s41205-025-00250-5","url":null,"abstract":"<p><strong>Background: </strong>The emergence of 3D printing has revolutionized medical training and preoperative planning. However, existing models have limitations, prompting the development of newly designed flexible 3D-printed bone fracture models.</p><p><strong>Methods: </strong>The designed flexible 3D-printed bone fracture models were evaluated by 133 trauma surgeons with different levels of experience for perceived value as educational tool or as preoperative planning tool.</p><p><strong>Results: </strong>The models allowed drilling and showed resistance to manipulation and sterilization. Surgeons found the flexible model helpful for teaching and planning the reduction of fractures, planning and simulating osteosynthesis, understanding fractures, visualizing fractures, and planning surgical approaches.</p><p><strong>Conclusions: </strong>Flexible 3D-printed bone fracture models offer a dynamic and realistic approach to understanding complex fractures, potentially improving surgical training and preoperative planning.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"2"},"PeriodicalIF":3.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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