{"title":"Identification of Funerary Food Residues in Clay Vessels of the Uelgi Burial Ground (Southern Trans-Urals) by Gas Chromatography and Mass Spectrometry","authors":"S. G. Botalov, K. G. Margarian, S. R. Gazizova","doi":"10.1134/S2635167625601780","DOIUrl":"10.1134/S2635167625601780","url":null,"abstract":"<p>The work presents the results of studying a series of samples of organic materials preserved on the internal surfaces of ancient ceramic vessels found in the burial mounds of the Uelgi burial complex during archaeological excavations. The composition of the organic compounds is determined using gas chromatography and mass-spectrometry methods. Six groups of products are identified: lamb, horse meat, lamb + plants, sheep’s milk, goat’s milk, and lamb + millet.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"950 - 960"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147335996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. I. Musorin, D. I. Archibasov, D. V. Shuleiko, S. A. Kozyukhin, P. K. Kashkarov, A. A. Fedyanin
{"title":"Polarization Properties of Amorphous Chalcogenide Films with Laser-induced Periodic Structures","authors":"A. I. Musorin, D. I. Archibasov, D. V. Shuleiko, S. A. Kozyukhin, P. K. Kashkarov, A. A. Fedyanin","doi":"10.1134/S2635167625601901","DOIUrl":"10.1134/S2635167625601901","url":null,"abstract":"<p>The need to replace bulk classical optical elements with their compact nanoscale counterparts stimulates research of new materials, their production and processing methods, optical properties calculation, and experimental verification. The possibility of using laser-induced periodic structures on the surface of thin chalcogenide As<sub>50</sub>Se<sub>50</sub> films as polarization optics elements has been studied. Designing the surface relief allows one to create waveplates with predetermined electromagnetic properties.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"943 - 949"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of Silver and Succinyl Chitosan Nanocomposites in the Presence of a Plant-Derived Antioxidant","authors":"A. M. Futoryanskaya, V. A. Aleksandrova","doi":"10.1134/S2635167625601767","DOIUrl":"10.1134/S2635167625601767","url":null,"abstract":"<p>A new approach to the creation of nanocomposites based on succinyl chitosan and silver nanoparticles is developed. The synthesis of silver nanoparticles from ions is carried out under microwave radiation. For the first time, an antioxidant of plant origin, syringic acid, is used as a reducing agent in such systems. The presence of silver nanoparticles in the obtained colloidal solutions is judged by the appearance of an absorption band in the electron plasmon resonance spectrum (λ<sub>max</sub> = 425–430 nm). It is shown that with an increase in the concentration of syringic acid in the system, the size of the silver nanoparticles formed decreases, and the main fraction of particles with a size of 9 nm is obtained.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"809 - 813"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. S. Gusev, O. A. Novodvorsky, L. S. Parshina, N. V. Potekhina, I. N. Nikolaeva, N. N. Eliseev, A. S. Sinko, A. P. Shkurinov
{"title":"Pulsed Laser Deposition of NiO/Pt and Fe/NiO/Pt Thin-Film Heterostructures for THz Applications","authors":"D. S. Gusev, O. A. Novodvorsky, L. S. Parshina, N. V. Potekhina, I. N. Nikolaeva, N. N. Eliseev, A. S. Sinko, A. P. Shkurinov","doi":"10.1134/S2635167625601585","DOIUrl":"10.1134/S2635167625601585","url":null,"abstract":"<p>Thin films of NiO, Fe, and Pt and NiO/Pt, Fe/NiO/Pt heterostructures are fabricated using the pulsed laser deposition in a droplet-free mode with the ablation of metal targets on single-crystal sapphire substrates with the orientation (0001) at room temperature. The heterostructures are obtained by the sequential deposition of layers within in a single technological cycle. The structural, optical, and electrophysical properties and surface morphology of the obtained films and heterostructures are studied. The presence of the 2M mode is established in the Raman spectra, which confirms antiferromagnetic ordering in the NiO layers in the synthesized heterostructures. The X-ray diffraction spectra of both the individual NiO films and heterostructures demonstrate NiO (111) diffraction peaks, which confirms the high crystalline perfection of the films synthesized at room temperature without additional annealing. Terahertz radiation generation is achieved in the Fe/NiO/Pt heterostructure upon excitation by femtosecond laser pulses.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"779 - 786"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. S. Plevako, A. Yu. Garanin, O. A. Vasileva, V. I. Yevtushenko, E. I. Yakubovich, A. V. Malek
{"title":"Comparative Analysis of Methods for the Formation and Cytostatic Activity of the Vesicular Form of Doxorubicin","authors":"D. S. Plevako, A. Yu. Garanin, O. A. Vasileva, V. I. Yevtushenko, E. I. Yakubovich, A. V. Malek","doi":"10.1134/S2635167625600518","DOIUrl":"10.1134/S2635167625600518","url":null,"abstract":"<p>The clinical efficacy of systemic therapies for oncological diseases is limited by their toxic effects on healthy tissues and the risk of fatal complications developing. One way to address this problem is to develop technologies for the targeted delivery of anticancer drugs. Autologous extracellular nanovesicles (ENVs) can serve as a basis for innovative systems for the targeted delivery of cytostatics. There are several methods for “loading” ENVs with cytostatics, but practical selection of the optimal approach is hampered by the lack of universal evaluation criteria and systematic comparative studies. Therefore, the aim of this work is to compare technologies for loading an anticancer drug (doxorubicin) into plasma ENVs. The ENVs are isolated from the plasma of healthy donors and analyzed using nanoparticle tracking analysis (NTA) and flow cytometry. Electroporation and sonoporation technologies in various modifications are used to load doxorubicin into the vesicles. The effect of the treatment is assessed using NTA, the efficiency of loading is assessed using absorption spectroscopy, and the cytostatic effect of the vesicular form of the drug is assessed using the MTT assay on MCF-7 and BT474 breast cancer cells. Based on analysis of ENV integrity, the optimal conditions for electroporation and sonoporation are determined. Sonoporation in the mode of 35 kHz, 40 W, 4 cycles (30–120 s) shows an advantage, with a loading efficiency of 32.2%. The cytostatic activity of the vesicular form of doxorubicin is higher compared to the drug solution under in vitro experimental conditions. Sonoporation is an effective method for loading doxorubicin into ENVs, based on which a vesicular delivery system for anticancer drugs can be developed.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"881 - 892"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Viscosity and Rheology of Drilling Fluids with Nanoparticles","authors":"V. Ya. Rudyak, A. V. Minakov, E. I. Lysakova","doi":"10.1134/S2635167624601293","DOIUrl":"10.1134/S2635167624601293","url":null,"abstract":"<p>This work is a systematic review of studies in the field of viscosity and rheology of drilling fluids modified with nanoparticles, based on results obtained over approximately the past 10 years. The viscosity and rheology of more than 40 different drilling fluids with silicon, aluminum, and titanium oxide nanoparticles and with diamond nanoparticles are studied. The mass concentration of nanoparticles varies from 0.06 to 4%, and their size ranges from 5 to 190 nm. Nanofluids are highly specific dispersed liquids; their properties are not described by classical theories for coarse-dispersed fluids. The presence of nanoparticles in drilling fluids, which have a much more complex structure than nanofluids, leads to extremely interesting and novel effects, which are also discussed in this paper.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"749 - 763"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Yu. Garanin, D. S. Plevako, O. A. Vasilyeva, A. V. Malek
{"title":"Vesicular Systems for Anticancer Drug Delivery","authors":"A. Yu. Garanin, D. S. Plevako, O. A. Vasilyeva, A. V. Malek","doi":"10.1134/S2635167625600506","DOIUrl":"10.1134/S2635167625600506","url":null,"abstract":"<p>Membrane-bound extracellular nanovesicles (ENVs) are a natural product of the secretory activity of living cells. One of the main biological functions of ENVs is considered to be intercellular transport. The size, stability, possibility of surface modification, and other characteristics indicate the possibility of using ENVs as a drug delivery system. The introduction of “vesicular” drug formulations into practice involves the development of a set of complementary technologies: obtaining ENVs, forming a vesicular dosage form, modifying the vesicular surface in accordance with the therapeutic purpose and the method of administration of the finished product. These aspects are covered in this review based on an analysis of studies devoted to the development of anticancer drugs. The final chapter discusses the stages of development and implementation of vesicular drug delivery systems into clinical practice.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"695 - 711"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. D. Musin, E. V. Varlamova, M. A. Marchenkova, A. V. Soldatov
{"title":"Artificial Intelligence As a Driver of Modern Science: from Biomedicine to International Megascience Projects","authors":"D. D. Musin, E. V. Varlamova, M. A. Marchenkova, A. V. Soldatov","doi":"10.1134/S2635167625601664","DOIUrl":"10.1134/S2635167625601664","url":null,"abstract":"<p>The key developments of the past two decades highlighting the transformation of scientific research driven by artificial intelligence (AI) are summarized. Both well-established and emerging applications of AI are explored: ranging from biomedicine, pharmaceuticals, nutrition science, education, data science, engineering, and fundamental disciplines to synchrotron radiation facilities and advanced megascience facilities. A detailed overview of AI approaches and architectures implemented in major international projects is provided, including the Large Hadron Collider and its High-Luminosity upgrade; the FAIR facility; the DUNE and Belle II experiments; the LIGO, Virgo, and KAGRA gravitational-wave observatories; the LSST survey telescope; the SKA radio interferometer; the Euclid space observatory; the ESS, SNS, and J-PARC neutron sources; the ITER and JT-60SA fusion reactors; the NIF laser facility; the ELI-NP laser complex; exascale climate simulation platforms; and cryo-electron microscopy systems powered by AlphaFold technology. The work is intended for a broad audience of specialists interested in the methodological, technical, and organizational aspects of AI integration into scientific research.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"712 - 717"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isolation and Properties of Extracellular Vesicles","authors":"O. V. Morozova, E. A. Obraztsova, D. V. Klinov","doi":"10.1134/S2635167625601949","DOIUrl":"10.1134/S2635167625601949","url":null,"abstract":"<p>For the prolonged intracellular action of pharmaceutical drugs, penetration through cell membranes and escape from endosomal-lysosomal entrapment are necessary. Inorganic and organic nanomaterials enter eukaryotic cells mainly through endocytosis with biodegradation with lysosomal enzymes; antigen presentation to the immune system; and the induction of innate, trained, and adaptive immunity. The fusion of extracellular vesicle membranes and cell membranes permit to escape from lysosomes, enzymatic hydrolysis, and cytokine gene expression. The study aims to isolate extracellular vesicles and analyze their physical and chemical properties. Vesicles with a diameter of 10–200 nm surrounded by membranes with a thickness of 7–10 nm were isolated from the conditioned culture media of embryonic and transformed human cells, as well from apple juice, using differential centrifugation at 20 800 <i>g</i>. They consisted of lipids and proteins, were stable during isolation, fluorescent labeling, and storage at +4°C for 5 months. Loaded extracellular vesicles were fabricated by hydration of a thin layer of dried cell membranes. Fluorescent vesicles were nontoxic to autologous and heterologous human cells and gradually accumulated in cells over 7 days of observation.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"865 - 870"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of the Active Electrode Material on the Characteristics of Parylene–MoOx-Based Memristors","authors":"A. D. Trofimov, A. V. Emelyanov","doi":"10.1134/S2635167625601858","DOIUrl":"10.1134/S2635167625601858","url":null,"abstract":"<p>The active electrode material plays a crucial role in resistive switching (RS) in memristors by the mechanism of electrochemical metallization (ECM). This affects the rate of formation/destruction and the shape of the conductive filament formed from the atoms of the active electrode penetrating into the dielectric layer, which, in turn, affects the type and stability of RS. One of the promising materials for memristors with ECM are nanocomposites based on poly-<i>p</i>-xylylene (PPX). The difference in the RS and synaptic properties of memristors based on PPX nanocomposite with molybdenum oxide nanoparticles with copper and silver active electrodes is studied.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"936 - 942"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}