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Magnetic Nanodiscs That Destroy Glioblastoma Cells in a Targeted Way in an Alternating Nonheating Magnetic Field 在交变非加热磁场中以靶向方式摧毁胶质母细胞瘤细胞的磁性纳米盘
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S2635167624600834
V. D. Fedotovskaya, S. S. Zamai, M. V. Zotova, A. N. Masyugin, F. V. Zelenov, N. A. Luzan, T. N. Zamai, A. A. Koshmanova, D. A. Kirichenko, E. D. Nikolaeva, O. S. Kolovskaya, I. A. Shchugoreva, G. S. Zamai, V. N. Zabluda, A. A. Borus, A. S. Bukatin, I. N. Lapin, V. A. Svetlichnyi, E. V. Morozov, K. A. Luk’yanenko, F. G. Zograf, F. N. Tomilin, A. E. Sokolov, A. A. Narodov, R. G. Galeev, A. S. Kichkailo
{"title":"Magnetic Nanodiscs That Destroy Glioblastoma Cells in a Targeted Way in an Alternating Nonheating Magnetic Field","authors":"V. D. Fedotovskaya,&nbsp;S. S. Zamai,&nbsp;M. V. Zotova,&nbsp;A. N. Masyugin,&nbsp;F. V. Zelenov,&nbsp;N. A. Luzan,&nbsp;T. N. Zamai,&nbsp;A. A. Koshmanova,&nbsp;D. A. Kirichenko,&nbsp;E. D. Nikolaeva,&nbsp;O. S. Kolovskaya,&nbsp;I. A. Shchugoreva,&nbsp;G. S. Zamai,&nbsp;V. N. Zabluda,&nbsp;A. A. Borus,&nbsp;A. S. Bukatin,&nbsp;I. N. Lapin,&nbsp;V. A. Svetlichnyi,&nbsp;E. V. Morozov,&nbsp;K. A. Luk’yanenko,&nbsp;F. G. Zograf,&nbsp;F. N. Tomilin,&nbsp;A. E. Sokolov,&nbsp;A. A. Narodov,&nbsp;R. G. Galeev,&nbsp;A. S. Kichkailo","doi":"10.1134/S2635167624600834","DOIUrl":"10.1134/S2635167624600834","url":null,"abstract":"<p>The need to develop a surgical instrument that can most effectively and minimally invasively remove a malignant tumor, and distinguish and destroy only tumor cells without damaging the normal cells of healthy tissue surrounding the tumor is being considered. To achieve this goal, it is proposed to use nanodiscs with special magnetic, electronic and optical properties. Nanodiscs modified with recognition ligands (aptamers) are able to bind to tumor cells and destroy them under the influence of a weak, nonheating alternating magnetic field. This allows for effective tumor destruction while minimizing the impact on surrounding healthy tissue.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"299 - 304"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Study of the Stability of PtCu/C Catalysts for Low-Temperature Fuel Cells 用于低温燃料电池的 PtCu/C 催化剂稳定性综合研究
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S2635167624600913
S. V. Belenov, E. E. Moguchikh, A. S. Pavlets, I. V. Pankov, V. S. Menshchikov
{"title":"Comprehensive Study of the Stability of PtCu/C Catalysts for Low-Temperature Fuel Cells","authors":"S. V. Belenov,&nbsp;E. E. Moguchikh,&nbsp;A. S. Pavlets,&nbsp;I. V. Pankov,&nbsp;V. S. Menshchikov","doi":"10.1134/S2635167624600913","DOIUrl":"10.1134/S2635167624600913","url":null,"abstract":"<div><p>The catalytic activity in the oxygen-reduction reaction and stability in various stress-testing modes are studied for bimetallic PtCu/C catalysts with platinum contents of 20 and 30 wt %, obtained by liquid-phase synthesis methods, is studied by cyclic-voltammetry methods on a rotating disk electrode in a three-electrode cell and as part of a membrane-electrode assembly in comparison with a commercial Pt/C catalyst. Significant differences in the degree of degradation of the studied PtCu/C and Pt/C catalysts for low-temperature fuel cells are shown, namely from 33 to 67% depending on the stress-testing method and catalyst composition.</p></div>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"243 - 252"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of ZIF-8/ZIF-67 Multilayer Films for NO2 and CO Detection ZIF-8/ZIF-67 多层薄膜在二氧化氮和一氧化碳检测中的应用
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S2635167624600949
O. I. Il’in, V. A. Polyakov, N. N. Rudyk, Yu. Yu. Zhityaeva, A. V. Saenko, M. A. Gritsai, A. A. Chefranov, M. A. Soldatov
{"title":"Application of ZIF-8/ZIF-67 Multilayer Films for NO2 and CO Detection","authors":"O. I. Il’in,&nbsp;V. A. Polyakov,&nbsp;N. N. Rudyk,&nbsp;Yu. Yu. Zhityaeva,&nbsp;A. V. Saenko,&nbsp;M. A. Gritsai,&nbsp;A. A. Chefranov,&nbsp;M. A. Soldatov","doi":"10.1134/S2635167624600949","DOIUrl":"10.1134/S2635167624600949","url":null,"abstract":"<div><p>Prototypes of gas sensors with sensitive elements are made based on ZIF-8 and ZIF-67 films obtained directly on a substrate by immersion. The sensitivity of the prototypes to NO<sub>2</sub> and CO is assessed by simultaneously analyzing the capacitive and resistive response. It is shown that the functionalization of ZIF-8 films with layers of ZIF-67/ZIF-8 leads to an increase in the sensitivity of the sensor to NO<sub>2</sub> by more than 2 times compared to ZIF-8 films, and also allows CO detection. A sensor prototype based on ZIF-67/ZIF-8 films shows a resistive and capacitive sensitivity to NO<sub>2</sub> of 3 and 6% (for 45 ppm), 14 and 15% (for 85 ppm), and to CO of 9 and 7% (for 6 ppm), 15 and 10% (for 10 ppm). It is shown that parallel analysis of the capacitive and resistive response makes it possible to increase the accuracy of the analysis of the sensor response when exposed to various gases and can be used as the basis for a software interface for training sensor operation using artificial intelligence.</p></div>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"275 - 281"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the Biomimetic Synthesis of Nanoparticles of Zinc Compounds 锌化合物纳米颗粒的仿生合成
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S2635167623601286
E. A. Mukhanova, K. Y. Cardenas Rodriguez, V. O. Shevchenko, P. D. Kuznetsova, A. N. Bulgakov, O. E. Polozhentsev
{"title":"On the Biomimetic Synthesis of Nanoparticles of Zinc Compounds","authors":"E. A. Mukhanova,&nbsp;K. Y. Cardenas Rodriguez,&nbsp;V. O. Shevchenko,&nbsp;P. D. Kuznetsova,&nbsp;A. N. Bulgakov,&nbsp;O. E. Polozhentsev","doi":"10.1134/S2635167623601286","DOIUrl":"10.1134/S2635167623601286","url":null,"abstract":"<div><p>The biomimetic synthesis of nanoparticles has many advantages over classical methods due to the possibility of combining special reaction conditions and a ready-made matrix to form a given particle morphology. The possibility of synthesizing zinc-sulfide nanoparticles in sprouts of <i>Vigna radiata</i> (<i>L.</i>) R. Wilczek and <i>Lentilla lens</i> (<i>L.</i>) W. Wight is investigated. It is established that the optimal biological matrix for synthesis is <i>Vigna radiata</i> (<i>L.</i>) R. Wilczek. The method used opens up a new way to producing other inorganic materials.</p></div>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"219 - 224"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142192858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technology of Application of the Multilayer Nanofilm ZIF-8/ZIF-67 for CO Detection 用于二氧化碳检测的多层纳米薄膜 ZIF-8/ZIF-67 的应用技术
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S263516762360133X
M. A. Gritsai, V. A. Polyakov, O. I. Il’in, N. N. Rudyk, Yu. Yu. Zhityaeva, P. V. Medvedev, A. V. Saenko, M. A. Soldatov
{"title":"Technology of Application of the Multilayer Nanofilm ZIF-8/ZIF-67 for CO Detection","authors":"M. A. Gritsai,&nbsp;V. A. Polyakov,&nbsp;O. I. Il’in,&nbsp;N. N. Rudyk,&nbsp;Yu. Yu. Zhityaeva,&nbsp;P. V. Medvedev,&nbsp;A. V. Saenko,&nbsp;M. A. Soldatov","doi":"10.1134/S263516762360133X","DOIUrl":"10.1134/S263516762360133X","url":null,"abstract":"<div><p>The process of the formation of gas-sensitive nanofilms ZIF-8 and ZIF-67 on substrates, which are glass chips with contact tracks formed on them, is studied. Multilayer ZIF-8/ZIF-67 nanofilms are grown on a substrate by cyclic layer-by-layer coating in solution. The film growth process is monitored after each cycle using X-ray diffraction, elemental analysis, and scanning electron microscopy. It is shown that at least three 30-minute growth cycles are required to form a strong, uniform ZIF-8 film. Additionally, the sensory properties of the obtained samples for the detection of carbon monoxide CO are studied.</p></div>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"230 - 236"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rational Optimization of an Aptamer Specific to the Surface of Lung-Cancer Cells Using Mathematical Modeling and Small-Angle X-ray Scattering 利用数学建模和小角 X 射线散射合理优化肺癌细胞表面特异性适配体
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S2635167624600731
P. V. Artyushenko, I. A. Shchugoreva, O. S. Kolovskaya, A. V. Rogova, R. V. Moryachkov, V. N. Zabluda, T. N. Zamay, A. V. Krat, R. A. Zukov, F. N. Tomilin, A. S. Kichkailo
{"title":"Rational Optimization of an Aptamer Specific to the Surface of Lung-Cancer Cells Using Mathematical Modeling and Small-Angle X-ray Scattering","authors":"P. V. Artyushenko,&nbsp;I. A. Shchugoreva,&nbsp;O. S. Kolovskaya,&nbsp;A. V. Rogova,&nbsp;R. V. Moryachkov,&nbsp;V. N. Zabluda,&nbsp;T. N. Zamay,&nbsp;A. V. Krat,&nbsp;R. A. Zukov,&nbsp;F. N. Tomilin,&nbsp;A. S. Kichkailo","doi":"10.1134/S2635167624600731","DOIUrl":"10.1134/S2635167624600731","url":null,"abstract":"<div><p>Aptamers, short oligonucleotides, are capable of high-affinity binding to targets due to their unique structure. Shortening the aptamer while maintaining the active site will increase the affinity and reduce the cost of synthesis. Using the example of the aptamer LC-224, a method for rational optimization of its length and verification of the validity of the developed approach is tested. The use of computer modeling and small-angle X‑ray scattering shows the possibility of optimizing the aptamer structure by removing nucleotides that do not participate in binding to the target. It is shown that truncation of the aptamer does not reduce the affinity and specificity of the DNA aptamer. Thus, theoretical and experimental studies demonstrate successful experience in optimizing the structure of a DNA aptamer by shortening it without compromising its affinity and specificity for its target.</p></div>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"183 - 187"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142192832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical Modeling of Indium Adatoms on Reconstructed GaAs(001) and AlAs(001) Surfaces 重构砷化镓（001）和砷化镓（001）表面铟原子的理论建模
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S2635167623601328
V. A. Roldugin, M. A. Soldatov
{"title":"Theoretical Modeling of Indium Adatoms on Reconstructed GaAs(001) and AlAs(001) Surfaces","authors":"V. A. Roldugin,&nbsp;M. A. Soldatov","doi":"10.1134/S2635167623601328","DOIUrl":"10.1134/S2635167623601328","url":null,"abstract":"<p>GaAs/AlAs(001) (2 × 4) is one of the most optimal substrates for optoelectronic and nanophotonic applications. Droplet epitaxy allows high-quality quantum dot (QD) arrays with the desired properties to be obtained, but the detailed mechanism of deposition and subsequent epitaxial growth is still questionable. In this paper, the growth mechanism of indium QDs on various GaAs/AlAs(001) surfaces is studied within calculations of density functional theory. Full geometry optimization, in which the coordinates of substrate atoms can be altered under adatom impact, is shown to be a straightforward technique for the simulation of adsorption processes. The obtained results are in good agreement with conventional methods and well-known findings. The proposed approach could become standard practice and extend the understanding of droplet epitaxy.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"225 - 229"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142192859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanical Properties of Individual Porous Chitosan Particles: Full Scale and Numerical Experiments 单个多孔壳聚糖颗粒的力学性能：全尺寸和数值实验
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-09-10 DOI: 10.1134/S2635167624600901
O. V. Nikulenkova, A. E. Krupnin, P. V. Dmitryakov, Yu. D. Zagoskin, S. N. Malakhov, T. E. Grigoriev, N. M. Kuznetsov, S. N. Chvalun
{"title":"Mechanical Properties of Individual Porous Chitosan Particles: Full Scale and Numerical Experiments","authors":"O. V. Nikulenkova,&nbsp;A. E. Krupnin,&nbsp;P. V. Dmitryakov,&nbsp;Yu. D. Zagoskin,&nbsp;S. N. Malakhov,&nbsp;T. E. Grigoriev,&nbsp;N. M. Kuznetsov,&nbsp;S. N. Chvalun","doi":"10.1134/S2635167624600901","DOIUrl":"10.1134/S2635167624600901","url":null,"abstract":"<p>The mechanical behavior of porous chitosan particles with various diameters obtained by freeze drying is investigated. The morphology of the particles is visualized by scanning electron microscopy. It is shown that the particles have a predominantly spherical shape and a honeycomb-like structure with interpenetrating pores. The mechanical characteristics of the particle material are modeled using the neo-Hookean, second-order Yeoh, Blatz-Ko, and third-order Ogden foam hyperelastic models, based on the results of mechanical compression tests between parallel plates and numerical solution of the reverse-engineering problem using the finite-element method. Force-displacement curves are plotted for the proposed models and then verified in a similar full-scale experiment with particles of another diameter.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 2","pages":"258 - 265"},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Viscoelastic Properties and Plasticity of Early and Late Wood of Pine and Spruce by Continuous Stiffness Measurement during Nanoindentation 通过纳米压痕过程中的连续刚度测量比较松木和云杉早期和晚期木材的粘弹性能和塑性
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-08-06 DOI: 10.1134/S2635167624600433
A. I. Tyurin, V. V. Korenkov, A. A. Gusev, I. A. Vasyukova, M. A. Yunak
{"title":"Comparison of the Viscoelastic Properties and Plasticity of Early and Late Wood of Pine and Spruce by Continuous Stiffness Measurement during Nanoindentation","authors":"A. I. Tyurin,&nbsp;V. V. Korenkov,&nbsp;A. A. Gusev,&nbsp;I. A. Vasyukova,&nbsp;M. A. Yunak","doi":"10.1134/S2635167624600433","DOIUrl":"10.1134/S2635167624600433","url":null,"abstract":"<p>Using a small oscillating load (continuous stiffness measurement, CSM), in addition to the main quasi-static load, we determine the hardness, Young’s modulus, storage and loss moduli, mechanical loss coefficient (<span>(tan delta )</span>), and the plasticity characteristics in various components of the nanostructure and microstructure of pine (<i>Pinus sylvestris</i>) and spruce (<i>Picea abies</i>) wood. The contribution of structures of different scales to the ratio of the viscoelastic properties of early and late wood in the composition of one annual ring is determined. The plasticity characteristic δ<sub>А</sub> is determined, and the influence of an additional oscillating load on the dynamic parameters of wood is assessed.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 1","pages":"116 - 124"},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141947915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Gold Glyconanoparticles on the Functioning of P-Glycoprotein In Vitro 金聚糖颗粒对体外糖蛋白功能的影响
IF 0.8
Nanotechnologies in Russia Pub Date : 2024-08-06 DOI: 10.1134/S2635167624600482
M. A. Kopanitsa, I. V. Chernykh, A. V. Shchulkin, P. Yu. Mylnikov, A. Yu. Ershov, I. V. Lagoda, A. A. Martynenkov, E. N. Yakusheva
{"title":"Influence of Gold Glyconanoparticles on the Functioning of P-Glycoprotein In Vitro","authors":"M. A. Kopanitsa,&nbsp;I. V. Chernykh,&nbsp;A. V. Shchulkin,&nbsp;P. Yu. Mylnikov,&nbsp;A. Yu. Ershov,&nbsp;I. V. Lagoda,&nbsp;A. A. Martynenkov,&nbsp;E. N. Yakusheva","doi":"10.1134/S2635167624600482","DOIUrl":"10.1134/S2635167624600482","url":null,"abstract":"<p>The aim of the work is to evaluate the effect of gold nanoparticles with a surface modified with fucose (Au-Fuc), lactose (Au-Lac), and galactose (Au-Gal) residues on the functional activity and expression of the transporter protein P-glycoprotein (Pgp). The work is performed using Caco-2 and HEK293 cells, which are incubated for 2 and 8 h with solutions of Au-Fuc, Au-Lac, and Au-Gal in a nutrient medium (450 and 300 µg/mL, 700 and 490 µg/mL, and 400 and 250 μg/mL, respectively). The amount of Pgp on the membranes of the Caco-2 cells is determined by the western blot method. The Pgp activity is assessed by the accumulation of fexofenadine Fex (150 µM) in cells by high-performance liquid chromatography (HPLC) with mass detection. Au-Fuc and Au-Gal do not change the amount of Pgp; Au-Lac increases the transporter level by 1.9 and 1.8 times upon 2 and 8 h of incubation respectively. Au-Fuc, Au-Lac, and Au-Gal increase the Pgp content in cells upon 8 h of incubation by 2.6, 3.5, and 5.3 times, which indicates a decrease in Pgp activity. When particles are incubated with HEK293 cells, no increase in the Fex levels are detected, which indicates the absence of a nonspecific increase in membrane permeability. Thus, the tested gold nanoparticles reduce the functional activity of Pgp in vitro.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 1","pages":"165 - 171"},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141947924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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