Comparative Analysis of Stabilization Methods for Silver Nanoprisms As Promising Nanobiomedicine Agents

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2025-03-16 DOI:10.1134/S2635167624601487

A. O. Antonova, O. A. Kolesnikova, P. M. Ivantcova, M. A. Gubaidullina, V. O. Shipunova

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Abstract

Silver nanoprisms are promising agents for both diagnostic and therapeutic applications in photoinduced hyperthermia of tumors within the transparency window of biological tissues. However, one of the primary challenges in utilizing silver nanoparticles in biological systems is their instability in physiological environments. To address this issue, a comprehensive comparative analysis of various stabilizing coatings was conducted to develop an effective stabilization method for nanoprisms intended for biomedical applications. The results demonstrated that among the tested polymers, a sulfhydryl derivative of polyethylene glycol provided the most effective stabilization for the nanoprisms while preserving the localized surface plasmon resonance effect. Furthermore, the synthesized nanoprisms showed significant potential for biovisualization. Specifically, the technique of intravital optical tomography effectively visualized body tissues using fluorescently labeled nanoprisms. This advancement paves the way for the application of these colloid-stable nanoprisms as agents for bioimaging and photothermal therapy.

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纳米银片稳定方法的比较分析

银纳米片在生物组织透明窗内光致肿瘤热疗的诊断和治疗方面具有广阔的应用前景。然而，在生物系统中应用纳米银的主要挑战之一是它们在生理环境中的不稳定性。为了解决这一问题，对各种稳定涂层进行了全面的比较分析，以开发用于生物医学应用的纳米棱镜的有效稳定方法。结果表明，在测试的聚合物中，聚乙二醇的巯基衍生物为纳米棱镜提供了最有效的稳定，同时保留了局部表面等离子体共振效应。此外，合成的纳米片显示出显著的生物可视化潜力。具体来说，活体光学断层扫描技术使用荧光标记的纳米棱镜有效地可视化身体组织。这一进展为这些胶体稳定的纳米棱镜作为生物成像和光热治疗剂的应用铺平了道路。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.