Nanotechnologies in Russia最新文献_第10页

Pulsed Laser Deposition of NiO/Pt and Fe/NiO/Pt Thin-Film Heterostructures for THz Applications 脉冲激光沉积NiO/Pt和Fe/NiO/Pt薄膜异质结构的太赫兹应用

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625601585

D. S. Gusev, O. A. Novodvorsky, L. S. Parshina, N. V. Potekhina, I. N. Nikolaeva, N. N. Eliseev, A. S. Sinko, A. P. Shkurinov

{"title":"Pulsed Laser Deposition of NiO/Pt and Fe/NiO/Pt Thin-Film Heterostructures for THz Applications","authors":"D. S. Gusev, O. A. Novodvorsky, L. S. Parshina, N. V. Potekhina, I. N. Nikolaeva, N. N. Eliseev, A. S. Sinko, A. P. Shkurinov","doi":"10.1134/S2635167625601585","DOIUrl":"10.1134/S2635167625601585","url":null,"abstract":"Thin films of NiO, Fe, and Pt and NiO/Pt, Fe/NiO/Pt heterostructures are fabricated using the pulsed laser deposition in a droplet-free mode with the ablation of metal targets on single-crystal sapphire substrates with the orientation (0001) at room temperature. The heterostructures are obtained by the sequential deposition of layers within in a single technological cycle. The structural, optical, and electrophysical properties and surface morphology of the obtained films and heterostructures are studied. The presence of the 2M mode is established in the Raman spectra, which confirms antiferromagnetic ordering in the NiO layers in the synthesized heterostructures. The X-ray diffraction spectra of both the individual NiO films and heterostructures demonstrate NiO (111) diffraction peaks, which confirms the high crystalline perfection of the films synthesized at room temperature without additional annealing. Terahertz radiation generation is achieved in the Fe/NiO/Pt heterostructure upon excitation by femtosecond laser pulses.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"779 - 786"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comparative Analysis of Methods for the Formation and Cytostatic Activity of the Vesicular Form of Doxorubicin 多柔比星囊状形成方法及细胞抑制活性的比较分析

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625600518

D. S. Plevako, A. Yu. Garanin, O. A. Vasileva, V. I. Yevtushenko, E. I. Yakubovich, A. V. Malek

{"title":"Comparative Analysis of Methods for the Formation and Cytostatic Activity of the Vesicular Form of Doxorubicin","authors":"D. S. Plevako, A. Yu. Garanin, O. A. Vasileva, V. I. Yevtushenko, E. I. Yakubovich, A. V. Malek","doi":"10.1134/S2635167625600518","DOIUrl":"10.1134/S2635167625600518","url":null,"abstract":"The clinical efficacy of systemic therapies for oncological diseases is limited by their toxic effects on healthy tissues and the risk of fatal complications developing. One way to address this problem is to develop technologies for the targeted delivery of anticancer drugs. Autologous extracellular nanovesicles (ENVs) can serve as a basis for innovative systems for the targeted delivery of cytostatics. There are several methods for “loading” ENVs with cytostatics, but practical selection of the optimal approach is hampered by the lack of universal evaluation criteria and systematic comparative studies. Therefore, the aim of this work is to compare technologies for loading an anticancer drug (doxorubicin) into plasma ENVs. The ENVs are isolated from the plasma of healthy donors and analyzed using nanoparticle tracking analysis (NTA) and flow cytometry. Electroporation and sonoporation technologies in various modifications are used to load doxorubicin into the vesicles. The effect of the treatment is assessed using NTA, the efficiency of loading is assessed using absorption spectroscopy, and the cytostatic effect of the vesicular form of the drug is assessed using the MTT assay on MCF-7 and BT474 breast cancer cells. Based on analysis of ENV integrity, the optimal conditions for electroporation and sonoporation are determined. Sonoporation in the mode of 35 kHz, 40 W, 4 cycles (30–120 s) shows an advantage, with a loading efficiency of 32.2%. The cytostatic activity of the vesicular form of doxorubicin is higher compared to the drug solution under in vitro experimental conditions. Sonoporation is an effective method for loading doxorubicin into ENVs, based on which a vesicular delivery system for anticancer drugs can be developed.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"881 - 892"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Viscosity and Rheology of Drilling Fluids with Nanoparticles 纳米颗粒钻井液的粘度和流变性

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167624601293

V. Ya. Rudyak, A. V. Minakov, E. I. Lysakova

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Vesicular Systems for Anticancer Drug Delivery 用于抗癌药物输送的囊泡系统

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625600506

A. Yu. Garanin, D. S. Plevako, O. A. Vasilyeva, A. V. Malek

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Artificial Intelligence As a Driver of Modern Science: from Biomedicine to International Megascience Projects 人工智能作为现代科学的驱动力：从生物医学到国际大科学项目

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625601664

D. D. Musin, E. V. Varlamova, M. A. Marchenkova, A. V. Soldatov

{"title":"Artificial Intelligence As a Driver of Modern Science: from Biomedicine to International Megascience Projects","authors":"D. D. Musin, E. V. Varlamova, M. A. Marchenkova, A. V. Soldatov","doi":"10.1134/S2635167625601664","DOIUrl":"10.1134/S2635167625601664","url":null,"abstract":"The key developments of the past two decades highlighting the transformation of scientific research driven by artificial intelligence (AI) are summarized. Both well-established and emerging applications of AI are explored: ranging from biomedicine, pharmaceuticals, nutrition science, education, data science, engineering, and fundamental disciplines to synchrotron radiation facilities and advanced megascience facilities. A detailed overview of AI approaches and architectures implemented in major international projects is provided, including the Large Hadron Collider and its High-Luminosity upgrade; the FAIR facility; the DUNE and Belle II experiments; the LIGO, Virgo, and KAGRA gravitational-wave observatories; the LSST survey telescope; the SKA radio interferometer; the Euclid space observatory; the ESS, SNS, and J-PARC neutron sources; the ITER and JT-60SA fusion reactors; the NIF laser facility; the ELI-NP laser complex; exascale climate simulation platforms; and cryo-electron microscopy systems powered by AlphaFold technology. The work is intended for a broad audience of specialists interested in the methodological, technical, and organizational aspects of AI integration into scientific research.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"712 - 717"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Isolation and Properties of Extracellular Vesicles 细胞外囊泡的分离与性质研究

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625601949

O. V. Morozova, E. A. Obraztsova, D. V. Klinov

{"title":"Isolation and Properties of Extracellular Vesicles","authors":"O. V. Morozova, E. A. Obraztsova, D. V. Klinov","doi":"10.1134/S2635167625601949","DOIUrl":"10.1134/S2635167625601949","url":null,"abstract":"For the prolonged intracellular action of pharmaceutical drugs, penetration through cell membranes and escape from endosomal-lysosomal entrapment are necessary. Inorganic and organic nanomaterials enter eukaryotic cells mainly through endocytosis with biodegradation with lysosomal enzymes; antigen presentation to the immune system; and the induction of innate, trained, and adaptive immunity. The fusion of extracellular vesicle membranes and cell membranes permit to escape from lysosomes, enzymatic hydrolysis, and cytokine gene expression. The study aims to isolate extracellular vesicles and analyze their physical and chemical properties. Vesicles with a diameter of 10–200 nm surrounded by membranes with a thickness of 7–10 nm were isolated from the conditioned culture media of embryonic and transformed human cells, as well from apple juice, using differential centrifugation at 20 800 g. They consisted of lipids and proteins, were stable during isolation, fluorescent labeling, and storage at +4°C for 5 months. Loaded extracellular vesicles were fabricated by hydration of a thin layer of dried cell membranes. Fluorescent vesicles were nontoxic to autologous and heterologous human cells and gradually accumulated in cells over 7 days of observation.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"865 - 870"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Influence of the Active Electrode Material on the Characteristics of Parylene–MoOx-Based Memristors 活性电极材料对聚苯二烯- moox基忆阻器特性的影响

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625601858

A. D. Trofimov, A. V. Emelyanov

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Synthesis and Characterization of Ruthenium Nanoparticles 钌纳米颗粒的合成与表征

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625601196

D. V. Korolev, M. V. Shumilo, M. V. Afonin

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β-Amyloid: Structure, Properties, and Link with Alzheimer’s Disease β-淀粉样蛋白：结构、性质及其与阿尔茨海默病的关系

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625601159

E. V. Kuznetsova, A. P. Chistyakov, A. I. Kulebyakina, P. De, S. N. Chvalun

{"title":"β-Amyloid: Structure, Properties, and Link with Alzheimer’s Disease","authors":"E. V. Kuznetsova, A. P. Chistyakov, A. I. Kulebyakina, P. De, S. N. Chvalun","doi":"10.1134/S2635167625601159","DOIUrl":"10.1134/S2635167625601159","url":null,"abstract":"Under certain conditions, peptides and proteins are capable of conversion from their soluble native form to insoluble, highly ordered fibrillar aggregates. Alzheimer’s disease is a progressive neurodegenerative disease, whose development is accompanied by a steady decline in the patient’s condition, loss of the ability to live independently, and ultimately death. Currently, there are tens of millions of people in the world with Alzheimer’s disease, but there are still no effective methods for combating this disease. One of the key pathomorphological attributes of Alzheimer’s disease is the formation of senile plaques: accumulations of β‑amyloid fibrils, the main components of which are β-amyloid peptides (Aβ), having a molecular weight and length of about 4 kDa and 40 amino acid residues, respectively. The review is devoted to the structural features of Aβ peptides, the mechanism of their aggregation leading to the formation of various Aβ oligomeric forms, protofibrils, protofilaments, and ultimately fibrils, as well as their biological role and link with Alzheimer’s disease. Modern scientific approaches aimed at inhibiting Aβ peptide aggregation by the action of various inhibitors on Aβ monomers, Aβ oligomers, as well as the surface of formed Aβ protofilaments and fibrils, are considered.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"647 - 681"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S2635167625601159.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Antimicrobial Properties of Cotton E-Textiles Modified with Graphene Oxide and Silver Nanoparticles 氧化石墨烯和纳米银改性棉质电子纺织品的抗菌性能

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Nanotechnologies in Russia Pub Date : 2026-03-02 DOI: 10.1134/S2635167625601251

S. A. Smagulova, F. D. Vasileva, L. A. Tarasova, Ya. A. Akhremenko, Z. I. Evseev

{"title":"Antimicrobial Properties of Cotton E-Textiles Modified with Graphene Oxide and Silver Nanoparticles","authors":"S. A. Smagulova, F. D. Vasileva, L. A. Tarasova, Ya. A. Akhremenko, Z. I. Evseev","doi":"10.1134/S2635167625601251","DOIUrl":"10.1134/S2635167625601251","url":null,"abstract":"This study investigates the bactericidal and fungicidal properties of graphene oxide flakes with an average lateral size of 1 μm and an oxygen content of ~45%, mildly oxidized graphene flakes with an average lateral size of 0.1 μm and an oxygen content of ~20%, and a silver nanoparticle–graphene oxide composite in aqueous suspensions and cotton textiles. It is shown that after 24 hours of microbial exposure to the graphene oxide flake suspension, Escherichia coli was reduced by 80%, Staphylococcus aureus by 40%, and Candida albicans by 100%, whereas the mildly oxidized graphene suspension eliminated E. coli and S. aureus by 100% but reduced C. albicans by only 40%. The use of silver nanoparticle–graphene oxide composites demonstrates more effective antimicrobial action, achieving 100% elimination of E. coli, S. aureus, and C. albicans within 24 hours of exposure. The antimicrobial efficacy of textiles treated with graphene oxide and mildly oxidized graphene against E. coli is similar and relatively high compared to their effectiveness against S. aureus and C. albicans. Textiles with silver nanoparticle–graphene oxide composites exhibited antimicrobial efficacy approximately twice as high as that of graphene oxide.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"20 6","pages":"927 - 935"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147335992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0