Nanotechnologies in Russia最新文献_第9页

Comparative Analysis of Stabilization Methods for Silver Nanoprisms As Promising Nanobiomedicine Agents 纳米银片稳定方法的比较分析

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624601487

A. O. Antonova, O. A. Kolesnikova, P. M. Ivantcova, M. A. Gubaidullina, V. O. Shipunova

{"title":"Comparative Analysis of Stabilization Methods for Silver Nanoprisms As Promising Nanobiomedicine Agents","authors":"A. O. Antonova, O. A. Kolesnikova, P. M. Ivantcova, M. A. Gubaidullina, V. O. Shipunova","doi":"10.1134/S2635167624601487","DOIUrl":"10.1134/S2635167624601487","url":null,"abstract":"Silver nanoprisms are promising agents for both diagnostic and therapeutic applications in photoinduced hyperthermia of tumors within the transparency window of biological tissues. However, one of the primary challenges in utilizing silver nanoparticles in biological systems is their instability in physiological environments. To address this issue, a comprehensive comparative analysis of various stabilizing coatings was conducted to develop an effective stabilization method for nanoprisms intended for biomedical applications. The results demonstrated that among the tested polymers, a sulfhydryl derivative of polyethylene glycol provided the most effective stabilization for the nanoprisms while preserving the localized surface plasmon resonance effect. Furthermore, the synthesized nanoprisms showed significant potential for biovisualization. Specifically, the technique of intravital optical tomography effectively visualized body tissues using fluorescently labeled nanoprisms. This advancement paves the way for the application of these colloid-stable nanoprisms as agents for bioimaging and photothermal therapy.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"921 - 928"},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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α-Synuclein Expression Causes Mitochondria Fragmentation and Increased Sensitivity to Oxidative Stress in the Yeast Yarrowia lipolytica α-突触核蛋白的表达会导致线粒体碎裂并增加酵母脂溶性酵母对氧化应激的敏感性

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624602377

V. O. Khvastunov, T. N. Goleva, Kh. Kh. Epremyan, A. G. Rogov

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Silver-Containing Nanodispersions on the Basis of Polymer Derivatives of Aromatic Amino Acids: Synthesis, Morphology, Spectral Characteristics, and Antimicrobial Activity 基于芳香族氨基酸聚合物衍生物的含银纳米分散体：合成、形态、光谱特性和抗菌活性

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624602298

S. V. Valueva, N. A. Nesterova, M. E. Vylegzhanina, P. Yu. Morozova, A. S. Ilchenko, E. P. Anan’eva, E. F. Panarin

{"title":"Silver-Containing Nanodispersions on the Basis of Polymer Derivatives of Aromatic Amino Acids: Synthesis, Morphology, Spectral Characteristics, and Antimicrobial Activity","authors":"S. V. Valueva, N. A. Nesterova, M. E. Vylegzhanina, P. Yu. Morozova, A. S. Ilchenko, E. P. Anan’eva, E. F. Panarin","doi":"10.1134/S2635167624602298","DOIUrl":"10.1134/S2635167624602298","url":null,"abstract":"Nanodispersions based on silver nanoparticles (Ag0) are synthesized In the presence of polymer complexones (copolymers of N-vinylpyrrolidone (VP) with p-methacryloylaminobenzoic (MABA-Na) and p-methacryloylaminosalicylic acid (MASA-Na)). The spectral and morphological characteristics of the nano-dispersions are investigated using ultraviolet (UV) spectroscopy and atomic force microscopy (AFM); the minimum energy (Eg) of electron transfer from the valence band to the conduction band of the metal is estimated; and the influence of the nature of the chelate unit on the band gap Eg, as well as on the size of spherical nanoparticles is shown. The reduction of silver ions in water in the presence of copolymers VP-MABA-Na and VP-MASA-Na, due to fairly good screening, makes it possible to obtain spherical nanostructures with a diameter not exceeding 200 nm. In the case of Ag0/VP-MASA-Na, massive dense oval-shaped aggregates are formed, which consist of small densely packed nanostructures. The silver-containing dispersions Ag0/VPрMABA-Na and Ag0/VP-MASA-Na tested against E. coli, P. aeruginosa, and S. aureus bacteria show pronounced antimicrobial activity, significantly superior to the activity of the reference drug, Protargol.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"966 - 972"},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Structure of Supramolecular Clusters of Creatine Kinases in the Intermembrane Space of Mitochondria 线粒体膜间隙肌酸激酶超分子簇的结构

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624601785

Yu. M. Chesnokov, S. V. Nesterov, K. S. Plokhikh, R. G. Vasilov

{"title":"Structure of Supramolecular Clusters of Creatine Kinases in the Intermembrane Space of Mitochondria","authors":"Yu. M. Chesnokov, S. V. Nesterov, K. S. Plokhikh, R. G. Vasilov","doi":"10.1134/S2635167624601785","DOIUrl":"10.1134/S2635167624601785","url":null,"abstract":"The structure of rat-heart mitochondria and mitochondrial membrane preparations is studied using cryoelectron tomography. It is found that pseudocrystalline clusters formed by densely packed proteins exist between the inner and outer membranes. Using subtomogram averaging, the structure of these clusters is obtained and it is shown that they are formed by tens or even hundreds of densely packed octamers of mitochondrial creatine kinases (mCK). In intact mitochondria, mCK octamers form a single membrane-parallel layer in which they are tightly coupled to the outer and inner membranes, as well as to each other. On membrane fragments in which there is no compression of the intermembrane space, the supramolecular mCK clusters are organized differently: they form two layers in which there are fewer contacts with the membrane, but more protein–protein contacts. In addition, bilayer clusters generally lack curvature and are larger in size, which is indicative of their increased rigidity and possible role in stabilizing the membrane when it is damaged. The obtained results are discussed in the context of previously known data on the functional role, structure, and location of creatine kinases in mitochondria.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"1008 - 1015"},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Conductive-Hydrogel-Based Electrodes for Invasive Neural Interfaces 用于侵入性神经界面的导电水凝胶电极

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624602535

D. A. Kirillova, N. A. Sharikova, A. O. Romanov, R. G. Vasilov, T. E. Grigoriev, P. M. Gotovtsev

{"title":"Conductive-Hydrogel-Based Electrodes for Invasive Neural Interfaces","authors":"D. A. Kirillova, N. A. Sharikova, A. O. Romanov, R. G. Vasilov, T. E. Grigoriev, P. M. Gotovtsev","doi":"10.1134/S2635167624602535","DOIUrl":"10.1134/S2635167624602535","url":null,"abstract":"Currently, technologies based on the use of electrode systems implanted in the head interacting with the human brain are under active development. Such systems are used both for stimulation of the brain in various diseases and as full-fledged neural interfaces. Electrodes in this case are one of the key elements, since they provide contact with the nervous tissue. Recently, considerable attention has been paid to polymer electrodes and, in particular, hydrogels due to the fact that they have mechanical properties close to body tissues and can carry various functional molecules. At the same time, the electrical conductivity of polymer electrodes is lower than that of metal or carbon materials. In this regard, this work provides an overview of publications in this area and notes the most promising trends. Also, based on the publications reviewed, it is noted that an important task for such electrodes remains their miniaturization. It is concluded that despite their shortcomings, electrodes based on polymer hydrogels are an extremely promising system for creating invasive neural interfaces.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"872 - 878"},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nanomaterials in Biosensors for Medical Applications 纳米材料在医学生物传感器中的应用

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624602353

Y. V. Plekhanova, S. E. Tarasov, A. N. Reshetilov

{"title":"Nanomaterials in Biosensors for Medical Applications","authors":"Y. V. Plekhanova, S. E. Tarasov, A. N. Reshetilov","doi":"10.1134/S2635167624602353","DOIUrl":"10.1134/S2635167624602353","url":null,"abstract":"Biosensors have long been an integral part of analytical laboratory equipment. Some developments have already been commercialized and mass produced for field-test analysis. The best-known biosensors at the moment are those for glucose determination, which are both disposable and long lasting. The use of biosensors for the early diagnosis of diseases would bring medicine to a qualitatively new level, allowing for the more accurate detection of a disease and its individual stages, the adjustment of treatment, and the monitoring of various parameters and biochemical indicators of health in the process of both treatment and during sports training. New electrode modifications, the application of new nanomaterials, the development of new analysis schemes, and the miniaturization of signal processing devices significantly expands the analytical capabilities of the developed biosensors. This paper presents new directions in the development of biosensors for the determination of both traditional markers of the human physiological state (glucose, lactate, etc.) and infectious pathologies (viral, cancerous, etc. diseases), wearable and implantable devices, as well as combined devices for simultaneous diagnostics and drug delivery.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"879 - 886"},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Phytotoxicity of Nanomaterials 纳米材料的植物毒性

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167623601419

V. O. Shevchenko, K. I. Cardenas Rodriguez, E. A. Mukhanova

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Polyurethane-Based Composite Materials Promising for Dielectric Actuators 聚氨酯基复合材料在介电致动器中的应用前景

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624602262

E. I. Zyrianova, S. V. Pak, V. A. Demina, A. E. Krupnin, S. N. Malakhov, P. V. Dmitryakov, A. V. Bakirov, A. A. Puchkov, E. P. Banin, T. E. Grigoriev, N. M. Kuznetsov, S. N. Chvalun

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Effects of Unbranched Polyamines on Rat-Liver Mitochondria 未支化多胺对大鼠肝脏线粒体的影响

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624602365

A. G. Rogov, V. O. Khvastunov, T. N. Goleva

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Influence of the Properties of Chitosan Sponges on the Accumulation and Release of C-Phycocyanin 壳聚糖海绵性质对c -藻蓝蛋白积累与释放的影响

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Nanotechnologies in Russia Pub Date : 2025-03-16 DOI: 10.1134/S2635167624600688

D. V. Sukhinov, A. A. Zakharevich, A. I. Koshkalda, K. G. Antipova, S. I. Viktorov, Ya. E. Sergeeva

{"title":"Influence of the Properties of Chitosan Sponges on the Accumulation and Release of C-Phycocyanin","authors":"D. V. Sukhinov, A. A. Zakharevich, A. I. Koshkalda, K. G. Antipova, S. I. Viktorov, Ya. E. Sergeeva","doi":"10.1134/S2635167624600688","DOIUrl":"10.1134/S2635167624600688","url":null,"abstract":"Damage to skin and subsequent wound healing are complex multistage biological processes that are inextricably linked with almost any human activity. That is why the search for biodegradable, inexpensive, and accessible materials to create wound dressings that are effective in healing and biocompatible continues. This work shows the influence of the properties of porous materials based on chitosan on the processes of incorporation and release of C-phycocyanin (C-PC), which is obtained from the biomass of the cyanobacteria Arthrospira platensis in in vitro experiments. Thus, the entry efficiency of C-PC exceeds 90% for sponges obtained from both studied chitosans, but the profiles of the incorporation process curves differ significantly. Furthermore, the maximum load capacity is 171.75 ± 1.47 and 184.03 ± 3.64 mg/g for chitosan sponges with different degrees of deacetylation. Evaluation of the C-PC release from the porous matrix also reveals significant differences. Within 24 h, more than 80 and 65% of the loaded C-PC is released from the chitosan sponges, depending on the degree of deacetylation of the initial sponge material. As a result of the studies, it is established that by correctly selecting the characteristics of the initial chitosans, it is possible to optimize the process of C-PC release from porous wound dressings.","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"912 - 920"},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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