{"title":"Effects of Unbranched Polyamines on Rat-Liver Mitochondria","authors":"A. G. Rogov, V. O. Khvastunov, T. N. Goleva","doi":"10.1134/S2635167624602365","DOIUrl":null,"url":null,"abstract":"<p>Unbranched polyamines perform a number of regulatory functions in the cell: they participate in the control of transcription and translation, modulate the activity of certain enzymes, and play an active role in maintaining calcium homeostasis. The intracellular level of polyamines is tightly regulated, and its alterations can lead to the development of a variety of pathologies. Thus, polyamines and their derivatives are both potential therapeutic agents and targets for therapy. In this work the effect of nonbranched polyamines with different structures on the energy parameters of rat-liver mitochondria is investigated. The effect of polyamines on the respiratory chain, their involvement in the activity of the nonspecific mitochondrial permeability transition pore, and their effect on ATP synthesis by mitochondria are shown.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"1038 - 1043"},"PeriodicalIF":0.8000,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnologies in Russia","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S2635167624602365","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0
Abstract
Unbranched polyamines perform a number of regulatory functions in the cell: they participate in the control of transcription and translation, modulate the activity of certain enzymes, and play an active role in maintaining calcium homeostasis. The intracellular level of polyamines is tightly regulated, and its alterations can lead to the development of a variety of pathologies. Thus, polyamines and their derivatives are both potential therapeutic agents and targets for therapy. In this work the effect of nonbranched polyamines with different structures on the energy parameters of rat-liver mitochondria is investigated. The effect of polyamines on the respiratory chain, their involvement in the activity of the nonspecific mitochondrial permeability transition pore, and their effect on ATP synthesis by mitochondria are shown.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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