Pullulan Graft Copolymers with Poly(2-oxazoline) Side Groups in Aqueous Solutions: Hydrodynamic Study

IF 0.8 Q3 Engineering
A. A. Lezov, I. Yu. Perevyazko, A. A. Lezova, V. B. Rogozhin, N. G. Mikusheva, P. A. Fetin, A. S. Senchukova, M. E. Mikhailova, A. V. Donets, M. A. Vovk, I. M. Zorin, N. V. Tsvetkov
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引用次数: 0

Abstract

Grafted copolymers based on natural polysaccharides are interesting from the standpoint of creating targeted drug delivery systems. The properties of graft copolymers of pullulan with side chains of poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline) are studied. The conformational and hydrodynamic characteristics of the indicated polymers, such as the coefficient of translational diffusion, characteristic viscosity, molecular weight, equilibrium rigidity, and hydrodynamic diameter of chains, are determined using nuclear magnetic resonance, dynamic light scattering, analytical ultracentrifugation, viscometry, and a number of combined techniques. Increase of the value of equilibrium rigidity of grafted polymers with poly(2-oxazoline) side chains was detected.

Abstract Image

聚(2-恶唑啉)侧基普鲁兰接枝共聚物在水溶液中的水动力学研究
从创建靶向药物传递系统的角度来看,基于天然多糖的接枝共聚物是有趣的。研究了聚(2-甲基-2-恶唑啉)和聚(2-乙基-2-恶唑啉)侧链普鲁兰接枝共聚物的性能。所述聚合物的构象和流体动力学特性,如平移扩散系数、特征粘度、分子量、平衡刚度和链的流体动力学直径,是通过核磁共振、动态光散射、分析超离心、粘度测定和一些综合技术来确定的。具有聚(2-恶唑啉)侧链的接枝聚合物的平衡刚度值增加。
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来源期刊
Nanotechnologies in Russia
Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍: Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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