Acta Informatica Medica最新文献

{"title":"A Multivariate Study on the Adherence With Non-invasive Ventilation in People With Obstructive Sleep Apnea.","authors":"Athanasios Karagiannis, Theodora Kafkia, Maria Tzitiridou, Michael Kourakos","doi":"10.5455/aim.2024.32.37-42","DOIUrl":"https://doi.org/10.5455/aim.2024.32.37-42","url":null,"abstract":"<p><strong>Background: </strong>Obstructive Sleep Apnea (OSA) is a sleep disorder that affects a significant number of people worldwide. While Continuous Positive Airway Pressure (CPAP) devices have been proven to be effective in relieving symptoms, ensuring consistent use of those devices throughout the year can be challenging for a lot of patients.</p><p><strong>Objective: </strong>The present quantitative observational study in non-invasive ventilation for OSA patients explores adherence and attempts to identify independent predicting factors and year-round adherence differences in a large sample of OSA patients from Greece.</p><p><strong>Methods: </strong>Data from 1987 OSA patients using Continuous Positive Airway Pressure (CPAP) devices were collected in 2023. Factors evaluated in the study included the Apnea-Hypopnea Index (AHI), mask type, mask leaks and hours of CPAP device usage.</p><p><strong>Results: </strong>The majority were males (77.2%), aged over 60 years (57.9%). CPAP use varied, with 14.0% in their first year, 44.2% for 2-4 years, and 41.7% for <4 years. Adherence was highest in more than 4 years users (54.9%) and nasal/pillow mask users (59.1%). Seasonal adherence varied, with summer having the most non-adherent patients (32.8%). Multinomial logistic regression showed BMI, mask type and seasonal severity influenced adherence. Full-face masks positively impacted adherence (OR=0.585, p=0.001). Non-adherence was associated with higher mask leaking in spring (OR=3.051, p=0.018) and usage of CPAP for < 4 years (OR=3.855, p=0.001). For 50% and 75% adherence, seasonal mask leaking and usage duration influenced adherence.</p><p><strong>Conclusion: </strong>CPAP device data can provide valuable insights to OSA therapy compliance. Seasonality plays an important role in adherence to the CPAP device use as is the type of mask with relation to air leaking.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Transmisive Diseases in Healthy Blood Donors: a Five-year Experience in University Clinical Center Tuzla.","authors":"Aida Zabic, Svetlana Jovic-Lackovic, Sunita Custendil Delic, Ahida Suljkanovic-Mahmutovic, Sabina Camdzic-Smajic, Alma Osmic-Husni","doi":"10.5455/aim.2024.32.24-27","DOIUrl":"https://doi.org/10.5455/aim.2024.32.24-27","url":null,"abstract":"<p><strong>Background: </strong>The safety of blood products is the most important task of transfusion medicine. Transfusion-transmitted diseases represent a serious public health problem throughout the world, although their percentage of transmission is minimal. Each blood donation is individually tested with serological and molecular tests for the presence of hepatitis B and C viruses, human immunodeficiency virus (HIV), and Treponema Pallidum, regardless of the number of blood donations.</p><p><strong>Objective: </strong>To determine the seroprevalence of blood-borne diseases in healthy blood donors at the University Clinical Center Tuzla, to analyze the possible causes of transmission of these diseases, and to compare with the results of research in countries in the region and beyond.</p><p><strong>Methods: </strong>The research was conducted retrospectively in the period January 1, 2018. until 31.12.2022. years. Samples of blood donors were tested for hepatitis B surface antigen (HBsAg), antibodies to human immunodeficiency virus (HIV1/2), antibodies to hepatitis C and syphilis, using the fourth generation ELISA method.</p><p><strong>Results: </strong>The highest frequency of transmisive disease markers was reactivity to HBsAg with a total of 63.7% of cases and a prevalence of 0.13%, and the lowest for HIV with a total of 1.4% and a prevalence of 0.003%.</p><p><strong>Conclusion: </strong>Bosnia and Herzegovina has a very low seroprevalence but there is still a risk of disease transmission in the population.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 1","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Artificial Intelligence Software in the Automated Analysis of Left Ventricular Function in Echocardiography in Central Vietnam.","authors":"Chi Thang Doan, Khanh Hung Tran, Viet Thang Luong, Ngoc Hai Dang-Nguyen, Victoria Ton-Nu","doi":"10.5455/aim.2024.32.32-36","DOIUrl":"https://doi.org/10.5455/aim.2024.32.32-36","url":null,"abstract":"<p><strong>Background: </strong>In recent years, there has been a significant focus on the development of artificial intelligence (AI) applications in healthcare. However, current scientific evidence is still not convincing enough for the general public and the medical community to widely adopt AI in clinical practice.</p><p><strong>Objective: </strong>We conducted this study to investigate the correlation between left ventricular function indices assessed by AI and those evaluated by physicians.</p><p><strong>Methods: </strong>This cross-sectional descriptive study was conducted on 136 patients who attended and received treatment at Hue University of Medicine and Pharmacy Hospital from April 2022 to June 2023. Using QLAB version 15, Philips Healthcare.</p><p><strong>Results: </strong>The AI software accurately identified 98.5% of the echocardiographic cine-loops. However, there were about 1.5% of cine-loops that the software failed to recognize. The sensitivity of Ejection Fraction (EF) calculated by AI was 73.3%, specificity was 81.3%, and accuracy stood at 78.6%. A strong positive correlation was observed between EF measured by AI and that assessed by physicians, r = 0.701, p < 0.01. The sensitivity of Global Longitudinal Strain (GLS) calculated by AI was 42.1%, specificity was 84.8%, and accuracy was 67.6%. A moderate positive correlation was found between GLS measured by AI and physician's assessment, r = 0.460, p < 0.01.</p><p><strong>Conclusion: </strong>The use of AI software for evaluating left ventricular function through ejection fraction and global longitudinal strain is rapid and yields results comparable to cardiologists' echocardiographic assessments. The AI-powered software holds a promising and feasible future in clinical practice.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 1","pages":"32-36"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRP/HDL-C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus.","authors":"Miralem Djesevic, Sabaheta Hasic, Orhan Lepara, Rijad Jahic, Avdo Kurtovic, Almir Fajkic","doi":"10.5455/aim.2023.31.254-259","DOIUrl":"10.5455/aim.2023.31.254-259","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) denotes a cluster of co-occurring medical conditions associated with regulating hyperglycemia and acute cardiovascular events and complications. The escalating frequency of MetS among individuals afflicted with type 2 diabetes mellitus (T2DM) underscores its burgeoning significance as a critical public health concern and a complex clinical conundrum. Timely identification is imperative to avert the expedited progression of diabetic complications.</p><p><strong>Objective: </strong>To investigate the role of CRP/HDL-C and Monocyte/HDL ratios in predicting MetS in T2DM individuals.</p><p><strong>Methods: </strong>The study was designed as a two-year prospective study and included 80 T2DM patients divided into MetS and non-MetS groups based on MetS development over two years. The patients' serums were analyzed for complete blood count parameters, lipid profile, and C-reactive protein (CRP). Based on the laboratory test results, Monocyte/HDL-C and CRP/HDL-C ratios were calculated and analyzed. The receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine prognostic accuracy.</p><p><strong>Results: </strong>Monocyte/HDL-C ratio and CRP/HDL-C ratio were significantly higher in MetS-T2DM2 than in nonMetS-T2DM (p=0.003 and p=0.029, respectively). The results of ROC curve analysis have shown that the CRP/HDL-C ratio (AUC of 0.695) and Monocytes/HDL-C ratio (AUC of 0.645) can serve as good predictors of MetS in T2DM patients.</p><p><strong>Conclusion: </strong>This study confirms the reliability of the Monocytes/HDL-C and CRP/HDL-C ratios as novel, simple, low-cost, and valuable predictors of MetS development in T2DM.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"31 4","pages":"254-259"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139911776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Failure Mode and Effect Analysis in Surgery Setting: A Bibliometrics Analysis and Literature Review.","authors":"Tito Sumarwoto, Muhana Fawwazy Ilyas, Arlina Dewi","doi":"10.5455/aim.2024.32.19-23","DOIUrl":"https://doi.org/10.5455/aim.2024.32.19-23","url":null,"abstract":"<p><strong>Background: </strong>In the ever-evolving healthcare landscape, the imperative to ensure patient safety has driven the adoption of robust safety approaches. One of the most popular methods is Healthcare Failure Mode and Effect Analysis (HFMEA).</p><p><strong>Objective: </strong>This study aims to conduct a bibliometric analysis of HFMEA research in a surgery setting to identify relevant authors, topics, and journals, highlighting the scholarly collaboration trends in this area. This analysis can provide valuable insights into the current state of research, emerging trends, and future research directions.</p><p><strong>Methods: </strong>The data was acquired online from the PubMed database on December 16th, 2023. The downloaded data were analyzed using Google Sheets to predict trends. The publication output was then analyzed using VOSviewer. Subsequently, Biblioshiny was used to analyze the characteristics of the study, productive author, institution, and country; thematic map analysis; and topic timeline analysis.</p><p><strong>Results: </strong>This study analyzes 25 documents spanning 2005 to 2022, reflecting a collaborative effort involving 155 contributors. The upward trend in annual scientific publications, notably the surge from 2014 onwards and significant peaks in 2019 and 2022, underscores the growing recognition of HFMEA in enhancing patient safety within surgical environments. The prominent influence from prolific authors like Ahmed K, leading institutions such as King's College London, and the substantial contributions from Norway and the USA in shaping the HFMEA research landscape.</p><p><strong>Conclusion: </strong>This study contributes valuable insights that can shape the trajectory of HFMEA in the evolving landscape of surgical healthcare, ensuring enhanced patient safety and quality improvement.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 1","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Decrease in Vision Aquity and Gadget Use During Online Lectures and COVID-19 Pandemic in Students of the Faculty of Medicine, Universitas Sumatera Utara.","authors":"Maya Savira, M Ammar Al Ghifari","doi":"10.5455/aim.2023.31.240-243","DOIUrl":"10.5455/aim.2023.31.240-243","url":null,"abstract":"<p><strong>Background: </strong>The use of gadgets for a long duration causes problems related to discomfort and causes various other eye complaints. Online lectures cause students to be more intense in using gadgets to support their learning. Therefore, it is necessary to conduct research on the relationship between decreased visual acuity and the use of gadgets during online lectures during the Covid-19 pandemic.</p><p><strong>Objective: </strong>Knowing the relationship between decreased visual acuity and the use of gadgets during online in Covid-19 pandemic for students of the Faculty of Medicine, Universitas Sumatera Utara class of 2019 and 2020.</p><p><strong>Methods: </strong>This research is an analytic research with cross sectional design. The sampling technique used in this study was stratified random sampling, in which 100 respondents were selected using simple random sampling.</p><p><strong>Results: </strong>There are 100 respondents, 81 of them used gadgets for more than 4 hours in one day, 67 of them used gadgets with a viewing distance of 30 cm to 40 cm, and 91 of them had normal visual acuity.</p><p><strong>Conclusion: </strong>There is no significant relationship between a decrease in visual acuity and the duration or distance of seeing in the use of gadgets as evidenced by the p-values of 0.653 and 0.095 respectively.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"31 4","pages":"240-243"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139911783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication of the Elderly During the COVID-19 Pandemic.","authors":"Silva Banovic,&nbsp;Osman Sinanovic,&nbsp;Slavica Jankovic,&nbsp;Nedim Patkovic,&nbsp;Samir Smajlovic","doi":"10.5455/aim.2022.30.324-328","DOIUrl":"https://doi.org/10.5455/aim.2022.30.324-328","url":null,"abstract":"<p><strong>Background: </strong>Restrictive measures implemented by governments around the world to control the coronavirus have an impact on communication, especially the communication of the elderly.</p><p><strong>Objective: </strong>The aim for the article is to determine the attitudes of the elderly towards the ways of communication during the COVID 19 pandemic, and to present the challenges faced by the elderly when using digital ways of communication. The goal is also to point out the importance of providing adequate social support to the elderly.</p><p><strong>Methods: </strong>The sample consisted of 71 respondents from Bosnia and Herzegovina, aged over 60 years, divided into two groups. The questionnaire was used to gather information from respondents on their demographic characteristics as well as to examine participants' attitudes and confidence regarding the manner and risk of communication associated with COVID-19.</p><p><strong>Results and discussion: </strong>The results of this research showed that the elderly are actively using digital technologies, but that they are largely dissatisfied with their skills in using digital technologies. Most of the information during the COVID 19 pandemic is given to elderly people via television and telephone (video) conversations with family members and friends. 57.7% of the elderly stated that they greatly lacked direct communication, and it turned out that people living in elderly homes were in a slightly more favorable position. As many as 4/5 of the respondents reported feelings of anxiety, fear, loneliness, and depression.</p><p><strong>Conclusion: </strong>The older part of the population (those over 60 years old), especially in developing countries, including Bosnia and Herzegovina, is facing the challenge of \"digitization of communication\". In the context of the COVID-19 pandemic, the elderly are \"calling\" for special support and the provision of training and access to technological resources in order to reduce negative psychological consequences and go one step further in creating an \"elder-friendly\" society.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"324-328"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2e/69/AIM-30-324.PMC9665417.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Coherence Tomography (OCT) Diagnostic of Retinitis Pigmentosa - Case Study.","authors":"Melita Adilovic,&nbsp;Emira Ignjatic,&nbsp;Arnes Cabric","doi":"10.5455/aim.2022.30.329-333","DOIUrl":"https://doi.org/10.5455/aim.2022.30.329-333","url":null,"abstract":"<p><strong>Background: </strong>Retinitis pigmentosa (RP) is a set of inherited rod-cone degenerative diseases that clinically presents with similar signs and symptoms. Mutations in one of more than 70 genes are involved. Patients will commonly present with bone-spicule pigment formation, waxy optic nerve pallor, and attenuated blood vessels in the posterior pole.Symptoms often begin with progressive night blindness, mid-peripheral visual field defects, and eventual tunnel vision. Central vision loss will ultimately occur following loss of rod function. Complete blindness is uncommon.</p><p><strong>Objective: </strong>The aim of this article is to present two cases of retinitis pigmentosa (mother and daughter) trough optalmologic exams in our clinic. The next aim it to show how to menage a low vision service and to treat cystoid macular oedema as a complication of retinitis pigmentosa.</p><p><strong>Methods: </strong>All medical reports are shown in this article. Every diagnostic tool as well as report is a part from our archived history of the patients and has been throughly analysed. We also reviewed available literature using the key words retinitis pigmentosa, cystoid macular oedema, gene therapy.</p><p><strong>Case presentation: </strong>A 38 year old female patient for a low vision consultation. The patient was legally blind secondary to retinitis pigmentosa, which was diagnosed in her late 20s. She reported gradually progressive hazy central vision and decreasing peripheral vision in both eyes as well as severe night blindness. Other than the diagnosis of retinitis pigmentosa in both eyes,the patient had no other remarkable ocular conditions. Findings at that visit included unaided distance visual acuities VOD: 0,04 VOS: 0,06. Pupils were round with brisk responses. Extraocular muscle motility was full in both eyes. Confrontation methode visual fields were noted as temporal loss in the right eye and superior and temporal loss in the left eye. The perimetry test could not be performed due to the lack of correspondece of the patient even after a couple repetitions of the perimetry. She had normal ocular adnexa and quiet lids, conjunctiva, and sclera in both eyes. Corneas in both eyes were noted as clear epithelium, clear stroma, and clear endothelium. Anterior chambers had normal depth, iris with no pathological findings in both eyes; lens incipient sclerotic. Intraocular pressures were noted as 22 mmHg in both eyes with Icare, 21mmHg and 19 mmHg with aplanation tonometry; pahimetry corretional factor was +1 on both eyes. The vitreous was clear in both eyes. Both optic nerves were measured as 0.4 cup-to-disc ratios with no disc edema, disc hemorrhages, notching, or thinning noted.Waxy disc pallor and attenuated blood vessels were observed in both eyes. The macula in both eyes had retinal pigment epithelium (RPE) changes with no edema or hemorrhages. Bone spicule changes were noted 360 in the periphery of both eyes with no holes or tears(Figu","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"329-333"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/66/AIM-30-329.PMC9665416.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the Development of a Mobile Application for Cardiac Patients.","authors":"Assiya Turgambayeva,&nbsp;Shynar Kulbayeva,&nbsp;Zhanat Sadibekova,&nbsp;Anar Tursynbekova,&nbsp;Gulzat Sarsenbayeva,&nbsp;Marina Zhanaliyeva,&nbsp;Tolkyn Zhakupova","doi":"10.5455/aim.2022.30.302-307","DOIUrl":"https://doi.org/10.5455/aim.2022.30.302-307","url":null,"abstract":"<p><strong>Background: </strong>An important global public health problem in many economically developed countries, in particular in Kazakhstan, is the leading cause of morbidity and mortality from cardiovascular disease (CVD), both in urban and rural areas.</p><p><strong>Objective: </strong>This study aims to develop the design of a mobile application for smartphones for cardiac patients, taking into account the specifics of outpatient care.</p><p><strong>Methods: </strong>This methodological study includes identified educational and prevention content for CVD patients to develop an education and monitoring tool using a smartphone app. The application was developed according to the stages of analysis, design, development, implementation and evaluation, which is a systematic training model of design. The levels of satisfaction with the developed application for smartphones among 65 outpatients with CVD were assessed using a questionnaire during their visit to a medical organization.</p><p><strong>Results: </strong>The «My Heart» smartphone app was developed based on a review of the literature related to educating patients with CVD, consulting specialists, monitoring and searching for medical smartphone applications that are already available. The content of education and registration includes three main sections, containing basic questions on registration and monitoring of the condition, materials on education and prevention of CVD, such as a daily questionnaire and nutritional advice. After modification based on expert feedback, the application was finally developed and evaluated by patients who reported being satisfied with the usefulness of the application.</p><p><strong>Conclusions: </strong>This application is developed as a research tool to further conduct a study in CVD patients. Current evaluation was a pilot testing wherein this application showed promising results.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"302-307"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/2f/AIM-30-302.PMC9665427.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Time-Varying Biomarkers in Mortality Outcome in COVID-19: an Application of Extended Cox Regression Model.","authors":"Zahra Geraili,&nbsp;Karimollah Hajian-Tilaki,&nbsp;Masomeh Bayani,&nbsp;Seyed Reza Hosseini,&nbsp;Soraya Khafri,&nbsp;Soheil Ebrahimpour,&nbsp;Mostafa Javanian,&nbsp;Arefeh Babazadeh,&nbsp;Mehran Shokri","doi":"10.5455/aim.2022.30.295-301","DOIUrl":"https://doi.org/10.5455/aim.2022.30.295-301","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 pandemic has created many challenges for clinicians. The monitoring trend for laboratory biomarkers is helpful to provide additional information to determine the role of those in the severity status and death outcome.</p><p><strong>Objective: </strong>This article aimed to evaluate the time-varying biomarkers by LOWESS Plot, check the proportional hazard assumption, and use to extended Cox model if it is violated.</p><p><strong>Methods: </strong>In the retrospective study, we evaluated a total of 1641 samples of confirmed patients with COVID-19 from October until March 2021 and referred them to the central hospital of Ayatollah Rohani Hospital affiliated with Babol University of medical sciences, Iran. We measured four biomarkers AST, LDH, NLR, and lymphocyte in over the hospitalization to find out the influence of those on the rate of death of COVID-19 patients.</p><p><strong>Results: </strong>The standard Cox model suggested that all biomarkers were prognostic factors of death (AST: HR=2.89, P<0.001, Lymphocyte: HR=2.60, P=0.004, LDH: HR=2.60, P=0.006, NLR: HR=1.80, P<0.001). The additional evaluation showed that the PH assumption was not met for the NLR biomarker. NLR biomarkers had a significant time-varying effect, and its effect increase over time (HR(t)=exp (0.234+0.261×log(t)), p=0.001). While the main effect of NLR did not show any significant effect on death outcome (HR=1.26, P=0.097).</p><p><strong>Conclusion: </strong>The reversal of results between the Cox PH model and the extended Cox model provides insight into the value of considering time-varying covariates in the analysis, which can lead to misleading results otherwise.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"295-301"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/30/AIM-30-295.PMC9665419.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}