Acta Informatica Medica最新文献

{"title":"Durian and Sapodilla Extracts Enhance Chemotherapy Sensitivity and Promote Apoptosis in Triple Negative Breast Cancer Model in Vitro: Systematic Review.","authors":"Suyatno, Muhammad Rusda, Kamal Basri Siregar, Adi Muradi Muhar, Denni Joko Purwanto, Iqbal PahleviNasution, Selvi Nafianti, Ferryan Sofyan, Muhammad Al Anas","doi":"10.5455/aim.2024.33.64-70","DOIUrl":"https://doi.org/10.5455/aim.2024.33.64-70","url":null,"abstract":"<p><strong>Background: </strong>Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with main option for therapeutic is chemotherapy. Natural compounds, such as durian (Durio zibethinus) and sapodilla (Manilkara zapota) extracts, have demonstrated anticancer properties, including apoptosis induction and the potential to overcome chemotherapy resistance.</p><p><strong>Objective: </strong>This systematic review evaluates the effects of these extracts on TNBC cells, focusing on their ability to enhance chemotherapy sensitivity with induced apoptosis and decreased chemotherapy resistance.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with PRISMA guidelines. Literature searches in PubMed, Scopus, Web of Science, and Google Scholar identified studies investigating the effects of durian and sapodilla extracts on breast cancer. Data extraction focused on study design, cell lines, preparation and concentrations of extracts, and outcomes such as apoptosis, chemotherapy sensitivity, and molecular marker expression.</p><p><strong>Results: </strong>Included studies demonstrated that durian and sapodilla extracts significantly enhanced the efficacy of chemotherapy agents such as paclitaxel and doxorubicin. Both extracts contained bioactive that reduced Fas, Caspase-3, Caspase-9, and XIAP expression. The combination treatments were shown to synergistically enhance chemotherapy-induced cytotoxicity while reducing resistance mechanisms.</p><p><strong>Conclusion: </strong>Bioactive compounds in durian and sapodilla extracts target multiple pathways involved in TNBC apoptosis, progression and chemotherapy resistance. These findings suggest their potential as natural adjuvants to enhance chemotherapy efficacy. Further studies are needed to validate these results in vivo and explore their clinical applicability.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"64-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic and Clinical Factors Associated with COVID-19 Mortality in India: a Retrospective Study.","authors":"Lokesh Parashar, Himanshu Shekhar, Hina Arya, Shankar Lal Vig, Jagdish Prasad, Girish Gulab Meshram","doi":"10.5455/aim.2024.33.23-29","DOIUrl":"https://doi.org/10.5455/aim.2024.33.23-29","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic significantly impacted global health, with India experiencing one of the highest case and death tolls. However, data specific to India's sociodemographic and clinical factors influencing COVID-19 mortality remains limited.</p><p><strong>Objective: </strong>This study aimed to identify sociodemographic and clinical factors associated with COVID-19 mortality in India.</p><p><strong>Methods: </strong>This retrospective, cross-sectional study analyzed medical records of 4961 adult COVID-19 patients admitted to a tertiary care center in North India, from April 2020 to December 2021. Sociodemographic and clinical data were captured using a structured proforma. Univariate analysis (chi-square test) and Kaplan-Meier survival analysis were performed to identify factors associated with mortality.</p><p><strong>Results: </strong>Of the 4961 patients, 557 (11.2%) died, and 4404 (88.8%) survived. Increased age, rural residency, professional occupation, and comorbidities (diabetes and hypertension), multimorbidity, increased disease severity, cold and flu symptoms, breathlessness, and the need for intensive care unit (ICU) admission and ventilator support were significantly (P <0.05) associated with higher COVID-19 mortality. While some associations were observed with sociodemographic factors like religion, education level, and monthly family income in univariate analysis, these were not significant in survival analysis.</p><p><strong>Conclusion: </strong>In this cohort of COVID-19 patients in India, advanced age, rural residency, professional occupation, comorbidities, multimorbidity, severe symptoms, and the need for ICU admission and ventilator support were identified as significant risk factors for mortality. Early identification and intervention for these high-risk groups may improve survival rates.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of High-Sensitivity Troponin I for Left Ventricular Ejection Fraction in Patients with Non-ST-Elevation Myocardial Infarction.","authors":"Tran Nguyen Phuong Hai, Nguyen Minh Kha, Do Nguyen Tuong Dat, Nguyen Nhat Tai, Truong Phi Hung, Hoang Van Sy","doi":"10.5455/aim.2024.33.40-46","DOIUrl":"https://doi.org/10.5455/aim.2024.33.40-46","url":null,"abstract":"<p><strong>Background: </strong>According to the World Health Organization's 2021 statistics, cardiovascular diseases (CVDs), particularly coronary artery disease (CAD), remain among the leading causes of global morbidity and mortality, affecting both high-income and low-income countries like Vietnam.</p><p><strong>Objective: </strong>Acute myocardial infarction (AMI) remains a major cause of mortality and cardiovascular complications, with a poor prognosis in patients with left ventricular systolic dysfunction (LVSD). High-sensitivity cardiac troponin I (hs-cTnI) is a specific biomarker of myocardial injury linked to infarct size and LVSD. However, its role in predicting left ventricular ejection fraction (LVEF) in non-ST-elevation myocardial infarction (NSTEMI) is underexplored. This study investigates the correlation between hs-cTnI and LVSD in NSTEMI patients.</p><p><strong>Methods: </strong>A descriptive, cross-sectional study was conducted on 117 patients with first-time NSTEMI treated at Cho Ray Hospital from February 2024 to April 2024. Admission hs-cTnI levels were measured and correlated with LVEF, assessed via echocardiography. The predictive value and optimal cut-off points of hs-cTnI for LVSD (LVEF < 50% and ≤ 40%) were determined using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Hs-cTnI levels showed a significant inverse correlation with LVEF (r = - 0.569, p < 0.001). Patients with moderate-to-severe LVSD (LVEF ≤ 40%) had the highest median hs-cTnI levels (25,000 pg/mL, p < 0.001). The area under the ROC curve (AUC) for predicting LVEF < 50% was 0.78, with a cut-off of 12,344 pg/mL (sensitivity 68.5%, specificity 82.5%). For LVEF ≤ 40%, the AUC was 0.82, with a cut-off of 20,979 pg/mL (sensitivity 73.3%, specificity 88.5%, accuracy 84.6%). These findings underscore hs-cTnI's utility in identifying LVSD.</p><p><strong>Conclusion: </strong>Hs-cTnI is inversely correlated with LVEF and serves as a reliable biomarker for predicting LVSD in NSTEMI patients, facilitating risk stratification and early management decisions.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State, Trait Anxiety and Insomnia in Hospitalized Patients With Cardiovascular Disease.","authors":"Panagiota Aroniada, Georgia Gerogianni, Angeliki Stamou, Maria Zaka, Vasiliki Tsoulou, Athanasia Tsami, Eftyhia Chamodraka, Leonidas Poulimenos, Maria Polikandrioti","doi":"10.5455/aim.2025.33.129-134","DOIUrl":"10.5455/aim.2025.33.129-134","url":null,"abstract":"<p><strong>Background: </strong>Hospitalized patients experience significant physical, emotional burden mainly due to a wide range of stressors, related to the hospital environment and their disease including the procedures they undergo.</p><p><strong>Objective: </strong>was to explore prevalence of anxiety and insomnia in hospitalized patients with cardiovascular disease and the associated factors with anxiety.</p><p><strong>Methods: </strong>In the present cross-sectional study were enrolled were enrolled 140 hospitalized patients with cardiovascular disease. The data collection was carried out via interviews using the \"State-Trait Anxiety Inventory (STAI)\" scale and the \"Athens Insomnia scale AIS\" which included patients' characteristics.</p><p><strong>Results: </strong>Regarding state and trait anxiety, half of participants scored below 43 and 49 respectively (median), while 25% scored above 52 and 53, respectively. These values indicate moderate levels of anxiety. Regarding insomnia, at least 50% of patients scored below 6 (median). These values indicate moderate levels of insomnia. The correlation between patients' anxiety and insomnia was positive linear (rho>0.2, p<0.05), meaning that an increase in the insomnia score implies an increase in the state and trait anxiety score (more anxiety). State anxiety was found to be statistically significantly related to family status (p=0.008), occupation (p=0.005), type of disease (p=0.048), and whether they suffered from other disease (p=0.005). Trait anxiety was found to be statistically significantly associated only with marital status (p=0.043).</p><p><strong>Conclusion: </strong>Improving mental health of hospitalized patients in a general hospital requires the attention by clinical health professionals. Knowledge of the association between insomnia and anxiety in hospitalized patients with cardiovascular diseases is important for identifying potential high-risk groups and implementing interventions to alleviate this burden.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Gene Polymorphisms in Benign Prostate Hyperplasia Patients Receiving Combination Therapy of Alpha Blocker (a-Blocker) and 5-Alpha Reductase Inhibitor (5-ARI).","authors":"Besut Daryanto, Taufiq Nur Budaya, Widodo, David Agustriawan, Edvin Prawira Negara, Reza Akbar Effendi","doi":"10.5455/aim.2024.33.54-57","DOIUrl":"https://doi.org/10.5455/aim.2024.33.54-57","url":null,"abstract":"<p><strong>Background: </strong>Out of 25-30% of individuals do not respond to 5-Alpha Reductase Inhibitors (5-ARI) as a primary treatment of Benign Prostatic Hyperplasia (BPH), 7% experience disease progression despite treatment. Personalized medicine, which leverages human genomics, offers an approach to tailor treatments based on individual genetic profiles, facilitating early detection of drug resistance and optimizing therapeutic strategies.</p><p><strong>Objective: </strong>The aim of the study was to advance personalized medicine in BPH by identifying genetic factors that influence treatment outcomes, thus improving therapeutic efficacy.</p><p><strong>Methods: </strong>This cohort study involved patients responsive and resistant to treatment of BPH. After prostate resection, DNA was extracted and subjected to protein sequencing. The quality of the DNA was assessed, and next-generation sequencing (NGS) was performed. The sequencing data analyzed using FastQC, Samtools, MuTect2, ANNOVAR, and VEP. Whole-genome sequencing (WGS) data were compared to the Human GRCh38 reference genome. Single nucleotide polymorphisms (SNPs) and their positions were visualized through Integrated Genomics Viewer (IGV). Statistical analyses were conducted using R software.</p><p><strong>Result: </strong>Two genetic variants associated with BPH, was a single nucleotide polymorphism (SNP) in the NOS3 gene at rs1799983 (T>A/G), and an SNP at rs61767072 in the SRD5A2 gene. All samples that exhibited resistance to combination drug therapy showed mutations in SNP rs61767072, specifically a deletion at base A in the SRD5A2 gene. Strong correlation reported between SNP rs61767072 and resistance to BPH combination therapy while mutations involving base A and base G in the NOS3 gene did not exhibit any significant correlation with resistance to BPH combination therapy.</p><p><strong>Conclusion: </strong>Variations in genetic makeup significantly affect personalized medical care. Identification of specific SNPs such as rs61767072 may be the basis for the development of more personalized therapies. This study provides evidence that pharmacogenomic approaches are needed in urology practice to improve treatment outcomes.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the Impact of Risk Factors on Hypertension at Amplas Community Health Center: A Case-Control Study.","authors":"Arlinda Sari Wahyuni, Isra Mega Siregar, Baharudin Yusuf, Ananda Ayu Paramita, M Sulaiman Fashya Fanani Lubis, Gaby Delila Secilia Pakpahan, Grace Diva Evivania Sitorus, Difa Sonia Marpaung","doi":"10.5455/aim.2025.33.118-122","DOIUrl":"10.5455/aim.2025.33.118-122","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a persistent elevation in blood pressure that poses serious health risks.</p><p><strong>Objective: </strong>This case-control study aimed to identify factors linked to hypertension at Amplas Health Center.</p><p><strong>Methods: </strong>This study asks questionnaires to all patients aged 30-65 years and not diagnosed with hypertension who sought treatment at the Amplas Health Center from September 2-13, 2024. The analysis used bivariate and multivariate logistic regression. Results with p-value <0.05 were statistically significant.</p><p><strong>Results: </strong>Participants were 110 individuals aged 30-65 without a prior hypertension diagnosis, aged 48-65 years, with elementary education level, a family history of hypertension, a salt intake pattern >1 teaspoon, a moderate stress level, low social support, and a poor quality of life had a p-value <0.05.</p><p><strong>Conclusion: </strong>Biopsychosocial factors influence hypertension risk. Older age, stress, and lack of social support notably increase the likelihood of developing the condition. These findings highlight the need for comprehensive strategies considering lifestyle, emotional well-being, and social support in hypertension prevention.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"118-122"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Relation Between Problem-based Learning Methods and Critical Thinking Skills of Undergraduate Nursing Students in Mental Health Sector.","authors":"Maria N Kriki, Nikos G Christodoulou, Evagelos C Fradelos, Theodosios Paralikas, Christos Kleisiaris, Maria Malliarou, Konstantinos Tsaras, Ioannis Moisoglou, Ioanna V Papathanasiou","doi":"10.5455/aim.2025.33.146-151","DOIUrl":"10.5455/aim.2025.33.146-151","url":null,"abstract":"<p><strong>Background: </strong>Mental health nurses often deal with complex clinical situations and face difficulties with the decision-making process. The development of educational techniques during nurses' clinical practice is crucial to improve nurses' skills in communication, assessment and effective intervention in patients with mental disorders. Problem Based Learning (PBL) teaching method is a student-centered educational method based on the integration of a real problem into the learning process.</p><p><strong>Objective: </strong>The aim of this study was to investigate the effect of the PBL on the development of critical thinking in undergraduate nursing students, in mental health clinical practice.</p><p><strong>Methods: </strong>A quasi - experimental study was conducted with a pre- and post-test design in an experimental group and a control group, in Greece, at the Larissa School of Nursing of the University of Thessaly. The study was conducted throughout the 6th spring semester of an undergraduate nursing program, in the course Psychiatry - Mental Health Nursing (clinical practice) during the academic year 2022-2023.</p><p><strong>Results: </strong>The study samples were comprised 67 students each. None of the students in either group had received PBL training previously. CTΑSS scores in intervention group differed statistically significantly in all subscales before and after the experimental procedure, p<0.05). Intervention group achieved significantly higher scores compared with the control group in certain subscales (interpretation, analysis, inference, and explanation-p=0.037, p=0.025, p=0.036 and p=0.001, respectively). Gender had an effect on explanation and inference; Women improved significantly their scores, whereas men had worse performance (p=0.001 and p=0.043 respectively).</p><p><strong>Conclusion: </strong>Our study confirms the effect of PBL on critical thinking development and implies a role of gender in PBL education process. Future research should assess the viability of PBL effects on critical thinking by monitoring and re-assessing the trajectories of critical thinking development in subsequent years.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"146-151"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Recovery and Reduced Complications with Minimally Invasive Coronary Artery Bypass Grafting Compared to Open Sternotomy.","authors":"Armin Sljivo, Haris Vukas, Muhamed Djedovic, Lana Lekic, Amina Al-Tawil, Arian Abdulkhaliq, Alden Begic, Ilirijana Haxhibeqiri Karabdic, Nermir Granov","doi":"10.5455/aim.2025.33.135-139","DOIUrl":"10.5455/aim.2025.33.135-139","url":null,"abstract":"<p><strong>Background: </strong>Minimally invasive coronary artery bypass grafting (MICS CABG) via left anterior thoracotomy has emerged as a less invasive alternative to conventional open sternotomy (OPEN CABG), offering potential benefits in perioperative outcomes and complication rates.</p><p><strong>Objective: </strong>The aim of this study was to compare procedural characteristics, ventilation duration, drainage volumes, and postoperative complications between MICS CABG and OPEN CABG in a single-center cohort in Bosnia and Herzegovina.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 262 patients who underwent surgical revascularization between January 2019 and June 2023.</p><p><strong>Results: </strong>MICS CABG was associated with a shorter median procedure time (2.5 vs. 3.5 hours, p<0.001) and reduced mechanical ventilation duration (11.0 vs. 14.0 hours, p<0.001). Although ICU stay was similar (3.0 days, p=0.001), total hospitalization was shorter for MICS CABG (6.0 vs. 7.0 days, p<0.001). Postoperative drainage was significantly lower at all measured time points (p<0.05), and transfusion requirements were reduced for red blood cells (0 vs. 2 units, p<0.001), fresh frozen plasma (0 vs. 2.5 units, p<0.001), and platelets (p=0.035). Use of inotropic agents was less frequent in MICS CABG, both at low (50.4% vs. 62.8%, p=0.043) and medium doses (4.0% vs. 16.0%, p=0.001). Wound infections were numerically lower in the MICS group (p=0.437).</p><p><strong>Conclusions: </strong>Compared to open sternotomy, MICS CABG demonstrated significant advantages in operative time, ventilation duration, blood loss, and complication rates, supporting its role as a safe and effective alternative for coronary revascularization.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"135-139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing Cardiovascular Risk Stratification in Vietnam: Insights from SCORE2 and the Original SCORE Model.","authors":"Tran Nguyen Phuong Hai, Nguyen Nhat Tai, Nguyen Minh Kha, Ly Quang Sang, Pham Thanh Truong Son, Ngo Minh Hung, Le Trung Nhan, Truong The Hiep, Hoang Van Sy","doi":"10.5455/aim.2025.33.112-117","DOIUrl":"10.5455/aim.2025.33.112-117","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, especially in low- and middle-income countries like Vietnam. Risk stratification models such as the original SCORE model have been widely used to guide preventive strategies. Recently, the updated SCORE2 model has been developed to enhance prediction accuracy by incorporating non-fatal events and recalibration for different European regions.</p><p><strong>Objective: </strong>This study aims to compare the performance and applicability of SCORE2 versus the original SCORE in a Vietnamese population undergoing general health check-ups.</p><p><strong>Methods: </strong>We conducted a cross-sectional study on individuals attending general health check-ups at Cho Ray Hospital, a leading tertiary hospital in Vietnam, from January 2024 to July 2024. Demographic, clinical, and laboratory data were collected to calculate cardiovascular risk scores using both the original SCORE and the updated SCORE2 models.</p><p><strong>Results: </strong>Among 477 individuals undergoing general health check-ups, 317 patients met the inclusion criteria with a median age of 54.5 years (IQR: 47-62) and 35% were male. Risk stratification using the original SCORE model classified 87.1% as low-to-moderate risk, 9.1% as high risk, and 3.8% as very high risk. In contrast, SCORE2 reclassified 48.6% as low-to-moderate risk, while high and very high-risk categories increased to 35.6% and 15.8%, respectively (p < 0.001). Notably, 122 out of 276 patients (44.2%) initially classified as low-to-moderate risk by SCORE were reclassified by SCORE2 into higher risk categories - 101 (high risk) and 21 (very high risk). Similarly, 58.6% (n = 17) of patients classified as high risk by SCORE were upgraded to very high risk by SCORE2. SCORE2 also identified more high and very high-risk individuals under 50 years old, particularly among male patients.</p><p><strong>Conclusion: </strong>Compared to the original SCORE model, SCORE2 significantly increased the detection of high and very high cardiovascular risk in Vietnamese individuals undergoing routine health check-ups. The findings suggest that SCORE2 may provide improved risk stratification, especially in younger and male populations, and may better support preventive cardiovascular strategies in clinical practice.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"112-117"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Dynamic Stability Study of VEGF Inhibitor in Patients with Bladder Cancer.","authors":"Ginanda Putra Siregar, Ida Parwati, Tjahjodjati Tjahjodjati, Ferry Safriadi, Gerhard Reinaldi Situmorang, Raden Yohana, Astrid Feinisa Khairani","doi":"10.5455/aim.2024.33.50-53","DOIUrl":"https://doi.org/10.5455/aim.2024.33.50-53","url":null,"abstract":"<p><strong>Background: </strong>Vascular endothelial growth factor (VEGF) plays a crucial role in bladder cancer progression. Brolucizumab, an anti-VEGF agent, has been studied in various diseases; however, its potential in bladder cancer remains largely unexplored.</p><p><strong>Objective: </strong>This study aimed to analyze the molecular docking and dynamic stability of Brolucizumab as a VEGF inhibitor in bladder cancer.</p><p><strong>Methods: </strong>Target protein and ligand data mining were conducted. Proteins were prepared by removing water molecules using Discovery Studio 2019. Ligand energy minimization was performed using Pyrx v.0.9.8. Protein-ligand docking was conducted, and protein-protein docking was performed using the HADDOCK server. The interactions between compounds and proteins were visualized with BioVia Discovery Studio 2019. Molecular dynamics simulations were carried out using the YASARA Dynamic program.</p><p><strong>Results: </strong>Brolucizumab binding induced smaller conformational changes compared to VEGFR2 binding. When VEGFR2 interacted with the VEGFA-Brolucizumab complex, significant conformational changes occurred, suggesting an inhibitory and blocking effect of Brolucizumab. Bond relaxation was observed when Brolucizumab bound to VEGFA and VEGFR, initiating conformational changes as part of its inhibitory activity. Brolucizumab demonstrated strong and competitive binding to VEGFA, with greater affinity than VEGFR2.</p><p><strong>Conclusion: </strong>Brolucizumab exhibits inhibitory and blocking activity against VEGFR2, suggesting its potential as a therapeutic agent in bladder cancer.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"50-53"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}