Acta Informatica Medica最新文献

{"title":"Comparative Analysis of Carbonic Anhydrase-II Expression Across Undescended Testes Sprague Dawley Model with Coenzyme Q10 Treatment.","authors":"Pradana Nurhadi, Besut Daryanto, Athaya Febriantyo Purnomo, Kusworini, Tommy Nazwar Alfandy","doi":"10.5455/aim.2024.33.11-15","DOIUrl":"https://doi.org/10.5455/aim.2024.33.11-15","url":null,"abstract":"<p><strong>Background: </strong>The study investigates the expression of Carbonic Anhydrase-II (CA-II) antibodies in both blood and tissue samples to understand their systemic and local effects.</p><p><strong>Objective: </strong>The research aims to identify effective dosages and assess the differences in antibody levels across various treatment groups of undescended testes Sprague Dawley model. To measure and compare the levels of CA-II antibodies in blood and tissue samples, determine the most effective dosage for reducing tissue CA-II levels, and analyze the systemic versus local impacts of these antibodies.</p><p><strong>Methods: </strong>The study employed immunohistochemistry to assess CA-II antibody expression in undescended testes model of Sprague Dawley tissue and blood, with brown-colored cells indicating positive expression. Levene's test confirmed homogeneity of variance (p=0.660), allowing for ANOVA to identify significant differences in CA-II levels among groups (p=0.000). Tukey's post hoc test was used to pinpoint specific group differences. <b>Results:</b> The analysis revealed significant differences in CA-II expression between groups. The dosage of 10 mg/KgBB was found to be most effective in reducing tissue CA-II levels. Blood CA-II concentrations were consistently higher than tissue levels across all groups, indicating a strong systemic presence.</p><p><strong>Conclusion: </strong>The study highlights the significant distinctions in CA-II antibody levels between blood and tissue samples. It underscores the importance of dosage in managing CA-II levels and the need to consider both systemic and local impacts in clinical settings. These findings provide a basis for future research into targeted therapies for conditions mediated by CA-II.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and Validity of the Vietnamese Cyberbullying Scale (CBS) Among University of Medicine and Pharmacy, Vietnam National University Students.","authors":"Thang Tran Quoc, Kim Chi Le Thi, Thuy Hoang, Son Dao Anh, Ly Tran Thi","doi":"10.5455/aim.2024.33.58-63","DOIUrl":"https://doi.org/10.5455/aim.2024.33.58-63","url":null,"abstract":"<p><strong>Background: </strong>The proportion of individuals utilizing the Internet has increased rapidly, and as a result, cyberbullying has garnered significant attention across various communities, emerging as a critical public health concern.</p><p><strong>Objective: </strong>This study aimed to validate the Vietnamese version of the Cyberbullying Scale (CBS) within the Vietnamese context.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 257 students at University of Medicine and Pharmacy, Vietnam National University (VNU-UMP) in Hanoi , Vietnam, from November 2023 to March 2024. The Cyberbullying Scale was administered through the RedCap software platform.</p><p><strong>Result: </strong>Among the 257 students, 64.9% were female. The average time spent using social networks per day was 5.6 ± 3.3 hours. The factor loadings for all items ranged from 0.76 to 0.92. The Cronbach's Alpha coefficient was calculated to be 0.98. The final measurement model of the CBS-M demonstrated good fit with the data, yielding acceptable fit indices: Comparative Fit Index (CFI) = 0.93, Tucker-Lewis Index (TLI) = 0.91, Standardized Root Mean Square Residual (SRMR) = 0.03, and Root Mean Square Error of Approximation (RMSEA) = 0.06.</p><p><strong>Conclusion: </strong>The Cyberbullying Scale was identified as a reliable and valid instrument for assessing cyberbullying in Vietnam.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"58-63"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Completion Cholecystectomy for Symptomatic Remnant Gallbladder Following Subtotal Cholecystectomy: a Report of Two Cases.","authors":"Fatima M Alsinan, Ali I Alaqoul","doi":"10.5455/aim.2024.33.79-81","DOIUrl":"https://doi.org/10.5455/aim.2024.33.79-81","url":null,"abstract":"<p><strong>Background: </strong>Subtotal cholecystectomy (SC) is considered a safe option for a bailout in the presence of a difficult laparoscopic cholecystectomy with a low incidence of complications.</p><p><strong>Objective: </strong>This report aims to describe the challenges in diagnosing and managing remnant gallbladder.</p><p><strong>Case presentation: </strong>Case 1 is a 31-year-old male who presented with right upper quadrant abdominal pain ten years following SC. Abdominal ultrasound (US) and computed tomography (CT) scan confirmed a ruminant gallbladder. He underwent successful completion of laparoscopic cholecystectomy. Case 2 is a 40-year-old male who was admitted as a case of ascending cholangitis. He had a history of subtotal cholecystectomy one year prior to his presentation. CT scan, Magnetic resonance cholangiography (MRCP), and US all confirmed the presence of a remnant gallbladder. The patient underwent endoscopic retrograde cholangiopancreatography (ERCP), followed by the completion of laparoscopic cholecystectomy.</p><p><strong>Conclusion: </strong>Recurring symptoms due to the remnant gallbladder are often challenging to diagnose and treat. Herein, we highlight the importance of adequate preoperative investigations and surgical planning prior to intervention.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"79-81"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory Parameters and Clinical Presentation of Children with Measles on Hospital Admission: Single-center Study from Sarajevo, Bosnia and Herzegovina.","authors":"Berina Hasanefendic, Lejla Avdagic, Semir Hrvo, Amila Muratspahic, Aleksandra Pasic, Selma Mutevelic, Emir Sehercehajic, Senita Beharic, Senad Murtic","doi":"10.5455/aim.2025.33.101-106","DOIUrl":"10.5455/aim.2025.33.101-106","url":null,"abstract":"<p><strong>Background: </strong>T Measles is a viral, highly contagious disease from the group of rash fevers, which mainly affects children. Persons suffering from measles are considered contagious four days before and four days during the period of the appearance of measles, which favors its faster spread. Clinical observation and laboratory diagnostics are essential for monitoring the course of the disease in order to prevent complications.</p><p><strong>Objective: </strong>Our study aimed to analyze the significance and usefulness of laboratory tests on admission to hospital in pediatric patients with measles.</p><p><strong>Methods: </strong>This prospective study included children with confirmed measles infection who came accompanied by parents to the Infectious Disease Clinic of the Clinical Center of the University of Sarajevo during nine months. Data on age, sex, symptoms and results of laboratory analyzes (biochemical, hematological and coagulation) were recorded.</p><p><strong>Results: </strong>The study included a total of 302 subjects, including 122 healthy controls and 180 measles patients. Significantly lower values observed for aPTT, absolute number of eosinophils and basophils, RBC, hemoglobin, hematocrit, MCV, MCH, MCHC in measles patients. Significantly higher values were observed for fibrinogen, D-dimer, WBC, neutrophils, lymphocytes, monocytes, RDW and MPV in measles patients in contrast to controls. Significantly higher values were also observed for serum chloride, glucose, CRP, AST, ALT and LDH values. AST/ALT, NLR, PLR, NPR, LMR, LCR, SII and AISI also showed significant differences in measles patients compared to controls.</p><p><strong>Conclusion: </strong>The results of our study showed that laboratory tests have great significance and potential in measles in pediatric patients admitted to the hospital. Lymphocyte/C-reactive protein ratio also showed good diagnostic potential.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Models for Mortality in Elderly Patients with Stenotrophomonas Maltophilia Bacteremia.","authors":"Hoang-Van Quang, Le-Thi Kim Nhung, Pham-Thi Thanh Thuy, Hoang-Van Loc, Ho Si Dung","doi":"10.5455/aim.2025.33.140-145","DOIUrl":"10.5455/aim.2025.33.140-145","url":null,"abstract":"<p><strong>Background: </strong>This study was to determine risk factors and prognostic models for mortality in elderly patients with Stenotrophomonas maltophilia bacteremia.</p><p><strong>Objective: </strong>The aim of this study was to address this gap, we conducted this study to investigate the predictors of mortality and develop prognostic models for clinical practice.</p><p><strong>Methods: </strong>A retrospective study was conducted on 195 patients ≥ 60 years of age (median age 78 (68-85) years, 59.5 % male) at Thong Nhat National Teaching Hospital in Vietnam between January 1st, 2017 and December 31st, 2022. Patients who were treated in the hospital with the first positive blood culture for Stenotrophomonas maltophilia bacteremia were chosen for enrolment in this study. This investigation evaluated demographic and clinical characteristics and prognostic models for mortality.</p><p><strong>Results: </strong>The mortality rate was 37.4 %. Multivariate analysis showed that the significant independent risk factors for mortality were age (aOR, 1.08; 95 % CI, 1.04-1.13; p < 0.001), SOFA score (aOR, 1.38; 95 % CI, 1.14-1.68; p < 0.001), and APACHE II score (aOR, 1.10, 95 % CI, 1.03-1.17; p = 0.005). Bayesian model averaging method identified four clinically applicable models: age combined with both SOFA score and APACHE II score (AUC 0.884, R2 0.564), age combined SOFA score (AUC 0.874, R2 0.516), age combined APACHE II score (AUC 0.800, R2 0.340), SOFA score combined APACHE II (AUC 0.846, R2 0.507).</p><p><strong>Conclusion: </strong>Stenotrophomonas maltophilia bacteremia was severe in elderly patients with high mortality. Risk factors for mortality included age, SOFA, and APACHE II scores. The model comprising age, SOFA, and APACHE II scores has the best predictive ability. However, the model including age and SOFA score was also clinically valid and simple.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"140-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in sVEGFR-1 and sVEGFR-2 Levels Following Fetoscopic Laser Photocoagulation in Twin-to-Twin Transfusion Syndrome: Implications for Fetal demise Prediction.","authors":"Nguyen Thi Thu Ha, Do Tuan Dat, Phan Thi Huyen Thuong, Nguyen Duy Anh","doi":"10.5455/aim.2024.33.30-34","DOIUrl":"https://doi.org/10.5455/aim.2024.33.30-34","url":null,"abstract":"<p><strong>Background: </strong>Twin-to-twin transfusion syndrome (TTTS) is a severe complication in monochorionic twin pregnancies, leading to high perinatal morbidity and mortality. Fetoscopic laser photocoagulation (FLP) is the gold standard treatment; however, fetal demiseremains a concern. The soluble vascular endothelial growth factor receptors, sVEGFR-1 and sVEGFR-2, play a crucial role in regulating angiogenesis and vascular function. This study evaluates changes in sVEGFR-1 and sVEGFR-2 levels before and after FLP and explores their role in predicting fetal demise post-surgery.</p><p><strong>Objective: </strong>Therefore, this study aims to evaluate pre- and post-surgical changes in sVEGFR-1 and sVEGFR-2 levels in TTTS cases treated with FLP and determine their predictive value for fetal demiseafter surgery. <b>Methods:</b> A prospective longitudinal study was done with 27 pregnant women with TTTS stage II-IV according to Quintero classification from 16 to 26 weeks of gestation undergoing FLS. Among them, 11 cases were carried out coagulation the placental vascular anastomoses, 16 cases were done ablation umbilical cord for the selective fetal reduction because of TTTS stage IV, selective intrauterine growth restriction (sIUGR) or proximate cord insertions. All the studies subject investigated the soluble levels of biomarkers. We quantified plasma levels of VEGF-R1, VEGF- R2 in twin pregnant with TTTS before and one week after surgery by ELISA. Many factors included maternal age, gestational age at surgery, stage of TTTS, placental location, level of polyhydramnios, FLS methods, sIUGR, amount of amniotic fluid drawn, duration of surgery, change of maternal circulating biomarker levels were analyzed to find out the association with fetal demise after FLS.</p><p><strong>Results: </strong>Statistics showed that VEGF-R1 levels were significantly decreased after surgery and change in soluble VEGF-R1 levels after surgery had a difference between the group of fetal demise and non-fetal demise. ROC curve showed that degree of VEGF-R1 levels reduction after surgery were higher, the risk of fetal demise was bigger (AUC: 0.8472), in which, cut-off point of degree of VEGF-R1 levels reduction after surgery was 36.5% (sensitivity: 66.67%, specificity: 95.83%).</p><p><strong>Conclusion: </strong>Our data suggest that change in VEGF-R1 after surgery could play a prognostic role of fetal demise after fetoscopic laser surgery.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Large Language Models in Generating Patient Education Materials: a Scoping Review.","authors":"Alhasan AlSammarraie, Mowafa Househ","doi":"10.5455/aim.2024.33.4-10","DOIUrl":"https://doi.org/10.5455/aim.2024.33.4-10","url":null,"abstract":"<p><strong>Background: </strong>Patient Education is a healthcare concept that involves educating the public with evidence-based medical information. This information surges their capabilities to promote a healthier life and better manage their conditions. LLM platforms have recently been introduced as powerful NLPs capable of producing human-sounding text and by extension patient education materials.</p><p><strong>Objective: </strong>This study aims to conduct a scoping review to systematically map the existing literature on the use of LLMs for generating patient education materials.</p><p><strong>Methods: </strong>The study followed JBI guidelines, searching five databases using set inclusion/exclusion criteria. A RAG-inspired framework was employed to extract the variables followed by a manual check to verify accuracy of extractions. In total, 21 variables were identified and grouped into five themes: Study Demographics, LLM Characteristics, Prompt-Related Variables, PEM Assessment, and Comparative Outcomes.</p><p><strong>Results: </strong>Results were reported from 69 studies. The United States contributed the largest number of studies. LLM models such as ChatGPT-4, ChatGPT-3.5, and Bard were the most investigated. Most studies evaluated the accuracy of LLM responses and the readability of LLM responses. Only 3 studies implemented external knowledge bases leveraging a RAG architecture. All studies except 3 conducted prompting in English. ChatGPT-4 was found to provide the most accurate responses in comparison with other models.</p><p><strong>Conclusion: </strong>This review examined studies comparing large language models for generating patient education materials. ChatGPT-3.5 and ChatGPT-4 were the most evaluated. Accuracy and readability of responses were the main metrics of evaluation, while few studies used assessment frameworks, retrieval-augmented methods, or explored non-English cases.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"4-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between rs243866 Polymorphism of the MMP-2 Gene and Target Organ Damage in Patients with Uncontrolled Hypertension.","authors":"Huynh Thi Ngoc Giau, Tran Viet An, Trinh Thi Hong Cua, Bui The Dung","doi":"10.5455/aim.2024.33.47-49","DOIUrl":"https://doi.org/10.5455/aim.2024.33.47-49","url":null,"abstract":"<p><strong>Background: </strong>Uncontrolled hypertension (UHT) is associated with an increased risk of target organ damage (TOD). Matrix metalloproteinase-2 (MMP-2) plays a role in vascular remodeling, and the rs243866 (-1575G/A) polymorphism has been implicated in cardiovascular diseases.</p><p><strong>Objective: </strong>This study aimed to evaluate the association between rs243866 and TOD in UHT patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 134 UHT patients at two hospitals in Vietnam. Genotyping of rs243866 was performed using PCR, and TOD was assessed via echocardiography (left ventricular hypertrophy - LVH), renal function tests (eGFR, albuminuria), and carotid ultrasound (carotid atherosclerosis).</p><p><strong>Results: </strong>The genotypic distribution was GG (79.9%), GA (18.6%), and AA (1.5%), with allele frequencies of 89.2% (G) and 10.8% (A). The A allele was associated with higher risks of LVH (OR=2.553, 95% CI: 1.052-6.196, p=0.035), CKD (OR=2.639, 95% CI: 0.986-7.066, p=0.048), and carotid atherosclerosis (OR=6.806, 95% CI: 2.203-21.024, p<0.001). These associations remained significant after adjusting for confounders.</p><p><strong>Conclusion: </strong>The rs243866 polymorphism of MMP-2 is independently associated with TOD in UHT, particularly LVH, CKD, and carotid atherosclerosis. Genetic screening for rs243866 may provide insights into risk stratification and personalized hypertension management.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"47-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirty-five Years from Accepting Former Yugoslavia Association of Medical Informatics (YAMI) at EFMI and IMIA During MIE'90 in Glasgow, Scotland.","authors":"Izet Masic","doi":"10.5455/aim.2025.33.170-175","DOIUrl":"10.5455/aim.2025.33.170-175","url":null,"abstract":"<p><p>This review is remembrance on occasion of 35 years of MIE '90 held in Glasgow which organized by UK and Scottish Association of Medical Informatics, and chaired by John Bryden and his team with support by European Federation for Medical Informatics (EFMI). It was my first participation at MIE Conferences, in that time as General Secretary of Yugoslav Association of Medical Informatics (YAMI) and officially accepted as a member of EFMI and IMIA. Besides our President of YAMI, Professor Gjuro Dezelic, one of founders YAMI (with Izet Masic, Stefan Adamic, Rajko Vukasinovic, as presidents of Bosnia and Herzegovina, Slovenian and Serbian Societies of Medical Informatics in 1987) participants at MIE '90 have been, also, our colleagues: Josipa Kern, Nada Dezelic, Silvije Vuletic, Visnja Lovrek, Miroslav Madjaric, etc. It was my first active participation at MIE Conferences, and after this meeting, year by year I continued until today. Let me say some important facts about it as my personal story -\"Medical Informatics Journey\", during the last 35 years, from Glasgow 1990 until today.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"170-175"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression of Left Ventricular Hypertrophy After Aortic Valve Replacement with Sorin Freedom Solo and St. Jude Regent Valves: a Comparative Study.","authors":"Alen Karic, Ervin Busevac, Alma Krajnovic, Ekrema Mujaric","doi":"10.5455/aim.2025.33.123-128","DOIUrl":"10.5455/aim.2025.33.123-128","url":null,"abstract":"<p><strong>Background: </strong>Aortic stenosis (AS) is the most common form of valvular disease in the elderly population, with degenerative calcified valves remaining the primary cause of this condition. Due to the progressive nature of the disease, a significant reduction in aortic valve area leads to increased left ventricular (LV) pressure overload, resulting in adaptive but ultimately maladaptive concentric hypertrophy and progressive myocardial remodeling.</p><p><strong>Objective: </strong>The main objectives of the study were to assess the regression of left ventricular (LV) hypertrophy.</p><p><strong>Methods: </strong>This retrospective study included 150 patients who underwent surgical aortic valve replacement (AVR) with the Sorin Freedom Solo (SFS) stentless bioprosthesis and the St. Jude Regent (STJ) mechanical valve. Patients were divided into three groups based on follow-up duration: six months, one year, and two years. changes in transvalvular gradient, perioperative outcomes, and survival rates.</p><p><strong>Results: </strong>The results showed a significant reduction in the transvalvular gradient for both valves (p < 0.0001), with a more pronounced decrease in patients with the SFS valve. The thickness of the interventricular septum (IVS) continuously decreased in SFS patients across all groups, whereas a significant reduction was observed only in Group 2 for STJ valves. Left ventricular ejection fraction (LVEF) showed a significantly greater increase in patients with the SFS valve (p < 0.024), particularly in Group 2. Overall mortality was 5.30% for STJ valves and 6.66% for SFS valves, with no statistically significant differences in Kaplan-Meier survival analysis (p > 0.05).</p><p><strong>Conclusion: </strong>The SFS valve demonstrated superior hemodynamic performance and more pronounced LV hypertrophy regression, making it a suitable option for high-risk patients. The STJ valve ensures stable long-term function and remains the preferred choice for younger patients with acceptable operative risk. These findings highlight the importance of a personalized approach in selecting valvular prostheses.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}