Acta Informatica Medica最新文献

{"title":"Fifteen Years Anniversary of MIE 2009 Conference Held in Sarajevo in the Period August 30th-September 2nd 2009 - Review.","authors":"Izet Masic","doi":"10.5455/aim.2024.32.139-146","DOIUrl":"10.5455/aim.2024.32.139-146","url":null,"abstract":"","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 2","pages":"139-146"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Occasion of Marking 30 Years of Editorial Work with the Journals \"Medical Archives\" and \"Acta Informatica Medica\".","authors":"Muharem Zildzic","doi":"10.5455/aim.2024.32.147-148","DOIUrl":"10.5455/aim.2024.32.147-148","url":null,"abstract":"","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 2","pages":"147-148"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessement of Radiological Anatomy of Prostatic Artery on 3D DECT in Symptomatic Benign Prostatic Hypertrophy.","authors":"Nguyen Thai Binh, Le Quy Thien, Dang Khanh Huyen, Ngo Quang Duy, Nguyen Thi Hai Anh, Le Thanh Dung, Nguyen Duy Hung","doi":"10.5455/aim.2024.32.107-111","DOIUrl":"10.5455/aim.2024.32.107-111","url":null,"abstract":"<p><strong>Background: </strong>Benign prostatic hyperplasia (BHP) is a common disease in the urinary system and often appears in old male patients with the incidence increasing proportionally to age.</p><p><strong>Objective: </strong>The study aimed to describe the anatomy and imaging findings of the prostatic artery (PAs) on 3D rendering dual-energy multi-sequence computed tomography (DECT) in patients with symptomatic benign prostatic hypertrophy (BPH) treated by prostatic artery embolisation (PAE).</p><p><strong>Methods: </strong>The study was conducted on 64 patients with BPH who underwent DECT scans with 3D rendering of the pelvic artery before intervention from August 2022 to November 2023. The PAs were independently evaluated for each side, focusing on the number of branches, origin, tortuosity, atherosclerotic plaque, and anastomoses with adjacent arteries.</p><p><strong>Results: </strong>Among 128 pelvic sides where the PAs can be observed, the rate of finding 01 prostate artery on each side was high (96.1%), and the rate of 02 prostate arteries on each side was rare (3.9%). In 133 prostatic arteries, the most common type of prostatic artery according to origin is type I (29.6%), followed by type III (24.6%). The atherosclerotic prostatic artery rate is 24.6%, and the average diameter is 1.5±0.4 mm. The tortuosity prostate artery accounted for 74.6%. The anastomosis to the contralateral prostatic artery rate is 48.4%, followed by the penis and rectum anastomoses.</p><p><strong>Conclusion: </strong>PAs have abundant original varies between the left and right sides and between patient to patient. The most common form arises from the internal pudendal artery.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 2","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Portal Hypertension and Hypersplenism in a Child With Congenital Diaphragmatic Hernia: A Rare Case Report.","authors":"Tran Thanh Tri, Luu-Nguyen An Thuan, Phan Tuan Kiet, Au Nhat Huy, Trinh-Nguyen Ha Vi","doi":"10.5455/aim.2024.32.135-138","DOIUrl":"10.5455/aim.2024.32.135-138","url":null,"abstract":"<p><strong>Background: </strong>T Congenital diaphragmatic hernia (Bochdalek hernia), which occurs in 1/2,200 live births, is typically diagnosed in the prenatal or immediate postnatal period. Diaphragmatic hernia is rare in older children and adults and can be presented with acute respiratory failure, incarcerated hernia, acute pancreatitis, or rare conditions such as left portal hypertension and hypersplenism.</p><p><strong>Objective: </strong>The aim of this case report was to present 15-year-old male with vomiting and mild upper abdominal pain who had mild epigastric tenderness with no guard and an IV grade splenomegaly caused by Congenital Diaphragmatic Hernia. Case presentation: We report a case of left portal hypertension and hypersplenism in an adolescent with congenital diaphragmatic hernia. Typical clinical presentations include abdominal pain, respiratory symptoms, or intestinal obstruction in incarcerated diaphragmatic hernia. Additionally, some uncommon symptoms reported in literature include gastrointestinal bleeding as a result of portal hypertension, thrombocytopenia due to hypersplenism, and acute pancreatitis.</p><p><strong>Conclusion: </strong>The treatment has released the obstruction in the splenic vein and reduce returned collateral gastric blood flow. Splenectomy should be considered based on many factors, such as anatomic anomalies or the degree of hypersplenism and portal hypertension. This is a rare clinical entity with only a few cases that have been reported in the literature.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 2","pages":"135-138"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Mental Disorders Among Healthcare Workers After the Pandemic in Vietnam and Associated Factors: a Cross-sectional Study.","authors":"Nguyen Phuong Sinh, Le Thi Thanh Hoa, Nguyen Dang Duc, Tran Hoa, Nguyen Tien Dung","doi":"10.5455/aim.2024.32.225-231","DOIUrl":"10.5455/aim.2024.32.225-231","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 was declared no longer a global health emergency. The mental health of healthcare workers has become a critical concern, highly impacted by the COVID-19 pandemic.</p><p><strong>Objective: </strong>This study aimed to determine the prevalence of mental disorders among healthcare workers in Vietnam and the associated factors in the post-pandemic era.</p><p><strong>Methods: </strong>A cross-sectional descriptive study was conducted at Hung Vuong Hospital, Vietnam. A self-administered questionnaire was distributed to 660 healthcare workers, and the outcomes were assessed using the DASS-21 scale.</p><p><strong>Results: </strong>The participants' ages ranged from 22 to 62 years, with 66.2% female. The majority were nurses (48.9%) and doctors (25.8%). A significant proportion worked in clinical sectors (77.9%) and had less than 10 years of work experience (84.4%). Overall, 39.5% of participants had at least one mental disorder, specifically, 31.7% had anxiety, 16.2% had stress, and 18.9% had depression. Significant associated factors included pressure from administrative duties (aOR = 2.15, 95% CI 1.39-3.35), intensive work (aOR = 1.69, 95% CI 1.13-2.55), relationships with colleagues (aOR = 1.59, 95% CI 1.10-2.29), and perceived fairness in work-performance evaluations (aOR = 1.88, 95% CI 1.22-2.91).</p><p><strong>Conclusion: </strong>The mental disorders among healthcare workers in Vietnam remained relatively high after the pandemic. Interventions should prioritize work-environmental factors including pressure from administrative duties, intensive working, the absence of good relationships with colleagues, and the fairness in work-performance evaluation.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 3-4","pages":"225-231"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Surgical Timing on Mortality and Functional Outcomes in Elderly Hip Fracture Patients: a Retrospective Cohort Study.","authors":"Suhaib Bani Essa, Yazan Anaqreh, Mutaz Abueed, Mutaz Alrawashdeh, Narmine Hussein, Yara Al-Sa'adi, Janit Batbouta, Mohammad Alkhatatba, Ziyad M Mohaidat, Ahmad Radaideh","doi":"10.5455/aim.2024.32.196-200","DOIUrl":"10.5455/aim.2024.32.196-200","url":null,"abstract":"<p><strong>Background: </strong>Hip fractures among the elderly stem from low-energy trauma and frequently coincide with osteoporosis or low bone mass, along with other related medical conditions that heighten, the risk of falls with the majority of hip fractures manifest in women aged over 65 years, with an estimated global annual incidence of approximately 1.7 million. The incidence is expected to rise in tandem with increasing life expectancy and the expanding population of elderly individuals and those grappling with chronic health conditions.</p><p><strong>Objective: </strong>The aim of this study was to assess the impact of surgical timing on mortality and functional outcomes in elderly hip fracture patients and identify systemic factors contributing to delays.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 236 patients aged ≥50 years with surgically treated hip fractures at King Abdullah University Hospital, Jordan (2019-2022). Patients were stratified into early (≤3 days post-admission) and delayed (>3 days) surgery groups. Data on demographics, comorbidities, surgical variables, and outcomes were extracted from electronic health records. Statistical analyses included Wilcoxon rank sum, Chi-squared tests, and logistic regression to evaluate associations between surgical delay and mortality.</p><p><strong>Results: </strong>Delayed patients (31.8%) exhibited significantly higher 1-year mortality (31% vs. 12%, p<0.001), longer hospital stays (11.2 vs. 5.9 days, p<0.001), and reduced ambulation at 3 months (36% vs. 16% non-ambulatory, p<0.001). Logistic regression identified surgical delay as an independent mortality predictor: delayed patients with ≥3 comorbidities had 9.02-fold higher odds of death (95% CI: 1.67-167.85, p=0.038), while those with <2 comorbidities had a 13.18-fold increase (95% CI: 2.27-251.18, p=0.017). Systemic barriers included preoperative ICU admissions (12% vs. 1.2%, p<0.001) and lower preoperative hemoglobin levels (11.26 vs. 11.87 g/dL, p=0.012).</p><p><strong>Conclusion: </strong>Surgical delay beyond three days independently elevates mortality and disability risks in hip fracture patients, irrespective of comorbidities. Timely intervention mitigates comorbidity-related risks, underscoring the need for multidisciplinary pathways and policy reforms to reduce delays.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 3-4","pages":"196-200"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Intronic Heterozygous Mutation in TSC2 Gene in Pediatric Patient with Tuberous Sclerosis Complex.","authors":"Rijad Konjhodzic, Lana Salihefendic, Naida Mulahuseinovic, Ivana Ceko, Selma Durgut, Nejira Handzic, Sadzida Orucevic, Sajra Uzicanin","doi":"10.5455/aim.2024.32.122-125","DOIUrl":"10.5455/aim.2024.32.122-125","url":null,"abstract":"<p><strong>Background: </strong>Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder and involves multiple organs, intellectual disability and epilepsy. Mutations in TSC1 and TSC2 genes are responsible for the molecular disease mechanism.</p><p><strong>Objective: </strong>The aim is to determine molecular background of a patient with a suspicion of TSC.</p><p><strong>Case presentation: </strong>In this case report, we describe a seven year old patient with the clinical manifestation of TSC that includes supratentorial changes, subependymal hamartomas and angifibromas in the facial area. Besides the brain and skin changes, no other TSC characteristics were observed. The patient was referred to molecular genetic testing using Next Generation Sequencing (NGS). Results: Clinical exome sequencing revealed intronic TSC2 c.4849+2T>G variant. The variant was confirmed using Sanger sequencing on the subject. However, the variant was not detected in the parents, which indicated that it arose de-novo. The RegSNP-intron, Mutation Taster and Human Splicing Finder were used as a bioinformatic tools to predict the possible effect on protein. Using bioinformatic tools, it was determined that the variant is possibly damaging to protein.</p><p><strong>Conclusion: </strong>This data suggest that observed splicing intronic variant could be the cause of TSC in this pediatric patient.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 2","pages":"122-125"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skopje Declaration on Scientific and Publishing Integrity in Biomedicine.","authors":"Dijana Plasheska Karanfilska, Valentin Mircheski, Doncho Donev, Gordana Ristovska, Nevzat Elezi, Vladimir Trajkovski, Ilija Gligorov","doi":"10.5455/aim.2024.32.96-98","DOIUrl":"10.5455/aim.2024.32.96-98","url":null,"abstract":"","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 2","pages":"96-98"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of MitoWizz: a Bioinformatics Solution for Mitochondrial DNA Analysis in Both Forensic and Clinical Applications.","authors":"Nejira Handzic, Dino Pecar, Selma Durgut, Lana Salihefendic, Rijad Konjhodzic","doi":"10.5455/aim.2024.32.221-224","DOIUrl":"10.5455/aim.2024.32.221-224","url":null,"abstract":"<p><strong>Background: </strong>MitoWizz is an advanced bioinformatics tool designed for the analysis of the human mitochondrial genome, offering precise and efficient data interpretation. It enables comparisons of sequencing results obtained from various instrumental methods with the reference Andersen genome (rCRS), aiding in the identification of alterations. This capability is particularly valuable in forensic and clinical mitochondrial DNA analysis.</p><p><strong>Objective: </strong>The primary goal of developing MitoWizz is to automate and streamline mitochondrial DNA analysis, providing researchers and forensic experts with a fast, reliable, and comprehensive tool for sequence comparison, variation detection, and data validation.</p><p><strong>Methods: </strong>MitoWizz compares query sequences in opposed to the reference genome and allows direct comparison of two sequences to identify genetic variations. To ensure accuracy, the results are validated through the Clustal Omega W by aligning sequences with the human mitochondrial DNA reference from GenBank (NC_012920.1).</p><p><strong>Results: </strong>The software detected genetic variations and generated a visual report, as demonstrated in an analysis where 11 mutations were identified in various genes, with an 88% sequence identity to the reference genome. The accuracy of the detected alterations was further validated using the Omega Clustal W program.</p><p><strong>Conslusion: </strong>MitoWizz significantly reduces analysis time and enhances result reliability by integrating multiple analytical steps into a single platform. By automating mtDNA comparisons and validation, it provides forensic and research laboratories with a high-throughput, efficient solution for precise mitochondrial genome analysis.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 3-4","pages":"221-224"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Effect of Croslinking Treatment for Keratoconus in a Pediatric Population.","authors":"Bojana Pandurevic, Melisa Ahmedbegovic-Pjano, Senad Grisevic, Nita Bejdic, Ajla Skopljak-Salkica, Ivana Mravicic, Alma Biscevic","doi":"10.5455/aim.2024.32.211-214","DOIUrl":"10.5455/aim.2024.32.211-214","url":null,"abstract":"<p><strong>Background: </strong>Keratoconus is a progressive condition that weakens the cornea and affects vision. Symptoms typically emerge in the second or third decade of life, though rare cases in young children occur. Early diagnosis is crucial to prevent vision deterioration.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the effectiveness of the accelerated crosslinking treatment for keratoconus in the pediatric population.</p><p><strong>Methods: </strong>This prospective study evaluated 20 eyes in 13 patients with keratoconus who underwent accelerated crosslinking procedures at Eye Clinic Svjetlost Sarajevo with a one-year follow-up. Participants aged 12 to 18 had a confirmed keratoconus diagnosis and corneal thickness over 400 microns. Preoperative examinations included visual acuity (LogMAR scale), keratometry measurements, central corneal thickness, and keratoconus grading using the ABCD system on a Pentacam.</p><p><strong>Results: </strong>Postoperative results showed stability and postoperative improvement of uncorrected and corrected visual acuity (P < 0.001). Postoperative keratometries, specifically Km and Kmax, showed a statistically significant decrease, flattening by approximately 1 diopter (D) and 1.5 diopters (D), respectively. Results of postoperative ABCD score showed stability, without postoperative deviation from the mean value and standard deviation. Central corneal thickness values decreased to 456.48 ± 27.2 μm at the one-year examination, and were statisticaly significant compared to preoperative values (P < 0.001).</p><p><strong>Conslusion: </strong>Stopping progression with crosslinking is the single most important part of management of the pediatric keratoconus patient, thus early diagnosis is imperative. Crosslinking is a safe procedure and the only treatment for pediatric keratoconus that has been proven to halt the progression of the disease and prevent prolonged reduction in a child's visual acuity.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 3-4","pages":"211-214"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}