Acta Informatica Medica最新文献

{"title":"Justification of Screening for Peripheral Arterial Disease in the Elderly Population Through Clinical and Financial Cost-benefit Analysis.","authors":"Muhamed Djedovic, Bedrudin Banjanovic, Amel Hadzimehmedagic, Ilirijana Haxhibeqiri Karabdic, Tarik Selimovic, Damir Kurtagic, Edin Kabil, Slavenka Straus","doi":"10.5455/aim.2024.33.35-39","DOIUrl":"https://doi.org/10.5455/aim.2024.33.35-39","url":null,"abstract":"<p><strong>Background: </strong>Peripheral arterial disease (PAD) is a chronic condition of reduced blood flow through the arteries. Early detection and prevention of PAD, especially in at-risk populations, is crucial to reducing morbidity and mortality.</p><p><strong>Objective: </strong>The aim of the study was to examine the clinical feasibility of vascular ultrasound screening for early detection of PAD, as well as potential financial savings through preventive measures.</p><p><strong>Methods: </strong>The study was conducted as a prospectively designed cross-sectional study with retrospective sample analysis, in which the sample consisted of 826 patients over 60 years of age, of both sexes, divided into two groups, conducted from January 2023 to May 2024.</p><p><strong>Results: </strong>The study included 826 patients aged 60 and over, divided into two groups after ultrasound examination of the arteries (Group A with atherosclerosis /63.8%/; Group B - without atherosclerosis /36.2%/). The average age was 65.44±5.9 years, 60-65 years was 64.3%, and over 65 years was 35.7%. A statistically significant difference was recorded between the analyzed groups in terms of comorbidities and risk factors. We found that age, gender, hypertension, hyperlipidemia, diabetes, smoking and chronic obstructive disease have a significant relationship with the degree of atherosclerosis. Multivariate analysis showed that the age of the subjects, hyperlipidemia, hypertension and smoking are significant predictors of atherosclerosis. The prevalence for hemodynamically significant stenosis of ACI/ACC was 5.0%, for peripheral arteries 4.2%, the prevalence of aneurysm abdominal aorta (>3 cm) was 2.3%, and 0.5% for diameter >5 cm.</p><p><strong>Conclusion: </strong>The results show the high efficiency of ultrasound diagnostics in identifying asymptomatic patients with advanced atherosclerosis, emphasizing the need for better organization of preventive programs, which could lead to potential savings in healthcare costs through earlier detection and treatment.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Results of Minimally Invasive Mitral Valve Repair with Non-Resection Techniques in the Treatment of Barlow Disease.","authors":"Luong Cong Hieu, Nguyen Hoang Dinh, Tran Minh Bao Luan, Pham Tho Tuan Anh","doi":"10.5455/aim.2025.33.107-111","DOIUrl":"10.5455/aim.2025.33.107-111","url":null,"abstract":"<p><strong>Background: </strong>Barlow's disease is characterized by excess myxomatous degenerative tissue, leaflets prolapse and/or billowing, chordal-elongation, and annular dilation. Various mitral valve repair techniques are in use. Resection techniques were conventionally performed. Non-resection techniques have been popularized; however, their efficacy in Barlow's disease is yet unclear.</p><p><strong>Objective: </strong>This study aimed to evaluate the early outcomes of minimally invasive mitral valve repair with non-resection approach compared to resection approach in patients with Barlow's disease.</p><p><strong>Methods: </strong>We reviewed our experience in minimally invasive mitral valve repair non-resection techniques to treat this complex mitral pathology. Between 2020 and 2024 a group of 61 patients was identified as Barlow's disease undergoing minimally invasive mitral valve repair. The diagnosis of Barlow disease was based upon preoperative echocardiography and confirmed by the surgeon's assessment during operation. Data were collected at the Medical University Center (UMC) in Ho Chi Minh City.</p><p><strong>Results: </strong>A total of 61 patients met the inclusion criteria. Successful valve repair was achieved in 57 patients (93.4%). Among the 57 patients who underwent repair, 26 patients (45.6%) received mitral valve repair using the non-resection approach, while 31 patients (54.4%) were treated with the resection approach. The mean cardiopulmonary bypass time and aortic cross-clamp time were 146.1 ± 23.8 minutes and 84.6 ± 15.9 minutes, respectively. During the 30-day postoperative follow-up, no mortality or SAM (systolic anterior motion) complications were observed, with one case of moderate mitral regurgitation post-surgery. Additionally, no reoperations were required during the follow-up period.</p><p><strong>Conclusion: </strong>Minimally invasive Barlow mitral valve repair has favorable 30-day postoperative outcomes. The non-resection approach is feasible and as safe as the resection approach.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nevus Spilus: A Review of Laser-Based Therapeutic Approaches.","authors":"Jamal Alqahtani","doi":"10.5455/aim.2025.33.158-161","DOIUrl":"10.5455/aim.2025.33.158-161","url":null,"abstract":"<p><strong>Background: </strong>Nevus spilus (NS) is a congenital melanocytic nevus with specific clinical characteristics. The condition generally appears in the first year of life and shows no gender preference while affecting individuals with lighter skin tones. It has a predilection for lower limbs and trunk areas the NS lesions consist of tiny heavily pigmented papules and macules accumulated on a well-bordered, lighter brown macular backdrop, comparable to a café-au-lait macule, frequently along Blaschko lines. The type of nevus has been reported as a blue nevus, centrofacial lentiginosis, nevus sebaceous, and bilateral nevus of Ito.</p><p><strong>Objective: </strong>To highlight laser options for nevus spilus.</p><p><strong>Methods: </strong>A review of various laser-based treatment modalities was conducted, focusing on their application in NS. The lasers included Q-switched ruby (QSRL), alexandrite (QSAL), Nd:YAG 532 and 1064 nm, carbon dioxide (CO2), intense pulsed light (IPL), and pulsed dye laser (PDL).</p><p><strong>Results and discussion: </strong>The laser modalities have shown varying degrees of success in improving the appearance of NS lesions. The QSRL, QSAL and QSNYL lasers are commonly used because they are specific for melanin. Ablative lasers like CO2 and broad-spectrum devices like IPL and PDL have also been employed, each offering different advantages depending on lesion characteristics and treatment goals.</p><p><strong>Conclusion: </strong>Regular monitoring for suspicious malignant degeneration should be done and if any signs of melanoma are present, histological examination is warranted. While no treatment is usually necessary, surgery has been proposed to eliminate the risk of melanoma. Aside from surgical management, various lasers have been tried to treat NS with varied success. QSRL, QSAL, QSNYL 532, and 1064 nm, CO2, IPL and PDL have all been demonstrated to improve NS.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"158-161"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Hypoalbuminemia on Inflammatory Markers, Serum Creatinine, Hemoglobin and Outcome in Critically ill Patients With COVID-19 Infection-Retrospective Observation Study.","authors":"Shaya Y Al Qahtani, Thabit Alotaibi, Tala M Aldossary, Mohammed Alharbi, Faleh Alotaibi, Mohammed Almulhim, Bader Alsolo, Bader Alanazi, Ahmed Alzahrani","doi":"10.5455/aim.2025.33.96-100","DOIUrl":"10.5455/aim.2025.33.96-100","url":null,"abstract":"<p><strong>Background: </strong>Hypoalbuminemia is a poor clinical indicator of mortality. However, data on the correlation between hypoalbuminemia and inflammatory markers in COVID-19 infections are scarce.</p><p><strong>Objective: </strong>The study aims to investigate the effects of hypoalbuminemia on inflammatory markers, serum creatinine, hemoglobin levels, and clinical outcomes in critically ill COVID-19 patients.</p><p><strong>Methods: </strong>A retrospective review of all adult patients admitted to the intensive care unit (ICU) in King Fahd University Hospital with a moderate to severe COVID-19 infection from January 2020 to August 2022 was performed. The value of serum albumin levels was obtained on the day of admission while, the serum ferritin, lactate dehydrogenase (LDH), C-reactive protein (CRP), creatinine, and hemoglobin levels on the first and third days of ICU admission. Demographic data, oxygen support modality, ICU length of stay (ICU-LOS), renal replacement therapy (RRT), and deaths were collected.</p><p><strong>Results: </strong>Of 420 patients, 255 were included, 131 (51.4%) of whom had hypoalbuminemia. The numbers of patients with hypoalbuminemia who had increases in ferritin, CRP, and LDH between the first and third days of admission were 65 (49.6%), 9 (6.9%), and 10 (7.6%), respectively. In contrast, to the cohort with normal albumin levels, increases in ferritin, CRP, and LDH were noted in 57 (46%), 7 (5.6%), and 14 (11.3%) patients, respectively. The decrease in hemoglobin levels was similar between both groups (p=0.1). No significant association was found between hypoalbuminemia and increases in serum creatinine, the requirement of RRT, the need for endotracheal intubation, and mortality.</p><p><strong>Conclusion: </strong>This study did not show a significant correlation between hypoalbuminemia and worsening inflammatory markers or clinical outcomes in critically ill COVID-19 patients.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"96-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Machine Learning Technique in Managing Emergency Triage Flow.","authors":"Mohammed Almulhim, Dunya Alfaraj, Dina Alabbad, Faisal A Alghamdi, Mubarak A AlKhudair, Khalid A AlKatout, Saud A AlShehri, Amal Alsulaibaikh","doi":"10.5455/aim.2025.33.152-157","DOIUrl":"10.5455/aim.2025.33.152-157","url":null,"abstract":"<p><strong>Background: </strong>Triage is a critical component of Emergency department care. Erroneous patient classification and mis-triaging are common in present triage systems worldwide. Therefore, several institutes worldwide have developed artificial intelligence-based algorithms that use machine learning approaches to sort and triage patients effectively.</p><p><strong>Objective: </strong>This study aims were to propose a machine learning model to predict the triage level for emergency medicine department patients and compare its performance to the standard nursing triage system.</p><p><strong>Methods: </strong>This retrospective pilot study collected the dataset of emergency department records from King Fahad Hospital of the University in khobar, between January 1, 2020, and December 31, 2022. A sample of 998 randomly selected patients was included in this cohort. The machine learning model was trained using 10-fold cross-validation. Two experiments were conducted, including five triage levels, and the second combing triage levels 2, 3, 4, and 5.</p><p><strong>Results: </strong>The machine learning model achieved an accuracy of 84% in experiment 1 and 64% in experiment 2. The mis-triage rates of the machine learning model were significantly lower than those of the standard nursing triage system.</p><p><strong>Conclusion: </strong>The machine learning model achieved higher accuracy and lower mis-triage rates than the standard nursing triage system. Thus, the proposed machine learning model can be a helpful tool for emergency department triage, enabling more efficient and accurate patient management.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"152-157"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Red-cell Transfusion Strategy Dilemma in Critically Ill Patients in ICU: Is Restrictive or Liberal the Answer?","authors":"Ayu Dilia Febriani Wisnawa, I Wayan Aryabiantara, Tjokorda Gde Agung Senapathi, I Made Gede Widnyana","doi":"10.5455/aim.2024.33.71-78","DOIUrl":"https://doi.org/10.5455/aim.2024.33.71-78","url":null,"abstract":"<p><strong>Background: </strong>The primary therapeutic approach for promptly increasing haemoglobin concentration is red blood cell transfusion. However, the risk associated with RBC transfusion and the overall accessibility exhibit significant variation.</p><p><strong>Objective: </strong>This meta-analysis evaluates the comparison and outcome of restrictive and liberal transfusion strategies in intensive care unit.</p><p><strong>Methods: </strong>A comprehensive search was carried out on various databases, including CENTRAL, PubMed, MEDLINE, and ScienceDirect for randomized control clinical trials evaluating the comparison of clinical outcomes of restrictive and liberal transfusion strategies in critically ill patients. The primary outcomes measure was mortality, which included ICU mortality and hospital mortality. In addition, data were pooled using random-effect models and heterogeneity was evaluated through I² statistics.</p><p><strong>Results: </strong>Out of 15 eligible RCTs obtained, involving 12,439 patients. The result demonstrated no significant difference of restrictive red-cell transfusion strategy over liberal red-cell transfusion strategy in reducing mortality outcomes with a pooled effect size (relative risk [RR] 0.92; 95% confidence interval [CI] 0.78 - 1.08; I2 = 0%, indicating minimal to no difference. Similarly, analyses of secondary outcomes identified no significant differences in several clinical results.</p><p><strong>Conclusion: </strong>This present meta-analysis provides evidence that restrictive red-cell transfusion strategy doesn't significantly difference in overall mortality and several secondary clinical results of critically ill patients in ICU compared to liberal red-cell transfusion strategy. Otherwise, restrictive transfusion strategy lowered RBC transfusion requirements, and was expected to be more cost-effective.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"71-78"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining Hopf Bifurcation for Epidemic Model by Quantifier Elimination (QE).","authors":"Mirna Udovicic","doi":"10.5455/aim.2025.33.162-169","DOIUrl":"10.5455/aim.2025.33.162-169","url":null,"abstract":"<p><strong>Background: </strong>An application of a novel method of a quantifier elimination for the SEIS model was presented in this paper. The appearance of the AIDS disease was crucial for developing numerous new epidemic models. We decided to analyse one of these complex models by QE method.</p><p><strong>Objective: </strong>A main aim was to investigate the existence of the Hopf bifurcation for the SEIS model. We have also analysed one complex epidemic model appropriate for AIDS disease by QE method. We applied the <b>SEIR</b> model in order to analyse the early phase of COVID-19 in BiH and different regions in Italy.</p><p><strong>Methods: </strong>The implementation of a new method for quantifier elimination for the theory of real closed fields (a method was implemented in Mathematica).</p><p><strong>Results: </strong>The main result was that the system which describes the SEIS model does not have a Hopf bifurcation for any parameter values for the epidemiological relevant cases.</p><p><strong>Conclusion: </strong>We applied an original implementation of QE method successfully in order to investigate the SEIS model. Considering the application of QE method to a model appropriate for AIDS disease, we were interested in change of the qualitative behaviour of a parametrized system of differential equations.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"162-169"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Modulatory Effects of Statins, Vitamin E, and Moringa Oleifera Extract on CD3 Expression in Ribociclib-Induced Hepatotoxicity in Rats.","authors":"Suha Khayri Ababneh, Alia Khwaldeh, Ali Ata Alsarhan, Israa Yousef, Ramadan Al-Shdefat, Aiman Shoiab, Sokiyna Ababneh","doi":"10.5455/aim.2025.33.90-95","DOIUrl":"10.5455/aim.2025.33.90-95","url":null,"abstract":"<p><strong>Background: </strong>The use of Ribociclib leads to hepatotoxicity that may be evaluated by the presence of infiltrated CD3 cells.</p><p><strong>Objective: </strong>To evaluate the expression level of CD3 in the liver tissue of the control group and other groups exposed to Ribociclib and groups received Ribociclib and other treatments including vitamin E, statin, and and Moringa Olifera.</p><p><strong>Methods: </strong>This experiment utilized fifty adult male albino rats (9 - 10 weeks old). The rats were randomly assigned into five groups (N = 10). Rats in the Group 1 (control) were given 2 ml normal saline. Group 2 rats received 5 mg/kg of ribociclib, while Group 3 rats received the same dose of ribociclib in conjunction with a daily dose of 200 mg/kg of a statin. Group 4 rats were given ribociclib treatment, alongside a daily dose of Vitamin E. Group 5 rats were given daily doses of 5 mg/kg ribociclib and a 200 mg/kg extract of Moringa Olifera. Following the end of the experiment, all rats were terminated and the liver tissues wee excised and fixed in formalin for 24 hours, processed, and stained for CD3 using indirect immunoperoxidase stain. Liver tissues were examined microscopically and the expression level was evaluated employing Adope photoshop. The relationships between groups were computed by independent T test.</p><p><strong>Results: </strong>The study showed ribociclib caused hepatotoxicity of liver through the increased expression of CD3 in comparison to the control group. Treatment with statin and vitamin E lowered the expression of CD3, but this was not statistically significant (p>0.05), while the treatment with Moringa Olifera extract lowered significantly the expression of CD3 in the liver (p=0.043).</p><p><strong>Conclusion: </strong>Giving Statin, Vitamin E, or Moringa Olifera extract can protect the liver from the liver toxicity that ribociclib causes.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 2","pages":"90-95"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Out-of-Hospital Cardiac Arrest with ROSC: Insights from a Specialized Referral Center in Vietnam.","authors":"Truong Phi Hung, Dang Tuong Vi, Nguyen Minh Kha, Nguyen Nhat Tai, Ly Quang Sang, Tran Hoa, Hoang Van Sy","doi":"10.5455/aim.2024.33.16-22","DOIUrl":"10.5455/aim.2024.33.16-22","url":null,"abstract":"<p><strong>Background: </strong>Anti-N-Out-of-hospital cardiac arrest (OHCA) remains a condition with high morbidity and mortality despite advancements in resuscitation strategies. Identifying prognostic factors in OHCA patients who achieve a return of spontaneous circulation (ROSC) is critical for optimizing post-resuscitation care and improving survival outcomes.</p><p><strong>Objective: </strong>This study evaluates clinical outcomes and predictors of in-hospital mortality in OHCA patients admitted to a tertiary referral center in Southern Vietnam.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on OHCA patients with ROSC admitted to Cho Ray Hospital, Ho Chi Minh City, Vietnam, from January 1, 2019, to June 15, 2024. Demographic characteristics, clinical variables, and survival outcomes were analyzed. Predictors of in-hospital mortality were identified through multivariate logistic regression.</p><p><strong>Results: </strong>Among 482 OHCA cases, 86 patients met the inclusion criteria. The mean age was 49.1 ± 17.2 years, with a male predominance (79.1%, male-to-female ratio: 3.8:1). Most cardiac arrests were witnessed (84.9%), and 32.5% presented with an initial shockable rhythm. Cardiac etiology was the predominant cause (67.4%). The overall in-hospital survival rate was 44.2%, with 25.6% achieving good neurological outcomes (Cerebral Performance Category [CPC] 1-2). Multivariate analysis identified lower Glasgow Coma Scale (GCS) scores (OR 1.42, 95% CI 1.01-2.00, p = 0.045), decreased estimated glomerular filtration rate (eGFR) (OR 1.03, 95% CI 1.00-1.06, p = 0.042), and higher cumulative epinephrine dose (OR 1.10, 95% CI 1.01-1.19, p < 0.05) as independent predictors of mortality. A predictive model incorporating these variables demonstrated strong discriminatory performance (AUC = 0.91). An epinephrine threshold of 7 mg was identified as a predictor of in-hospital mortality, with a sensitivity of 0.68 and specificity of 0.91.</p><p><strong>Conclusion: </strong>In OHCA patients with ROSC, the in-hospital survival rate was 44.2%, with 25.6% achieving good neurological outcomes (CPC 1-2). Lower GCS scores, reduced eGFR, and higher total epinephrine doses were independently associated with increased mortality. These findings underscore the need for early risk stratification and individualized post-resuscitation management to improve patient outcomes.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"33 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IVF/ICSI Outcomes on Hyperthyroidism - Treated Patients at Hanoi Medical University Hospital.","authors":"Nguyen Thanh Hoa, Do Thi Minh Tam, Nguyen Manh Ha","doi":"10.5455/aim.2024.32.207-210","DOIUrl":"10.5455/aim.2024.32.207-210","url":null,"abstract":"<p><strong>Background: </strong>The relationship between the thyroid hormones and reproductive function is complex. Increased thyroid function can directly affect ovarian function and can lead to infertility. After treatment to achieve a euthyroid state, symptoms such as menstrual disorders, shakiness, or rapid heartbeat are resolved, but the question is whether fertility problems can persist even when thyroid function is improved or restored to normal.</p><p><strong>Objective: </strong>Our study aimed to initially evaluate the impact of women's hyperthyroid status on the outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) when the patients have been treated to achieve a euthyroid state.</p><p><strong>Methods: </strong>This retrospective study included 48 infertile couples with hyperthyroidism-treated females (HT group) and 48 infertile couples due to blocked fallopian tubes as a control group from January 2022 to April 2024 at IVF and Tissue Engineering Center, Hanoi Medical University Hospital. The outcomes were the characteristics of IVF cycles and pregnancy rates in the first embryo transfers compared between the two groups.</p><p><strong>Results: </strong>There were no significant differences in baseline characteristics, including age, type of infertility, or quality of semen, between the two groups. The BMI of the HT group was significantly lower than that of the control group. The number and rate of mature oocytes in the HT group tended to be lower than in the group without this disorder (7.2 ± 4.4 vs. 9.2 ± 5.6 mature oocytes per cycle, p = 0.055, and 63.0 ± 24.3% vs. 70.3 ± 15.6%, p = 0.079). However, no difference in pregnancy rates was observed between the HT group and the control group.</p><p><strong>Conclusion: </strong>In our study, it seems that hyperthyroidism could affect the oocyte maturation in the ovarian stimulation cycle even after treatment to achieve a euthyroid state, but there was no difference in pregnancy rates between the HT group and the control group.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":"32 3-4","pages":"207-210"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}