IVF/ICSI Outcomes on Hyperthyroidism - Treated Patients at Hanoi Medical University Hospital.

Abstract

Background: The relationship between the thyroid hormones and reproductive function is complex. Increased thyroid function can directly affect ovarian function and can lead to infertility. After treatment to achieve a euthyroid state, symptoms such as menstrual disorders, shakiness, or rapid heartbeat are resolved, but the question is whether fertility problems can persist even when thyroid function is improved or restored to normal.

Objective: Our study aimed to initially evaluate the impact of women's hyperthyroid status on the outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) when the patients have been treated to achieve a euthyroid state.

Methods: This retrospective study included 48 infertile couples with hyperthyroidism-treated females (HT group) and 48 infertile couples due to blocked fallopian tubes as a control group from January 2022 to April 2024 at IVF and Tissue Engineering Center, Hanoi Medical University Hospital. The outcomes were the characteristics of IVF cycles and pregnancy rates in the first embryo transfers compared between the two groups.

Results: There were no significant differences in baseline characteristics, including age, type of infertility, or quality of semen, between the two groups. The BMI of the HT group was significantly lower than that of the control group. The number and rate of mature oocytes in the HT group tended to be lower than in the group without this disorder (7.2 ± 4.4 vs. 9.2 ± 5.6 mature oocytes per cycle, p = 0.055, and 63.0 ± 24.3% vs. 70.3 ± 15.6%, p = 0.079). However, no difference in pregnancy rates was observed between the HT group and the control group.

Conclusion: In our study, it seems that hyperthyroidism could affect the oocyte maturation in the ovarian stimulation cycle even after treatment to achieve a euthyroid state, but there was no difference in pregnancy rates between the HT group and the control group.