Acta Informatica Medica最新文献

{"title":"On the Occasion of 70th Anniversary of Life and 45 Years of Academic Work of Academician Izet Masic.","authors":"Slobodan M Jankovic,&nbsp;Doncho M Donev,&nbsp;Muharem Zildzic,&nbsp;Izet Hozo,&nbsp;Jacob Bergsland","doi":"10.5455/aim.2022.30.268-282","DOIUrl":"https://doi.org/10.5455/aim.2022.30.268-282","url":null,"abstract":"<p><p>In the hilly Balkans, a folk proverb has been circulating for a long time, \"It is most difficult to be a prophet in one's own village\", which reflects the age-old mistrust of the population towards new ideas. This is not surprising in the least, because since the written history of the peoples of the Balkans has existed, a continuous series of conquerors and local rulers who subjugated the common folks and imposed their world view can be traced. Nevertheless, from time to time, people with great strength appear who not only break the shackles imposed by the powerful, but through their actions find a way to the souls of their compatriots and gain their unreserved trust. One of such spontaneous creators is professor Izet Mašić, who achieved a miracle of medical publishing in his Sarajevo and Bosnia and Herzegovina and traced the path of medical science. There may be thousands of medical journals in the world, more or less reputable, and researchers from the Balkans can publish their work in them, but only domestic medical journals can initiate and direct domestic medical research, and educate young researchers in the right way. Professor Mašić made it possible for authors from Bosnia and Herzegovina and other Balkan countries to present their results to the world and receive an incentive from impartial experts to continue their work and progress more and more by editing and publishing three domestic journals at once, which are visible in the most important world bases,. The progress in research then translated into improving medical practice and health care of the population. The following details from Professor Mašić's biography tell us how this miracle happened. This year, academician Izet Mašić, Editor-in-Chief of a few biomedical journals, including Acta Informatica Medica journal, celebrates his 70th birthday and also 45 years of his academic and scientific work.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"268-282"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/d1/AIM-30-268.PMC9665420.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35347276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Surveillance Model of Tuberculosis Transmission Control Based on Geographic Information System in the Primary Health Care.","authors":"Bahtera Bindavid Purba,&nbsp;Albiner Siagian,&nbsp;Juanita,&nbsp;Evawany Aritonang,&nbsp;Dahlia Purba","doi":"10.5455/aim.2022.30.287-294","DOIUrl":"https://doi.org/10.5455/aim.2022.30.287-294","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis can cause a substantial challenge against public health, especially in the developing countries which have low level of socio-economic condition that does not support the control over tuberculosis transmission and infection.</p><p><strong>Objective: </strong>To find a new surveillance model of tuberculosis transmission control based on geographic information system data in improving the tuberculosis transmission control and treatment outcome.</p><p><strong>Methods: </strong>Effectiveness test of the self-monitoring of calendar documentation on the tuberculosis transmission control and outcome treatment with quasi-experimental post-test only with control group design. The analytical unit consisted of 96 tuberculosis cases as the self-monitoring group of calendar documentation (intervention) and 87 tuberculosis cases as the control group sourced of two different primary health care.</p><p><strong>Results: </strong>The self-monitoring intervention of calendar documentation increased the average treatment effect on medicines intake control 0.11 (95% CI: 0.01-0.21), environment control 0.32 (95% CI: 0.19-46), droplets nuclei control 0.49 (95% CI: 0.36-0.61), cured 0.22 (95% CI: 0.09-0.36), completed 0.18 (95% CI: 0.09-0.26), drop out 0.09 (95% CI: 0.01-0.16), and failure of treatment 0.18 (95% CI: 0.09-0.26) of the control group (baseline).</p><p><strong>Conclusion: </strong>The final result of this research found a new surveillance model of tuberculosis transmission control in google earth mapping aplication based on Geographic Information system.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"287-294"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/b3/AIM-30-287.PMC9665415.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35347278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PD-L1 Expression Among Triple-Negative Breast Cancer Patients in Universitas Sumatera Utara Teaching Hospital, Indonesia.","authors":"Dedy Hermansyah,&nbsp;Dede Kurniawan,&nbsp;Daniel KristianPrawira Lesmana,&nbsp;Yolanda Rahayu Simamora,&nbsp;Desiree Anggia Paramita,&nbsp;Edwin Saleh Siregar","doi":"10.5455/aim.2022.30.308-311","DOIUrl":"https://doi.org/10.5455/aim.2022.30.308-311","url":null,"abstract":"<p><strong>Background: </strong>The emerging role of precision medicine among in oncologic science is a potentially explorable area to solve long-standing implication of triple-negative breast cancer (TNBC)'s management, especially by identifying programmed cell death ligand-1 (PD-L1) in its population.</p><p><strong>Objective: </strong>To describe the PD-L1's expression among TNBC populations in our Indonesia-based centers.</p><p><strong>Methods: </strong>This descriptive study was conducted in the teaching hospitals of Universitas Sumatera Utara ranging from April 2019 to July 2020. Our investigation encompassed female individuals with histopathologically confirmed TNBC and complete medical record data, especially the status of PD-L1 expression to be reported in this study. We use Daco 22C3 antibodies to confirm the latter protein immunohistochemical positivity after thorough specimen preparation and staining.</p><p><strong>Results: </strong>This study included 60 females with TNBC of which 40 participants were issued in the final report. Our populations were dominated by middle-aged individuals (41-50 years old; 45%), and remarkable presentation of LVSI, angioinvasion, or lymph-node metastatic status. In PD-L1 expression status, our study reported that 45.0% patients were confirmed with confirmed PD-L1 positivity.</p><p><strong>Conclusion: </strong>PD-L1 expression among TNBC patients is concordant with the global report hence anti-PD-1-based treatment trial in Asia or even Indonesia region should be considered.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"308-311"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/69/AIM-30-308.PMC9665422.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Most Influential Scientists in the Development of Medical Informatics (34): Steven Huesing (1944- 2009).","authors":"Izet Masic","doi":"10.5455/aim.2022.30.334-335","DOIUrl":"https://doi.org/10.5455/aim.2022.30.334-335","url":null,"abstract":"<jats:p />","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"334-335"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/29/AIM-30-334.PMC9665414.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation of PANSS Scores and P100 Latency in Patients with Schizophrenia and Migrene Hedache Using Visual Evoked Potentials (VEPS) According to Gender and Age.","authors":"Gorana Sulejmanpasic,&nbsp;Amra Memic-Serdarevic,&nbsp;Selma Sabanagic-Hajric,&nbsp;Nermina Bajramagic","doi":"10.5455/aim.2022.30.318-323","DOIUrl":"https://doi.org/10.5455/aim.2022.30.318-323","url":null,"abstract":"<p><strong>Background: </strong>The VEPs provide an objective measure of brain function, analyzing integrity of visual processing. With patients affected with schizophrenia, the changes with the implementation of VEP are evident, such as symmetrical deceleration of the impulse and the continuance of latency, which points to a degenerative illness, suggesting the presence of optical neuritis or hemianopsia conjoined with mentioned intracranial illness.</p><p><strong>Objective: </strong>The aim of the study was to determine the correlation of positive and negative symptoms (PANSS scores) and P100 latency between patients with schizophrenia and patients with migraine headache according to gender and age. Visual evoked potentials (VEPs) were applied.</p><p><strong>Methods: </strong>The sample included 80 subjects: a) S group- 40 patients with schizophrenia (21 males; 19 females); b) H group-40 healthy subjects with migraine headache (10 males; 30 females). The study was conducted at the Department of Psychiatry and Neurology University Clinical Center Sarajevo.</p><p><strong>Results: </strong>Our research revealed positive correlation of the P100 latency and the PANSS score of negative symptoms, which means that the subjects of the observed group with a higher latency of the P100 wave of the entire visual field in both eyes have higher PANSS scores of negative symptoms. The correlation is significantly higher in female subjects (37% shared variance) than in male subjects (12% shared variance). All male subjects have a PANSS negative symptoms score of 17 or higher, while all female subjects have a PANSS negative symptoms score of less than 17 positive correlations were registered in P100 latency in left view field of both eyes and in P100 amplitude in the region of right eye (p=0.01) in comparation with left eye region (p=0.05) in patients with schizophrenia.</p><p><strong>Conclusion: </strong>Results imply that the cognitive impairment seen in schizophrenia is not just due to deficits in higher order aspects of cognition but also encompasses significant deficits in early sensory processing. Our study is useful to initiate new questions and recommendations for further studies, specifically on changes in the occipital lobe in the schizophrenic patient's brain.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"318-323"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/43/AIM-30-318.PMC9665418.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Aging Activity of Andaliman (Zanthoxylum Acanthopodium DC) Fruit Ethanol Extract on Brain Weight and p16INK4a Expression of Hippocampus in Aging Model Rats.","authors":"Dwi Rita Anggraini,&nbsp;Syafruddin Ilyas,&nbsp;Poppy Anjelisa Zaitun Hasibuan,&nbsp;Yetty Machrina,&nbsp;Ambrosius Purba,&nbsp;Delfitri Munir,&nbsp;Imam Budi Putra,&nbsp;Betty","doi":"10.5455/aim.2022.30.283-286","DOIUrl":"https://doi.org/10.5455/aim.2022.30.283-286","url":null,"abstract":"<p><strong>Background: </strong>Physiological aging and due to oxidative stress in long term will have an impact on cellular response disorders, can caused aging of hippocampus and senility. Brain weight is known to decrease with age and p16INK4a as aging biomarkers have been investigated. Andaliman is one of typical herbal plants from North Sumatra has been widely used as an antioxidant, anti-inflammatory and anti-aging.</p><p><strong>Objective: </strong>This study was evaluated effect of andaliman (Zanthoxylum acanthopodium DC) fruit ethanol extract (AEE) on brain weight and p16INK4a expression in aging model rats.</p><p><strong>Methods: </strong>This study was carried out experimentally of 24 male wistar rats. The treatment group consisted of 4 groups; KN= negatif control (normal), KP= positif control (aging model rat), P1 and P2= aging model rat + AEE at dose 150 and 300mg/kgbw, respectively. The aging model rats were D-galactose-induced at dose of 150mg/kgbw for 8 weeks. Brain weigth were recorded by digital scales. p16INK4a expression using immunohistochemical methods. The data analysis with Anova test.</p><p><strong>Results: </strong>This study showed differences brain weight between groups (p=0.523). Brain weight in P1 (1.34±0,06) and P2 (1.30±0.09) tendency increased than KP (1.29±0.62). The p16INK4a expression between groups significant difference (p=0.041), continued with post hoc Least Significant Difference (LSD) showed p16INK4a expression in KN significant decreased than KP (p=0.027). Likewise, p16INK4a expression in P2 was significant decreased than KP (p=0.010).</p><p><strong>Conclusion: </strong>Andaliman ethanol extract at a dose 300mg/kgbw for 8 weeks was improved aging process caused D-galactose induced.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"283-286"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/63/AIM-30-283.PMC9665423.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kawasaki Disease Shock Syndrome Presented with Giant Coronary Artery Dilatation - Presentation of Two Cases and a Literature Review.","authors":"Ramush Bejiqi,&nbsp;Nafije Pajaziti,&nbsp;Shqipe Agushi","doi":"10.5455/aim.2022.30.253-256","DOIUrl":"https://doi.org/10.5455/aim.2022.30.253-256","url":null,"abstract":"<p><strong>Background: </strong>Kawasaki disease is an acute, self-limited vasculitis of childhood characterized by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy. Coronary artery aneurysms or ectasia develop in approximately 15 to 25% of untreated children with the disease and may lead to myocardial infarction, sudden death, or ischemic heart disease. Despite an overlap of clinical features with toxic shock syndrome, children with Kawasaki disease generally do not develop shock.</p><p><strong>Objective: </strong>Here we present two adolescent boys who had KDSS and discuss their differentiating features from MIS-C.</p><p><strong>Case reports: </strong>Two adolescent children presented with a toxic shock-like illness, and were subsequently diagnosed with Kawasaki disease shock syndrome when coronary artery abnormalities were found on transthoracic echocardiography.</p><p><strong>Conclusion: </strong>Pediatricians and paediatric cardiologists alike should be aware of this potentially severe form of manifestation of the Kawasaki disease which needs to be differentiated from the multisystem inflammatory syndrome in children.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"253-256"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/39/AIM-30-253.PMC9559664.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40670949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Recent Advances of Mobile Healthcare in Cardiology Practice.","authors":"Shynar Kulbayeva,&nbsp;Karlygash Tazhibayeva,&nbsp;Laura Seiduanova,&nbsp;Indira Smagulova,&nbsp;Aiman Mussina,&nbsp;Shynar Tanabayeva,&nbsp;Ildar Fakhradiyev,&nbsp;Timur Saliev","doi":"10.5455/aim.2022.30.236-250","DOIUrl":"https://doi.org/10.5455/aim.2022.30.236-250","url":null,"abstract":"<p><strong>Background: </strong>Digitalization of healthcare led to the optimization of monitoring, diagnostics, and treatment of the range of disorders. Taking into account recent situation with COVID-19 pandemics, digital technologies allowed to improve management of viral infections via remote monitoring and diagnostics of infected patients. Up to date, various mobile health applications (apps) have been proposed, including apps for the patients diagnosed with cardiovascular pathologies.</p><p><strong>Objective: </strong>The presented review aimed at the analyses of a range of mHealth solutions used to improve primary cardiac care. In addition, we studied the factors driving and hindering the wide introduction of mHealth services in the clinics.</p><p><strong>Methods: </strong>The work was based on the guidelines of the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. The publication search was carried out using PubMed, Web of Science, Cochrane Library, Scopus, and Google Scholar databases. Studies published during the period from 2014 until January 2022 were selected for the analysis. The evaluation of risk of bias for the included studies was conducted using the Cochrane Collaboration Risk of Bias tool.</p><p><strong>Results and discussion: </strong>An overall 5513 studies were assessed for eligibility after which 39 studies were included.. The main trend in the mobile health for cardiological applications is the use of different types of wearable devices and Artificial Intelligence-platforms. In fact, mobile technology allows remotely to monitor, interpret, and analyze biomedical data collected from the patient.</p><p><strong>Conclusion: </strong>The results of this literature search demonstrated that patients diagnosed with cardiovascular disorders can potentially benefit from the application of mHealth in cardiology. However, despite the proven advantages of mHealth for cardiology, there are many challenges and concerns regarding effectiveness, safety, reliability and the lack of official regulation and guidelines from official organizations. Such issues require solutions and further work towards a wide implementation of mHealth technologies in cardiac practice.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"236-250"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/3d/AIM-30-236.PMC9559778.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40670950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Assessment Metabolic Markers and Cardio Risk Index Among Controlled and Uncontrolled Type 2 Diabetic Patients in Primary Health Clinics in Medan City, North Sumatera, Indonesia: Cross-sectional Study.","authors":"Rusdiana Rusdiana,&nbsp;Ahmad Moradi,&nbsp;Sry Suryani Widjaja,&nbsp;Mila Hayati Daulay,&nbsp;Rusmalawaty Rusmalawaty","doi":"10.5455/aim.2022.30.201-204","DOIUrl":"https://doi.org/10.5455/aim.2022.30.201-204","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus is the most common metabolic disorder affecting people worldwide. Diabetes mellitus has been known to be associated with lipid metabolic disorders and macrovascular and microvascular complications.</p><p><strong>Objective: </strong>This study assesses the correlation between cardio risk index and metabolic markers in type 2 diabetes mellitus patients.</p><p><strong>Methods: </strong>This study was conducted on type 2 diabetes mellitus with the cross-sectional analytic method. The inclusion criteria of the samples were all the patients diagnosed with type 2 diabetes mellitus of both sexes. We recorded Body Mass Index, Blood Pressure, disease duration, and family history. The laboratory parameters, including Fasting Blood Sugar, Hba1c, HDL, LDL, TG, and Cholesterol, were examined by Paramita Laboratory Clinic. The data of the samples were processed using a computer with the SPSS program..</p><p><strong>Results: </strong>There were significantly different mean of age, abdominal circumference, FBG, Hba1c, cardio risk index, and HDL controlled and uncontrolled type 2 diabetes groups, but the mean cholesterol and LDL levels were not different in the two groups.At uncontrolled type 2 diabetic we found that there was a significant correlation between the cardio risk index with Cholesterol (r= 0.3 p=0,004), triglycerides (r=0.5 p=0,001), and negative correlation cardio risk index with HDL (r= -0.5 p=0.012). There was no significant correlation between the cardio risk index with LDL (r=0.157 p=0.101).</p><p><strong>Conclusion: </strong>Hba1c and FBS are higher in uncontrolled type 2 diabetes accompanied by lipid profile and cardio risk index levels that are higher than expected values are the risk of complications in type 2 diabetes mellitus.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"201-204"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/45/AIM-30-201.PMC9559990.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40443331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Toll-Like Receptor 7 Gene Polymorphism and ABO Blood Groups on the Severity of COVID-19 Patients.","authors":"Zainab H D Al-Tamimi, Abdulsamie H Alta'ee, Ahmed H Jasim","doi":"10.5455/aim.2022.30.191-195","DOIUrl":"10.5455/aim.2022.30.191-195","url":null,"abstract":"<p><strong>Background: </strong>The most current threat to global health is the continuous spread of a respiratory disease known as COVID-19 Disease 2019 in recent years. COVID-19 was recognized in December 2019. It was quickly determined that a novel COVID-19 virus, which is structurally linked to the virus that causes the severe acute respiratory syndrome, was to cause (SARS).</p><p><strong>Objective: </strong>The aim of this study is to investigate the presence of effect between the rs179008 (A/T) SNP polymorphism in TLR7 gene and blood group on the severity of COVID-19.</p><p><strong>Methods: </strong>The study included 90 patients divided into three groups mild, moderate, severe, and experimental research work was conducted during the period of sample collection extended from November 2021 to February, PCR-RFLP technique was used to determine SNP rs179008 polymorphism in TLR7 in the blood.</p><p><strong>Results: </strong>A present study found non-significant differences between patient groups for TLR7 rs179008 (A, T) allele were (p=0.79152) for mild to moderate and severe, (p=0.84872) for mild and moderate and (p=0.58741) for mild and severe. When comparison (AA, AT, TT) genotypes in three groups found a significant difference between mild and moderate groups (p=0.036) for the AA genotype. Found (A blood group) more frequency than other groups but observes no significant difference between patients' group.</p><p><strong>Conclusion: </strong>We conclude that the (AA) genotype for TLR7 rs179008 polymorphism was a risk factor and effect on severity of COVID-19 infection, so (AA) can consider an independent risk factor for development of COVID-19.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"191-195"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/c9/AIM-30-191.PMC9559784.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40443329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}