Acta clinica Croatica最新文献

{"title":"CORRELATION BETWEEN VISUAL FIELD SENSITIVITY AND RETINAL NERVE FIBER LAYER THICKNESS IN UNILATERAL EXFOLIATION SYNDROME.","authors":"Marija Šimić Prskalo, Zrinko Prskalo, Željka Tomić, Teo Tomić","doi":"10.20471/acc.2024.63.03-04.04","DOIUrl":"10.20471/acc.2024.63.03-04.04","url":null,"abstract":"<p><p>This study aimed to evaluate retinal nerve fiber layer thickness in exfoliation syndrome (XFS), present unilaterally, using optical coherence tomography (OCT). This prospective study included 90 examinees with unilateral syndrome. However, examinees with higher intraocular pressure or findings implicative of glaucoma were excluded from the study, as well as examinees with optic nerve changes. In individuals with unilateral XFS, OCT findings were compared between the two groups: the affected eye group and the fellow eye group. The study results show that the average thinning of the retinal nerve fiber layer, especially in the inferior and superior quadrants, has not resulted in visual field defects in examinees with unilateral XFS. In the group of eyes without XFS, 85.55% exhibited reference inferior quadrant thickness values, and 91.11% exhibited reference superior quadrant thickness values. In the group of eyes with manifest XFS, 82.22% exhibited reference inferior quadrant thickness values, and 88.88% exhibited reference superior quadrant thickness values. Most examinees in both groups had normal average retinal nerve fiber layer (RNFL) thickness (72.22%). In examinees with clinically unilateral XFS, RNFL thinning occurs in both eyes before XFS becomes bilateral and before hypertensive intraocular pressure can be measured.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"482-486"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRENATAL AND OBSTETRIC RISK FACTORS FOR DEVELOPMENT OF DISABILITIES IN CHILDHOOD.","authors":"Ksenija Romstein, Dubravko Habek, Tena Velki, Maja Košuta Petrović","doi":"10.20471/acc.2024.63.03-04.27","DOIUrl":"10.20471/acc.2024.63.03-04.27","url":null,"abstract":"<p><p>The main objective was to analyze prenatal and obstetric risk factors in relation to the development of disabilities. For that purpose, data on medication, i.e., use of benzodiazepines during pregnancy, gestational weeks, mode of delivery (vaginal or cesarean section), duration of delivery, and fetal presentation were retrieved from medical records and semi-structured interviews with mothers/legal guardians. Trained professionals clinically assessed the children's developmental status (N=107). Fisher exact test with post hoc analysis of standardized residuals showed that a statistically significant number of children with multiple disabilities were born by cesarean section (z=3.7, p<0.001), prematurely (z=4.8, p<0.001), and by mothers using benzodiazepines (z=2.6, p<0.01). Children with autism spectrum disorders were more often delivered post-term (z=2.0, p<0.05) by induced delivery (z=2.9, p<0.01). Children with developmental coordination disorder were more often born post-term (z=2.2, p<0.05). As for the duration of delivery and fetal presentation, there was no statistically significant correlation with developmental disabilities. There is a cumulative risk of developmental disabilities rather than just a single risk factor. More interdisciplinary and longitudinal research on developmental disabilities, including children's educational outcomes should be conducted.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"670-677"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROGNOSTIC VALUE OF TUMOR BUDDING IN SPORADIC COLORECTAL CANCER STAGE II PATIENTS WITH A LOW NUMBER OF LYMPH NODES EXAMINED.","authors":"Josip Baković, Čedna Tomasović-Lončarić, Arijana Pačić, Iva Škifić, Valentin Lisek, Karolina Krstanac, Petra Čičak, Paško Konjevoda","doi":"10.20471/acc.2024.63.03-04.37","DOIUrl":"10.20471/acc.2024.63.03-04.37","url":null,"abstract":"<p><p>Stage II colorectal cancer (CRC) is a major therapeutic challenge because it is not easy to decide whether patients will benefit from adjuvant chemotherapy or not. This study was designed as a retrospective prognostic study combining standard histopathologic parameters with tumor budding and microsatellite instability. The study included 89 patients on elective treatment for stage II primary colorectal adenocarcinoma from January 2011 to December 2015. Study results indicated that the prognosis of patients with stage II CRC depended on the combination of three factors, (in the order of importance): number of lymph nodes examined; total number of buds <i>per</i> 0.785 mm2 (≥5.5); and positive lymphovascular invasion. There is increasing evidence that tumor biology and non-anatomic characteristics are important in the prognosis and treatment of CRC. One of them is tumor budding which is not yet an integral part of the AJCC staging system. A low number of the lymph nodes examined is associated with high-risk patients. All patients without an adequate number of lymph nodes examined (less than 8 lymph nodes) should <i>a priori</i> be considered a very high-risk group, with a very low survival rate, and chemotherapy should be used.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"758-768"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERCUTANEOUS CORONARY INTERVENTION ON SAPHENOUS VEIN GRAFT IN SECOND GENERATION DRUG ELUTING STENT ERA.","authors":"Milenko Čanković, Andrej Preveden, Vladimir Ivanović, Aleksandra Milovančev, Milovan Petrović, Mila Kovačević, Tatjana Miljković, Marija Bjelobrk, Lazar Velicki","doi":"10.20471/acc.2024.63.03-04.20","DOIUrl":"10.20471/acc.2024.63.03-04.20","url":null,"abstract":"<p><p>The aim of the study was to determine major adverse cardiac events (MACE) related to the percutaneous coronary intervention (PCI) on saphenous vein graft (SVG) with a second-generation drug eluting stents in patients with previous coronary artery bypass graft (CABG). The research was conducted as a unicenter retrospective observational study which analyzed consecutive patients of both genders who had PCI on SVG from January 1, 2016 until June 30, 2019. The aim was to investigate the occurrence of MACE defined as development of periprocedural myocardial infarction, acute heart failure in the first 24 hours after PCI, unstable angina after PCI, periprocedural stroke, contrast induced nephropathy, death, acute/subacute/late stent thrombosis, and target lesion revascularization. The study included 97 consecutive patients. MACE was recorded in 20.6% of patients, more often in patients with thrombolysis in myocardial infarction grade flow ≤2. High thrombus burden (HTB) was detected in 44.3% of patients and it significantly contributed to the development of MACE. In conclusion, PCI on SVG is a highly challenging procedure, especially in patients with an acute coronary syndrome. In patients who have HTB recorded in SVG, the usage of thrombus aspiration and distal protection device can reduce the frequency of no-reflow phenomenon and consequential MACE.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"611-618"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRANSIENT HYPOPHOSPHATEMIA AS POSSIBLE ADVERSE OUTCOME AFTER IRON DEFICIENCY ANEMIA TREATMENT WITH FERRIC CARBOXYMALTOSE - SINGLE CENTER EXPERIENCE.","authors":"Nikolina Brkić, Ivana Vučinić Ljubičić, Hrvoje Holik, Božena Coha","doi":"10.20471/acc.2024.63.03-04.03","DOIUrl":"10.20471/acc.2024.63.03-04.03","url":null,"abstract":"<p><p>The aim of this study was to determine the frequency of hypophosphatemia in female patients with iron deficiency anemia (IDA) treated parenterally with ferric carboxymaltose (FCM). Thirty-two female patients examined for IDA at the Hematology and Oncology Department of one General Hospital were included in the study. The inclusion criteria were hemoglobin <110 g/L, transferrin saturation <50%, ferritin <30 ng/mL, and ineffective oral iron therapy. The hemoglobin values were significantly increased 6 weeks after therapy in comparison with initial values. The onset of the asymptomatic hypophosphatemia was observed in 17 of 32 patients two weeks after the FCM therapy. Only one of 32 patients had severe asymptomatic hypophosphatemia (serum phosphate <0.3 mmol/L). Prolonged hypophosphatemia (6 weeks after FCM therapy) was observed in five of 32 patients, of which only one patient had initial hypophosphatemia. The difference between the phosphate values measured two weeks after the FCM therapy and the phosphate values at the first and last follow-up was statistically significant. Serum phosphate values should be routinely measured before and after parenteral FCM therapy.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"475-481"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF UNCOMPLICATED ULTRASOUND PHACOEMULSIFICATION CATARACT SURGERY ON CENTRAL MACULAR THICKNESS CHANGES IN THE EARLY POSTOPERATIVE PERIOD IN DIABETIC PATIENTS.","authors":"Ivana Pivić-Kovačević, Suzana Matić, Josip Barać, Marija Jelić Vuković, Tvrtka Benašić, Željka Salinger","doi":"10.20471/acc.2024.63.03-04.21","DOIUrl":"10.20471/acc.2024.63.03-04.21","url":null,"abstract":"<p><p>The aim of this prospective study was to determine changes in central macular thickness in the early postoperative period after uncomplicated phacoemulsification cataract surgery in diabetic patients using spectral domain optical coherence tomography (SD-OCT). Uncomplicated ultrasound phacoemulsification cataract surgery causes minimal changes of retinal layer thickness, which may result in subclinical cystoid macular edema development. This prospective study included 55 patients divided into two groups. Group 1 included diabetic patients with cataract, and group 2 included patients with cataract and without diabetes. All patients underwent uncomplicated ultrasound phacoemulsification cataract surgery at the Department of Ophthalmology, University Hospital Osijek in the period from November 2017 to January 2018. Patients were followed-up for one month after surgery. At each examination, OCT recording of the eye undergoing cataract surgery was performed. A statistically significant difference in central macular thickness in the diabetic group and control group (p=0.0005 both) was confirmed preoperatively and one month after cataract surgery. A statistically significant difference in central macular thickness was confirmed in diabetic group (p=0.006), as well as in the control group of patients (p=0.01) seven days and one month after cataract surgery. There was no statistically significant difference in macular thickness changes between the diabetic and control group of patients preoperatively (p=0.618), seven days (p=0.6848) or one month after cataract surgery (p=1). The effect of HbA1c on macular thickness change in diabetic patients was not statistically significant. The mean HbA1c in diabetic patients was 7.24±1.34%. There was no statistically significant difference in the effect of cumulative dissipated energy on macular thickness change in either group. This study confirmed a statistically significant correlation of the effect of fluid volume consumption on macular thickness changes in diabetic patients. There was no statistically significant effect of fluid volume consumption on macular thickness change in the control group of patients. Uncomplicated ultrasound phacoemulsification cataract surgery caused changes in cen-tral macular thickness in the early postoperative period in both patient groups. Changes in central macular thickness in the observed period were not manifested with clinically significant macular edema or by a more significant decrease in visual acuity. All patients had significant improvement in visual acuity seven days and one month after cataract surgery.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"619-625"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF TREATMENT WITH TEMSIROLIMUS VERSUS INTERFERON ALPHA ON SURVIVAL OF PATIENTS WITH METASTATIC RENAL CELL CARCINOMA - SINGLE-CENTER REAL-WORLD EXPERIENCE.","authors":"Ivan Levakov, Saša Vojinov, Miloš Maletin, Dimitrije Jeremić, Mladen Popov, Olivera Levakov, Dragan Grbić","doi":"10.20471/acc.2024.63.03-04.19","DOIUrl":"10.20471/acc.2024.63.03-04.19","url":null,"abstract":"<p><p>Vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors are two main groups of drugs for targeted treatment of metastatic renal cell carcinoma (mRCC). Inhibition of angiogenesis and other growth pathways that are pivotal for tumor progression lead to significant improvement of survival in patients with mRCC. The main aim of this study was to compare the effects of temsirolimus (mTOR inhibitor) and interferon alpha-2a (IFN-alpha-2a) on overall survival (OS) and progression-free survival (PFS) in patients with T3 stage mRCC who developed lung metastasis in the first two years after radical nephrectomy. A total of 60 patients diagnosed with T3 stage renal cancer who developed metastases in the lungs within two years after radical nephrectomy were included in a prospective study conducted at the Department for Urology, Clinical Center of Vojvodina and partially retrospective study at the Oncology Institute in Sremska Kamenica. Patients were divided into two groups consisting of 30 patients according to treatment with temsirolimus or IFN-alpha. During the first year of treatment, OS of patients treated with temsirolimus was 23.33%, whereas in patients treated with IFN-alpha it was 16.67%. Median survival in patients treated with temsirolimus was 9.3 months, whereas in patients treated with IFN-alpha it was 6.9 months, yielding a statistically significant difference (p=0.028). Patients treated with temsirolimus showed a statistically significantly longer median PFS compared to patients treated with IFN-alpha (p<0.0085). In conclusion, temsirolimus therapy had a significantly positive effect on survival in patients with mRCC. Patients treated with temsirolimus showed significantly longer median survival and median PFS compared to patients treated with IFN-alpha.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"604-610"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEW INSIGHTS INTO DEVELOPMENT OF MATERNITY HOSPITALS IN THE REPUBLIC OF CROATIA AFTER WORLD WAR II: OUTPATIENT MATERNITY DEPARTMENT IN KLANJEC, HRVATSKO ZAGORJE, CROATIA.","authors":"Rajko Fureš, Milan Stanojević, Žana Stanić, Dora Fureš, Vesna Ćosić, Željka Fureš, Sanja Malinac Malojčić, Martin Gredičak, Zlatko Hrgović, Ivana Erceg Ivkošić, Nika Mikelin","doi":"10.20471/acc.2024.63.03-04.39","DOIUrl":"10.20471/acc.2024.63.03-04.39","url":null,"abstract":"<p><p>In the area of today's Krapina-Zagorje County, after World War II, there were three outpatient maternity departments (OMD) in Krapina, Klanjec and Pregrada, making a considerable step forward in public health improvement. The first and biggest OMD was located in the Klanjec Public Health Center. In parallel with establishment of the maternity hospital (MH) in Zabok, all OMDs throughout today's Krapina-Zagorje County were closed. The aim of our research was to present the activities of Klanjec OMD (KOMD) and show its impact on perinatal health. Data on KOMD activities were obtained from the Birth Registry. Major obstetric procedures, including delivery by cesarean section, were not performed in KOMD. Based on the above, numerous transports of women in labor and postpartum transports were organized to maternity wards in large centers. The most common cause for transport were transports during childbirth caused by prolonged labor. In conclusion, organization of OMD in the area of today's Krapina-Zagorje County significantly improved perinatal care in the 1950s. It was followed by gradual closure of OMD which could not meet the newly set spatial, material and personnel demands, along with the establishment of maternity hospitals in general and university hospitals. The trend of perinatal and maternal mortality reduction in the Zagorje region that began with the establishment of inpatient maternity department at the Zabok Hospital continues to this day.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"778-783"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MILD COGNITIVE IMPAIRMENT AND CARDIOMETABOLIC RISK FACTORS IN BOSNIAN AND HERZEGOVINIAN PATIENTS WITH HEART FAILURE.","authors":"Jasna Ibrahimović-Pašić, Orhan Lepara, Amela Dervišević, Nermina Babić, Nesina Avdagić, Amina Valjevac, Asija Začiragić","doi":"10.20471/acc.2024.63.03-04.38","DOIUrl":"10.20471/acc.2024.63.03-04.38","url":null,"abstract":"<p><p>The aim of the present study was to assess mild cognitive impairment (MCI) and cardiometabolic risk factors (CMRF) in Bosnian and Herzegovinian patients with heart failure (HF). This study included 80 patients with HF and 40 healthy controls. Montreal Cognitive Assessment (MoCA) testing was used to evaluate cognitive function. Abdominal obesity was assessed by waist circumference, and hypertension was assessed by the auscultatory method. Data on other CMRF and comorbidities, such as diabetes, smoking, alcohol consumption, and atrial fibrillation (AF), were gathered with a specially designed questionnaire. Lipids, C-reactive protein (CRP), and fibrinogen were assessed with standard laboratory methods. Student, Mann-Whitney, and Chi-square tests were used to determine significant differences between groups. Associations between categorical variables and correlation coefficients were assessed by the Chi-square and Spearman test, respectively. The prevalence of MCI in patients with HF was 77.5%. We found significant associations between MCI and diabetes, hypertension, AF, and smoking in patients with HF. We found no significant associations between MCI, abdominal obesity, and alcohol consumption. A significant positive correlation between MCI and total cholesterol was observed in patients with HF. Furthermore, a lower MoCA score was associated with higher values of CRP and fibrinogen in HF patients. The present study showed a high prevalence of MCI in Bosnian and Herzegovinian HF patients as well as its association with various CMRFs. These results suggest it is necessary to begin MCI screening in HF patients, especially since data from the literature point to improvement in cognitive performance with appropriate HF and concomitant CMRF treatment.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"769-777"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RELATIONSHIP OF IMMUNOHISTOCHEMICAL EXPRESSION OF CD86/CD163 POSITIVE INTRATUMORAL MACROPHAGES WITH PROGNOSIS OF PANCREATIC DUCTAL ADENOCARCINOMA.","authors":"Goran Glavčić, Mario Zovak, Slavica Sović, Silvija Mašić, Nina Blažević, Zvonimir Misir, Zdenko Bilić, Marin Glavčić, Petra Radulović","doi":"10.20471/acc.2024.63.03-04.29","DOIUrl":"10.20471/acc.2024.63.03-04.29","url":null,"abstract":"<p><p>Recent studies have shown an association of the number of tumor-associated macrophages (TAM) with the prognosis and treatment outcomes of ductal pancreatic adenocarcinoma. This study aimed to examine the correlation between CD86 and CD163 macrophage expression and clinical-pathological characteristics of the disease in patients operated on for pancreatic carcinoma. A retrospective research was conducted in which the archival materials of the Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center were used together with all relevant patient clinical data obtained from the Hospital Information System on 76 patients operated on for pancreatic adenocarcinoma. In our study, the number of CD86 macrophages and the CD86/CD163 ratio showed a statistically significant correlation with increasing T and N stages of the disease. The number of CD163 macrophages did not show a statistically significant correlation with the mentioned variables. These results indicated that in our clinical conditions, proinflammatory (M1) macrophages were more expressed in locally advanced tumor stages with worse long-term prognoses. In conclusion, TAMs could be a valid prognostic marker or even a target for therapeutic agents but more studies will be needed to fully comprehend the impact of M1/M2 differentiation.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"684-692"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}