Seda Ozkan, Necmi Baykan, Omer Salt, Sule Yakar, Ahmet Sen, Polat Durukan
{"title":"THE ROLE OF PLASMA COPEPTIN LEVEL IN DETERMINING THE SEVERITY AND MORTALITY OF SUBARACHNOID HEMORRHAGE.","authors":"Seda Ozkan, Necmi Baykan, Omer Salt, Sule Yakar, Ahmet Sen, Polat Durukan","doi":"10.20471/acc.2023.62.04.3","DOIUrl":"10.20471/acc.2023.62.04.3","url":null,"abstract":"<p><p>The study aimed to investigate the role of plasma copeptin level in setting the diagnosis, severity and mortality of patients with subarachnoid hemorrhage (SAH) admitted to the emergency department. We included patients aged ≥18 years who were diagnosed with SAH. Blood samples were collected from patients at the time of admission to the emergency department for assessment of plasma copeptin levels. The Glasgow Coma Scale (GCS), World Federation of Neurological Surgeons (WFNS), modified Fisher score, in-hospital mortality and one-year mortality rates were determined in patients. There was a statistically significant difference in plasma copeptin levels between the patients (mean: 0.78±0.41 ng/mL) and healthy controls (mean: 0.48±0.27 ng/mL) (p=0.001). There was no significant correlation of plasma copeptin levels with the GCS, WFNS, and modified Fisher scores. There was no significant difference in copeptin levels between the patients who died in the hospital (mean: 0.73±0.42 ng/mL) and those who did not (mean: 0.80±0.41 ng/mL) (p=0.41). Although plasma copeptin level may be used in the diagnosis of SAH, it does not have a role in determining the patient condition severity and mortality.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"595-604"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Goran Knezović, Jelena Milojković, Dmitar Vlahović, Aleksandra Lučić-Prokin, Timea Kokai-Zekić, Slobodan Torbica, Vedran Žigić, Vladimir Knezović, Svetlana Simić, Željko Živanović
{"title":"BASILAR ARTERY REOCCLUSION WITHIN 24 HOURS AFTER MECHANICAL THROMBECTOMY SUCCESSFULLY TREATED WITH NEW INTERVENTION.","authors":"Goran Knezović, Jelena Milojković, Dmitar Vlahović, Aleksandra Lučić-Prokin, Timea Kokai-Zekić, Slobodan Torbica, Vedran Žigić, Vladimir Knezović, Svetlana Simić, Željko Živanović","doi":"10.20471/acc.2023.62.03.20","DOIUrl":"10.20471/acc.2023.62.03.20","url":null,"abstract":"<p><p>Acute basilar artery occlusion (BAO) may cause ischemia in the region of brainstem, parts of the thalamus, occipital lobes, and cerebellum, resulting in severe disability or mortality rate above 70%. Recurrent BAO has been described in only a small number of cases. We present a case of repeated mechanical thrombectomy (MT) for the tip of basilar artery (BA) reocclusion within 24 hours. A previously healthy 37-year-old male presented with occipital headache, nausea, vomiting, right-sided hemiparesis, within 30 minutes from the onset and NIHSS 18. The patient was vaccinated against COVID-19 with Pfizer-BioNTech vaccine seven days before the onset. On initial computed tomography (CT) scan, the pc-ASPECTS was 10 and CT angiography (CTA) showed the tip of BA thrombosis. Intravenous thrombolytic therapy was administered, followed by MT, achieving mTICI 3 and NIHSS 5 after the procedure. Within 24 hours from the first MT, there was neurological deterioration followed by coma. Urgent CT/CTA was performed and rethrombosis of BA was confirmed with pc-ASPECTS 10. MT was repeated with mTICI 2b. Stroke etiology was undetermined. After 17 days, the patient was discharged and referred to continue rehabilitation treatment. After 90 days of stroke, his NIHSS was 2 and mRS 1. We can consider that early recurrent BAO can be successfully treated with repeated MT.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"561-566"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DOES THE PRESENCE OF CHRONIC LYMPHOCYTIC THYROIDITIS AFFECT DIAGNOSTIC VALUE OF FINE NEEDLE ASPIRATION BIOPSY IN BETHESDA CATEGORY III NODULES?","authors":"Şevki Pedük, Belma Koçer","doi":"10.20471/acc.2023.62.03.8","DOIUrl":"10.20471/acc.2023.62.03.8","url":null,"abstract":"<p><p>This study aimed to determine the relationship between the presence of Hashimoto's thyroiditis (HT) and malignancy rates with prognostic factors in thyroid nodules diagnosed as Bethesda category III, and to examine the effect of HT on diagnostic value of fine-needle aspiration biopsy (FNAB). Demographic information, preoperative examination, and final pathological evaluation of patients with Bethesda category III (AUS-FLUS) nodules who had been operated on in our department over the last 6 years were analyzed. Statistical analyses were performed using the Student's t-test, Mann-Whitney U test and χ<sup>2</sup>-test and logistic regression analysis using SPSS version 22 software. The malignancy rate on final pathology of 159 patients was 24.5%. Malignancy rates were found to be higher in patients with HT coexistence (30.7% <i>vs.</i> 21.5%, p=0.20). Poor prognostic factors such as multifocality, number of metastatic lymph nodes (p=0.04), and extrathyroidal extension were more common in patients with cancer in the pathology specimen who were in the non-HT group. It cannot be said that HT decreases diagnostic value of FNAB in lesions diagnosed with AUS-FLUS. The lower incidence of poor prognostic factors in the HT group may be attributed to cytotoxic cell dominance in tumor immunity.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"464-472"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mia Lorencin, Željko Orihovac, Roko Žaja, Ines Begović
{"title":"ORBITAL BLOWOUT FRACTURES: A RETROSPECTIVE STUDY WITH LITERATURE REVIEW.","authors":"Mia Lorencin, Željko Orihovac, Roko Žaja, Ines Begović","doi":"10.20471/acc.2023.62.03.14","DOIUrl":"10.20471/acc.2023.62.03.14","url":null,"abstract":"<p><p>Blowout fractures of the orbit are relatively common injuries of the viscerocranium. However, there is still no general consensus on the optimal timing and method of treatment. This article gives a comprehensive review of the pathology of the fracture, process of diagnosis, management and follow-up, including results of a retrospective study done in the Department of Maxillofacial and Oral Surgery, Dubrava University Hospital, Zagreb, in which we collected and analyzed medical records of 91 patients treated for blowout fractures in our institution over a period of three years. Our study showed that the patients admitted to our department more than 48 hours from the injury were more than 4 times likely to develop a complication that would require additional treatment. In other words, of our 91 patients, those admitted to our department in the first 48 hours from the injury had a more than 4 times lower rate of complications, likely due to early recognition of the injury with early intravenous antibiotic and corticosteroid administration, multidisciplinary treatment, and early recognition of candidates for emergency and early surgical treatment. The results of our study show the importance of treating blowout fractures in a tertiary care facility with expertise on the subject.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"519-526"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dejan Živanović, Vesna Mijatović Jovin, Jovan Javorac, Isidora Samojlik, Aleksandar Rašković, Marija Jevtić, Svetlana Stojkov, Nataša Jovanović Lješković, Nataša Perković Vukčević
{"title":"PHARMACOVIGILANCE IN SERBIA: A TEN-YEAR PHARMACOEPIDEMIOLOGIC ANALYSIS.","authors":"Dejan Živanović, Vesna Mijatović Jovin, Jovan Javorac, Isidora Samojlik, Aleksandar Rašković, Marija Jevtić, Svetlana Stojkov, Nataša Jovanović Lješković, Nataša Perković Vukčević","doi":"10.20471/acc.2023.62.03.11","DOIUrl":"10.20471/acc.2023.62.03.11","url":null,"abstract":"<p><p>Pharmacovigilance as a science and group of activities related to detection, collection, analysis, understanding and prevention of adverse drug reactions (ADRs) is an essential activity in the regulatory system of drugs of any country. Defining increased patient safety as the main purpose of ADR reporting, a well-designed national pharmacovigilance system achieves its ultimate goal, i.e., protection of public health. In organizational and technical terms, the Republic of Serbia has a well-developed system of pharmacovigilance, created on the basis of a proven reliable system of the former SFR Yugoslavia, and carried out by the National Agency for Medicines and Medical Devices of Serbia (ALIMS), which conducts all organized activities aimed at strengthening the national system of ADR monitoring and reporting. Unlike the neighboring Croatia and Montenegro with similar pharmacovigilance systems, Serbia has only recently approached the WHO standard of 200 reports <i>per</i> million inhabitants despite a significant increase of 180 ADR reports <i>per</i> million inhabitants in 2019 (1251 in total). Considering this, our study aimed to provide a critical insight into the practice of pharmacovigilance in Serbia by pharmacoepidemiologic analysis of a ten-year period of ADR monitoring and reporting activities.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"486-501"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Meyra Potkonjak, Hrvoje Vraneš, Ivka Djaković, Hrvojka Soljačić Vraneš
{"title":"THE EFFECT OF EDUCATION AND EMPLOYMENT ON SEXUAL ACTIVITY AFTER CHILDBIRTH.","authors":"Ana Meyra Potkonjak, Hrvoje Vraneš, Ivka Djaković, Hrvojka Soljačić Vraneš","doi":"10.20471/acc.2023.62.03.9","DOIUrl":"10.20471/acc.2023.62.03.9","url":null,"abstract":"<p><p>The aim of the study was to explore the relationship between educational level, employment status and sexual activity after delivery. The study was conducted on 286 women with experience of vaginal delivery who completed the questionnaire about age, education, employment, and health status for themselves and partners. Time of the first intercourse and its frequency in the first year after childbirth was observed. Relationship between the variables observed was explored by using multiple linear regression. The mean pregnancy duration was 39 weeks. The mean age of participants was 29.9 (16 to 44) years. Most women had high education (n=170, 59.4%), 114 (39.9%) had secondary, and 2 (0.7%) had primary educational level. Although there were significant differences in the time of the first intercourse and maternal educational level (p=0.013872), partner's employment status (p=0.007403) and maternal age (p= 0.01107), as well as differences in the frequency of intercourse in the first year following delivery and partner's educational level (p=0.016929), multiple correlation coefficients indicated a very weak correlation. According to study results, the correlation of educational level, employment status and sexual activity after childbirth is weak.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"473-477"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mateja Šegović, Iva Mihatov Štefanović, Ivan Pavić
{"title":"THE ROLE OF INTERFERON-GAMMA RELEASE ASSAYS IN DIAGNOSIS OF LATENT TUBERCULOSIS INFECTION IN CHILDREN.","authors":"Mateja Šegović, Iva Mihatov Štefanović, Ivan Pavić","doi":"10.20471/acc.2023.62.03.15","DOIUrl":"10.20471/acc.2023.62.03.15","url":null,"abstract":"<p><p>Despite numerous published papers, diagnosis of latent tuberculosis infection (LTBI) in children is still an undefined area. The importance of this topic lies in the fact that one third of the world's population is infected with <i>Mycobacterium (M.) tuberculosis</i>. The majority of infected individuals are LTBI cases which make a reservoir for future active tuberculosis (TB) patients. The gold standard for LTBI detection is still undetermined and this is due to the effect of various confounding factors on existing diagnostic tests. Until a decade or so ago, throughout the last century, tuberculin skin test (TST) was the only diagnostic test for LTBI. Due to scientific advances, new <i>in vitro</i> assays, interferon-gamma release assays (IGRAs) were discovered recently. The sensitivities of IGRAs are a bit better than those of TST, while great progress has been made in increasing the specificity of IGRA relative to TST. Nevertheless, in the diagnosis of LTBI in children, TST still has some advantages. However, generations of IGRAs have brought many diagnostic advantages that are emphasized in this review. In a difficult procedure of diagnosing LTBI in children, performance of IGRA could be the key factor in making decision whether to use preventive therapy or not.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"527-538"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nebojša Ladjević, Maja Milinić, Vesna Jovanović, Jelena Jovičić, Ivana Likić, Nikola Ladjević
{"title":"CHRONIC POSTOPERATIVE PAIN.","authors":"Nebojša Ladjević, Maja Milinić, Vesna Jovanović, Jelena Jovičić, Ivana Likić, Nikola Ladjević","doi":"10.20471/acc.2023.62.s4.13","DOIUrl":"10.20471/acc.2023.62.s4.13","url":null,"abstract":"<p><p>Chronic postoperative pain (CPOP) is a serious health issue that affects millions of patients every year. The incidence of CPOP is the highest after amputations, inguinal hernioplasty, thoracotomies, cardiac surgery and breast surgery. In addition to surgical factors, the other risk factors are: female gender, younger age, preoperative pain, psychological state and acute postoperative pain. The most common expression of CPOP is neuropathic pain after surgical trauma. The treatment of chronic postoperative neuropathic pain (CPNP) is difficult. Various methods have been recommended for its prevention, the most important being techniques that avoid nerve damage and adequate perioperative analgesia. The goal of this review was to discuss data from published studies examining the incidence, risk factors and mechanisms of CPOP, with a focus on surgery, the unique opportunity to implement pharmacological strategies for prevention of CPNP and current pharmacotherapy approaches for treatment of CPNP. Commonly used drugs to prevent and treat CPNP in the current clinical setting are: opioids, α2-adrenergic agonists, cyclooxygenase antagonists, gabapentin, pregabalin, steroids, N-methyl-D-aspartate receptor antagonists and local anesthetics.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 Suppl4","pages":"88-96"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE EFFECT OD EPIDUROLYSIS IN TREATMENT OF LOW BACK PAIN - AN EVIDENCE BASED REVIEW.","authors":"Jana Kogler, Daniel Rajačić, Dino Bobovec","doi":"10.20471/acc.2023.62.s4.7","DOIUrl":"10.20471/acc.2023.62.s4.7","url":null,"abstract":"<p><p>Low back pain is the most common musculoskeletal condition in the adult population and still represents a global health problem. The initial and the most common treatment in 80% of all patients includes conservative management with pharmacotherapy for pain relief. If the symptoms persist or if there is minimal functional improvement after conservative treatment, minimally invasive interventions such as epidural steroid injections or percutaneous epidural adhesiolysis can be applied, or, in the worst cases, the patient should be considered for an open surgery procedure. Failed back surgery syndrome is a condition with a complex etiology, and many factors that predispose patients towards chronic pain. Epidural lysis of adhesions (LOA) represents an important element of the interventions for the treatment of low back pain that is refractory to more conventional methods.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 Suppl4","pages":"46-52"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dino Budrovac, Marko Pavošević, Ivan Radoš, Dijana Hnatešen, Ozana Katarina Tot, Ivana Haršanji-Drenjančević, Darija Venžera Azenić, Marica Kristić, Ivan Omrčen, Anja Petričević
{"title":"THE INFLUENCE OF DIFFERENT MINIMALLY INVASIVE METHODS ON THE OUTCOME OF LUMBAR RADICULAR PAIN TREATMENT.","authors":"Dino Budrovac, Marko Pavošević, Ivan Radoš, Dijana Hnatešen, Ozana Katarina Tot, Ivana Haršanji-Drenjančević, Darija Venžera Azenić, Marica Kristić, Ivan Omrčen, Anja Petričević","doi":"10.20471/acc.2023.62.s4.2","DOIUrl":"10.20471/acc.2023.62.s4.2","url":null,"abstract":"<p><p>Lumbar radicular pain is a major public health, social and economic problem and is often the cause of professional disability. The aim of this study was to compare pain intensity, disability and neuropatic pain depending on the method of treatment (epidural steroid injection or percutaneous laser disc decompression) in the treatment of lumbar radicular pain caused by intervertebral disc herniation with or without discoradicular contact. Data were collected from 28 patients at 3 measurement points (before the procedure and at examinations on the 15th and 30th day after the procedure) using the Numeric Rating Scale (NRS), Oswestry Disabilitiy Indeks (ODI) and Pain Detect. The reduction of the pain after the procedure was statistically significant only in the group of patients with discoradicular contact in whom PLDD was performed (P=0.04). From the obtained results, it can be concluded that percutaneous laser disc decompression (PLDD) led to a greater reduction in disability (P=0.009) in patients with discorradicular contact, whereas lumbar transforaminal epidural steroid injection (ESI TF) led to greater reduction in patients without discorradicular contact (P=0.02). The results indicate that there was a significant (P=0.01) reduction in neuropathic pain in patients without discorradicular contact who were treated with ESI TF and in patients with discoradicular contact who were treated with PLDD (P=0.04).</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 Suppl4","pages":"12-18"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}