Acta clinica Croatica最新文献_第9页

SCREENING OF ASYMPTOMATIC COVID-19 CASES FROM THE ASPECT OF VIRUS SPREAD. 从病毒传播角度筛选新冠肺炎无症状病例

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.08

Mesut Ortatatli, Zahir Kilic, Ahu Pakdemirli, Levent Kenar

{"title":"SCREENING OF ASYMPTOMATIC COVID-19 CASES FROM THE ASPECT OF VIRUS SPREAD.","authors":"Mesut Ortatatli, Zahir Kilic, Ahu Pakdemirli, Levent Kenar","doi":"10.20471/acc.2024.63.03-04.08","DOIUrl":"10.20471/acc.2024.63.03-04.08","url":null,"abstract":"The COVID-19 pandemic has hit the entire world. While symptomatic patients can be taken out of the infection chain, asymptomatic cases are very important for the spread of SARS-CoV-2. We investigated the relationship between isolating asymptomatic COVID-19 cases with close contacts by identifying and breaking the infection chain. This study included 3 asymptomatic COVID-19 cases identified during screening and 25 close contacts as a result of filiation. Twenty-five people with close contact were classified into groups A (n=8), B (n=6) and C (n=11). On SARS-CoV-2 PCR tests performed in close contacts, all of them were negative on day 0, whereas two group C subjects were positive on day 7. On antibody test applied on day 28, six subjects were positive in group A, two subjects were positive in group B, and one subject was positive in group C. A statistically significant decrease was observed in the number of infected people in the group where asymptomatic cases were identified and removed (p=0.04). It was determined that asymptomatic COVID-19 cases who were not isolated from the community had a 5-fold increased risk of infection. Screening and identification of asymptomatic cases is also essential to augment the effectiveness of quarantine and isolation measures.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"513-517"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DENGUE FEVER IN TURKEY: CASES AND PUBLIC HEALTH IMPLICATIONS. 土耳其的登革热：病例和公共卫生影响。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.01

Tugba Sari, Dilek Menemenlioglu, Perihan Alkan, Ebru Aydin, Hasan Irmak, Irfan Sencan

{"title":"DENGUE FEVER IN TURKEY: CASES AND PUBLIC HEALTH IMPLICATIONS.","authors":"Tugba Sari, Dilek Menemenlioglu, Perihan Alkan, Ebru Aydin, Hasan Irmak, Irfan Sencan","doi":"10.20471/acc.2024.63.03-04.01","DOIUrl":"10.20471/acc.2024.63.03-04.01","url":null,"abstract":"Dengue virus is endemic in almost all tropical and sub-tropical countries which also are popular tourist destinations, and it is a major international public health problem. Presented herein are six travel-associated dengue fever cases diagnosed between 2016 and 2017 in Turkey. The current situation in Turkey and in the world, as well as epidemiological data regarding the vector and relationship between the disease and traveling are also discussed. This retrospective study evaluated dengue fever cases identified using serological and molecular methods between January 2016 and February 2017 in the National Virology Reference Laboratory. Two patients had a travel history to Maldives, two patients to Thailand, one patient to Sri Lanka, and one patient to Guiana. Fever was present in all cases. The most common other symptoms were fatigue, myalgia, and arthralgia. Increased liver enzymes (50%) and thrombocytopenia (66%) were the most commonly encountered laboratory changes. In conclusion, imported dengue fever cases are increasingly reported due to facilitation of international travels and increasing commercial activities. Before traveling to a region where dengue fever is endemic, consulting a travel medicine counseling desk or a doctor is suggested. Dengue fever should be kept in mind in a patient with travel history presenting with fever, elevated liver enzyme and thrombocytopenia.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"461-467"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DISTRIBUTION OF RESPIRATORY VIRUSES IN CHILDREN ADMITTED TO PEDIATRIC INTENSIVE CARE UNIT. 儿科重症监护病房收治儿童呼吸道病毒的分布

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.06

Gokhan Ceylan, Ozlem Sandal, Ferhat Sari, Rana Isguder, Ahu Kara, Gamze Gülfidan, Yuce Ayhan, Ilker Devrim, Hasan Ağın

{"title":"DISTRIBUTION OF RESPIRATORY VIRUSES IN CHILDREN ADMITTED TO PEDIATRIC INTENSIVE CARE UNIT.","authors":"Gokhan Ceylan, Ozlem Sandal, Ferhat Sari, Rana Isguder, Ahu Kara, Gamze Gülfidan, Yuce Ayhan, Ilker Devrim, Hasan Ağın","doi":"10.20471/acc.2024.63.03-04.06","DOIUrl":"10.20471/acc.2024.63.03-04.06","url":null,"abstract":"Acute lower respiratory tract infection (LRTI) is common in children and associated with high morbidity and mortality. The aim of this study was to determine the distribution of respiratory viruses leading to admission of a child with the diagnosis of LRTI to pediatric intensive care unit (PICU). The distribution of viral pathogens was determined using viral multiplex polymerase chain reaction (PCR) in children with LRTI admitted to PICU at a tertiary-level reference pediatric hospital. The LRTI patients without a positive viral multiplex PCR finding were excluded from the study. Most patients were under 2 years of age (78.3%), and the most common viral pathogen resulting in PICU admission due to viral LRTI was RSV A/B (32.8%). Thirty three patients had an underlying disease. Ten (16.6%) patients required invasive mechanical ventilation (IMV), 37 (61.6%) required high-flow oxygen therapy (HFOT), and two patients (3.3%) progressed to pediatric acute respiratory distress syndrome (PARDS). Underlying chronic disease presence was the highest in the IMV group with 90%, which decreased to 54% and 30.7% in the HFOT and standard oxygen treatment groups, respectively (p=0.018). The patients with IMV requirements had significantly longer hospital stay (median 8 days, range 6-13 days) compared to HFOT group (median 6 days, range 4-7.5 days] and regular oxygen treatment group (median 3 days, range 2-3.5 days) (p<0.001). The use of multiplex PCR for respiratory viruses may help in discriminating etiologic viral agents in patients admitted to PICU and estimating possible complications associated with viral-specific disease. The presence of an underlying disease in a patient with viral LRTI affects the treatment level, and treatment level affects the duration of PICU stay.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"494-500"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE EFFECTS OF INTRAARTICULAR AND PERIARTICULAR KNEE PAIN MANAGEMENT ON THE REHABILITATION OF PATIENTS WITH KNEE OSTEOARTHRITIS AFTER CEPHALOMEDULLARY FIXATION OF PERTROCHANTERIC FRACTURES. 膝关节关节内和关节周围疼痛管理对股骨粗隆骨折头髓内固定后膝关节骨性关节炎患者康复的影响。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.28

Maki Grle, Stefan Moro, Damir Franjić, Dajana Vladić, Robert Karlović, Ivana Grle, Jerko Prlić

{"title":"THE EFFECTS OF INTRAARTICULAR AND PERIARTICULAR KNEE PAIN MANAGEMENT ON THE REHABILITATION OF PATIENTS WITH KNEE OSTEOARTHRITIS AFTER CEPHALOMEDULLARY FIXATION OF PERTROCHANTERIC FRACTURES.","authors":"Maki Grle, Stefan Moro, Damir Franjić, Dajana Vladić, Robert Karlović, Ivana Grle, Jerko Prlić","doi":"10.20471/acc.2024.63.03-04.28","DOIUrl":"10.20471/acc.2024.63.03-04.28","url":null,"abstract":"The gold standard for pertrochanteric fractures is closed reduction with traction and intramedullary osteosynthesis. A significant number of patients report knee pain after surgery, which could be associated with gonarthrosis and traction. In this research we wanted to determine if managing knee pain affects the rehabilitation of patients. There were three groups: the first group received a post-operative intra-articular (IA) injection containing methylprednisolone with lidocaine; the second group received the same combination periarticularly (PA); and the control group did not receive any form of injection. We measured the Visual Analogue Scale (VAS) score on the 3rd and 12th postoperative days, as well as six weeks after surgery. We measured knee range of motion (ROM) on the 12th postoperative day and six weeks after surgery. We calculated the Harris Hip Score (HHS) on the 3rd day and six weeks postoperatively. There were 27 patients. Preoperative Kellgren-Lawrence and VAS pain scores were similar. The IA group demonstrated the lowest VAS pain score after six weeks. ROM did not improve between groups on the 12th day and six weeks postoperatively. HHS was best in the IA group after 6 weeks. Injection of methylprednisolone with lidocaine into the knee improved postoperative rehabilitation in patients with knee osteoarthritis undergoing ipsilateral cephalomedullary fixation for a pertrochanteric fracture.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"678-683"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE EFFECT OF ANESTHESIA ON POSTOPERATIVE COGNITIVE DYSFUNCTION. 麻醉对术后认知功能障碍的影响。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.33

Miro Bilić, Martina Lukšić, Martina Miklić Bublić, Zrinka Orešković, Davor Mijatović, Vilena Vrbanović Mijatović

{"title":"THE EFFECT OF ANESTHESIA ON POSTOPERATIVE COGNITIVE DYSFUNCTION.","authors":"Miro Bilić, Martina Lukšić, Martina Miklić Bublić, Zrinka Orešković, Davor Mijatović, Vilena Vrbanović Mijatović","doi":"10.20471/acc.2024.63.03-04.33","DOIUrl":"10.20471/acc.2024.63.03-04.33","url":null,"abstract":"Postoperative cognitive dysfunction (POCD) is a newly developed cognitive function deficit after surgery. The aim of the study was to determine the incidence of POCD after anesthesia and possible risk factors. A prospective study was conducted on 90 patients scheduled for elective surgery under general (60 patients) or regional (30 patients) anesthesia. Each patient completed the Montreal cognitive assessment (MoCa) test the day before and the day after surgery. Data on comorbidities, previous COVID-19 infection, demographic and anesthesia related data were also collected. The day after surgery, POCD defined according to the 2 scores rule was present in 38 (42.2%) patients. A lower level of education (p=0.023), previous COVID-19 infection (p=0.032), higher Charlson comorbidity index (CCI) (p=0.014), and general anesthesia (p=0.035) were identified as risk factors, whereas a statistically significant negative correlation with preoperative (p=0.001) and postoperative result (p=0.001) was proven for age. The results indicated that a significant proportion of patients after general or regional anesthesia developed POCD depending on patient education, CCI, COVID-19 infection, and type of anesthesia. It was also shown that older age correlated with poorer MoCa test result independently of anesthesia. These factors can be identified before the procedure under anesthesia, thus offering the possibility of adjusting anesthesia and postoperative care in patients at risk of developing POCD.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"724-732"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF CORNEAL DENSITOMETRY AND VISUAL ACUITY REFRACTIVE RESULTS AFTER ALCOHOL-ASSISTED AND MECHANICAL (ROTATING BRUSH) EPITHELIUM REMOVAL TECHNIQUES IN MYOPIC PHOTOREFRACTIVE KERATECTOMY. 酒精辅助和机械（旋转刷）上皮去除技术在近视屈光性角膜切除术中角膜密度测定和视力屈光结果的比较。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.23

Igor Knezović, Sara Djurić, Nada Vrkić, Andjelko Parać, Nina Jovanović

{"title":"COMPARISON OF CORNEAL DENSITOMETRY AND VISUAL ACUITY REFRACTIVE RESULTS AFTER ALCOHOL-ASSISTED AND MECHANICAL (ROTATING BRUSH) EPITHELIUM REMOVAL TECHNIQUES IN MYOPIC PHOTOREFRACTIVE KERATECTOMY.","authors":"Igor Knezović, Sara Djurić, Nada Vrkić, Andjelko Parać, Nina Jovanović","doi":"10.20471/acc.2024.63.03-04.23","DOIUrl":"10.20471/acc.2024.63.03-04.23","url":null,"abstract":"The aim was to compare corneal densitometry, haze development, visual and refractive results after photorefractive keratectomy (PRK) performed with different epithelial removal techniques. This study included 42 patients (84 eyes) who underwent PRK with one eye de-epithelialized with 20% ethanol solution (PRK-a group) and another one with rotating brush (PRK-b group). The procedures were performed by the same surgeon on the same laser platform after comprehensive preoperative assessment. Follow up examinations of the patients were scheduled on postoperative day 4, then 1, 3 and 12 months postoperatively. Faster recovery of visual acuity was achieved in the PRK-b group during 12-month postoperative period but differences were statistically nonsignificant. Haze was significantly less present in the brush group measured 12 months after surgery. Also, eyes in the PRK-b group returned close to its basal corneal densitometry values faster than those that underwent PRK-a. Short-term visual recovery occurred faster in the PRK-b group. Less haze development and better corneal transparency were achieved in the PRK-b group throughout the 12-month follow-up period. However, both procedures showed great results and patient satisfaction was high regardless of the de-epithelialization method.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"638-646"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FROM THE ARCHIVES OF THE ZAGREB ANTIRABIES CLINIC: HOSPITALIZED PERSONS DUE TO ANIMAL BITES FROM 2007 TO 2021 (PART TWO). 萨格勒布抗狂犬病诊所档案：2007年至2021年因动物咬伤住院的人数（第二部分）。

IF 0.5 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.40

Radovan Vodopija, Dora Primorac, Jelena Boneta, Kruno Sokol, Daniela Vojvodić

{"title":"FROM THE ARCHIVES OF THE ZAGREB ANTIRABIES CLINIC: HOSPITALIZED PERSONS DUE TO ANIMAL BITES FROM 2007 TO 2021 (PART TWO).","authors":"Radovan Vodopija, Dora Primorac, Jelena Boneta, Kruno Sokol, Daniela Vojvodić","doi":"10.20471/acc.2024.63.03-04.40","DOIUrl":"10.20471/acc.2024.63.03-04.40","url":null,"abstract":"The aim of this paper is to present data on hospitalized patients in Zagreb clinics and hospitals, from 2007 to 2021. This paper is a continuation of our previous paper, but for a different time period. All data were collected from the official patient registry of the Zagreb Antirabies Clinic, which operates within the Reference Center for Rabies at Andrija Štampar Teaching Institute of Public Health. During this period, there were 9960 patients examined for injuries inflicted by animals, of which 98 (0.98%) were hospitalized in different departments and hospitals in Zagreb due to wound severity. All the hospitalized patients were examined to exclude the possible risk of rabies. The official patient registry of the Zagreb Antirabies Clinic is the source of the presented data, which were collected and analyzed retrospectively. We conducted a descriptive analysis. The ages of the hospitalized patients ranged from 17 days to 82 years, 55 (56.12%) were adults, and 43 (43.88%) were children; among the adults, there were 29 (29.59%) men and 26 (26.53%) women, while among the children there were 25 (25.51%) boys and 18 (18.37%) girls. The most common causes of hospitalization after an animal bite were infectious diseases (cat-scratch disease, rat-bite fever) and severity of wounds, which is comparable to the data available from other countries. There is no statistically significant difference in the frequency of hospitalization between children and adults, while dogs are statistically significantly more likely to inflict injuries that result in hospitalization than other animals. However, no specific anatomical location exhibited a statistically significant higher frequency of bites compared to others, as one might expect.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"784-794"},"PeriodicalIF":0.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORRELATION OF TPO ANTIBODY CONCENTRATION WITH THYROID HORMONES AS A PREDICTOR OF CLINICAL HYPOTHYROIDISM. tpo抗体浓度与甲状腺激素的相关性作为临床甲状腺功能减退的预测因子。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.12

Mila Vasilj-Mihaljević, Ivan Mihaljević, Sanja Bekić, Željko Zubčić, Ana Vasilj, Danijela Daus-Šebeđak, Ivana Škrlec, Jasminka Talapko

{"title":"CORRELATION OF TPO ANTIBODY CONCENTRATION WITH THYROID HORMONES AS A PREDICTOR OF CLINICAL HYPOTHYROIDISM.","authors":"Mila Vasilj-Mihaljević, Ivan Mihaljević, Sanja Bekić, Željko Zubčić, Ana Vasilj, Danijela Daus-Šebeđak, Ivana Škrlec, Jasminka Talapko","doi":"10.20471/acc.2024.63.03-04.12","DOIUrl":"10.20471/acc.2024.63.03-04.12","url":null,"abstract":"This study aimed to determine the relationship between the concentration of thyroid peroxidase antibodies (TPO-Ab) and thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) in patients with chronic lymphocytic thyroiditis. This cross-sectional study included 144 patients diagnosed with chronic lymphocytic thyroiditis whose mean age was 46±15 years at the time of diagnosis. According to their TSH concentration, the patients were either euthyroid or hypothyroid. After 59 patients were excluded due to TSH levels below the reference range, no TPO-Ab findings, substitution therapy, immune hyperthyroidism, or TPO-Ab and TSH levels outside the reso- lution limits of the laboratory tests, 85 patients remained in the study. A positive correlation was found between TPO-Ab and TSH concentration within the euthyroid and hypothyroid range and a negative correlation between TPO-Ab and FT4 concentration. The result suggests that the TSH and TPO-Ab concentration could be used to identify individuals at risk for the development of hypothyroidism in the general population.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"542-551"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INCIDENCE AND PREVALENCE OF INFLAMMATORY BOWEL DISEASE IN OSIJEK-BARANJA COUNTY, CROATIA, 2000-2014. 2000-2014年克罗地亚奥西耶克-巴拉尼亚县炎症性肠病的发病率和患病率

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.22

Marinko Žulj, Marija Raguž, Ana Petrović, Kristina Kralik, Brankica Juranić, Štefica Mikšić, Marko Boban, Robert Smolić

{"title":"INCIDENCE AND PREVALENCE OF INFLAMMATORY BOWEL DISEASE IN OSIJEK-BARANJA COUNTY, CROATIA, 2000-2014.","authors":"Marinko Žulj, Marija Raguž, Ana Petrović, Kristina Kralik, Brankica Juranić, Štefica Mikšić, Marko Boban, Robert Smolić","doi":"10.20471/acc.2024.63.03-04.22","DOIUrl":"10.20471/acc.2024.63.03-04.22","url":null,"abstract":"The etiology of inflammatory bowel disease (IBD) is unknown. Data on the incidence and prevalence in different regions can help identify factors relevant to the occurrence of IBD. From 2000 to 2014, 517 patients were newly diagnosed with IBD, including 329 (63.6%) patients with ulcerative colitis (UC) and 188 (36.4%) patients with Crohn's disease (CD). The incidence of UC was 71.4/100,000 in the 2000-2010 period and 30.5/100,000 in the 2011-2014 period. The incidence of CD was 37.5/100,000 in the 2000-2010 period and 21/100,000 in the 2011-2014 period. The prevalence of IBD showed an increasing trend during the study period. It increased from 3/100,000 in 2000 to 109.5/100,000 in 2014 for UC, and from 2.5/100000 in 2000 to 63.3 in 2014 for CD. The results from Osijek-Baranja County are consistent with most studies on IBD, except for the distribution by gender and education. There was a statistically significantly higher number of males with CD compared to UC, and patients diagnosed with CD had a significantly higher level of education.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"626-637"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TUMOR RESPONSE TO NEOADJUVANT LONG-COURSE CHEMORADIOTHERAPY DEPENDS ON THE RECTAL CANCER PATIENT GENDER. 肿瘤对新辅助长疗程放化疗的反应取决于直肠癌患者的性别。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.04.10

Velda Smajlbegović, Snježana Ramić, Iva Kirac, Meliha Solak Mekić, Loris Ćurt, Danko Velimir Vrdoljak

{"title":"TUMOR RESPONSE TO NEOADJUVANT LONG-COURSE CHEMORADIOTHERAPY DEPENDS ON THE RECTAL CANCER PATIENT GENDER.","authors":"Velda Smajlbegović, Snježana Ramić, Iva Kirac, Meliha Solak Mekić, Loris Ćurt, Danko Velimir Vrdoljak","doi":"10.20471/acc.2024.63.04.10","DOIUrl":"10.20471/acc.2024.63.04.10","url":null,"abstract":"Our study aimed to analyze the correlation of cancer-related parameters with tumor regression grade (TRG) and disease-free survival (DFS) by gender in 192 rectal cancer patients operated on after neoadjuvant long-course chemoradiotherapy (LCCRT). Preoperative diagnostics revealed no significant gender differences in any clinical parameters other than obesity (p=0.031). We found that slightly overweight men had a lower incidence of distant metastases (p=0.042). The post-LCCRT pathologic finding showed that women had more positive lymph nodes (ypN, p=0.002) while no other pathologic parameter differed significantly between the genders. Overall, a poor response to therapy correlated with a shorter time to disease progression (p=0.002). Women achieved ypN0 in 50% of cases, but only 27% had a good TRG compared to 40.5% of men (p=0.073). Women had a worse DFS than men, even when complete response to therapy was achieved (p=0.003), and greater depth of residual tumor invasion (ypT, p=0.035) and higher ypN (p=0.002) correlated with shorter DFS. Positive resection margins (p<0.001), higher ypN stage (p=0.003), and poor TRG (p=0.025) correlated with shorter DFS in men. We conclude that women have a poorer response to LCCRT with the possibility that therapeutic approach to the neoadjuvant treatment of rectal cancer may be gender-specific.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"523-532"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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