Acta clinica Croatica最新文献_第10页

NOVEL APPROACHES IN DRUG TREATMENT OF MIGRAINES. 偏头痛药物治疗的新途径。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.s4.6

Davor Jančuljak, Zvonimir Popović

{"title":"NOVEL APPROACHES IN DRUG TREATMENT OF MIGRAINES.","authors":"Davor Jančuljak, Zvonimir Popović","doi":"10.20471/acc.2023.62.s4.6","DOIUrl":"10.20471/acc.2023.62.s4.6","url":null,"abstract":"Migraine treatment can be aimed at the acute treatment of pain attacks and accompanying symptoms and at preventing the recurrence of headaches. The choice of drug depends on clinical effectiveness based on scientific evidence. If general analgesics are not appropriate for the acute treatment of migraines, the first choice are specific drug agonists of serotonin receptors class 1B and 1D triptans. Since triptans are contraindicated in patients with vascular diseases due to their vasoconstrictor effects, lasmiditan, a class 1 F agonist that does not have such an effect, was developed. A revolution in the treatment of migraine was achieved through the use of antagonist molecules against calcitonin gene-related peptide (CGRP) and its receptor. There are two types of such molecules: large molecules of monoclonal antibodies (Mabs) that are exclusively used as prophylaxis for migraines, and small molecules called gepants that can be used in acute treatment as well as for prophylaxis in migraines. Due to the pharmacological profile of Mabs, they are suitable for treatment in the parenteral form at longer application intervals (4 weeks / 1 month, or 3 months). They have an excellent clinical effect on reducing the frequency of frequent episodic and chronic migraines, which ca be achieved in a few weeks with good tolerability, in contrast to non-specific prophylactics that have lower effectiveness and tolerability. According to the latest European guidelines, CGRP Mabs may be given as the first choice in migraine prophylaxis.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 Suppl4","pages":"40-45"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CENTRAL SENSITIZATION IN PATIENTS WITH CHRONIC MUSCULOSKELETAL PAIN. 慢性肌肉骨骼疼痛患者的中枢致敏。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.s4.15

Snežana Tomašević-Todorović, Tijana Spasojević

{"title":"CENTRAL SENSITIZATION IN PATIENTS WITH CHRONIC MUSCULOSKELETAL PAIN.","authors":"Snežana Tomašević-Todorović, Tijana Spasojević","doi":"10.20471/acc.2023.62.s4.15","DOIUrl":"10.20471/acc.2023.62.s4.15","url":null,"abstract":"Central sensitization is the mechanism of nociplastic pain and leads to an overemphasized response to a painful stimulus (hyperalgesia) or pain to stimuli that do not otherwise cause pain (allodynia). Persistent nociceptive pain is a risk factor for nociplastic pain, which can often occur in isolation or combination with other types of pain, most often in patients with chronic musculoskeletal pain (osteoarthritis, lumbar and cervical syndrome, fibromyalgia, rheumatoid arthritis, complex regional pain syndrome, tendinopathy, etc.). Diagnosis of central sensitization is established through clinical examination, questionnaires and quantitative sensory testing (QST), which serves to assess and quantify sensory functions, i.e., determine the threshold for detection of sensory stimuli (heat-cold, pressure, vibration). Conditioned Pain Modulation (CPM) testing is important for clarifying pain modulation profiles, which can be pro-nociceptive (less effective CPM facilitation) and anti-nociceptive (effective, inhibitory CPM effect). In the pronociceptive modulation profile that is common in patients with musculoskeletal disorders, there is a higher risk of developing chronic pain, a higher prevalence of pain conditions and higher pain associated with injury. CPM testing is also important in the individualization of drug therapy for pain, based on predicting the effectiveness of drugs in the treatment.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 Suppl4","pages":"102-106"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PERCUTANEOUS LASER DISC DECOMPRESSION FOR LUMBAR RADICULAR PAIN: A SYSTEMATIC REVIEW OF PUBMED IN THE LAST FIVE YEARS. 经皮激光椎间盘减压治疗腰椎神经根性疼痛：近五年来pubmed的系统回顾。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.s4.9

Ivan Radoš, Mirjana Lončarić Katušin, Dino Budrovac, Iva Dimitrijević, Dijana Hnatešen, Ivan Omrčen

{"title":"PERCUTANEOUS LASER DISC DECOMPRESSION FOR LUMBAR RADICULAR PAIN: A SYSTEMATIC REVIEW OF PUBMED IN THE LAST FIVE YEARS.","authors":"Ivan Radoš, Mirjana Lončarić Katušin, Dino Budrovac, Iva Dimitrijević, Dijana Hnatešen, Ivan Omrčen","doi":"10.20471/acc.2023.62.s4.9","DOIUrl":"10.20471/acc.2023.62.s4.9","url":null,"abstract":"The most common causes of lumbar radicular pain are pathological changes in the intervertebral disc. Lumbar disc herniation (LDH) is the most common cause of lumbosacral radicular syndrome. It affects 1-2% of the general population, burdening health services and the economy worldwide. Excessive scar tissue after lumbar microdiscectomy can increase postoperative pain. Postoperative fibrosis is one of the most important causes of failed back surgery syndrome after lumbar disc surgery. Percutaneous laser disc decompression (PLDD) is a minimally invasive procedure in which thermal energy produced by a LASER probe is used to reduce the intervertebral disc herniation located within the annulus fibrosus. Evaporation of a small volume in a closed hydraulic space (nucleus pulposus) leads to decreased intradiscal pressure. It causes a thermal \"shrinkage effect\" with the retreat of the herniated disc and the decompression of the nerve root, which reduces lumbar radicular pain. Previous research has shown effective reduction of pain after PLDD and only a small number of complications of the procedure itself. PLDD is a safe and effective procedure in well-selected patients. Unfortunately, there is still a need for extensive, randomized prospective studies on PLDD in lumbar radicular pain in order to confirm or dispute the results obtained so far.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 Suppl4","pages":"63-67"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMBINED FIRST TRIMESTER SCREENING FOR FETAL DOWN SYNDROME AT THE SPLIT UNIVERSITY HOSPITAL CENTER: A SEVEN-YEAR EXPERIENCE. 分裂大学医院中心对胎儿唐氏综合征的首次孕期联合筛查：七年经验。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.03.16

Dora Jakus, Damir Roje, Ivana Alujević Jakus, Leida Tandara, Katarina Čepić

{"title":"COMBINED FIRST TRIMESTER SCREENING FOR FETAL DOWN SYNDROME AT THE SPLIT UNIVERSITY HOSPITAL CENTER: A SEVEN-YEAR EXPERIENCE.","authors":"Dora Jakus, Damir Roje, Ivana Alujević Jakus, Leida Tandara, Katarina Čepić","doi":"10.20471/acc.2023.62.03.16","DOIUrl":"10.20471/acc.2023.62.03.16","url":null,"abstract":"The aim of this study was to present the results and to explore the success of combined screening at the Split University Hospital Center. A cross-sectional retrospective study was performed, including all pregnant women who underwent combined screening at the Split University Hospital Center from 2011 to 2017. Data were collected from the hospital archives. During the research period, a total of 6898 pregnant women underwent combined screening. With the high risk cut-off value set at 1:250, the sensitivity of combined screening was 81.0% and specificity 96.8% (AUC 0.929, 95% CI 0.859-1.000; p<0.001). The mean value of a priori risk of Down syndrome based on age was higher than the one calculated by combined screening (1:487.57 vs. 1:13216.9; p<0.001). The number of women who were a priori at a high risk of Down syndrome was significantly higher than the number of those at a high risk based on combined screening results (1457 vs. 239; p<0.001). With the increase in women's age, a statistically significant increase was detected in the mean value of a priori risk of Down syndrome, as well as in the risk based on combined screening results (p<0.001). Combined screening detected a high risk in 8.09% (118/1457) of pregnant women a priori at a high risk of Down syndrome, as well as in 2.22% (121/5441) of pregnant women a priori at a low risk of it. Thus, combined screening placed 121 pregnant women a priori at a low risk in the high-risk group. Down syndrome was subsequently confirmed in 17 (14.05%) women. Analysis of the combined screening results confirmed the validity of using the said fetal Down syndrome screening method in the study population of pregnant women.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"539-545"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOFILM AND HISTOPATHOLOGICAL GRADING OF MAXILLARY SINUS MUCOSA IN PATIENTS WITH ANTROCHOANAL POLYPS. 生物膜和上颌窦粘膜组织病理学分级。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.03.2

Gorazd Poje, Mario Bilić, Krsto Dawidowsky, Lana Kovač Bilić

{"title":"BIOFILM AND HISTOPATHOLOGICAL GRADING OF MAXILLARY SINUS MUCOSA IN PATIENTS WITH ANTROCHOANAL POLYPS.","authors":"Gorazd Poje, Mario Bilić, Krsto Dawidowsky, Lana Kovač Bilić","doi":"10.20471/acc.2023.62.03.2","DOIUrl":"10.20471/acc.2023.62.03.2","url":null,"abstract":"The aim of this cross-sectional study was to determine the signs of biofilm in the maxillary sinus of patients with antrochoanal polyps (ACP), and status of the mucosa on which the biofilm occurred. Mucosal samples from maxillary sinus in 40 ACP patients who underwent endoscopic sinus surgery were analyzed histopathologically and by scanning electron microscopy. Results were compared with maxillary mucosa samples of 40 patients without endoscopic and radiological signs of sinus disease. The existence of biofilm and its relation to the degree of histopathological changes according to Terrier classification of chronic mucosal inflammation of maxillary sinus were statistically analyzed. Biofilm was detected in 23 of 40 (57.5%) ACP patients; the incidence was significantly lower in the control group (2/40, 5%). Biofilm was not found in type 1 mucosa according to Terrier classification. In conclusion, biofilm showed a significant incidence in the maxillary sinus mucosa of ACP patients (57.5%). Occasionally, biofilm can be found in patients with no signs of sinus disease, but not on histologically normal mucosa. Results of this study support the theory that biofilm formation does not represent the initial stage of the inflammatory process.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"406-414"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDY HYPOTHESIS: AGE, GENDER, PRESENCE OF DIABETES MELLITUS OR HYPERTENSION, AND ANTI-HYPERTENSIVE DRUGS ARE INDEPENDENT RISK FACTORS FOR COVID-19 MORTALITY. 研究假设：年龄、性别、是否患有糖尿病或高血压以及是否服用降压药是导致 covid-19 死亡的独立风险因素。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.03.6

Faruk Karandere, Hakan Kocoglu, Ramazan Korkusuz, Betul Erismis, Mehmet Hursitoglu, Kadriye Yasar Kart

{"title":"STUDY HYPOTHESIS: AGE, GENDER, PRESENCE OF DIABETES MELLITUS OR HYPERTENSION, AND ANTI-HYPERTENSIVE DRUGS ARE INDEPENDENT RISK FACTORS FOR COVID-19 MORTALITY.","authors":"Faruk Karandere, Hakan Kocoglu, Ramazan Korkusuz, Betul Erismis, Mehmet Hursitoglu, Kadriye Yasar Kart","doi":"10.20471/acc.2023.62.03.6","DOIUrl":"10.20471/acc.2023.62.03.6","url":null,"abstract":"We aimed to investigate the effects of comorbid diseases and antihypertensive drugs on the clinical outcome of hospitalized patients with COVID-19 infection. A total of 1045 patients whose data could be gathered and confirmed from both hospital files and Turkish National Health Network records were retrospectively screened, and 264 of 1045 patients were excluded because of having more than one comorbid disease. The study population consisted of a total of 781 patients, of which 482 had no comorbid disease, while the remaining 299 patients had only one comorbid disease. The mortality risk was 7.532 times higher in those over 65 years of age compared to cases younger than 30 years (OR: 7.532; 95% CI: 1.733-32.730); the risk of mortality in men was 2.131 times higher than in women (OR: 2.131; 95% CI: 1.230-3.693); and presence of diabetes mellitus (DM) increased mortality risk 2.784 times (OR: 2.784; 95% CI: 1.288-6.019). While hypertension was not found to be an independent risk factor for COVID-19 mortality, age, gender, and presence of DM were independent risk factors for COVID-19 mortality. There was no association between antihypertensive drugs and mortality. Accordingly, age (>65 years), gender (male), and presence of DM were independent risk factors for COVID-19 mortality, whereas hypertension and use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and their combinations with other antihypertensive drugs were not risk factors for COVID-19 mortality.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"447-456"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACUTE PAINFUL THYROIDITIS AND THYROTOXICOSIS AFTER PCI - A CASE STUDY. PCI 后急性疼痛性甲状腺炎和甲状腺毒症--病例研究。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.03.18

Ena Kurtić, Ivica Premužić Meštrović, Matija Marković, Vinko Roso, Valentina Obadić, Mario Stipinović, Tomislav Letilović

{"title":"ACUTE PAINFUL THYROIDITIS AND THYROTOXICOSIS AFTER PCI - A CASE STUDY.","authors":"Ena Kurtić, Ivica Premužić Meštrović, Matija Marković, Vinko Roso, Valentina Obadić, Mario Stipinović, Tomislav Letilović","doi":"10.20471/acc.2023.62.03.18","DOIUrl":"10.20471/acc.2023.62.03.18","url":null,"abstract":"Destructive thyroiditis is a self-limited disease characterized by acute release of preformed thyroid hormones. We present a patient with extremely rare acute painful thyroiditis after percutaneous coronary intervention (PCI) in acute myocardial infarction without ST-elevation. The acute onset of thyroid pain and increase of fT3, fT4 and parameters of inflammation were compatible with acute destructive thyroiditis. Such acute thyroiditis probably resulted from local inflammation induced by a large amount of iodine given to the patient via iodinated contrast media used during PCI. Because of the increasing number of patients referred to cardiac catheterization, invasive cardiologists should be aware of the potentially serious thyroid dysfunction that can result from iodinated contrast use. The aim of our paper is, in the light of the patient presented, to discuss the pathophysiology, clinical presentations, therapy and potential preventive measures in patients that develop thyroid dysfunction after PCI.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"551-555"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DOES GALLIC ACID HAVE A POTENTIAL REMEDIAL EFFECT IN EXPERIMENTAL CORROSIVE BURN INJURY TO THE ESOPHAGUS? 没食子酸对食道的实验性腐蚀性烧伤有潜在的补救作用吗？

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.03.5

Erol Basuguy, Ebru Gokalp Ozkorkmaz

{"title":"DOES GALLIC ACID HAVE A POTENTIAL REMEDIAL EFFECT IN EXPERIMENTAL CORROSIVE BURN INJURY TO THE ESOPHAGUS?","authors":"Erol Basuguy, Ebru Gokalp Ozkorkmaz","doi":"10.20471/acc.2023.62.03.5","DOIUrl":"10.20471/acc.2023.62.03.5","url":null,"abstract":"Gallic acid, acting as an antioxidant, anti-precipitant and cytoprotective agent, was used as a possible remedial natural component for treating experimentally induced esophageal burn. Wistar rats (n=24) were divided into three groups. Control group was given 1 mL 0.9% NaCl. Experimental esophageal burn was induced with 1 mL 40% NaOH application to the esophagus in groups 2 and 3. Gallic acid® (20 mg/kg) was administered to the treated group via oral gavage for 10 days. Removed tissues were fixed and paraffin blocks were prepared. Histopathological examination was performed after the sections had been stained with hematoxylin-eosin. Tumor necrosis factor alpha and caspase-3 antibodies were used on immunohistochemical analysis. In the esophageal burn group, necrosis, degeneration and numerous apoptotic cells, as well as intense inflammatory cell infiltration and fibrosis in the muscle layer were observed under light microscope. In the treated group, remodeling of epithelial cells with marked reduction in the connective tissue collagen content was observed, as well as marked reduction in the volume of collagen and abundance of inflammatory cells in blood vessels. Gallic acid treatment may help heal esophageal burns and prevent complications.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"437-446"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLANNING TO 'NEW NORMAL' DURING COVID-19 PANDEMIC AT GENERAL SURGERY DEPARTMENT: A TURKEY EXPERIENCE. 普外科在科维德-19 大流行期间的 "新常态 "规划：火鸡的经验。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.03.7

Mehmet Fatih Ekici, Ali Cihat Yıldırım, Sezgin Zeren, Faik Yaylak, Özlem Arık, Mustafa Cem Algın

{"title":"PLANNING TO 'NEW NORMAL' DURING COVID-19 PANDEMIC AT GENERAL SURGERY DEPARTMENT: A TURKEY EXPERIENCE.","authors":"Mehmet Fatih Ekici, Ali Cihat Yıldırım, Sezgin Zeren, Faik Yaylak, Özlem Arık, Mustafa Cem Algın","doi":"10.20471/acc.2023.62.03.7","DOIUrl":"10.20471/acc.2023.62.03.7","url":null,"abstract":"Planning of non-postponable treatments for cancer, trauma, emergency diseases, and follow-up and treatment of chronic diseases are inevitable for the ongoing pandemic and future pandemics. In this study, we evaluated the capacity of surgical applications and treatments made to the surgery department in the first 3 months of the onset of the COVID-19 pandemic. A retrospective cohort study was performed from March 12, 2020 to June 1, 2020. COVID-19 negative general surgery patients were included. Demographics, diagnosis and management were recorded, as well as bed turnover and length of stay in the hospital. Similar data were collected on patients admitted during the same period in 2019 and 2018 to allow for comparison. A total of 1764 operations were included. There was a reduction in surgeries when comparing 2020 with 2019 and 2018 (164 vs. 713 and 890); however, there was no difference in the length of stay in the hospital (4.12 vs. 4.37 and 4.07 days, p=0.626). During 2020, appendectomies decreased (53 vs. 102 and 100, p=0.013). There was no difference in the number of emergency oncologic surgeries during 2020 as compared with 2019 and 2018 (16 vs. 8 and 13, p=0.149). In conclusion, COVID-19 significantly impacted the number of admissions to general surgery. However, cancer and emergency operations continued to be required, thus provisions need to be made to enable planning these interventions.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 3","pages":"457-463"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THERAPEUTIC GENICULAR NERVE BLOCK FOR CHRONIC PAIN MANAGEMENT IN PATIENTS WITH KNEE OSTEOARTHRITIS. 膝神经阻滞治疗膝关节骨性关节炎患者的慢性疼痛。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-11-01 DOI: 10.20471/acc.2023.62.s4.5

Vlasta Orlić-Karbić, Alan Šustić

{"title":"THERAPEUTIC GENICULAR NERVE BLOCK FOR CHRONIC PAIN MANAGEMENT IN PATIENTS WITH KNEE OSTEOARTHRITIS.","authors":"Vlasta Orlić-Karbić, Alan Šustić","doi":"10.20471/acc.2023.62.s4.5","DOIUrl":"10.20471/acc.2023.62.s4.5","url":null,"abstract":"Background: Therapeutic genicular nerve block (TGNB) is both an effective and safe treatment procedure for pain related to chronic osteoarthritis of the knee (OA). It is most common amongst the elderly. It is characterized by joint stiffness, pain and disability.Aim: The aim of this study was to examine the analgesic and functional impact of ultrasound-guided TGNB in patients with chronic knee OA and to evaluate the efficacy of local anesthetics and corticosteroids.Patients and methods: The study included 20 patients. Pain was assessed according to the numerical pain scale (NRS), and improvement of the functional capacity was assessed according to the WOMAC Index (Western Ontario and McMaster Universities Osteoarthritis Index). SLGN, SMGN and IMGN were identified, and 3 mL of a mixture of local anesthetic (ropivacaine 0.75%) and corticosteroid (triamcinolone 40 mg) were applied to each nerve.Results: The average NRS value before TGNB was 5.1, and the WOMAC score was 58.55. After the TGNB was performed, NRS was 2.4 (47% decrease in pain intensity) and WOMAC was 30.1 (51% decrease in the intensity of ailment).Conclusion: TGNB is effective and not harmful in treating pain and enhances the functional capacity in patients with knee OA. The clinical benefits of corticosteroid administration suggest that it may be an appropriate adjuvant in TGNB for knee OA.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 Suppl4","pages":"34-39"},"PeriodicalIF":0.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0