Ana Mojsović Ćuić, Lana Feher Turković, Sandra Domjanić Drozdek, Ivan Jurak, Domagoj Đikić, Irena Landeka Jurčević, Marija Skoko, Nina Rotim, Danko Velimir Vrdoljak, Nikola Đaković
{"title":"克罗地亚患者血清抗氧化酶活性和丙二醛浓度作为结直肠癌分期的预测因子。","authors":"Ana Mojsović Ćuić, Lana Feher Turković, Sandra Domjanić Drozdek, Ivan Jurak, Domagoj Đikić, Irena Landeka Jurčević, Marija Skoko, Nina Rotim, Danko Velimir Vrdoljak, Nikola Đaković","doi":"10.20471/acc.2024.63.01.13","DOIUrl":null,"url":null,"abstract":"<p><p>One of the factors involved in the colorectal cancer development is intracellular oxidative stress and antioxidative imbalance. The study aimed to explore the link between oxidative stress measured by the activity of antioxidative markers and lipid peroxidation product malondialdehyde (MDA) as possible cancer predictors of colorectal cancer by using several statistical methods. The study included 50 adult colorectal cancer patients of both genders. MDA level, the activity of antioxidative markers superoxide dismutase and catalase, and glutathione concentration were determined in patient sera. There was no age difference between male and female patients (p=0.579), and no gender differences according to cancer site (p=0.995), stage (p=0.083), and size (p=0.245). There were no differences in the levels of studied enzymes. Correlation analysis of antioxidative markers and MDA with cancer size and patient age revealed strongest individual correlation between the MDA and cancer size variables (r=-0.56).</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 1","pages":"106-114"},"PeriodicalIF":0.7000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827401/pdf/","citationCount":"0","resultStr":"{\"title\":\"SERUM ACTIVITY OF ANTIOXIDATIVE ENZYMES AND CONCENTRATION OF MALONDIALDEHYDE AS PREDICTORS OF COLORECTAL CANCER STAGE IN CROATIAN PATIENTS.\",\"authors\":\"Ana Mojsović Ćuić, Lana Feher Turković, Sandra Domjanić Drozdek, Ivan Jurak, Domagoj Đikić, Irena Landeka Jurčević, Marija Skoko, Nina Rotim, Danko Velimir Vrdoljak, Nikola Đaković\",\"doi\":\"10.20471/acc.2024.63.01.13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>One of the factors involved in the colorectal cancer development is intracellular oxidative stress and antioxidative imbalance. The study aimed to explore the link between oxidative stress measured by the activity of antioxidative markers and lipid peroxidation product malondialdehyde (MDA) as possible cancer predictors of colorectal cancer by using several statistical methods. The study included 50 adult colorectal cancer patients of both genders. MDA level, the activity of antioxidative markers superoxide dismutase and catalase, and glutathione concentration were determined in patient sera. There was no age difference between male and female patients (p=0.579), and no gender differences according to cancer site (p=0.995), stage (p=0.083), and size (p=0.245). There were no differences in the levels of studied enzymes. Correlation analysis of antioxidative markers and MDA with cancer size and patient age revealed strongest individual correlation between the MDA and cancer size variables (r=-0.56).</p>\",\"PeriodicalId\":7072,\"journal\":{\"name\":\"Acta clinica Croatica\",\"volume\":\"63 1\",\"pages\":\"106-114\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827401/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta clinica Croatica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.20471/acc.2024.63.01.13\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta clinica Croatica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20471/acc.2024.63.01.13","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
SERUM ACTIVITY OF ANTIOXIDATIVE ENZYMES AND CONCENTRATION OF MALONDIALDEHYDE AS PREDICTORS OF COLORECTAL CANCER STAGE IN CROATIAN PATIENTS.
One of the factors involved in the colorectal cancer development is intracellular oxidative stress and antioxidative imbalance. The study aimed to explore the link between oxidative stress measured by the activity of antioxidative markers and lipid peroxidation product malondialdehyde (MDA) as possible cancer predictors of colorectal cancer by using several statistical methods. The study included 50 adult colorectal cancer patients of both genders. MDA level, the activity of antioxidative markers superoxide dismutase and catalase, and glutathione concentration were determined in patient sera. There was no age difference between male and female patients (p=0.579), and no gender differences according to cancer site (p=0.995), stage (p=0.083), and size (p=0.245). There were no differences in the levels of studied enzymes. Correlation analysis of antioxidative markers and MDA with cancer size and patient age revealed strongest individual correlation between the MDA and cancer size variables (r=-0.56).
期刊介绍：
Acta Clinica Croatica is a peer reviewed general medical journal that publishes original articles that advance and improve medical science and practice and that serve the purpose of transfer of original and valuable information to journal readers. Acta Clinica Croatica is published in English four times a year.
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