Acta clinica Croatica最新文献_第6页

PREDICTORS OF INTRAOPERATIVE HYPERTENSION IN NECK SURGERY: A SINGLE CENTER RETROSPECTIVE STUDY. 颈外科术中高血压的预测因素：单中心回顾性研究。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.5

Tjaša Ivošević, Biljana Miličić, Aleksandar Trivić, Bojana Bukurov, Nenad Arsović, Nikola Slijepčević, Hristina Ugrinović, Nemanja Radivojević, Nevena Kalezić

{"title":"PREDICTORS OF INTRAOPERATIVE HYPERTENSION IN NECK SURGERY: A SINGLE CENTER RETROSPECTIVE STUDY.","authors":"Tjaša Ivošević, Biljana Miličić, Aleksandar Trivić, Bojana Bukurov, Nenad Arsović, Nikola Slijepčević, Hristina Ugrinović, Nemanja Radivojević, Nevena Kalezić","doi":"10.20471/acc.2023.62.04.5","DOIUrl":"10.20471/acc.2023.62.04.5","url":null,"abstract":"Intraoperative hypertension (IOHTA) during neck surgery is undesirable because this type of surgery has a propensity to bleed profoundly even in normotensive anesthesia. The purpose of our study was to detect predictors of IOHTA in patients undergoing neck surgery. This single center retrospective study included 880 adult patients who underwent neck surgery under general anesthesia. The impact of gender, age, comorbidity, difficult tracheal intubation, anesthesia duration, and induced hypotension on IOHTA was studied. IOHTA was present in 57 (6.7%) patients. The highest incidence of IOHTA was recorded in patients with ASA 4 status and those with Cormack-Lehane grade 4,: (22.2% and 21.4%, respectively). Significantly more patients with hypertension, hyperlipoproteinemia and ventricular extrasystoles had IOHTA compared with patients without these comorbidities. Statistically significant predictors of IOHTA were age (OR 1.438; 95% CI 1.144-1.808; p=0.002), cardiac arrhythmia (OR 1.702; 95% CI 1.129-2.566; p=0.011), Cormack-Lehane grade (OR 1.407; 95% CI 1.054-1.878; p=0.020), and duration of anesthesia (OR 1.005; 95% CI 1.001-1.008; p=0.005). The risk of IOHTA occurrence was lower in patients with induced hypotension (OR 0.024; 95% CI 0.003-0.185; p=0.000). During neck surgery, special attention is needed in patients of older age, those with cardiac arrhythmia, difficult intubation, and longer anesthesia duration because they are at risk of IOHTA.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"615-622"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RELATIONSHIP OF MASTOID PNEUMATIZATION AND AGE WITH COMPUTED TOMOGRAPHY MEASURED SPHENOID SINUS VOLUME. 用计算机断层扫描测量蝶窦容积与乳突充气与年龄的关系。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.1

Rozita Gulić, Andrej Šribar, Davor Vagić

{"title":"RELATIONSHIP OF MASTOID PNEUMATIZATION AND AGE WITH COMPUTED TOMOGRAPHY MEASURED SPHENOID SINUS VOLUME.","authors":"Rozita Gulić, Andrej Šribar, Davor Vagić","doi":"10.20471/acc.2023.62.04.1","DOIUrl":"10.20471/acc.2023.62.04.1","url":null,"abstract":"The aim was to measure sphenoid sinus volume on the basis of computed tomography data post processing and to investigate the possible relationship with age, gender and mastoid pneumatization. Sphenoid sinus volume was measured using the semi-automatic post processing algorithm of MSCT DICOM datasets of 66 patients. There were 35 female and 31 male subjects. Median age was 54 (range 17-84) years. Datasets were selected retrospectively from computer archives of our hospital radiology department. Subjects with healthy sphenoid sinuses were included. Relationship of total sphenoid volume with age, gender and mastoid pneumatization was analyzed. Data acquisition was performed using Siemens Somatom Emotion scanner. Measurements were performed using volumetric module of Syngo 2006G software. Virtual endoscopy and three-dimensional volume rendering were also performed. Median sphenoid total volume (left and right together) was 10.12 cm3. Median volume of the right mastoid was 4.86 cm3 and 5.31 cm3 on the left side. We found a significant positive correlation between total sphenoid volume and both left and right mastoid pneumatization (Spearman ρ=0.528, p<0.001 and ρ=0.450, p<0.001, respectively). Sphenoid volume was positively correlated with age, but without statistical significance (ρ=0.186; p=0.136). Sphenoid volumes were larger in males than in females, but mastoid air cells showed no gender difference. In conclusion, volumetric measurements of paranasal sinuses may be accurately performed on the basis of MSCT data post processing. Sphenoid volume was positively correlated with mastoid pneumatization and age. Virtual endoscopy and 3D volume rendering may accurately display anatomic structures of sphenoid sinuses.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"577-584"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPUTATIONAL FLUID DYNAMICS IN PATIENTS WITH TRIGEMINAL NEURALGIA - A PRELIMINARY STUDY. 三叉神经痛患者的计算流体动力学初步研究。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.13

Dragan Jankovic, Kento Sasaki, Kristina Kralik, Mayank Nakipuria, Komatsu Fuminari, Yoko Kato

{"title":"COMPUTATIONAL FLUID DYNAMICS IN PATIENTS WITH TRIGEMINAL NEURALGIA - A PRELIMINARY STUDY.","authors":"Dragan Jankovic, Kento Sasaki, Kristina Kralik, Mayank Nakipuria, Komatsu Fuminari, Yoko Kato","doi":"10.20471/acc.2023.62.04.13","DOIUrl":"10.20471/acc.2023.62.04.13","url":null,"abstract":"Although earlier studies showed higher values of wall shear stress in neurovascular conflict, hemodynamic patterns in the blood vessel after microvascular decompression are unknown. This study aimed to analyze the hemodynamic features of the offending artery preoperatively and postoperatively using computational fluid dynamics. We retrospectively analyzed 11 patients with trigeminal neuralgia who were surgically treated in our department during 2022. All patients underwent pre- and postoperative computed tomography angiography. Hemoscope software was used for computational fluid dynamics analysis. This analysis included 11 patients, median age 71 years (54.5% of female patients). Superior cerebellar artery was the most common offending vessel. In all 11 patients, elevated values of wall shear stress were found in the area of neurovascular contact. Postoperatively, with improvement of the patient clinical status, there was also a decrease in wall shear stress. Computational fluid dynamics analysis of offending vessels in trigeminal neuralgia can be a useful tool in preoperative planning and in assessing treatment outcomes and prognosis.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"672-676"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

URINARY NEPHRIN AS AN EARLY BIOMARKER OF HYPERTENSIVE NEPHROPATHY. 尿肾素作为高血压肾病的早期生物标志物。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.8

Irena Kostovska, Katerina Tosheska Trajkovska, Danica Labudović, Ognen Kostovski

{"title":"URINARY NEPHRIN AS AN EARLY BIOMARKER OF HYPERTENSIVE NEPHROPATHY.","authors":"Irena Kostovska, Katerina Tosheska Trajkovska, Danica Labudović, Ognen Kostovski","doi":"10.20471/acc.2023.62.04.8","DOIUrl":"10.20471/acc.2023.62.04.8","url":null,"abstract":"Hypertensive nephropathy (HN) is characterized by kidney damage due to chronic high blood pressure. Podocytes play a crucial role in the pathogenesis of HN, thus, nephrin could be important in the early diagnosis of HN. The aim of the study was to investigate the association of urinary nephrin (u-nephrin) levels with clinical and laboratory characteristics in patients with HN and to test diagnostic relevance of u-nephrin as an early biomarker of HN. In this cross-sectional study, 114 subjects were recruited, 84 patients with chronic hypertension (CH) and 30 healthy controls. All patients with CH were classified according to the urinary microalbumin/creatinine ratio (UM/CR) and according to the chronic kidney disease (CKD) stage. Urine samples were collected to estimate the u-nephrin level by ELISA and to determine UM/CR. Blood samples were used for biochemical analyses. We found elevated u-nephrin in 78.3% of normoalbuminuric subjects with CH. The levels of u-nephrin increased gradually with the stage of CKD. ROC curve plotted for u-nephrin showed 89.7% sensitivity and 88.8% specificity, while UM/CR showed a sensitivity of 44.8% and specificity of 86.1% to detect HN in the early stage. It is concluded that u-nephrin can be useful as an early biomarker of HN.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"635-643"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETROSPECTIVE OBSERVATIONAL STUDY OF VITAMIN D STATUS IN NEUROLOGICAL PATIENTS. 神经系统患者维生素 d 状态的回顾性观察研究。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.16

Lucija Zadro Matovina, Helena Trputac, Antonia Nicinger, Petra Magdalena Kes, Vanja Bašić Kes

{"title":"RETROSPECTIVE OBSERVATIONAL STUDY OF VITAMIN D STATUS IN NEUROLOGICAL PATIENTS.","authors":"Lucija Zadro Matovina, Helena Trputac, Antonia Nicinger, Petra Magdalena Kes, Vanja Bašić Kes","doi":"10.20471/acc.2023.62.04.16","DOIUrl":"10.20471/acc.2023.62.04.16","url":null,"abstract":"The main objective of this study was to investigate the prevalence of insufficient serum 25-hydroxyvitamin D level in a sample of neurological patients and to compare it to the estimate in the general Croatian population. The secondary aim was to test for the possible significant differences in vitamin D2 insufficiency between the groups of patients according to gender, season, region, vitamin D3 supplementation, and diagnosis of autoimmune disease. This retrospective study involved 371 neurological patients in one-year period. The data collected included gender, age at the time of admission, region, season at the time of admission, main neurological diagnosis at discharge, serum 25-hydroxyvitamin D level at the time of hospitalization, and use of vitamin D3 substitutes prior to hospitalization. The proportion of neurological patients with 25-hydroxyvitamin D insufficiency (<75 nmol/L) was estimated at 74.66% (95% confidence interval, p<0.0001), which is slightly lower than in the Croatian general population. There were no significant differences in 25-hydroxyvitamin D insufficiency according to gender, season and region. Significant differences in 25-hydroxyvitamin D insufficiency were found according to vitamin D3 supplementation and diagnosis of autoimmune disease.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"697-703"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MANAGEMENT OF ACUTE APPENDICITIS DURING COVID-19 PANDEMIC IN CROATIA: A SINGLE-CENTER STUDY. 克罗地亚COVID-19大流行期间急性阑尾炎的管理：一项单中心研究

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.19

Goran Glavčić, Zvonimir Misir, Suzana Janković, Zdenko Bilić, Petra Radulović, Nina Blažević, Marin Glavčić

{"title":"MANAGEMENT OF ACUTE APPENDICITIS DURING COVID-19 PANDEMIC IN CROATIA: A SINGLE-CENTER STUDY.","authors":"Goran Glavčić, Zvonimir Misir, Suzana Janković, Zdenko Bilić, Petra Radulović, Nina Blažević, Marin Glavčić","doi":"10.20471/acc.2023.62.04.19","DOIUrl":"10.20471/acc.2023.62.04.19","url":null,"abstract":"The aim of the study was to evaluate the impact of the COVID-19 pandemic on the number of patients presenting to the emergency room with acute appendicitis and subsequent results of surgical treatment. Our single center retrospective study was conducted in Sestre milosrdnice University Hospital Center, Zagreb, Croatia. We analyzed data on the patients diagnosed with acute appendicitis, their duration of symptoms, length of hospital stay, histopathologic diagnosis, and operative techniques, recorded from September 1, 2019 to October 17, 2020. The results showed a statistically significant increase in the ratio of open laparotomies (p=0.006) and ratio of perforated appendicitis (p=0.047) during the COVID-19 pandemic in relation to the pre-pandemic period. The time between symptom onset and hospitalization, measured in days, did not demonstrate a statistically significant increase (p=0.379), and minor increase in the postoperative length of stay was not statistically significant either (p=0.879).","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"724-727"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SEBACEOUS CARCINOMA OF THE EYELID AND MUIR-TORRE SYNDROME. 眼睑皮脂腺癌及鼻托综合征。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.21

Karla Ranđelović, Renata Iveković, Ognjen Zrinšćak, Hrvoje Čupić, Snježana Ramić, Zoran Vatavuk, Ivanka Petric Vicković

引用次数: 0

EFFECTS OF PREOPERATIVE ANXIETY, DEPRESSION AND PAIN ON QUALITY OF POSTOPERATIVE RECOVERY AND ACUTE POSTOPERATIVE PAIN AFTER RADICAL PROSTATECTOMY: A PROSPECTIVE OBSERVATIONAL STUDY. 术前焦虑、抑郁和疼痛对根治性前列腺切除术术后恢复质量和急性术后疼痛的影响：一项前瞻性观察研究

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.14

Nina Sulen, Tatjana Šimurina, Ivan Požgain, Miroslav Župčić, Tomislav Sorić, Eugenija Basioli Kasap, Boris Mraović

{"title":"EFFECTS OF PREOPERATIVE ANXIETY, DEPRESSION AND PAIN ON QUALITY OF POSTOPERATIVE RECOVERY AND ACUTE POSTOPERATIVE PAIN AFTER RADICAL PROSTATECTOMY: A PROSPECTIVE OBSERVATIONAL STUDY.","authors":"Nina Sulen, Tatjana Šimurina, Ivan Požgain, Miroslav Župčić, Tomislav Sorić, Eugenija Basioli Kasap, Boris Mraović","doi":"10.20471/acc.2023.62.04.14","DOIUrl":"10.20471/acc.2023.62.04.14","url":null,"abstract":"Patients with prostate cancer are often in psychological distress and pain preoperatively. The aim of this study was to examine the effects of preoperative anxiety, depression and pain on the quality of postoperative recovery and acute postoperative pain after radical prostatectomy. One hundred and sixty patients scheduled for open or laparoscopic radical prostatectomy were enrolled in a prospective observational study. Psychological distress was assessed with the State-Trait Anxiety Inventory (STAI-S and STAI-T) and Center for Epidemiological Studies Depression Scale (CES-D). Postoperative recovery was assessed on postoperative days 1-3 using the Quality of Recovery-40 score (QoR-40). Numeric rating scale 0-10 was used to assess the intensity of postoperative pain at rest and on movement at 1, 6 and 24 hours post-surgery. In linear regression models, STAI-S was predictor of QoR-40 on postoperative days 1-3 (ß=-17.32; p<0,001, ß=-0.345; p=0.004, and ß=-0.326; p=0.002, respectively), and preoperative pain was predictor of pain at rest (ß=0.666; p=0.008) and on movement (ß=0.691; p=0.006). In logistic regression models, preoperative pain was predictor of clinically significant pain at rest (OR, 2.86; 95% CI 1.11-7.36) and STAI-S of clinically significant pain on movement (OR, 2.21; 95% CI, 1.08-4.52). In conclusion, state anxiety had negative impact on QoR and acute pain after radical prostatectomy. Preoperative pain was associated with acute postoperative pain.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"677-687"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASPARTATE AMINOTRANSFERASE AND GAMMA-GLUTAMYL TRANSFERASE: INTRIGUING CLINICAL BIOMARKERS IN DISCRIMINATION OF HEPATIC LESION BETWEEN HEPATITIS C INFECTED PATIENTS AND HEALTHY CONTROLS. 天门冬氨酸氨基转移酶和γ-谷氨酰转移酶：区分丙型肝炎感染者和健康对照者肝脏病变的有趣临床生物标志物。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.15

Biljana Ilkovska, Bisera Kotevska Trifunova, Maja Avramovska, Biljana Taleva, Stefan Talev, Kosta Sotiroski, Petar Avramovski

{"title":"ASPARTATE AMINOTRANSFERASE AND GAMMA-GLUTAMYL TRANSFERASE: INTRIGUING CLINICAL BIOMARKERS IN DISCRIMINATION OF HEPATIC LESION BETWEEN HEPATITIS C INFECTED PATIENTS AND HEALTHY CONTROLS.","authors":"Biljana Ilkovska, Bisera Kotevska Trifunova, Maja Avramovska, Biljana Taleva, Stefan Talev, Kosta Sotiroski, Petar Avramovski","doi":"10.20471/acc.2023.62.04.15","DOIUrl":"10.20471/acc.2023.62.04.15","url":null,"abstract":"Over 1.5 million new cases of chronic hepatitis C virus (HCV) infection occur each year, infecting an estimated 58 million people worldwide. We aimed to find differences in peripheral blood count, liver enzymes and degradation products between HCV infected and healthy controls, and their impact on detection of the disease and discrimination of the diseased from non-diseased subjects. We performed laboratory testing for peripheral blood count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (γ-GT) and bilirubin in 40 HCV patients and 40 healthy controls. There were statistically significant differences in leukocytes (p=0.001), ALT (p<0.0001), AST (p<0.0001), ALP (p<0.0001), γ-GT (p<0.0001), total bilirubin (p<0.018) and indirect bilirubin (p<0.030) between the HCV infected and control groups. On multiple regression, the independent variables of HCV titer (p=0.5091), granulocytes (p=0.7061) and total bilirubin (p=0.2022) showed no impact on liver lesion estimated by a dependent variable of γ-GT. On logistic regression, only AST [p=0.0112, odds ratio (OR)1.2161, area under the curve (AUC) 0.887] and γ-GT (p=0.0283, OR 1.1041, AUC 0.815) showed a statistically significantly positive predicting value when discriminating healthy subjects and diseased patients. In conclusion, HCV titer, granulocytes and total bilirubin did not show a statistically significant impact on hepatic lesion expressed by γ-GT, whereas only AST and γ-GT showed a statistically significant positive predicting value to discriminate infected patients from healthy controls. Each unit increase in AST and γ-GT resulted in 21.6% and 10.4% higher possibility of HCV infection, respectively.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"688-696"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INCREASED SEVERE COVID-19-RELATED FATALITY IN HOSPITALIZED MULTIPLE SCLEROSIS PATIENTS. 住院治疗的多发性硬化症患者中与严重柯维-19相关的死亡率增加。

IF 0.7 4区医学

Acta clinica Croatica Pub Date : 2023-12-01 DOI: 10.20471/acc.2023.62.04.11

Maja Budimkić Stefanović, Jovana Ivanović, Olivera Tamaš, Nikola Veselinović, Nikola Momčilović, Mirjana Ždraljević, Šarlota Mesaroš, Tatjana Pekmezović, Jelena Drulović

{"title":"INCREASED SEVERE COVID-19-RELATED FATALITY IN HOSPITALIZED MULTIPLE SCLEROSIS PATIENTS.","authors":"Maja Budimkić Stefanović, Jovana Ivanović, Olivera Tamaš, Nikola Veselinović, Nikola Momčilović, Mirjana Ždraljević, Šarlota Mesaroš, Tatjana Pekmezović, Jelena Drulović","doi":"10.20471/acc.2023.62.04.11","DOIUrl":"10.20471/acc.2023.62.04.11","url":null,"abstract":"The aim of this study was to assess the case fatality ratio (CFR) in persons with multiple sclerosis (PwMS) hospitalized due to severe COVID-19, and to investigate the role of risk factors for fatal outcome in this well-defined cohort. This case series study included all PwMS (N=32) with severe COVID-19, who were hospitalized in the COVID-19 referral center in Belgrade from January 2021 to January 2022. Eight out of these 32 patients died from COVID-19 (CFR 25%). The cause of death was sepsis in 7 patients and pulmonary embolism in one patient. Results of univariate logistic regression analyses demonstrated that older age, EDSS higher than 6.0, progressive multiple sclerosis (MS) forms, cardiovascular comorbidities, and longer duration of hospital stay statistically significantly increased the risk of COVID-19-related death in MS patients. Treatment with ocrelizumab was associated with more than 2-fold increased death risk (p=0.408). Multivariate logistic regression analysis showed that progressive forms of MS (p=0.044) and longer hospitalization (p=0.006) significantly increased the risk of death in our MS cohort. In our study, older age, presence of comorbidities, and progressive disease course were independent predictors of increased lethality of COVID-19 in PwMS. More intense monitoring may be warranted in PwMS treated with anti-CD20 agents.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"62 4","pages":"659-665"},"PeriodicalIF":0.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0