Acta clinica Croatica最新文献_第6页

SKIN SURFACE TEMPERATURE CHANGES BEFORE AND AFTER MEDIAN NERVE DECOMPRESSION IN CARPAL TUNNEL SYNDROME. 腕管综合征正中神经减压前后皮肤表面温度的变化。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.41

Lucija Pavljak, Krešimir Bulić, Maksimilian Mrak, Anko Antabak

{"title":"SKIN SURFACE TEMPERATURE CHANGES BEFORE AND AFTER MEDIAN NERVE DECOMPRESSION IN CARPAL TUNNEL SYNDROME.","authors":"Lucija Pavljak, Krešimir Bulić, Maksimilian Mrak, Anko Antabak","doi":"10.20471/acc.2024.63.03-04.41","DOIUrl":"10.20471/acc.2024.63.03-04.41","url":null,"abstract":"Carpal tunnel syndrome is the most common upper extremity compression neuropathy caused by compression of the median nerve at the wrist. Along with motor and sensory fibers, sympathetic fibers also pass through the median nerve, playing an important role in the regulation of blood flow to the skin which interacts between the body interior and its environment. The aim of this study was to examine the preand postoperative correlation between skin temperature changes in the area innervated by compressed median nerve compared to the skin areas innervated by radial and ulnar nerve and median nerve of the unaffected hand. The study included 16 patients with carpal tunnel syndrome with an indication for open carpal tunnel decompression. Skin temperature was measured preoperatively, at 2-week, 2and 6-month follow-ups on the areas innervated by median, ulnar and radial nerve of the affected hand and median nerve of the non-affected hand. On the affected hand, median nerve innervated skin temperature showed maximum increase at 2-month follow-up before decreasing to a level higher than preoperatively. Radial nerve innervated skin temperature was lower than the preoperative value at 2-week follow-up, increasing to higher levels afterwards. Ulnar nerve temperature followed the curve of the median nerve innervated skin at all follow-ups. Unaffected median nerve innervated skin temperature increased at all follow-ups compared to the preoperative values. In conclusion, two or even five additional measurements should be made after at least one year. The results should be correlated with clinical and electromyoneurography recovery.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"795-800"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KNOWLEDGE, ATTITUDES AND BEHAVIOR OF MEDICAL STUDENTS REGARDING APPROPRIATE COVID-19 PROTECTION: A CROSS-SECTIONAL STUDY OF CROATIAN AND BOSNIAN MEDICAL STUDENTS. 医学生关于COVID-19适当防护的知识、态度和行为：克罗地亚和波斯尼亚医学生的横断面研究

IF 0.5 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.32

Petra Kovačević, Ivana Gusar, Marija Ljubičić, Nika Samardžić, Doroteja Caktaš, Matej Lovrić, Klara Lauš, Petra Pantalon, Juraj Pantalon, Ana-Marija Gusar, Katarina Vukojević

{"title":"KNOWLEDGE, ATTITUDES AND BEHAVIOR OF MEDICAL STUDENTS REGARDING APPROPRIATE COVID-19 PROTECTION: A CROSS-SECTIONAL STUDY OF CROATIAN AND BOSNIAN MEDICAL STUDENTS.","authors":"Petra Kovačević, Ivana Gusar, Marija Ljubičić, Nika Samardžić, Doroteja Caktaš, Matej Lovrić, Klara Lauš, Petra Pantalon, Juraj Pantalon, Ana-Marija Gusar, Katarina Vukojević","doi":"10.20471/acc.2024.63.03-04.32","DOIUrl":"10.20471/acc.2024.63.03-04.32","url":null,"abstract":"The aim of this cross-sectional study was to determine the knowledge, attitudes and behavior of medical students in relation to COVID-19 according to different medical schools and duration of studies. A validated questionnaire was administered to 192 medical students at two universities in Croatia and one from Bosnia and Herzegovina. Fisher-Freeman-Halton and Kruskal-Wallis tests were used to examine differences among study groups. The association of variables was tested with a linear regression model. A negative correlation was found between adherence to measures and attitudes (ß=-0.36; p<0.001). Studying at the University of Zagreb was positively associated with students' knowledge about COVID-19 (ß=0.24; p=0.033) but negatively with students' attitudes (ß= 0.26; p=0.013). Compared to the last study year students, second-year students had lower knowledge (ß=-0.28; p=0.040) and statistically nonsignificant negative attitudes (ß=-0.24; p=0.055). Fifth-year students had more negative attitudes (ß=-0.24; p=0.008) compared to sixth-year students. The association between knowledge and attitudes was weak and statistically borderline nonsignificant (ß=0.14; p=0.056). The lack of association between knowledge and attitudes requires additional research to identify the potential factors that favor the formation of attitudes toward appropriate protection against COVID-19.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"710-723"},"PeriodicalIF":0.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ESOPHAGEAL DIAMETER ON HIGH-RESOLUTION COMPUTED TOMOGRAPHY - A POTENTIAL USEFUL MARKER FOR INTERSTITIAL LUNG DISEASE SEVERITY IN PATIENTS WITH SYSTEMIC SCLEROSIS. 高分辨率计算机断层扫描显示食管直径——系统性硬化症患者间质性肺疾病严重程度的潜在有用标志物

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.30

Anja Ljilja Posavec, Lea Šalamon, Renata Huzjan Korunić, Nevenka Piskač Živković, Joško Mitrović

{"title":"ESOPHAGEAL DIAMETER ON HIGH-RESOLUTION COMPUTED TOMOGRAPHY - A POTENTIAL USEFUL MARKER FOR INTERSTITIAL LUNG DISEASE SEVERITY IN PATIENTS WITH SYSTEMIC SCLEROSIS.","authors":"Anja Ljilja Posavec, Lea Šalamon, Renata Huzjan Korunić, Nevenka Piskač Živković, Joško Mitrović","doi":"10.20471/acc.2024.63.03-04.30","DOIUrl":"10.20471/acc.2024.63.03-04.30","url":null,"abstract":"Patients with systemic sclerosis (SSc) are at an increased risk of developing interstitial lung disease (ILD) and esophageal dysfunction, with frequently present esophageal dilatation. Our study aimed to investigate the relationship between esophageal diameter (ED) analyzed on high-resolution computed tomography (HRCT) with lung function tests and ILD evaluated with Warrick score. Thirty-nine patients with SSc were enrolled in this study. ED and Warrick score were evaluated by HRCT. The relationships between Warrick score, lung function, and ED were analyzed. Multivariate regression analysis was used to determine the effect of individual predictors on SSc-ILD. ILD was present in 25 (64%) patients. ED >10 mm in one or more of the measured locations on HRCT was present in 25 (64%) patients and 19 (76%) of these patients had concurrent ILD. Subjects with esophageal dilatation had a higher Warrick score and lower lung function tests. The measurement of ED was able to predict the presence of ILD in 69% of patients. Results suggest that evaluation of ED during regular HRCT follow-up could be useful in patients with SSc due to the association of esophageal dilatation with worse lung function tests and a more severe form of ILD.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"693-700"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CHANGES IN PRE-AND POST-INTERVENTION HAND HYGIENE COMPLIANCE IN ICU ON WHO HANDWASHING POSTERS. 世卫组织洗手海报对icu患者干预前后手卫生依从性的影响

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.17

Lada Lijović, Josip Jaman, Yannick Mudrovčić, Dominik Ivanković, Katarina Jelić, Lana Videc Penavić, Tomislav Radočaj, Hrvoje Silovski

{"title":"CHANGES IN PRE-AND POST-INTERVENTION HAND HYGIENE COMPLIANCE IN ICU ON WHO HANDWASHING POSTERS.","authors":"Lada Lijović, Josip Jaman, Yannick Mudrovčić, Dominik Ivanković, Katarina Jelić, Lana Videc Penavić, Tomislav Radočaj, Hrvoje Silovski","doi":"10.20471/acc.2024.63.03-04.17","DOIUrl":"10.20471/acc.2024.63.03-04.17","url":null,"abstract":"Healthcare-associated infections (HAI) cause more deaths in the European Union than all other infectious diseases. Hand hygiene (HH) has been considered the most important means of preventing HAIs but HH compliance is generally less than 50%. One of the five steps that the World Health Organization (WHO) guidelines identify to be specifically implemented are poster reminders. The aim of this study was to evaluate compliance with HH by healthcare workers before and after an intervention on standardized WHO HH poster reminders. An observational one-month study was conducted in a university hospital center surgical intensive care unit. HH compliance was measured through direct observation using WHO observation tool. Intervention was done on day 15 by replacement of standard WHO posters with posters containing a message aimed to call for personal responsibility in patient outcome. A total of 1113 HH opportunities were observed. Overall, HH was performed in 15.4% of cases pre-intervention and 28.3% of cases post-intervention (p<0.001). The preferred method of HH was soap and water. Healthcare workers mostly chose to perform HH after exposure to body fluids, where compliance was 35.1% pre-intervention and 58.7% post-intervention. Gloves were used in 98% of cases of clean/aseptic procedures where HH was not performed. In conclusion, using standard posters to convey additional messages of awareness of consequences and personal responsibility may improve HH and should be considered in multimodal approaches to improve HH compliance.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"588-594"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAPID ANTIGEN TESTING FOR COVID-19 SHOULD BE AVOIDED AS SCREENING TEST AT LARGE SPORTING EVENTS WITH CLOSE PHYSICAL CONTACT BETWEEN COMPETITORS. 在运动员之间有密切身体接触的大型体育赛事中，应避免将COVID-19快速抗原检测作为筛查检测。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.14

Ivan Bohaček, Mihovil Plečko, Hrvoje Lindi, Drago Plečko, Mirna Vranić Ladavac, Jasmina Kučinar, Tomislav Čengić, Aleksandar Stojanović, Domagoj Delimar

{"title":"RAPID ANTIGEN TESTING FOR COVID-19 SHOULD BE AVOIDED AS SCREENING TEST AT LARGE SPORTING EVENTS WITH CLOSE PHYSICAL CONTACT BETWEEN COMPETITORS.","authors":"Ivan Bohaček, Mihovil Plečko, Hrvoje Lindi, Drago Plečko, Mirna Vranić Ladavac, Jasmina Kučinar, Tomislav Čengić, Aleksandar Stojanović, Domagoj Delimar","doi":"10.20471/acc.2024.63.03-04.14","DOIUrl":"10.20471/acc.2024.63.03-04.14","url":null,"abstract":"Large sporting events during the pandemic are organized as 'COVID-19 free zones', function under quarantine measures, and are regularly testing all participants. Recently, point-of-care tests (POCT) for rapid detection of COVID-19 antigen were presented as a cheaper, faster, and easier-to-perform option than reverse transcription polymerase chain reaction (RT-PCR) testing. However, no study confirmed the efficacy of POCT used at a large sporting event that includes close physical contact, such as judo. An observational study was conducted that included 670 participants from 36 countries attending two consecutive judo competitions. In total, 839 RT-PCR tests and 839 POCT tests for COVID-19 were performed. There were 508 participants tested at one time point when entering the venue, while 162 were tested at two time points in order to participate in both competitions. Seven subjects had positive RT-PCR results, while 4 had positive POCT results, meaning the prevalence of COVID-19 at the competitions was 1.04% according to the RT-PCR results. The main finding of this study was that POCT testing proved to be an effective method in detecting true-negative results. However, due to sensitivity that is insufficient to detect all true-positive cases, POCT should always be used in combination with RT-PCR at large sporting events with close physical contact between competitors in order to avoid COVID-19 outbreak.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"560-567"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMOKING EFFECT ON OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY OF CERVICAL MUCUS IN WOMEN WITH PRIMARY IDIOPATHIC STERILITY - OBSERVATIONAL CASE-CONTROL STUDY. 吸烟对原发性特发性不孕症妇女宫颈粘液氧化应激和抗氧化能力的影响——观察性病例对照研究。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.15

Gordana Planinić Radoš, Željko Duić, Boris Lovrić, Josip Juras

{"title":"SMOKING EFFECT ON OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY OF CERVICAL MUCUS IN WOMEN WITH PRIMARY IDIOPATHIC STERILITY - OBSERVATIONAL CASE-CONTROL STUDY.","authors":"Gordana Planinić Radoš, Željko Duić, Boris Lovrić, Josip Juras","doi":"10.20471/acc.2024.63.03-04.15","DOIUrl":"10.20471/acc.2024.63.03-04.15","url":null,"abstract":"The aim of the study was to determine the effects of smoking on cervical mucus in women with primary idiopathic sterility. A prospective, case-control, observational, quantitative, and analytical study was carried out over a five-year period through ambulatory care. The first part of the study involved 140 healthy women (85 smokers and 55 non-smokers). The second part included 90 women (58 healthy, 32 suffering from sterility), grouped according to their smoking status. Concentrations of total proteins in cervical mucus solutions and homogenates of cervical surface cells and their mitochondria, thiocyanate and ascorbic acid, rhodanese activity, concentrations of cytochrome P-450 (mitochondria), lipid peroxidation and the total antioxidant capacity in homogenates of cervical surface cells, concentrations of superoxide O2, reduced gluthatione (GSH), advanced oxidation protein products (AOPP), and ferric reducing ability of plasma (FRAP) were measured. The measurements showed higher concentrations of thiocyanate, cytochrome P-450 and lipid peroxidation values, and lower concentrations of ascorbic acid, cytochrome P-450 activity and FRAP in smokers. Higher concentrations of superoxide O2, GSH, AOPP, and lower FRAP were found among smokers and women suffering from sterility. In conclusion, changes in oxidative stress and antioxidant capacity caused by smoking indicate that the quality of cervical mucus among patients suffering from sterility is lower compared to healthy women.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"568-577"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SUBCLINICAL HYPOTHYROIDISM PREVALENCE AND SELENIUM LEVELS IN WOMEN OF NORTH KHORASAN, IRAN: A CROSS-SECTIONAL STUDY. 伊朗北呼罗珊妇女亚临床甲状腺功能减退患病率和硒水平：一项横断面研究。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.35

Kimiya Hadavi, Ali Esmaeili, Zeynab Moallemi, Javad Hashemi

{"title":"SUBCLINICAL HYPOTHYROIDISM PREVALENCE AND SELENIUM LEVELS IN WOMEN OF NORTH KHORASAN, IRAN: A CROSS-SECTIONAL STUDY.","authors":"Kimiya Hadavi, Ali Esmaeili, Zeynab Moallemi, Javad Hashemi","doi":"10.20471/acc.2024.63.03-04.35","DOIUrl":"10.20471/acc.2024.63.03-04.35","url":null,"abstract":"Individuals with subclinical hypothyroidism have an increased risk of developing clinical hypothyroidism. The thyroid gland, which has the highest concentration of selenium per gram of tissue among adults, plays a crucial role in the metabolism of thyroid hormones. This study aimed to investigate the prevalence of subclinical hypothyroidism in the North Khorasan province of Iran and assess the serum selenium levels in affected individuals. We conducted a prospective study involving 550 females aged 20-55. Serum samples were collected from individuals based on the study's inclusion and exclusion criteria. We measured the serum levels of thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3). Subsequently, individuals with high TSH but normal T4 and T3 levels were selected for further analysis (group I). The serum levels of TSH, T4, T3 (using the ELISA method), and selenium (using the atomic absorption method) were measured and compared with those of a control group comprising healthy women matched to group I in terms of number, age, and body mass index. The overall prevalence of subclinical hypothyroidism in the study population was 6.48%. Significant differences were observed in serum TSH and selenium levels between the subclinical hypothyroidism group and the control group. Furthermore, a positive correlation between TSH and selenium levels was found exclusively within the subclinical hypothyroidism group. The occurrence of subclinical hypothyroidism was positively correlated with serum selenium levels.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"745-750"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SUPERFICIAL VESSEL DENSITY, RETINAL NERVE FIBER LAYER THICKNESS, AND VISUAL FIELD LOSS IN PRIMARY OPEN-ANGLE AND PSEUDOEXFOLIATIVE GLAUCOMA. 原发性开角型和假剥脱性青光眼的浅血管密度、视网膜神经纤维层厚度和视野丧失。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.36

Ante Prpić, Iva Ferček, Kim Kasa, Armin Kasumović, Ines Matoc, Idoia Goñi Guarro, Vedrana Vukić, Katia Novak-Lauš, Ivan Sabol, Zoran Vatavuk

{"title":"SUPERFICIAL VESSEL DENSITY, RETINAL NERVE FIBER LAYER THICKNESS, AND VISUAL FIELD LOSS IN PRIMARY OPEN-ANGLE AND PSEUDOEXFOLIATIVE GLAUCOMA.","authors":"Ante Prpić, Iva Ferček, Kim Kasa, Armin Kasumović, Ines Matoc, Idoia Goñi Guarro, Vedrana Vukić, Katia Novak-Lauš, Ivan Sabol, Zoran Vatavuk","doi":"10.20471/acc.2024.63.03-04.36","DOIUrl":"10.20471/acc.2024.63.03-04.36","url":null,"abstract":"The aim was to examine peripapillary and macular superficial vessel density, peripapillary thickness of the nerve fiber layer, and inner thickness of the macula in eyes with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG) depending on the visual field impairment. A total of 50 eyes were diagnosed as POAG and 50 as PXG. Both groups were divided into 3 subgroups according to HAP2 criteria of visual field impairment. All eyes underwent optical coherence tomography angiography (OCT-A). Radial peripapillary capillary (RPC) density, peripapillary retinal nerve fiber layer (pRNFL) thickness, superficial macular vessel density (SMVD), and macular thickness between the inner limiting membrane and inner plexiform layer (ILM-IPL) were compared. The overall mean measured values did not show a statistically significant difference between the groups. All measured parameters were statistically significantly lower with more extensive visual field damage within the group. The strongest positive correlation was found between the pRNFL thickness and RPC density values (p=0.893), and strongest negative correlation between the mean defect of visual field and ILM-IPL (p=-0.824). No statistically significant difference was found between POAG and PXG in all values measured on OCT-A. In conclusion, visual field loss is more strongly correlated with the loss of nerve fiber layer thickness than the superficial vessel density, which may suggest that the loss of RNFL precedes the loss of superficial vessel density.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"751-757"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DIFFERENCES IN CLINICAL CHARACTERISTICS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) IN OSIJEK AND ZADAR AND POSSIBLE ASSOCIATION WITH GLOBAL DNA METHYLATION AS AN EPIGENETIC BIOMARKER. 奥西耶克和扎达尔地区慢性阻塞性肺疾病（copd）患者临床特征的差异，以及作为表观遗传生物标志物的整体DNA甲基化的可能关联

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.16

Eugenia Basioli Kasap, Ljubica Glavaš Obrovac, Marijana Jukić, Ivica Mihaljević, Ana Posavi, Sanda Škrinjarić Cincar

{"title":"DIFFERENCES IN CLINICAL CHARACTERISTICS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) IN OSIJEK AND ZADAR AND POSSIBLE ASSOCIATION WITH GLOBAL DNA METHYLATION AS AN EPIGENETIC BIOMARKER.","authors":"Eugenia Basioli Kasap, Ljubica Glavaš Obrovac, Marijana Jukić, Ivica Mihaljević, Ana Posavi, Sanda Škrinjarić Cincar","doi":"10.20471/acc.2024.63.03-04.16","DOIUrl":"10.20471/acc.2024.63.03-04.16","url":null,"abstract":"Environmental factors play an important role in the onset and development of chronic obstructive pulmonary disease (COPD). Previous studies have shown that global DNA methylation could be a useful biomarker in COPD. We hypothesized that COPD patients from two different Croatian regions might have clinical characteristics, quality of life, and global DNA methylation, which could be used as a possible epigenetic marker. The study included 136 COPD patients with an average age of 70 years, of whom about 70% were men. Among them, 37% were active smokers, 58% ex-smokers, and 5% non-smokers. There were 69 patients in Osijek and 67 in Zadar. The control group consisted of 64 subjects who were not diagnosed with COPD or other respiratory diseases, 32 from each center. We analyzed risk factors, severity and type of symptoms, exacerbations, comorbidities, and numerous parameters of lung function, phenotypic characteristics, quality of life, and global DNA methylation. We found that COPD patients in Zadar had more pronounced emphysema (P<0.001), while COPD patients from Osijek had more severe symptoms of cough and expectoration (P<0.001 for both). Patients from Osijek had more cardiovascular comorbidities (P<0.001) and depression (P=0.01) than patients from Zadar. Analysis of global DNA methylation found that patients with COPD had lower values than the control group, but the difference was not statistically significant.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"578-587"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THYROID-ASSOCIATED OPHTHALMOPATHY IN A HYPOTHYROID PATIENT. 甲状腺功能减退患者的甲状腺相关性眼病。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.46

Dorotea Filipan, Renata Iveković, Tomislav Gregurić, Zvonko Kusić, Tomislav Jukić

{"title":"THYROID-ASSOCIATED OPHTHALMOPATHY IN A HYPOTHYROID PATIENT.","authors":"Dorotea Filipan, Renata Iveković, Tomislav Gregurić, Zvonko Kusić, Tomislav Jukić","doi":"10.20471/acc.2024.63.03-04.46","DOIUrl":"10.20471/acc.2024.63.03-04.46","url":null,"abstract":"Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder of the orbit that occurs predominantly in Grave's hyperthyroidism, while it is an uncommon clinical finding in patients with Hashimoto's thyroiditis (HT) and hypothyroidism. We report the case of a 62-year-old female patient who presented with left eyelid edema, proptosis, diplopia, and lateral paralysis of the left eye. Magnetic resonance imaging of the orbits showed retrobulbar mass in the left orbit with hyperintense signals within left medial rectus muscle, offsetting but not infiltrating the optic nerve. An 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) scan revealed pathological 18F-FDG uptake of expansive mass within rectus medialis muscle of the left eye (SUVmax=11.0) and similar findings in the right eye (SUVmax=7.1). It also displayed increased glucose metabolism in the thyroid gland (SUVmax=6.4). Laboratory findings showed increased thyrotropin level, while thyroid-stimulating-hormone-receptor antibodies were negative. The patient was diagnosed with HT and TAO, so levothyroxine therapy was introduced. Gradual improvement of TAO symptoms was attained a year later. Diplopia subsided and the patient regained complete eye movements. In conclusion, correction of hypothyroidism can significantly improve symptoms of TAO. Additional value of this case report lies in 18F-FDG PET/CT images displaying increased metabolic activity, which can advance clinical evaluation; however, further research is needed.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"822-827"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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