Gokhan Ceylan, Ozlem Sandal, Ferhat Sari, Rana Isguder, Ahu Kara, Gamze Gülfidan, Yuce Ayhan, Ilker Devrim, Hasan Ağın
{"title":"DISTRIBUTION OF RESPIRATORY VIRUSES IN CHILDREN ADMITTED TO PEDIATRIC INTENSIVE CARE UNIT.","authors":"Gokhan Ceylan, Ozlem Sandal, Ferhat Sari, Rana Isguder, Ahu Kara, Gamze Gülfidan, Yuce Ayhan, Ilker Devrim, Hasan Ağın","doi":"10.20471/acc.2024.63.03-04.06","DOIUrl":"10.20471/acc.2024.63.03-04.06","url":null,"abstract":"<p><p>Acute lower respiratory tract infection (LRTI) is common in children and associated with high morbidity and mortality. The aim of this study was to determine the distribution of respiratory viruses leading to admission of a child with the diagnosis of LRTI to pediatric intensive care unit (PICU). The distribution of viral pathogens was determined using viral multiplex polymerase chain reaction (PCR) in children with LRTI admitted to PICU at a tertiary-level reference pediatric hospital. The LRTI patients without a positive viral multiplex PCR finding were excluded from the study. Most patients were under 2 years of age (78.3%), and the most common viral pathogen resulting in PICU admission due to viral LRTI was RSV A/B (32.8%). Thirty three patients had an underlying disease. Ten (16.6%) patients required invasive mechanical ventilation (IMV), 37 (61.6%) required high-flow oxygen therapy (HFOT), and two patients (3.3%) progressed to pediatric acute respiratory distress syndrome (PARDS). Underlying chronic disease presence was the highest in the IMV group with 90%, which decreased to 54% and 30.7% in the HFOT and standard oxygen treatment groups, respectively (p=0.018). The patients with IMV requirements had significantly longer hospital stay (median 8 days, range 6-13 days) compared to HFOT group (median 6 days, range 4-7.5 days] and regular oxygen treatment group (median 3 days, range 2-3.5 days) (p<0.001). The use of multiplex PCR for respiratory viruses may help in discriminating etiologic viral agents in patients admitted to PICU and estimating possible complications associated with viral-specific disease. The presence of an underlying disease in a patient with viral LRTI affects the treatment level, and treatment level affects the duration of PICU stay.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"494-500"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radovan Vodopija, Dora Primorac, Jelena Boneta, Kruno Sokol, Daniela Vojvodić
{"title":"FROM THE ARCHIVES OF THE ZAGREB ANTIRABIES CLINIC: HOSPITALIZED PERSONS DUE TO ANIMAL BITES FROM 2007 TO 2021 (PART TWO).","authors":"Radovan Vodopija, Dora Primorac, Jelena Boneta, Kruno Sokol, Daniela Vojvodić","doi":"10.20471/acc.2024.63.03-04.40","DOIUrl":"10.20471/acc.2024.63.03-04.40","url":null,"abstract":"<p><p>The aim of this paper is to present data on hospitalized patients in Zagreb clinics and hospitals, from 2007 to 2021. This paper is a continuation of our previous paper, but for a different time period. All data were collected from the official patient registry of the Zagreb Antirabies Clinic, which operates within the Reference Center for Rabies at Andrija Štampar Teaching Institute of Public Health. During this period, there were 9960 patients examined for injuries inflicted by animals, of which 98 (0.98%) were hospitalized in different departments and hospitals in Zagreb due to wound severity. All the hospitalized patients were examined to exclude the possible risk of rabies. The official patient registry of the Zagreb Antirabies Clinic is the source of the presented data, which were collected and analyzed retrospectively. We conducted a descriptive analysis. The ages of the hospitalized patients ranged from 17 days to 82 years, 55 (56.12%) were adults, and 43 (43.88%) were children; among the adults, there were 29 (29.59%) men and 26 (26.53%) women, while among the children there were 25 (25.51%) boys and 18 (18.37%) girls. The most common causes of hospitalization after an animal bite were infectious diseases (cat-scratch disease, rat-bite fever) and severity of wounds, which is comparable to the data available from other countries. There is no statistically significant difference in the frequency of hospitalization between children and adults, while dogs are statistically significantly more likely to inflict injuries that result in hospitalization than other animals. However, no specific anatomical location exhibited a statistically significant higher frequency of bites compared to others, as one might expect.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"784-794"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivan Novak, Igor Grubišić, Ivan Pezelj, Tihana Regović Džombeta, Ivan Svaguša, Goran Štimac, Monika Ulamec, Božo Krušlin
{"title":"A MAN WITH UTERINE LEIOMYOMA AS PART OF PERSISTENT MÜLLERIAN DUCT SYNDROME - A CASE REPORT AND REVIEW OF THE LITERATURE.","authors":"Ivan Novak, Igor Grubišić, Ivan Pezelj, Tihana Regović Džombeta, Ivan Svaguša, Goran Štimac, Monika Ulamec, Božo Krušlin","doi":"10.20471/acc.2024.63.03-04.47","DOIUrl":"10.20471/acc.2024.63.03-04.47","url":null,"abstract":"<p><p>We present a clinical case of a 59-year-old man, father of two children, who complained of irritative voiding of the bladder. An unknown retrovesical structure was detected by ultrasound and computed tomography, and was surgically removed later. Histopathologic analysis reported uterine tissue with a leiomyoma, thus the diagnosis of persistent müllerian duct syndrome (PMDS) was established. It is a rare disorder characterized by the appearance of müllerian derivatives (fallopian tubes, uterus, and upper two-thirds of vagina) in males with normally developed external and internal genitalia. Patients usually present with cryptorchidism and inguinal hernia. Irritative voiding has not yet been described as the main symptom of PMDS. The major complications of the disorder are infertility, testicular tumorigenesis, and malignant transformation of müllerian structures. To the best of our knowledge, in addition to our case, only one case of PMDS with uterine leiomyoma has been described in the literature so far.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"828-833"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mila Vasilj-Mihaljević, Ivan Mihaljević, Sanja Bekić, Željko Zubčić, Ana Vasilj, Danijela Daus-Šebeđak, Ivana Škrlec, Jasminka Talapko
{"title":"CORRELATION OF TPO ANTIBODY CONCENTRATION WITH THYROID HORMONES AS A PREDICTOR OF CLINICAL HYPOTHYROIDISM.","authors":"Mila Vasilj-Mihaljević, Ivan Mihaljević, Sanja Bekić, Željko Zubčić, Ana Vasilj, Danijela Daus-Šebeđak, Ivana Škrlec, Jasminka Talapko","doi":"10.20471/acc.2024.63.03-04.12","DOIUrl":"10.20471/acc.2024.63.03-04.12","url":null,"abstract":"<p><p>This study aimed to determine the relationship between the concentration of thyroid peroxidase antibodies (TPO-Ab) and thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) in patients with chronic lymphocytic thyroiditis. This cross-sectional study included 144 patients diagnosed with chronic lymphocytic thyroiditis whose mean age was 46±15 years at the time of diagnosis. According to their TSH concentration, the patients were either euthyroid or hypothyroid. After 59 patients were excluded due to TSH levels below the reference range, no TPO-Ab findings, substitution therapy, immune hyperthyroidism, or TPO-Ab and TSH levels outside the reso- lution limits of the laboratory tests, 85 patients remained in the study. A positive correlation was found between TPO-Ab and TSH concentration within the euthyroid and hypothyroid range and a negative correlation between TPO-Ab and FT4 concentration. The result suggests that the TSH and TPO-Ab concentration could be used to identify individuals at risk for the development of hypothyroidism in the general population.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"542-551"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marinko Žulj, Marija Raguž, Ana Petrović, Kristina Kralik, Brankica Juranić, Štefica Mikšić, Marko Boban, Robert Smolić
{"title":"INCIDENCE AND PREVALENCE OF INFLAMMATORY BOWEL DISEASE IN OSIJEK-BARANJA COUNTY, CROATIA, 2000-2014.","authors":"Marinko Žulj, Marija Raguž, Ana Petrović, Kristina Kralik, Brankica Juranić, Štefica Mikšić, Marko Boban, Robert Smolić","doi":"10.20471/acc.2024.63.03-04.22","DOIUrl":"10.20471/acc.2024.63.03-04.22","url":null,"abstract":"<p><p>The etiology of inflammatory bowel disease (IBD) is unknown. Data on the incidence and prevalence in different regions can help identify factors relevant to the occurrence of IBD. From 2000 to 2014, 517 patients were newly diagnosed with IBD, including 329 (63.6%) patients with ulcerative colitis (UC) and 188 (36.4%) patients with Crohn's disease (CD). The incidence of UC was 71.4/100,000 in the 2000-2010 period and 30.5/100,000 in the 2011-2014 period. The incidence of CD was 37.5/100,000 in the 2000-2010 period and 21/100,000 in the 2011-2014 period. The prevalence of IBD showed an increasing trend during the study period. It increased from 3/100,000 in 2000 to 109.5/100,000 in 2014 for UC, and from 2.5/100000 in 2000 to 63.3 in 2014 for CD. The results from Osijek-Baranja County are consistent with most studies on IBD, except for the distribution by gender and education. There was a statistically significantly higher number of males with CD compared to UC, and patients diagnosed with CD had a significantly higher level of education.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"626-637"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stanko Biočić, Josip Vincelj, Mario Udovičić, Sandra Jakšić Jurinjak, Jadranka Martinko
{"title":"GIANT ATRIAL SEPTAL ANEURYSM WITH THROMBI IN A PATIENT WITH ATRIAL SEPTAL DEFECT AND CEREBRAL ISCHEMIC EVENTS: A CASE REPORT.","authors":"Stanko Biočić, Josip Vincelj, Mario Udovičić, Sandra Jakšić Jurinjak, Jadranka Martinko","doi":"10.20471/acc.2024.63.03-04.44","DOIUrl":"10.20471/acc.2024.63.03-04.44","url":null,"abstract":"<p><p>Atrial septal aneurysm is a congenital abnormality that may occur as an isolated malformation or in combination with other cardiac abnormalities. More than half of the cases of atrial septal aneurysm are associated with an atrial shunt. We present a case with a thrombus at a giant atrial septal aneurysm associated with atrial septal defect and thrombus in the left atrial appendage, detected by transesophageal echocardiography after cerebral ischemic events. To the best of our knowledge, this combination has not been described in the literature so far.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"812-815"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EVALUATION OF ULTRASOUND AS AN IMAGING MODALITY IN THE ASSESSMENT OF CAROTID ARTERY INVASION IN PATIENTS WITH HEAD AND NECK CANCER.","authors":"Tijana Pandurović, Damir Štimac, Tajana Turk, Siniša Pešić, Vedran Zubčić, Matea Bogović, Nenad Čekić, Luka Šimić","doi":"10.20471/acc.2024.63.03-04.31","DOIUrl":"10.20471/acc.2024.63.03-04.31","url":null,"abstract":"<p><p>Tumor invasion of carotid arteries (CA) is found in 2%-7% of patients with head and neck cancer (HNC). There are no standardized criteria to evaluate the invasion. Tumor invasion of CA is assessed by using computerized tomography (CT) and magnetic resonance imaging. Ultrasound was also used but the method has not become daily routine. The aim of this study was to examine the effect of tumor invasion on CA dynamics and to evaluate the role of ultrasonography in the diagnosis of invasion. The study was conducted on two groups of 22 patients each. The first group consisted of patients with confirmed HNC and CA infiltration, while the second group consisted of patients without any data of HNC. Motion of the CA wall was assessed using ultrasound from which a CA was segmented and then the amount of motion was assessed by optical flow calculation. All patients with a CT-verified CA infiltration had an altered CA motion. The research showed that tumor-infiltrated CA had an altered dynamic when viewed on ultrasound.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"701-709"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoran Sulje, Damir Starčević, Ana Aljinović, Katarina Barbarić Starčević
{"title":"SURGICAL METHODS IN THE TREATMENT OF BASAL THUMB ARTHRITIS - FROM ARTHROSCOPY TO ARTHROPLASTY.","authors":"Zoran Sulje, Damir Starčević, Ana Aljinović, Katarina Barbarić Starčević","doi":"10.20471/acc.2024.63.02.16","DOIUrl":"10.20471/acc.2024.63.02.16","url":null,"abstract":"<p><p>The first carpometacarpal joint is the second most common joint affected by degenerative arthritis. The prevalence of the first carpometacarpal joint arthritis increases with age, especially in postmenopausal women. Ligamentous laxity or injury of the first carpometacarpal joint is thought to be the starting point of development of degenerative changes, accompanied with altered biomechanics of the thumb. As the disease progresses, the joint is destroyed and the thumb and hand function are deteriorating. Although many patients, in different stages of disease, experience pain relief with conservative treatment, surgery is often needed. Decision on the type of surgical procedure depends on the age of the patient, functional demands, and stage of the disease. In early stages of the disease, stabilization of the first carpometacarpal joint, extension osteotomy of the first metacarpal and arthroscopic procedures are used. These are joint-preserving procedures, and they slow down progression of the disease and reduce symptoms. In late stages of the disease, joint arthroplasty procedures and first carpometacarpal arthrodesis are performed. In recent years, late stages of the disease can also be treated arthroscopically. This paper describes different surgical methods, their advantages and drawbacks, with respect to different stages of the disease.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 2","pages":"393-402"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jelena Stojčević-Maletić, Iva Barjaktarović, Mirjana Đerić, Velibor Čabarkapa, Vladimir Petrović, Aleksandra Patić, Slobodanka Bogdanović-Vasić
{"title":"COMPARISON OF ABBOTT REAL TIME SARS-COV-2 ASSAY AND LIFERIVER NOVEL CORONAVIRUS REAL TIME MULTIPLEX KIT FOR THE RT-PCR BASED DETECTION OF SARS-COV-2 FROM NASOPHARYNGEAL SWABS.","authors":"Jelena Stojčević-Maletić, Iva Barjaktarović, Mirjana Đerić, Velibor Čabarkapa, Vladimir Petrović, Aleksandra Patić, Slobodanka Bogdanović-Vasić","doi":"10.20471/acc.2024.63.02.3","DOIUrl":"10.20471/acc.2024.63.02.3","url":null,"abstract":"<p><p>The objective of this study was to compare performance of two authorized tests, the Abbott Real Time SARS-CoV-2 (ACOV) assay (Abbott Molecular Inc., North Chicago, IL, USA) and Liferiver Novel Coronavirus Real Time Multiplex RT-PCR (Liferiver 2019-nCoV) kit (BioVendor Group, Brno, Czech Republic), and to determine whether the selection of targeted genes has an impact on test specificity. We included 105 nasopharyngeal swabs from adult individuals with symptoms or suspected of coronavirus disease 2019 (COVID-19), aged from 26 to 91 years, previously tested by the ACOV and subsequently tested by the Liferiver 2019-nCoV. In this comparative analysis, we found that the ACOV assay detected more cases of COVID-19 infection than the Liferiver 2019-nCoV assay. The Liferiver 2019-nCoV kit showed a high level of agreement with the ACOV assay. The positive percent agreement was 88.89% (95% confidence intervals (95% CI): 77.42%-100.0%), and the kappa coefficient (kappa) was 0.901 (95% CI: 0.817-0.985). The negative percent agreement was 94.12% (95% CI: 89.74%-98.50%), while 4.76% of SARS-CoV-2 cases were false-negative using the Liferiver test. However, due to the possible false-negative results using the Liferiver 2019-nCOV test, we recommend complete testing with the ACOV assay.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 2","pages":"275-282"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ARE COVID-19 PNEUMONIA FINDINGS DIFFERENT BETWEEN COMORBID AND NON-COMORBID PATIENTS? THE HIGH RESOLUTION COMPUTED TOMOGRAPHY FEATURES OF THE 108 FOLLOW-UP PATIENTS.","authors":"Ayşe Özlem Balık, Buket Yagci, Recep Balik, Ulaş Yalim Uncu","doi":"10.20471/acc.2024.63.02.2","DOIUrl":"10.20471/acc.2024.63.02.2","url":null,"abstract":"<p><p>The aim was to compare the computed tomography (CT) semi-quantitative severity scoring (CT-SS) system assessments of COVID-19 pneumonia on initial and follow-up examinations according to the presence of comorbidities. Of the 278 real-time reverse transcription-polymerase chain reaction positive patients, 108 with a follow-up CT scan were evaluated. Then, all CT images were independently reviewed for CT-SS analysis by two reviewers. Reviewers were unaware of the patient laboratory and clinical findings. A quarter of patients had negative findings on their initial CTs. Sixty-one (56.4%) patients showed progression. Disease progression was more frequently observed in patients with type 2 diabetes mellitus (DM) and malignancies (p=0.044 and p=0.019, respectively). Follow-up CTs of patients with comorbidities, especially those with cardiovascular disease (56.4%) and type 2 DM (70.0%), demonstrated an increased frequency of diffuse involvement. The white lung sign was more frequently observed in patients with malignancies (60.0%). In this study, COVID-19 patients with comorbidity showed a higher rate of disease progression than those without comorbidity. Patients with comorbidities more frequently had severe CT findings with high CT-SS. These findings may serve as a guide in the COVID-19 pneumonia follow-up and treatment.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 2","pages":"260-274"},"PeriodicalIF":0.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}