Acta clinica Croatica最新文献

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HOW TO REACH 70% RESPONSE RATE IN THE NATIONAL BREAST CANCER SCREENING PROGRAM IN CROATIA? 克罗地亚国家乳腺癌筛查项目如何达到70%的有效率?
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2025-03-01 DOI: 10.20471/acc.2025.64.01.09
Jasmina Kovačević, Vera Musil, Slavica Sović, Dejvid Zombori, Vesna Jureša
{"title":"HOW TO REACH 70% RESPONSE RATE IN THE NATIONAL BREAST CANCER SCREENING PROGRAM IN CROATIA?","authors":"Jasmina Kovačević, Vera Musil, Slavica Sović, Dejvid Zombori, Vesna Jureša","doi":"10.20471/acc.2025.64.01.09","DOIUrl":"10.20471/acc.2025.64.01.09","url":null,"abstract":"<p><p>A mammography response rate exceeding 70% is one of the parameters for monitoring the success of a national breast cancer screening program (BCS). The aim was to explore the potential for improving the response rate in the BCS in Croatia, based on the accuracy of the invitation database and availability of mammography services. In this cross-sectional study, data from the fifth and sixth implementation cycles were collected through a questionnaire from the BCS county coordinators (N=21). The quality of the invitation database and the number of available mammography appointments were analyzed using Microsoft Office Excel. Seventeen percent of women were not available at the address listed in the database and could not be invited for mammography, with variations observed across counties ranging from 31% (Lika-Senj County) to 7% (Krapina-Zagorje County). Only eight counties had a sufficient number of mammography appointments for initial and repeat invitations. With a higher estimate of unavailable women by counties at the end of the fifth cycle, the response rate at the end of the cycle was lower (<sup>ρ</sup>=-0.51, p=0.018). In conclusion, participation in the BCS could be increased with a more accurate invitation database, thereby freeing up additional mammography appointments for both initial and repeat invitations.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 1","pages":"81-92"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12671709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PREVALENCE OF 25-HYDROXYCHOLECALCIFEROL DEFICIENCY AND METABOLIC SYNDROME IN CROATIAN WOMEN WITH NEWLY DIAGNOSED BREAST CANCER. 克罗地亚新诊断乳腺癌妇女25-羟基胆钙化醇缺乏症和代谢综合征的患病率
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2025-03-01 DOI: 10.20471/acc.2025.64.01.02
Katarina Vučić, Ljiljana Mayer, Ljilja Štefančić, Siniša Tomić, Iva Kirac, Mario Šekerija
{"title":"PREVALENCE OF 25-HYDROXYCHOLECALCIFEROL DEFICIENCY AND METABOLIC SYNDROME IN CROATIAN WOMEN WITH NEWLY DIAGNOSED BREAST CANCER.","authors":"Katarina Vučić, Ljiljana Mayer, Ljilja Štefančić, Siniša Tomić, Iva Kirac, Mario Šekerija","doi":"10.20471/acc.2025.64.01.02","DOIUrl":"10.20471/acc.2025.64.01.02","url":null,"abstract":"<p><p>The aim of this study was to determine the prevalence of vitamin D deficiency (VDD) and metabolic syndrome (MetS) including individual MetS components in Croatian women with newly diagnosed breast cancer (BC), exploring differences according to menopausal status. This cross-sectional, observational study recruited 203 adult female patients with newly diagnosed BC of any stage from all Croatian regions (median age 59, range 28-87 years), hospitalized consecutively for their first treatment between December 2016 and August 2017. We analyzed pretreatment fasting serum concentrations of 25-hydroxycholecalciferol (25(OH)D), high density lipoprotein, low density lipopro- tein, triglycerides, plasma glucose, and measured systolic and diastolic blood pressure, weight and waist circumference; defining VDD as 25(OH)D concentrations <50 nmol/L and MetS according to the 2006 International Diabetes Federation consensus. Consistency of the results was explored according to sampling periods, regions and size of settlements. In total sample, 28.6% of patients presented with concomitant VDD+MetS, whilst VDD was found in 55.1% of women (the finding was consistent by menopausal status), and 48.3% had MetS (65.4% of postmenopausal <i>vs</i>. 15.7% of premenopausal wom- en). Concomitant VDD+MetS was more frequent in the inland region (p=0.043), and VDD in inland postmenopausal women (p=0.024), whereas in premenopausal women VDD was more frequent during winter period (p=0.038). In conclusion, a high prevalence of VDD and MetS was found in newly diag- nosed BC patients, with some regional and seasonal differences.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 1","pages":"15-26"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12671703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CROATIAN VERSION OF TINNITUS HANDICAP INVENTORY - THI-HR. 克罗地亚版耳鸣障碍库存-这一小时。
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2025-03-01 DOI: 10.20471/acc.2025.64.01.01
Boris Jelavić, Ivona Čarapina Zovko, Irena Pehar, Tomislav Sušac, Josip Lesko, Miro Leventić
{"title":"CROATIAN VERSION OF TINNITUS HANDICAP INVENTORY - THI-HR.","authors":"Boris Jelavić, Ivona Čarapina Zovko, Irena Pehar, Tomislav Sušac, Josip Lesko, Miro Leventić","doi":"10.20471/acc.2025.64.01.01","DOIUrl":"10.20471/acc.2025.64.01.01","url":null,"abstract":"<p><p>In this study, we translated the Tinnitus Handicap Inventory questionnaire into Croatian language, and determined the reliability and validity of the Croatian adaptation (THI-HR). Tinnitus sufferers (N=130) underwent audiometry and completed the THI-HR, the Depression Anxiety Stress Scale (DASS), and the Eysenck Personality Questionnaire Revised/Short Scale (EPQ R/S). Sociodemographic data on the patients and descriptive data on tinnitus were collected. The THI-HR internal consistency, construct validity, factor structure and repeatability were evaluated. The Cronbach's alpha coefficients for the THI-HR Total, Functional, Emotional, and Catastrophic subscales were 0.96, 0.76, 0.78, and 0.76, respectively. Moderate correlations of the THI-HR total and subscales with the three DASS subscales (r<sub>s</sub>=0.42 to r<sub>s</sub>=0.61) and the EPQ R/S-Neuroticism subscale (r<sub>s</sub>=0.56 to r<sub>s</sub>=0.64) were observed. The THI-HR factor analysis revealed that the original THI three-factor solution was a good fit to the data. Three factors explained 48.7% of the total variance. The test-retest reliability was high (r<sub>p</sub>=0.89 to r<sub>p</sub>=0.93). It was established that the THI-HR had high internal consistency reliability and good construct validity. The THI-HR is a valid and reliable measure of tinnitus complaint that can be used for assessment of the impact of tinnitus symptoms in daily life in the adult Croatian population.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 1","pages":"3-13"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12671706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE EFFECT OF ARTESUNATE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS. 青蒿琥酯对博莱霉素所致肺纤维化的影响。
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2025-03-01 DOI: 10.20471/acc.2025.64.01.03
Aysun Şengul, Oğuzhan Okutan, Bülent Altınsoy, Ceyda Anar, Onur Yazıcı, Fazilet Dede, Sibel Köktürk, Cüneyt Özer, Osman Fuat Sönmez, Gökhan Metin
{"title":"THE EFFECT OF ARTESUNATE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS.","authors":"Aysun Şengul, Oğuzhan Okutan, Bülent Altınsoy, Ceyda Anar, Onur Yazıcı, Fazilet Dede, Sibel Köktürk, Cüneyt Özer, Osman Fuat Sönmez, Gökhan Metin","doi":"10.20471/acc.2025.64.01.03","DOIUrl":"10.20471/acc.2025.64.01.03","url":null,"abstract":"<p><p>Despite new drug alternatives, no curative treatment for idiopathic pulmonary fibrosis (IPF) currently exists. This study aimed to evaluate the effects of artesunate on fibrosis, pulmonary hypertension, and inflammation-related changes in IPF. We divided a total of 32 male Wistar albino rats into four groups: a control group (group A, n=7), a group receiving artesunate (group B, n=7), a group receiving bleomycin (group C, n=9), and a group receiving both bleomycin and artesunate (group D, n=9). Groups A and B received intratracheal saline (0.1 mL), and groups C and D received intratracheal bleomycin (2.5 mg/kg). Groups A and C received intraperitoneal (i.p.) saline (0.1 mL/day), and groups B and D received i.p. artesunate (30 mg/kg/day) for 21 days. We measured the rats' exercise capacity by using a treadmill. We also examined heart and pulmonary tissues for right ventricular hypertrophy (RVH) and pulmonary arteriolar wall thickness for fibrosis, respectively. Finally, for immunohistochemistry, we performed Masson's trichrome stain and a macrophage marker antibody. The rats' measured exercise capacity was 1665 ± 145 m in the control group, 1142 ± 280 m in the group receiving bleomycin, 1490 ± 185 m in the group receiving artesunate, and 1207 ± 231 m in the group receiving both bleomycin and artesunate. The intergroup difference was statistically significant (p=0.001), but the difference between the bleomycin + artesunate and bleomycin-only groups was not statistically significant (p=0.95). RVH was common in the bleomycin group (0.44 ± 0.02). The difference between the bleomycin + a rtesunate and bleomycin groups was significant (0.37 ± 0.03). The medial wall of the pulmonary arterioles was thicker in bleomycin recipients than in artesunate recipients and controls, whereas it was thinner in bleomycin + artesunate recipients (p<0.001, p=0.026, respectively). Fibrosis and inflammatory changes improved in the bleomycin + artesunate group (p<0.001). The authors conclude that artesunate improved fibrosis, inflammatory changes, medial layer thickness of the pulmonary arterioles, and RVH in rats with bleomycin-induced pulmonary fibrosis.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 1","pages":"27-36"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12671695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFICACY OF NASAL IRRIGATION WITH ISOTONIC AND HYPERTONIC SOLUTIONS AFTER ENDOSCOPIC SINUS SURGERY FOR CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS. 鼻内窥镜手术后等渗及高渗溶液冲洗治疗慢性鼻窦炎伴鼻息肉病的疗效观察。
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2025-03-01 DOI: 10.20471/acc.2025.64.01.12
Ana Penezić, Livije Kalogjera, Marko Velimir Grgić, Goran Geber, Dejan Tomljenović, Konstantinos Alevizopoulos, Tomislav Baudoin
{"title":"EFFICACY OF NASAL IRRIGATION WITH ISOTONIC AND HYPERTONIC SOLUTIONS AFTER ENDOSCOPIC SINUS SURGERY FOR CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS.","authors":"Ana Penezić, Livije Kalogjera, Marko Velimir Grgić, Goran Geber, Dejan Tomljenović, Konstantinos Alevizopoulos, Tomislav Baudoin","doi":"10.20471/acc.2025.64.01.12","DOIUrl":"10.20471/acc.2025.64.01.12","url":null,"abstract":"<p><p>Endoscopic sinus surgery (ESS) is often involved in the treatment of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Nasal irrigation after ESS is recommended to improve healing and nasal symptoms in these patients. This study compared the efficacy of nasal irrigation with either an isotonic solution of 0.9% NaCl or a hypertonic solution of 2.3% NaCl comprising algal extracts. This was a randomized cohort study that included patients with CRSwNP after ESS who used isotonic solution and hypertonic 2.3% solution enriched with algal extracts (<i>Undaria pinnatifida</i> and <i>Spir- ulina platensis</i>). Patients filled out the total nasal symptom score (TNSS) questionnaire on visual analog scale of five symptoms, i.e., nasal obstruction, nasal secretion and/or postnasal discharge, sense of pressure in the face, headache, loss of the sense of smell preoperatively, and on postoperative days 7 and 14. Endo- scopic Lund-Kennedy (LK) score was also recorded. The study included 54 patients with CRSwNP that had undergone ESS, mean age 49.5 years. There were 53.7% of male patients. Thirty (55.56%) patients had other comorbidities such as allergic rhinitis, allergy to food, or/and asthma. Five (9.25%) patients had CRSwNP, asthma and allergy to nonsteroidal anti-inflammatory drugs. TNSS improved after 7 and 14 days in both groups; greater improvement of TNSS and LK score was observed in the group of patients that used hypertonic solution with algae, but it did not reach statistical significance. Improvement in particular symptoms was also recorded in the hypertonic solution group both on postoperative days 7 and 14, especially of sneezing and itching. The results of this study confirmed therapeutic benefits of nasal ir- rigation in CRSwNP patients following ESS. Patients who used hypertonic solution enriched with algae experienced greater improvement in sneezing and itching over the 14-day period.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 1","pages":"111-117"},"PeriodicalIF":0.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12671714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ETIOLOGY OF URINARY TRACT INFECTIONS IN NEONATES AND BACTERIAL RESISTANCE IN CROATIA. 克罗地亚新生儿尿路感染的病因学和细菌耐药性。
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.26
Ana-Meyra Potkonjak, Ivana Terzić, Mario Lovrić, Vesna Gall, Hrvojka Soljačić Vraneš, Danko Milošević, Neven Tučkar, Goran Vujić, Vesna Košec, Ana Budimir, Boris Filipović-Grčić
{"title":"ETIOLOGY OF URINARY TRACT INFECTIONS IN NEONATES AND BACTERIAL RESISTANCE IN CROATIA.","authors":"Ana-Meyra Potkonjak, Ivana Terzić, Mario Lovrić, Vesna Gall, Hrvojka Soljačić Vraneš, Danko Milošević, Neven Tučkar, Goran Vujić, Vesna Košec, Ana Budimir, Boris Filipović-Grčić","doi":"10.20471/acc.2024.63.03-04.26","DOIUrl":"10.20471/acc.2024.63.03-04.26","url":null,"abstract":"<p><p>Urinary tract infection (UTI) occurs in approximately 15% of full-term neonates and 8% of those born before 37 weeks of gestation. Severe UTI can lead to sepsis or long-term complications such as renal scarring and hypertension. Given the rising concern of bacterial resistance to antibiotics, this research aimed to examine the epidemiology of neonatal UTI, most common antibiotic prescription patterns, as well as resistance of the causative agents in Croatia. This retrospective multicenter analysis was focused on neonates born in 2005 and 2015. Of the 103 bacterial UTI cases, 78.6% affected term neonates. Male neonates constituted 62.1% of the study population. Eutrophic neonates accounted for 87.4%, and hospital-acquired infections were prevalent in 47.6% of cases. The main causative pathogens were <i>Escherichia coli</i> (60.2%) and <i>Klebsiella pneumoniae</i> (28.2%). Most commonly prescribed empirical antibiotics included ceftriaxone (31.1%) and the ampicillin-gentamicin combination (10.7%). In 2005, 72.7% of isolates were sensitive to empirical therapy. In 2015, sensitivity to empirical antibiotic therapy was observed in 75.6% of cases. In this study, <i>Escherichia coli</i> frequently exhibited antibiotic resistance to ampicillin, amoxicillin, trimethoprim-sulfamethoxazole, and gentamicin. For UTIs attributed to <i>Klebsiella pneumoniae</i>, the prevailing bacterial resistance was observed against gentamicin, ceftibuten, ampicillin, cefazolin, and piperacillin. The predominance of <i>Escherichia coli</i> as the most common pathogen causing UTI was consistent with global trends. Founded on continuous differences in bacterial resistance, this study can serve as a basis for comprehending local resistance patterns of pathogens causing neonatal UTI, highlighting the need of additional prospective research.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"662-669"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CLINICAL EVALUATION, DIAGNOSIS AND TREATMENT OF PHEOCHROMOCYTOMA. 嗜铬细胞瘤的临床评价、诊断与治疗。
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.07
Romana Marušić, Tajana Turk, Tatjana Bačun
{"title":"CLINICAL EVALUATION, DIAGNOSIS AND TREATMENT OF PHEOCHROMOCYTOMA.","authors":"Romana Marušić, Tajana Turk, Tatjana Bačun","doi":"10.20471/acc.2024.63.03-04.07","DOIUrl":"10.20471/acc.2024.63.03-04.07","url":null,"abstract":"<p><p>Pheochromocytomas are rare neuroendocrine tumors that originate in chromaffin cells of the adrenal medulla and excessively secrete catecholamines, which leads to a multitude of different symptoms. The most common symptoms include headaches, palpitations, and sweating. Because of a diverse clinical presentation, pheochromocytomas pose a major diagnostic challenge and often go unidentified. These tumors can occur sporadically or as a part of hereditary syndromes. The diagnosis is confirmed by measuring plasma and 24-hour urinary metanephrine and normetanephrine. Computed tomography, magnetic resonance imaging, and functional morphological examinations are used for tumor localization. The treatment is operative and requires special preoperative patient preparation to prevent hypertensive crisis and arrhythmias. Due to the possibility of recurrence, the patient needs to be monitored. Pheochromocytoma has a high fatality rate if not recognized on time due to the effect of catecholamines on the cardiovascular system.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"501-512"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACOUSTIC RHINOMETRY STUDY IN PATIENTS WITH ALLERGIC RHINITIS. 变应性鼻炎患者的声学鼻测量研究。
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.42
Atanas Vlaykov
{"title":"ACOUSTIC RHINOMETRY STUDY IN PATIENTS WITH ALLERGIC RHINITIS.","authors":"Atanas Vlaykov","doi":"10.20471/acc.2024.63.03-04.42","DOIUrl":"10.20471/acc.2024.63.03-04.42","url":null,"abstract":"<p><p>Acoustic rhinometry is a non-invasive technique that requires minimal cooperation from patients compared to other diagnostic methods. This technique can be used even in children under 3 years of age, which makes it widely applicable in the practice of rhinologists. The aim of this research was to study nasal patency and nasal volume in patients with persistent allergic rhinitis (PAR) and intermittent allergic rhinitis (IAR) using acoustic rhinometry and to compare the degree of swelling of the nasal mucosa in patients with different forms of the disease. The study was conducted on the territory of the University Hospital \"Prof. Dr. St. Kirkovich\" (Stara Zagora, Bulgaria), where 139 participants (111 with allergic rhinosinusitis [AR] and 28 controls), aged 19 to 84 years, were examined. To compare the results, an acoustic rhinometry study was performed on the participants and the control group. The main indicators considered were the volume of the nasal cavity, the minimum cross-section area of the left and right halves, as well as the distance from the nasal entrance where it is located. To check the reactivity of the nasal mucosa, the same test was repeated after using a nasal decongestant. Increased nasal mucosal swelling in patients with IAR than those with PAR has been found. More manifested nasal congestion is observed in patients with IAR, probably because pollen has a stronger immunological stimulus and causes more manifested expression of symptoms than allergens provoking year-round forms of AR. A severely reduced reactive response to nasal decongestants has been demonstrated in participants with persistent AR.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"801-807"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP) CAUSED BY ANTIBIOTIC POLYTHERAPY: A CASE REPORT. 抗生素综合治疗致急性广泛性脓疱病1例。
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.48
Siniša Jolić, Zdenka Šitum Čeprnja, Toni Čeprnja, Ognjen Jolić, Mirna Šitum
{"title":"ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP) CAUSED BY ANTIBIOTIC POLYTHERAPY: A CASE REPORT.","authors":"Siniša Jolić, Zdenka Šitum Čeprnja, Toni Čeprnja, Ognjen Jolić, Mirna Šitum","doi":"10.20471/acc.2024.63.03-04.48","DOIUrl":"10.20471/acc.2024.63.03-04.48","url":null,"abstract":"<p><p>Acute generalized exanthematous pustulosis (AGEP) is a rare disease, usually associated with drug intake or infections. It is characterized by generalized acute pustules and non-follicular exanthema together with systemic symptoms. Histologically, it is characterized by a subcorneal intraepidermal spongiform pustule, papillary edema and dermal vasodilatation surrounded by a polymorphous infiltrate of neutrophils, eosinophils and mononuclear cells. The aim of this article is to present current knowledge regarding the etiology and treatment, as well as the clinical and histologic features of AGEP. We present a case of a 50-year-old male patient who was prescribed several antibiotics and developed a drug-related cutaneous adverse effect. Treatment involved rapid identification of the causative agent and its discontinuation together with supportive measures, with resolution of symptoms within two weeks. Early diagnosis and timely treatment result in a favorable outcome and prevent systemic complications.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"834-838"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPARISON OF CT REPORTING SYSTEMS IN PATIENTS UNDERGOING THORAX COMPUTED TOMOGRAPHY FOR COVID-19 PNEUMONIA. 新型冠状病毒肺炎胸部ct报告系统的比较
IF 0.8 4区 医学
Acta clinica Croatica Pub Date : 2024-12-01 DOI: 10.20471/acc.2024.63.03-04.11
Uğur Bozlar, Hatice Merve Sahin, Cantürk Tasci, Eda Karaismailoglu, Sümeyra Altekin, Kenan Saglam, Mustafa Tasar
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