Acta Biotheoretica最新文献

A Decolonial Lexicon for Immunology. 一本非殖民化的免疫学词典。

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-05-09 DOI: 10.1007/s10441-026-09527-6

Claudio Vieira da Silva

{"title":"A Decolonial Lexicon for Immunology.","authors":"Claudio Vieira da Silva","doi":"10.1007/s10441-026-09527-6","DOIUrl":"https://doi.org/10.1007/s10441-026-09527-6","url":null,"abstract":"<p><p>The discipline of immunology has historically been foundationally framed by metaphors of war, portraying the body as a sovereign state defending its territory against foreign invaders. This paradigm, however, is not strictly a biological necessity but also a historical artifact of colonial logic that arguably limits our understanding of symbiosis, tolerance, and the nature of relational pathologies. This paper argues for a decolonial paradigm shift, proposing a comprehensive reframing of the immune system not as a military force but as a sophisticated system of communication, governance, and diplomacy within a multi-species community, the holobiont. We trace the colonial genealogy of war metaphors and expose its conceptual inadequacies in the face of modern biology, distinguishing between historical rhetorical resonances and causal scientific developments. Drawing inspiration from relational and ecological philosophies, we then propose a new conceptual lexicon, using the metaphor of the body as a quilombo, a diverse and resilient community. By separating canonical biological mechanisms from metaphorical interpretation, this framework reframes core immunological processes: inflammation becomes an urgent community assembly, the adaptive response a journey of information, and pathologies like autoimmunity, cancer, and immunodeficiency become crises of communication and social cohesion. Offered as a conceptual heuristic rather than a wholesale structural equivalent, this relational approach offers not only new avenues for research and therapy but also serves as a powerful pedagogical tool to foster a more holistic, integrated, and ecologically conscious view of life itself.</p>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian Inferential Analysis of Genetic Risks Based on Family History 基于家族史的遗传风险的贝叶斯推理分析

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-05-04 DOI: 10.1007/s10441-026-09525-8

Mehmet Cevri, Dursun Ustundag

{"title":"Bayesian Inferential Analysis of Genetic Risks Based on Family History","authors":"Mehmet Cevri, Dursun Ustundag","doi":"10.1007/s10441-026-09525-8","DOIUrl":"10.1007/s10441-026-09525-8","url":null,"abstract":"<div><p>Classical statistical analysis is a frequently employed methodology in numerous domains of genetic research. In recent times, however, there has been a notable increase in the interest accorded to the deployment of Bayesian statistics in the field of genetics, as it incorporates a priori hypotheses about genetic knowledge into the problem. The potential risk of developing a genetic disease is influenced by the patient’s genetics, ethnicity, gender, age, and family history. The objective of this study is there<span>(^{1})</span>fore to provide molecular pathologists working with genetic testing with a comprehensive overview of the basic principles of Bayesian analysis and genetic risk assessment. Furthermore, the study aims to develop a computer code that estimates the probability of transmission of genetic traits between generations and performs risk analysis within the framework of Bayesian logical inference. This framework facilitates the calculation of the probability of a specific hypothesis, whether it pertains to disease state or a determination of carrier status, by integrating familial data and/or the results obtained from genetic testing. The present algorithm was utilized for the purpose of evaluating the genetic risk of everyone within a given pedigree, in addition to predicting the likelihood of cystic fibrosis (CF) manifesting in human genetics. This objective was accomplished by employing transition matrices in Markov chains and subsequently calculating the final probability vector of the transmission of genetic traits. The primary function of this tool is to evaluate the genetic susceptibility of individuals within a family history to cystic fibrosis and to predict the probability of developing the condition. The results demonstrate the effectiveness of the proposed algorithm in performing reliable genetic risk assessments for patients and family members with cystic fibrosis disease or other autosomal recessive disorders.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of Bone Remodeling and Damage Accumulation: A Preliminary Computational Framework for Physiological and Pathological Responses 骨重塑和损伤积累的整合：生理和病理反应的初步计算框架

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-05-04 DOI: 10.1007/s10441-026-09522-x

Diego A. Garzón-Alvarado, Carlos A. Duque-Daza, Dorian L. Linero, Boumediene Nedjar, Abdelghani May, Estevam Barbosa Las Casas, Salah Ramtani

{"title":"Integration of Bone Remodeling and Damage Accumulation: A Preliminary Computational Framework for Physiological and Pathological Responses","authors":"Diego A. Garzón-Alvarado, Carlos A. Duque-Daza, Dorian L. Linero, Boumediene Nedjar, Abdelghani May, Estevam Barbosa Las Casas, Salah Ramtani","doi":"10.1007/s10441-026-09522-x","DOIUrl":"10.1007/s10441-026-09522-x","url":null,"abstract":"<div>\u0000 \u0000 <p>This study presents a computational model that integrates bone remodeling dynamics with damage accumulation, focusing on both physiological and pathological conditions. Building upon Komarova’s classical model of osteoclast and osteoblast interactions, this work introduces fatigue-induced damage using a stress-life (S-N) approach. By simulating bone responses under sinusoidal and random mechanical loads, the model captures the cyclical nature of bone turnover. The results show that under normal physiological conditions, bone is able to repair microdamage and maintain structural integrity. However, in pathological scenarios such as osteoporosis and tumors, the remodeling cycle is disrupted, leading to an increase in damage accumulation and eventual structural failure. Through numerical simulations, the study also demonstrates the significant impact of fatigue on bone health, showing that repetitive mechanical loads, even below critical stress levels, can result in bone degradation over time. By capturing the accumulation of microdamage and its repair, the model offers potential applications in personalized medicine to assess fracture risks in varying stress and health scenarios. This approach provides a framework for understanding how different stress patterns contribute to bone damage and offers insights into the progression of bone diseases. The model could be extended using metabolic and age-related characteristics and serves as a potential tool for personalized medicine, helping to predict bone failure risks in individuals when they are submitted to repetitive mechanical loads.</p>\u0000 </div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10441-026-09522-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Impact of Vaccination Strategies on COVID-19 Dynamics Via Time-varying Copulas 通过时变copula评估疫苗接种策略对COVID-19动态的影响

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-05-04 DOI: 10.1007/s10441-026-09523-w

Atina Ahdika, Muhammad Fakhruddin, Putu Veri Swastika

{"title":"Assessing the Impact of Vaccination Strategies on COVID-19 Dynamics Via Time-varying Copulas","authors":"Atina Ahdika, Muhammad Fakhruddin, Putu Veri Swastika","doi":"10.1007/s10441-026-09523-w","DOIUrl":"10.1007/s10441-026-09523-w","url":null,"abstract":"<div>\u0000 \u0000 <p>The COVID-19 pandemic has presented an unprecedented global challenge, significantly impacting public health, economies, and daily life worldwide. In response to this crisis, scientists and researchers around the world have worked tirelessly to understand the virus, its transmission dynamics, and most importantly, to develop effective vaccines. However, questions remain about the comparative effectiveness of these vaccines, particularly in real-world scenarios. This paper aimed to address this critical issue by employing advanced statistical techniques, including time-varying copulas. In this study, we employed four types of copula, namely Gaussian, Student-<i>t</i>, Clayton, and Gumbel, to model the temporal association between vaccination and the emergence of COVID-19 cases. The results of this study suggested that the number of subsequent vaccinations, especially the first to fourth vaccines, has a significant impact on the occurrence and spread of COVID-19 under particular conditions. Furthermore, we proposed several modeling scenarios for COVID-19 cases based on their temporal interactions with the number of subsequent vaccinations. The findings of this research provided a comprehensive understanding of the temporal relationship between vaccination and its impact on reducing COVID-19 cases.</p>\u0000 </div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Reliability of Data-Driven Compartmental Model (SIR or VH) on Dengue Fever for the Ongoing Outbreak in America 评估数据驱动的区室模型（SIR或VH）在美国持续爆发登革热的可靠性。

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-03-16 DOI: 10.1007/s10441-026-09520-z

Amit Kumar Roy, Priti Kumar Roy

{"title":"Evaluating the Reliability of Data-Driven Compartmental Model (SIR or VH) on Dengue Fever for the Ongoing Outbreak in America","authors":"Amit Kumar Roy, Priti Kumar Roy","doi":"10.1007/s10441-026-09520-z","DOIUrl":"10.1007/s10441-026-09520-z","url":null,"abstract":"<div><p>The compartmental epidemiological model is commonly used to study dengue dynamics; some of these models precisely consider the mosquito population, and others indirectly capture its role in disease transmission term. In this article, we have performed a comparative analysis between a simple SIR model and a vector-host interaction model (VH model) by fitting the dengue fever data of the ongoing outbreak in America. Parameter estimations for both models have been performed using the Nelder-Mead simplex algorithm, considering the normalized root mean square error (NRMSE) as an optimization function. The significance and reliability of the estimated parameters towards the models’ predictions have been analysed through uncertainty and sensitivity analyses. Uncertainty analysis utilizing the Latin hypercube sampling (LHS) method has been performed to evaluate how various parameters within the models influence the basic reproduction number (<span>(mathcal {R}_0)</span>). Sensitivity analysis for the basic reproduction number (<span>(mathcal {R}_0)</span>), has been carried out by the partial rank correlation coefficients (PRCC) method. Additionally, we have computed the parameter regions ensuring the persistence of equilibrium points of both models. This study offers profound insights into model selection, parameter estimation, and forecasting future data trends for the ongoing dengue outbreak in America. However, this article focuses on exploring two key scientific questions: (1) Which type of compartmental model (SIR or VH) is more suitable to capture the trend of data on dengue fever for the ongoing outbreak in America? (2) Is America likely to face a prolonged dengue outbreak in the near future?</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasticity as a Historical and Philosophical Problem 可塑性作为一个历史和哲学问题

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-03-08 DOI: 10.1007/s10441-026-09521-y

Yoshinari Yoshida

引用次数: 0

Mess and Method 混乱和方法。

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-03-01 DOI: 10.1007/s10441-026-09519-6

Rose Novick, Joyce C. Havstad

{"title":"Mess and Method","authors":"Rose Novick, Joyce C. Havstad","doi":"10.1007/s10441-026-09519-6","DOIUrl":"10.1007/s10441-026-09519-6","url":null,"abstract":"<div>\u0000 \u0000 <p>Bill Wimsatt and Mark Wilson are each the author of a body of work whose fruitfulness is rivaled only by its forbiddingness. Despite deep sympathies between their approaches and conclusions, their work has not yet been read together. This paper makes the case for doing so. We identify a shared question at the heart of their work: how is it that limited beings such as ourselves come to possess genuine knowledge of a complex world? We then show that Wimsatt and Wilson arrive at similar answers to this question. Over a range of topics (investigative strategies, the uses of models, and theoretical and conceptual structure), both scholars emphasize the functional messiness of science. This is complemented by a pragmatist-leaning philosophical methodology that recognizes that one of the core uses of knowledge is to scaffold the acquisition of more knowledge. The core of the paper traces the mutually supportive interplay between their philosophical doctrines and methods. We end with two brief discussions: one a defense of their winding, playful writing styles, the other a brief consideration of the relationship between their work and Arthur Fine’s natural ontological attitude.</p>\u0000 </div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Emergence of Turing Instability and Pattern Formation in a Nonlinear Stochastic Spatiotemporal Epidemic Model with Reinfections 具有再感染的非线性随机时空流行病模型的图灵不稳定性和模式形成。

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-02-19 DOI: 10.1007/s10441-026-09518-7

Aman Kumar Singh, Rasha Almsheks, Manish Kumar, Subramanian Ramakrishnan

{"title":"The Emergence of Turing Instability and Pattern Formation in a Nonlinear Stochastic Spatiotemporal Epidemic Model with Reinfections","authors":"Aman Kumar Singh, Rasha Almsheks, Manish Kumar, Subramanian Ramakrishnan","doi":"10.1007/s10441-026-09518-7","DOIUrl":"10.1007/s10441-026-09518-7","url":null,"abstract":"<div>\u0000 \u0000 <p>Instabilities and Turing patterns in stochastic spatiotemporal systems in which a fraction of an evolving population, after undergoing a series of dynamic transitions, returns to its original state, remain largely unexplored. Adopting an epidemic model incorporating reinfections as an exemplar of such a system, we present stability and pattern-formation analyses of the stochastic reaction-diffusion equations that represent the model. Saturation effects in epidemic spread lead to nonlinear considerations, while random environmental effects motivate a stochastic term. Turing bifurcation and the emergence of equilibrium patterns are analysed with respect to three fundamental parameters - reinfection, saturation, and noise intensity. Using higher-order stability analysis and stochastic averaging, we find the Turing instability and also uncover self–organized, distinct equilibrium patterns of infection spread. Additionally, results elucidating the effects of stochastic excitation and its intensity, as well as the competing influence of saturation and reinfection on stability and pattern formation, are presented. The results are also expected to be broadly significant beyond epidemic modelling, for studies of noise-induced instabilities and morphogenesis in spatiotemporal nonlinear dynamical systems.</p>\u0000 </div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FitzHugh–Nagumo Model in Neutral Delay Differential Equation Representation 中立型时滞微分方程表示中的FitzHugh-Nagumo模型。

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-02-12 DOI: 10.1007/s10441-025-09513-4

M. A. Elfouly, M. A. Sohaly, M. E. Fares

{"title":"FitzHugh–Nagumo Model in Neutral Delay Differential Equation Representation","authors":"M. A. Elfouly, M. A. Sohaly, M. E. Fares","doi":"10.1007/s10441-025-09513-4","DOIUrl":"10.1007/s10441-025-09513-4","url":null,"abstract":"<div>\u0000 \u0000 <p>We present a neutral delay differential equation (NDDE) modification of the FitzHugh–Nagumo (FHN) model. One linear and three nonlinear variants are proposed to capture the interaction between delayed effects in the membrane potential and the stimulating current, including a delayed rate (neutral) term. We derive fixed points, compute eigenvalues, and obtain Hopf conditions to map regions of stability, instability, and oscillation. Parameter studies show how the neutral delay reorganizes dynamics and modulates the robustness of nerve firing. Numerical simulations quantify frequency, ISI, amplitude, and spike counts and reproduce canonical phenotypes: regular spiking adapts to large stimulus delays, intrinsic bursting yields rapid spikes, chattering shows high-frequency bursts with moderate delays, fast-spiking exhibits high rates, and low-threshold neurons adapt to high frequencies with small delays. Overall, the NDDE representation provides a compact, physically motivated framework in which time delay governs stability and synchronization, offering insight for diagnostic modeling and potential therapies for disorders with irregular firing.</p>\u0000 </div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Oxygen Distribution on the Tumor Necrotic Region: A Two-phase Model 氧分布对肿瘤坏死区的影响：一个两阶段模型。

IF 1.5 4区生物学

Acta Biotheoretica Pub Date : 2026-02-12 DOI: 10.1007/s10441-026-09516-9

Gopinath Sadhu, K. S. Yadav, Siddhartha Sankar Ghosh, D. C. Dalal

{"title":"The Impact of Oxygen Distribution on the Tumor Necrotic Region: A Two-phase Model","authors":"Gopinath Sadhu, K. S. Yadav, Siddhartha Sankar Ghosh, D. C. Dalal","doi":"10.1007/s10441-026-09516-9","DOIUrl":"10.1007/s10441-026-09516-9","url":null,"abstract":"<div>\u0000 \u0000 <p>In an <i>in vivo</i> situation, the tissue near a blood vessel is rich in oxygen supply compared to the one far from a blood vessel. In this article, our objective is to explore the effect of non-uniform oxygen supply on the development of the necrotic core of a tumor. We adopt a multiphase continuum-based approach to model the growth of a tumor. To simulate the model, a finite-difference-based numerical approach in line with the “Semi-Implicit Method for Pressure-Linked Equations\" (SIMPLE) algorithm is adopted. Investigations reveal that the necrotic core develops near the boundary with lower oxygen concentration. The position of the necrotic core strongly depends on the oxygen supply through the tumor boundary. The results predict asymmetrical tumor growth under unequal oxygen supply at tumor boundaries. Also, it is hinted that a tumor with a larger necrotic core grows more slowly than a tumor containing a smaller necrotic core. The present model has the potential to anticipate <i>in vivo</i> and <i>in vitro</i> situations. The findings will be beneficial for clinicians and medical practitioners in predicting the stage of a tumor.</p>\u0000 </div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"74 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0