Acta Biotheoretica最新文献_第10页

Teaching Biologists the Philosophy of Their Time 教授生物学家时代哲学

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-01-14 DOI: 10.1007/s10441-020-09404-w

S. J. Veigl

引用次数: 1

Optimal Control and Cost-Effectiveness Analysis of an HPV–Chlamydia trachomatis Co-infection Model hpv -沙眼衣原体共感染模型的最优控制及成本-效果分析

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2021-01-03 DOI: 10.1007/s10441-020-09401-z

A. Omame, C. U. Nnanna, S. C. Inyama

{"title":"Optimal Control and Cost-Effectiveness Analysis of an HPV–Chlamydia trachomatis Co-infection Model","authors":"A. Omame, C. U. Nnanna, S. C. Inyama","doi":"10.1007/s10441-020-09401-z","DOIUrl":"10.1007/s10441-020-09401-z","url":null,"abstract":"<div><p>In this work, a co-infection model for human papillomavirus (HPV) and <i>Chlamydia trachomatis</i> with cost-effectiveness optimal control analysis is developed and analyzed. The disease-free equilibrium of the co-infection model is shown not to be globally asymptotically stable, when the associated reproduction number is less unity. It is proven that the model undergoes the phenomenon of backward bifurcation when the associated reproduction number is less than unity. It is also shown that HPV re-infection (<span>(varepsilon_{textsc{p}} ne 0)</span>) induced the phenomenon of backward bifurcation. Numerical simulations of the optimal control model showed that: (i) focusing on HPV intervention strategy alone (HPV prevention and screening), in the absence of <i>C. trachomatis</i> control, leads to a positive population level impact on the total number of individuals singly infected with <i>C. trachomatis</i>, (ii) Concentrating on <i>C. trachomatis</i> intervention controls alone (<i>C. trachomatis</i> prevention and treatment), in the absence of HPV intervention strategies, a positive population level impact is observed on the total number of individuals singly infected with HPV. Moreover, the strategy that combines and implements HPV and <i>C. trachomatis</i> prevention controls is the most cost-effective of all the control strategies in combating the co-infections of HPV and <i>C. trachomatis</i>.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 3","pages":"185 - 223"},"PeriodicalIF":1.3,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09401-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38774549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Photosynthetic Systems Suggest an Evolutionary Pathway to Diderms 光合作用系统揭示了一种进化途径

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-12-07 DOI: 10.1007/s10441-020-09402-y

Scott O. Rogers

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引用次数: 1

The Continuity Principle and the Evolution of Replication Fidelity 连续性原理与复制保真度的演化

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-11-29 DOI: 10.1007/s10441-020-09399-4

Seymour Garte

引用次数: 3

Fitness Beats Truth in the Evolution of Perception 在感知的进化中，健康胜过真理

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-11-24 DOI: 10.1007/s10441-020-09400-0

Chetan Prakash, Kyle D. Stephens, Donald D. Hoffman, Manish Singh, Chris Fields

{"title":"Fitness Beats Truth in the Evolution of Perception","authors":"Chetan Prakash, Kyle D. Stephens, Donald D. Hoffman, Manish Singh, Chris Fields","doi":"10.1007/s10441-020-09400-0","DOIUrl":"10.1007/s10441-020-09400-0","url":null,"abstract":"<div><p>Does natural selection favor veridical percepts—those that accurately (if not exhaustively) depict objective reality? Perceptual and cognitive scientists standardly claim that it does. Here we formalize this claim using the tools of evolutionary game theory and Bayesian decision theory. We state and prove the “Fitness-Beats-Truth (FBT) Theorem” which shows that the claim is false: If one starts with the assumption that perception involves inference to states of the objective world, then the FBT Theorem shows that a strategy that simply seeks to maximize expected-fitness payoff, with no attempt to estimate the “true” world state, does consistently better. More precisely, the FBT Theorem provides a quantitative measure of the extent to which the <i>fitness-only</i> strategy dominates the <i>truth</i> strategy, and of how this dominance increases with the size of the perceptual space. The FBT Theorem supports the <i>Interface</i> <i>Theory</i> <i>of</i> <i>Perception</i> (e.g. Hoffman et al. in Psychon Bull Rev https://doi.org/10.3758/s13423-015-0890-8, 2015), which proposes that our perceptual systems have evolved to provide a species-specific interface to guide adaptive behavior, and not to provide a veridical representation of objective reality.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 3","pages":"319 - 341"},"PeriodicalIF":1.3,"publicationDate":"2020-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09400-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38738148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Mechanical Properties of Long Leaves: Experiment and Theory 长叶的力学性能:实验与理论

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-31 DOI: 10.1007/s10441-020-09397-6

A. Jakubska-Busse, M. W. Janowicz, L. Ochnio, B. Jackowska-Zduniak, J. M. A. Ashbourn

引用次数: 0

The Metaphysics of Causation in Biological Mechanisms: A Case of the Genetic Switch in Lambda Phage 生物学机制中因果关系的形而上学:以Lambda噬菌体基因开关为例

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-27 DOI: 10.1007/s10441-020-09395-8

Zvonimir Anić

{"title":"The Metaphysics of Causation in Biological Mechanisms: A Case of the Genetic Switch in Lambda Phage","authors":"Zvonimir Anić","doi":"10.1007/s10441-020-09395-8","DOIUrl":"10.1007/s10441-020-09395-8","url":null,"abstract":"<div><p>The emphasis on the organization of entities and their activities and interactions has been labeled one of the most distinct contributions of mechanistic philosophy. In this paper I discuss the manner in which the organization of entities and their activities and interactions participates in bringing about phenomena. I present a well-known example from molecular biology—the functioning of the genetic switch in phage lambda—and discuss Marco J. Nathan’s notion of causation by concentration. Nathan introduces causation by concentration to account for the irreducible causal role that the concentration ratio between two kinds of proteins possesses in the genetic switch mechanism in phage lambda. I discuss what the irreducibility of this causal role amounts to and provide a mechanistic interpretation of Nathan’s causation by concentration; that is, I explain this irreducible causal role as one organizational feature of this mechanism. The paper concludes that biological mechanisms need a causal pluralist framework [similar to Glennan’s account in (2009), (2010) and (2017) but slightly modified] where organizational features such as the concentration ratio have a causally relevant role, yet all the causally productive relations occur at the level of entities or individuals.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 3","pages":"435 - 448"},"PeriodicalIF":1.3,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09395-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38535206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of From Darwin to Derrida by David Haig 大卫·黑格的《从达尔文到德里达》书评

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-22 DOI: 10.1007/s10441-020-09398-5

Samir Okasha

引用次数: 0

Inheritance as Evolved and Evolving Physiological Processes 遗传进化和进化的生理过程

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-21 DOI: 10.1007/s10441-020-09396-7

Francesca Merlin, Livio Riboli-Sasco

引用次数: 1

Different Mechanisms of Cigarette Smoking-Induced Lung Cancer 吸烟诱发肺癌的不同机制

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-09-26 DOI: 10.1007/s10441-020-09394-9

Ahmed Nagah, Asmaa Amer

{"title":"Different Mechanisms of Cigarette Smoking-Induced Lung Cancer","authors":"Ahmed Nagah, Asmaa Amer","doi":"10.1007/s10441-020-09394-9","DOIUrl":"10.1007/s10441-020-09394-9","url":null,"abstract":"<div><p>The risk of cigarette smoking plays a pivotal role in increasing the incidence rates of lung cancer. This paper sheds new light on modeling the impact of cigarette smoking on lung cancer evolution, especially genetic instability and the number of gene mutations in the genome of stem cells. To handle this issue, we have set up stochastic multi-stage models to fit the data set of the probabilities of current and former smokers from the Nurses’ Health Study cohort of females (NHS) and the Health Professionals Follow up Study cohort of men (HPFS). Throughout this paper, we consider both mutation rates and clonal expansion rates as parameters in each compartment. For current and former smokers, three-driver mutations are most likely to take place in the progression of lung cancer under smoking risk. For current smokers, our findings reveal that two to sixteen gene mutations are required to obtain a cancerous cell among men and women in US. Moreover, two to six (eleven) cancer-mutations are available in the pathway to lung cancer among former smokers who have quit smoking for more (less) than ten years for both male and female patients. This highlights that cigarette smoking stimulates the number of driver mutations during lung tumorigenesis in both sexes. It is very crucial to examine the role of cigarette smoking in determining whether genomic instability is an early stage or late stage in the process of lung carcinogenesis.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"69 1","pages":"37 - 52"},"PeriodicalIF":1.3,"publicationDate":"2020-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09394-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38422258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7