Acta Biotheoretica最新文献_第10页

The Continuity Principle and the Evolution of Replication Fidelity 连续性原理与复制保真度的演化

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-11-29 DOI: 10.1007/s10441-020-09399-4

Seymour Garte

引用次数: 3

Fitness Beats Truth in the Evolution of Perception 在感知的进化中，健康胜过真理

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-11-24 DOI: 10.1007/s10441-020-09400-0

Chetan Prakash, Kyle D. Stephens, Donald D. Hoffman, Manish Singh, Chris Fields

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引用次数: 23

Mechanical Properties of Long Leaves: Experiment and Theory 长叶的力学性能:实验与理论

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-31 DOI: 10.1007/s10441-020-09397-6

A. Jakubska-Busse, M. W. Janowicz, L. Ochnio, B. Jackowska-Zduniak, J. M. A. Ashbourn

引用次数: 0

The Metaphysics of Causation in Biological Mechanisms: A Case of the Genetic Switch in Lambda Phage 生物学机制中因果关系的形而上学:以Lambda噬菌体基因开关为例

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-27 DOI: 10.1007/s10441-020-09395-8

Zvonimir Anić

{"title":"The Metaphysics of Causation in Biological Mechanisms: A Case of the Genetic Switch in Lambda Phage","authors":"Zvonimir Anić","doi":"10.1007/s10441-020-09395-8","DOIUrl":"10.1007/s10441-020-09395-8","url":null,"abstract":"<div><p>The emphasis on the organization of entities and their activities and interactions has been labeled one of the most distinct contributions of mechanistic philosophy. In this paper I discuss the manner in which the organization of entities and their activities and interactions participates in bringing about phenomena. I present a well-known example from molecular biology—the functioning of the genetic switch in phage lambda—and discuss Marco J. Nathan’s notion of causation by concentration. Nathan introduces causation by concentration to account for the irreducible causal role that the concentration ratio between two kinds of proteins possesses in the genetic switch mechanism in phage lambda. I discuss what the irreducibility of this causal role amounts to and provide a mechanistic interpretation of Nathan’s causation by concentration; that is, I explain this irreducible causal role as one organizational feature of this mechanism. The paper concludes that biological mechanisms need a causal pluralist framework [similar to Glennan’s account in (2009), (2010) and (2017) but slightly modified] where organizational features such as the concentration ratio have a causally relevant role, yet all the causally productive relations occur at the level of entities or individuals.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09395-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38535206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of From Darwin to Derrida by David Haig 大卫·黑格的《从达尔文到德里达》书评

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-22 DOI: 10.1007/s10441-020-09398-5

Samir Okasha

引用次数: 0

Inheritance as Evolved and Evolving Physiological Processes 遗传进化和进化的生理过程

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-10-21 DOI: 10.1007/s10441-020-09396-7

Francesca Merlin, Livio Riboli-Sasco

引用次数: 1

Different Mechanisms of Cigarette Smoking-Induced Lung Cancer 吸烟诱发肺癌的不同机制

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-09-26 DOI: 10.1007/s10441-020-09394-9

Ahmed Nagah, Asmaa Amer

{"title":"Different Mechanisms of Cigarette Smoking-Induced Lung Cancer","authors":"Ahmed Nagah, Asmaa Amer","doi":"10.1007/s10441-020-09394-9","DOIUrl":"10.1007/s10441-020-09394-9","url":null,"abstract":"<div><p>The risk of cigarette smoking plays a pivotal role in increasing the incidence rates of lung cancer. This paper sheds new light on modeling the impact of cigarette smoking on lung cancer evolution, especially genetic instability and the number of gene mutations in the genome of stem cells. To handle this issue, we have set up stochastic multi-stage models to fit the data set of the probabilities of current and former smokers from the Nurses’ Health Study cohort of females (NHS) and the Health Professionals Follow up Study cohort of men (HPFS). Throughout this paper, we consider both mutation rates and clonal expansion rates as parameters in each compartment. For current and former smokers, three-driver mutations are most likely to take place in the progression of lung cancer under smoking risk. For current smokers, our findings reveal that two to sixteen gene mutations are required to obtain a cancerous cell among men and women in US. Moreover, two to six (eleven) cancer-mutations are available in the pathway to lung cancer among former smokers who have quit smoking for more (less) than ten years for both male and female patients. This highlights that cigarette smoking stimulates the number of driver mutations during lung tumorigenesis in both sexes. It is very crucial to examine the role of cigarette smoking in determining whether genomic instability is an early stage or late stage in the process of lung carcinogenesis.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2020-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09394-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38422258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Probability of Disease Extinction or Outbreak in a Stochastic Epidemic Model for West Nile Virus Dynamics in Birds 鸟类西尼罗病毒动态的随机流行模型中疾病灭绝或爆发的概率

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-09-05 DOI: 10.1007/s10441-020-09391-y

Milliward Maliyoni

{"title":"Probability of Disease Extinction or Outbreak in a Stochastic Epidemic Model for West Nile Virus Dynamics in Birds","authors":"Milliward Maliyoni","doi":"10.1007/s10441-020-09391-y","DOIUrl":"10.1007/s10441-020-09391-y","url":null,"abstract":"<div><p>Thresholds for disease extinction provide essential information for the prevention and control of diseases. In this paper, a stochastic epidemic model, a continuous-time Markov chain, for the transmission dynamics of West Nile virus in birds is developed based on the assumptions of its analogous deterministic model. The branching process is applied to derive the extinction threshold for the stochastic model and conditions for disease extinction or persistence. The probability of disease extinction computed from the branching process is shown to be in good agreement with the probability approximated from numerical simulations. The disease dynamics of both models are compared to ascertain the effect of demographic stochasticity on West Nile virus dynamics. Analytical and numerical results show differences in model predictions and asymptotic dynamics between stochastic and deterministic models that are crucial for the prevention of disease outbreaks. It is found that there is a high probability of disease extinction if the disease emerges from exposed mosquitoes unlike if it emerges from infectious mosquitoes and birds. Finite-time to disease extinction is estimated using sample paths and it is shown that the epidemic duration is shortest if the disease is introduced by exposed mosquitoes.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2020-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09391-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40543491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The Epistemology of a Positive SARS-CoV-2 Test 新冠病毒阳性检测的认识论

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-09-04 DOI: 10.1007/s10441-020-09393-w

Rainer Johannes Klement, Prasanta S. Bandyopadhyay

{"title":"The Epistemology of a Positive SARS-CoV-2 Test","authors":"Rainer Johannes Klement, Prasanta S. Bandyopadhyay","doi":"10.1007/s10441-020-09393-w","DOIUrl":"10.1007/s10441-020-09393-w","url":null,"abstract":"<div><p>We investigate the epistemological consequences of a positive polymerase chain reaction SARS-CoV test for two relevant hypotheses: (i) V is the hypothesis that an individual has been infected with SARS-CoV-2; (ii) C is the hypothesis that SARS-CoV-2 is the cause of flu-like symptoms in a given patient. We ask two fundamental epistemological questions regarding each hypothesis: First, how much confirmation does a positive test lend to each hypothesis? Second, how much evidence does a positive test provide for each hypothesis against its negation? We respond to each question within a formal Bayesian framework. We construe degree of confirmation as the difference between the posterior probability of the hypothesis and its prior, and the strength of evidence for a hypothesis against its alternative in terms of their likelihood ratio. We find that test specificity—and coinfection probabilities when making inferences about C—were key determinants of confirmation and evidence. Tests with < 87% specificity could not provide strong evidence (likelihood ratio > 8) for V against ¬V regardless of sensitivity. Accordingly, low specificity tests could not provide strong evidence in favor of C in all plausible scenarios modeled. We also show how a positive influenza A test disconfirms C and provides weak evidence against C in dependence on the probability that the patient is influenza A infected given that his/her symptoms are not caused by SARS-CoV-2. Our analysis points out some caveats that should be considered when attributing symptoms or death of a positively tested patient to SARS-CoV-2.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2020-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10441-020-09393-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38346110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Computational and Theoretical Analysis of the Association Between Gender and HSV-2 Treatment Adherence 性别与HSV-2治疗依从性关系的计算与理论分析

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2020-09-03 DOI: 10.1007/s10441-020-09392-x

A. Mhlanga, S. Mushayabasa

引用次数: 2