M. I. Romero Rodríguez, J. C. Vargas Pino, E. L. Sierra-Ballén
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引用次数: 0
摘要
骨肉瘤是最常见的原发性骨癌。根据医学和生物学的研究,该病具有高度的遗传复杂性,因此,区分该病的出现和进化机制是一项艰巨的任务。在本文中,我们使用三个最简单和众所周知的数学模型来描述几种骨肉瘤细胞系的行为。首先,我们用一个势律来描述免疫抑制小鼠的肿瘤生长;用它证明了肿瘤生长的变化具有亚线性行为,没有爆炸现象。其次,在体外实验中,使用逻辑模型对细胞融合增殖率进行了很好的近似。第三,我们使用线性反应扩散模型;利用它,我们描述了一些细胞系的扩散行为。这三种模型使我们能够根据肿瘤生长和增殖的速率以及扩散系数对细胞系进行分类。发现了肿瘤生长速率、扩散系数和致瘤性之间的关系。实验数据摘自Lauvrak et al.(英国癌症杂志109(8):2228-2236,2013)。
Tumor Growth, Proliferation and Diffusion in Osteosarcoma
Osteosarcoma is the most common primary bone cancer. According to medical and biological studies, it has a high genetic complexity, thus, to differentiate the mechanisms of appearance and evolution of this disease is a difficult task. In this paper, we use three simplest and well known mathematical models to describe the behavior of several cell lines of osteosarcoma. First, we use a potential law to describe the tumor growth in immunosuppressed mice; with it we show that the variation of tumor growth has a sublinear behavior without the blow-up phenomenon. Second, the logistic model is used to obtain a good aproximation to the rates of proliferation in cell confluency in in vitro experiments. Third, we use a linear reaction-diffusion model; with it, we describe the diffusion behavior for some cell lines. These three models allow us to give a classification of cell lines according to the rates of tumor growth and proliferation and to the diffusion coefficient. A relationship is found between the rates of the tumor growth, the diffusion coefficient and tumorigenicity. Experimental data are extracted from Lauvrak et al. (British Journal of Cancer 109(8):2228–2236, 2013).
期刊介绍:
Acta Biotheoretica is devoted to the promotion of theoretical biology, encompassing mathematical biology and the philosophy of biology, paying special attention to the methodology of formation of biological theory.
Papers on all kind of biological theories are welcome. Interesting subjects include philosophy of biology, biomathematics, computational biology, genetics, ecology and morphology. The process of theory formation can be presented in verbal or mathematical form. Moreover, purely methodological papers can be devoted to the historical origins of the philosophy underlying biological theories and concepts.
Papers should contain clear statements of biological assumptions, and where applicable, a justification of their translation into mathematical form and a detailed discussion of the mathematical treatment. The connection to empirical data should be clarified.
Acta Biotheoretica also welcomes critical book reviews, short comments on previous papers and short notes directing attention to interesting new theoretical ideas.