Acta Biotheoretica最新文献_第2页

Model of Calcium Dynamics Regulating [Formula: see text], ATP and Insulin Production in a Pancreatic [Formula: see text]-Cell. 调节胰腺[公式：见正文]细胞[公式：见正文]、ATP 和胰岛素分泌的钙动力学模型。

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2024-02-09 DOI: 10.1007/s10441-024-09477-x

Vaishali, Neeru Adlakha

{"title":"Model of Calcium Dynamics Regulating [Formula: see text], ATP and Insulin Production in a Pancreatic [Formula: see text]-Cell.","authors":"Vaishali, Neeru Adlakha","doi":"10.1007/s10441-024-09477-x","DOIUrl":"10.1007/s10441-024-09477-x","url":null,"abstract":"<p><p>The calcium signals regulate the production and secretion of many signaling molecules like inositol trisphosphate ([Formula: see text]) and adenosine triphosphate (ATP) in various cells including pancreatic [Formula: see text]-cells. The calcium signaling mechanisms regulating [Formula: see text], ATP and insulin responsible for various functions of [Formula: see text]-cells are still not well understood. Any disturbance in these mechanisms can alter the functions of [Formula: see text]-cells leading to diabetes and metabolic disorders. Therefore, a mathematical model is proposed by incorporating the reaction-diffusion equation for calcium dynamics and a system of first-order differential equations for [Formula: see text], ATP-production and insulin secretion with initial and boundary conditions. The model incorporates the temporal dependence of [Formula: see text]-production and degradation, ATP production and insulin secretion on calcium dynamics in a [Formula: see text]-cell. The piecewise linear finite element method has been used for the spatial dimension and the Crank-Nicolson scheme for the temporal dimension to obtain numerical results. The effect of changes in source influxes and buffers on calcium dynamics and production of [Formula: see text], ATP and insulin levels in a [Formula: see text]-cell has been analyzed. It is concluded that the dysfunction of source influx and buffers can cause significant variations in calcium levels and dysregulation of [Formula: see text], ATP and insulin production, which can lead to various metabolic disorders, diabetes, obesity, etc. The proposed model provides crucial information about the changes in mechanisms of calcium dynamics causing proportionate disturbances in [Formula: see text], ATP and insulin levels in pancreatic cells, which can be helpful for devising protocols for diagnosis and treatment of various metabolic diseases.</p>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139705763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Multicellular Systems: Physiological Control and Degrees of Biological Individuality 整合多细胞系统：生理控制与生物个体化程度》。

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-12-27 DOI: 10.1007/s10441-023-09476-4

Leonardo Bich

{"title":"Integrating Multicellular Systems: Physiological Control and Degrees of Biological Individuality","authors":"Leonardo Bich","doi":"10.1007/s10441-023-09476-4","DOIUrl":"10.1007/s10441-023-09476-4","url":null,"abstract":"<div><p>This paper focuses on physiological integration in multicellular systems, a notion often associated with biological individuality, but which has not received enough attention and needs a thorough theoretical treatment. Broadly speaking, physiological integration consists in how different components come together into a cohesive unit in which they are dependent on one another for their existence and activity. This paper argues that physiological integration can be understood by considering how the components of a biological multicellular system are controlled and coordinated in such a way that their activities can contribute to the maintenance of the system. The main implication of this perspective is that different ways of controlling their parts may give rise to multicellular organizations with different degrees of integration. After defining control, this paper analyses how control is realized in two examples of multicellular systems located at different ends of the spectrum of multicellularity: biofilms and animals. It focuses on differences in control ranges, and it argues that a high degree of integration implies control exerted at both medium and long ranges, and that insofar as biofilms lack long-range control (relative to their size) they can be considered as less integrated than other multicellular systems. It then discusses the implication of this account for the debate on physiological individuality and the idea that degrees of physiological integration imply degrees of individuality.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10441-023-09476-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical Assessment of the Impact of Water Stress on Plants Production: Case of Banana-Plantain 水分胁迫对植物生产影响的理论评价——以香蕉大蕉为例。

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-11-15 DOI: 10.1007/s10441-023-09473-7

Carmelle Kabiwa Kadje, André Nana Yakam, Samuel Bowong, Gisèle Mophou

{"title":"Theoretical Assessment of the Impact of Water Stress on Plants Production: Case of Banana-Plantain","authors":"Carmelle Kabiwa Kadje, André Nana Yakam, Samuel Bowong, Gisèle Mophou","doi":"10.1007/s10441-023-09473-7","DOIUrl":"10.1007/s10441-023-09473-7","url":null,"abstract":"<div><p>The aim of this paper is to investigate the role of water stress on plants production. We propose a mathematical model for the dynamics growth of plants that takes into account the concentration of available water in the soil, water stress, plant production and plants compensation. Sensitivity analysis of the model has been performed in order to determine the impact of related parameters on the dynamics growth of plants. We present the theoretical analysis of the model with and without water stress. More precisely, we show that the full model is well-posedness. For each model, we compute the trivial equilibria and derive two thresholds parameters that determine the outcome of water stress within a plantation. Further, we perform numerical simulation on the case of banana-plantain simulations to support the theory. We found that the Hopf bifurcation occurs for a specific value of the water absorption rate of unstressed plants. The impact of the water stress on the banana-plantain production is also numerically investigated. After, the role of the water stress on the plant production is numerically investigated. We found that the water stress can cause about 68.16% of loss of banana-plantain production within a plantation with 1600 rejets initially planted. This suggests that climate change plays a detrimental role on banana-plantains production.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107589946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First Nucleic Acid Strands May Have Grown on Peptides via Primeval Reverse Translation 第一个核酸链可能是通过原始反向翻译在肽上生长的。

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-11-10 DOI: 10.1007/s10441-023-09474-6

Arturo Tozzi, Marco Mazzeo

{"title":"The First Nucleic Acid Strands May Have Grown on Peptides via Primeval Reverse Translation","authors":"Arturo Tozzi, Marco Mazzeo","doi":"10.1007/s10441-023-09474-6","DOIUrl":"10.1007/s10441-023-09474-6","url":null,"abstract":"<div><p>The central dogma of molecular biology dictates that, with only a few exceptions, information proceeds from DNA to protein through an RNA intermediate. Examining the enigmatic steps from prebiotic to biological chemistry, we take another road suggesting that primordial peptides acted as template for the self-assembly of the first nucleic acids polymers. Arguing in favour of a sort of archaic “reverse translation” from proteins to RNA, our basic premise is a Hadean Earth where key biomolecules such as amino acids, polypeptides, purines, pyrimidines, nucleosides and nucleotides were available under different prebiotically plausible conditions, including meteorites delivery, shallow ponds and hydrothermal vents scenarios. Supporting a protein-first scenario alternative to the RNA world hypothesis, we propose the primeval occurrence of short two-dimensional peptides termed “selective amino acid- and nucleotide-matching oligopeptides” (henceforward SANMAOs) that noncovalently bind at the same time the polymerized amino acids and the single nucleotides dispersed in the prebiotic milieu. In this theoretical paper, we describe the chemical features of this hypothetical oligopeptide, its biological plausibility and its virtues from an evolutionary perspective. We provide a theoretical example of SANMAO’s selective pairing between amino acids and nucleosides, simulating a poly-Glycine peptide that acts as a template to build a purinic chain corresponding to the glycine’s extant triplet codon GGG. Further, we discuss how SANMAO might have endorsed the formation of low-fidelity RNA’s polymerized strains, well before the appearance of the accurate genetic material’s transmission ensured by the current translation apparatus.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72012965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences 基于质体全基因组序列的模式分支分析。

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-11-03 DOI: 10.1007/s10441-023-09475-5

Evgeny V. Mavrodiev, Alexander Madorsky

{"title":"On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences","authors":"Evgeny V. Mavrodiev, Alexander Madorsky","doi":"10.1007/s10441-023-09475-5","DOIUrl":"10.1007/s10441-023-09475-5","url":null,"abstract":"<div><p>The fundamental Hennigian principle, grouping <i>solely</i> on synapomorphy, is seldom used in modern phylogenetics. In the submitted paper, we apply this principle in reanalyzing five datasets comprising 197 complete plastid genomes (plastomes). We focused on the latter because plastome-based DNA sequence data gained dramatic popularity in molecular systematics during the last decade. We show that pattern-cladistic analyses based on complete plastid genome sequences can successfully resolve affinities between plant taxa, simultaneously simplifying both the genomic and analytical frameworks of phylogenetic studies. We developed “Matrix to Newick” (M2N), a program to represent the standard molecular alignment of plastid genomes in the form of trees or <i>relationships</i> directly. Thus, massive plastome-based DNA sequence data can be successfully represented in a <i>relational</i> form rather than as a standard molecular alignment. Application of methods of median supertree construction (the Average Consensus method has been used as an example in this study) or Maximum Parsimony analysis to relational representations of plastome sequence data may help systematist to avoid the complicated assumption-based frameworks of Maximum Likelihood or Bayesian phylogenetics that are most used today in massive plastid sequence data analyses. We also found that significant amounts of pure genomic information that typically accommodate the majority of current plastid phylogenomic studies can be effectively dropped by systematists if they focus on the pattern-cladistics or relational analyses of plastome-based molecular data. The proposed pattern-cladistic approach is a powerful and straightforward heuristic alternative to modern plastome-based phylogenetics. </p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71433893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interior Operators and Their Relationship to Autocatalytic Networks 内部算子及其与自催化网络的关系。

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-10-27 DOI: 10.1007/s10441-023-09472-8

Mike Steel

{"title":"Interior Operators and Their Relationship to Autocatalytic Networks","authors":"Mike Steel","doi":"10.1007/s10441-023-09472-8","DOIUrl":"10.1007/s10441-023-09472-8","url":null,"abstract":"<div><p>The emergence of an autocatalytic network from an available set of elements is a fundamental step in early evolutionary processes, such as the origin of metabolism. Given the set of elements, the reactions between them (chemical or otherwise), and with various elements catalysing certain reactions, a Reflexively Autocatalytic F-generated (RAF) set is a subset <i>R</i><span>(')</span> of reactions that is self-generating from a given food set, and with each reaction in <i>R</i><span>(')</span> being catalysed from within <i>R</i><span>(')</span>. RAF theory has been applied to various phenomena in theoretical biology, and a key feature of the approach is that it is possible to efficiently identify and classify RAFs within large systems. This is possible because RAFs can be described as the (nonempty) subsets of the reactions that are the fixed points of an (efficiently computable) interior map that operates on subsets of reactions. Although the main generic results concerning RAFs can be derived using just this property, we show that for systems with at least 12 reactions there are generic results concerning RAFs that cannot be proven using the interior operator property alone.\u0000</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54227284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Targeted Hypermutation as a Survival Strategy: A Theoretical Approach 靶向超突变作为一种生存策略:一种理论方法

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-09-05 DOI: 10.1007/s10441-023-09471-9

Seymour Garte

引用次数: 0

Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes 细分种群总体方差有效大小的评估及其与其他有效大小的关系

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-07-17 DOI: 10.1007/s10441-023-09470-w

Ola Hössjer, Linda Laikre, Nils Ryman

{"title":"Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes","authors":"Ola Hössjer, Linda Laikre, Nils Ryman","doi":"10.1007/s10441-023-09470-w","DOIUrl":"10.1007/s10441-023-09470-w","url":null,"abstract":"<div><p>The variance effective population size (<span>(N_{eV})</span>) is frequently used to quantify the expected rate at which a population’s allele frequencies change over time. The purpose of this paper is to find expressions for the global <span>(N_{eV})</span> of a spatially structured population that are of interest for conservation of species. Since <span>(N_{eV})</span> depends on allele frequency change, we start by dividing the cause of allele frequency change into genetic drift within subpopulations (<i>I</i>) and a second component mainly due to migration between subpopulations (<i>II</i>). We investigate in detail how these two components depend on the way in which subpopulations are weighted as well as their dependence on parameters of the model such a migration rates, and local effective and census sizes. It is shown that under certain conditions the impact of <i>II</i> is eliminated, and <span>(N_{eV})</span> of the metapopulation is maximized, when subpopulations are weighted proportionally to their long term reproductive contributions. This maximal <span>(N_{eV})</span> is the sought for global effective size, since it approximates the gene diversity effective size <span>(N_{eGD})</span>, a quantifier of the rate of loss of genetic diversity that is relevant for conservation of species and populations. We also propose two novel versions of <span>(N_{eV})</span>, one of which (the backward version of <span>(N_{eV})</span>) is most stable, exists for most populations, and is closer to <span>(N_{eGD})</span> than the classical notion of <span>(N_{eV})</span>. Expressions for the optimal length of the time interval for measuring genetic change are developed, that make it possible to estimate any version of <span>(N_{eV})</span> with maximal accuracy.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10441-023-09470-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Social Pressure from a Core Group can Cause Self-Sustained Oscillations in an Epidemic Model 在流行病模型中，来自核心群体的社会压力可能导致自我持续振荡

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-06-22 DOI: 10.1007/s10441-023-09469-3

A. P. Baccili Jr., L. H. A. Monteiro

{"title":"Social Pressure from a Core Group can Cause Self-Sustained Oscillations in an Epidemic Model","authors":"A. P. Baccili Jr., L. H. A. Monteiro","doi":"10.1007/s10441-023-09469-3","DOIUrl":"10.1007/s10441-023-09469-3","url":null,"abstract":"<div><p>Let the individuals of a population be divided into two groups with different personal habits. The core group is associated with health risk behaviors; the non-core group avoids unhealthy activities. Assume that the infected individuals of the core group can spread a contagious disease to the whole population. Also, assume that cure does not confer immunity. Here, an epidemiological model written as a set of ordinary differential equations is proposed to investigate the infection propagation in this population. In the model, migrations between these two groups are allowed; however, the transitions from the non-core group into the core group prevail. These migrations can be either spontaneous or stimulated by social pressure. It is analytically shown that, in the scenario of spontaneous migration, the disease is either naturally eradicated or chronically persists at a constant level. In the scenario of stimulated migration, in addition to eradication and constant persistence, self-sustained oscillations in the number of sick individuals can also be found. These analytical results are illustrated by numerical simulations and discussed from a public health perspective.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9738939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Information in Evolutionary Biology 信息在进化生物学中的作用

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-05-15 DOI: 10.1007/s10441-023-09468-4

Thomas E. Dickins

引用次数: 0