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Acta medica Academiae Scientiarum Hungaricae最新文献

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Pancreatic tissue pH in experimental acidosis and alkalosis. 实验性酸中毒和碱中毒的胰腺组织pH值。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
S Farkas, J Lantos, G Halmágyi, Z Molnár
{"title":"Pancreatic tissue pH in experimental acidosis and alkalosis.","authors":"S Farkas,&nbsp;J Lantos,&nbsp;G Halmágyi,&nbsp;Z Molnár","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pH was studied in pancreatic tissue and arterial blood in 22 dogs. Respiratory acidosis was induced by CO2 inhalations in 5 dogs, respiratory alkalosis by hyperventilation in 5 dogs, metabolic acidosis by intravenous(i.v.) infusion of 0.1 N HCl in 5 dogs, metabolic alkalosis by i.v. infusion of 4.2% Na bicarbonate in 5 dogs. The differences between the shifts of blood pH and tissue pH were not significant statistically. Infusion of Ringer's solution failed to affect the pH in blood and pancreatic tissue in two control animals. It is concluded, that with an adequate tissue blood flow the pancreatic tissue pH is uninformative unless the blood pH is known.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17832453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental evidence for cytoprotective effect of atropine on the rat gastric mucosa. 阿托品对大鼠胃粘膜细胞保护作用的实验证据。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
G Mózsik, L Lovász, G Kutor, L Nagy, F Tárnok
{"title":"Experimental evidence for cytoprotective effect of atropine on the rat gastric mucosa.","authors":"G Mózsik,&nbsp;L Lovász,&nbsp;G Kutor,&nbsp;L Nagy,&nbsp;F Tárnok","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The inhibitory effect of atropine on the gastric mucosal damage produced by topical aspirin has been studied in the rat, in the presence and in the absence of intragastrically applied 160 mmole/l HCl. The gastric mucosal damage was produced by aspirin given intragastrically in doses of 192 mg/kg. The topical application was done alone or in the presence of 160 mmole/l HCl. The ulcer incidence, the number and size of gastric mucosal damage were studied during 4 h. The aspirin solutions were administered with or without atropine (in doses of 4 and 10 mg/kg). The atropine was added immediately after the administration of aspirin. The results were as follows 1. A dose-dependent inhibition of ulcer incidence, number and size of gastric mucosal damage was produced by atropine in both groups of animals, when the aspirin was given alone or together with 160 mmole/l HCl; 2. The inhibitory effect of atropine was significantly weaker in the group treated with aspirin plus 160 mmole/l HCl than in th aspirin-treated group. It has been concluded the ulcer-preventing effect of atropine is mediated partly through the inhibition of gastric H+ secretion, and partly some \"cytoprotective effect\"; the extent of the \"cytoprotective effect\" of atropine was about half that on gastric H+ secretion.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18248494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of triiodinated contrast media on the blood flow of isolated jejunal loop. 三碘化造影剂对离体空肠袢血流的影响。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
I Bali, N Kovács, G A Bálint, J Kelemen
{"title":"Effect of triiodinated contrast media on the blood flow of isolated jejunal loop.","authors":"I Bali,&nbsp;N Kovács,&nbsp;G A Bálint,&nbsp;J Kelemen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies on isolated canine jejunal loops revealed that hypertonic solutions of triiodinated contrast media produce a significant increase in intestinal blood flow together with a significant elevation of intraluminal pressure. The effect involves two factors, hyperosmolality and the nature of the medium itself.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18464838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Influence of drinking water supply on iodine metabolism by experimental animals]. [饮水对实验动物碘代谢的影响]。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
K Hartmann, A Weber, N Hartmann
{"title":"[Influence of drinking water supply on iodine metabolism by experimental animals].","authors":"K Hartmann,&nbsp;A Weber,&nbsp;N Hartmann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18464843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic and hepatic changes in guinea pigs after immunization with vascular tissue antigens. Immunological and immune electron microscopic studies. 血管组织抗原免疫后豚鼠主动脉和肝脏的变化。免疫学和免疫电镜研究。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
J Fehér, G Filipp, M Horváth, E Fehér
{"title":"Aortic and hepatic changes in guinea pigs after immunization with vascular tissue antigens. Immunological and immune electron microscopic studies.","authors":"J Fehér,&nbsp;G Filipp,&nbsp;M Horváth,&nbsp;E Fehér","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human vascular tissue antigens were administered to guinea pigs for the study of humoral immune responses and of the microscopic and ultrastructural features of the changes produced in the aorta and liver. Immunization was followed by a definite humoral reaction. The passive haemagglutination test gave a cross reaction between the two antigenic effects. Histologic, immunofluorescent and electron microscopic studies revealed changes in the intima and the liver structure. IgG-containing immunocomplexes were demonstrable by means of ferritin-labelled monospecific antiserum in the aortic endothelium and hepatocytes.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18466925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune complex phagocytosis of human peripheral blood polymorphonuclear leukocytes. 人外周血多形核白细胞的免疫复合物吞噬作用。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
K Török, P Gergely, G Petrányi
{"title":"Immune complex phagocytosis of human peripheral blood polymorphonuclear leukocytes.","authors":"K Török,&nbsp;P Gergely,&nbsp;G Petrányi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An increased percentage of intracellular immunoglobulin containing-polymorphonuclear (PMN) leukocytes was found in patients with elevated level of circulating immune complexes. A more pronounced increase of positive cells was observed when PMN leukocytes of normal controls or patients were incubated in the presence of serum derived from patients with an elevated level of circulating immune complexes. Sera from patients with a normal immune complex level did not cause such an increase. Since both autologous and allogeneic serum (with higher immune complex levels) increased the percentage of positive cells of patients with elevated circulating immune complex levels, it is not likely that a \"saturated\" state would occur in these patients.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18466927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes induced by O-xylene inhalations in the rat liver. 邻二甲苯吸入对大鼠肝脏的影响。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
E Tátrai, G Ungváry
{"title":"Changes induced by O-xylene inhalations in the rat liver.","authors":"E Tátrai,&nbsp;G Ungváry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rats subjected to inhalation of 3500 ppm o-xylene for 6 weeks were found to increase their body-weight at a lower rate than did the controls, despite an increased food and fluid intake, and to develop hepatic enlargement. Post mortem studies revealed no other abnormality. The distribution of the hepatocellular nuclei according to size was, however, modified. The proportion of large nuclei was higher in the test animals than in the controls, and the number of cells per unit area was lower, as a sign of cellular hypertrophy. Electron microscopic studies revealed a loss of glycogen, and increase of rough and smooth endoplasmic reticulum and of peroxisomes. These changes which are typical of the adaptational phase of poisoning may be connected with the induction of the mixed function oxidase system. Enzyme histochemical and ultrastructural studies also revealed a slight hepatocellular damage.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18467831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monocyte chemotaxis and effect of levamisole in Hodgkin's disease. 左旋咪唑在霍奇金病中的单核细胞趋化性及作用。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
K Lukács, G Frendl, E Berényi, M Kávai, G Szabó, G Szegedi
{"title":"Monocyte chemotaxis and effect of levamisole in Hodgkin's disease.","authors":"K Lukács,&nbsp;G Frendl,&nbsp;E Berényi,&nbsp;M Kávai,&nbsp;G Szabó,&nbsp;G Szegedi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monocyte chemotaxis and its response to levamisole were studied in patients with Hodgkin's disease. Levamisole caused a significant improvement of the deficient monocyte chemotaxis of the patients. By enhancing monocyte functions including chemotaxis, levamisole may contribute to the improvement of cellular immune reactivity, thus increasing the resistance to infections and prolonging the periods of remission.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18466926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between the dipole moment and rate of absorption of drugs. 偶极矩与药物吸收率的关系。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
T Past, Z Tapsonyi, I Hortobágyi
{"title":"Relationship between the dipole moment and rate of absorption of drugs.","authors":"T Past,&nbsp;Z Tapsonyi,&nbsp;I Hortobágyi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ten drugs were measured for the rate of buccal absorption and examined for the relationships between the rate constant for absorption and molecular physicochemical parameters. On the ground of the results the molecular dipole moment seems to provide more reliable information on the rate constant of buccal absorption than does the water-lipid partition coefficient or the diffusion constant. Additional perfusion studies on isolated gut were also performed in some cases. A mathematical model was developed for the calculation of the rate constants for those cases in which pH of the system changes linearly with the logarithm of time.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11265713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of His bundle recording to study disorders of atrioventricular and intraventricular conduction. 应用他束记录研究房室及室内传导障碍。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
G Veress, J Borbola, L Szatmáry
{"title":"Application of His bundle recording to study disorders of atrioventricular and intraventricular conduction.","authors":"G Veress,&nbsp;J Borbola,&nbsp;L Szatmáry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper briefly describes the techniques available for evaluation of conduction in our catheterization laboratory. The application of the technique for recording His-bundle potentials has greatly enhanced our understanding of rhythm and conduction disturbances and has provided useful and important information in the management of atrioventricular and intraventricular conduction disorders.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11750488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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