Aortic and hepatic changes in guinea pigs after immunization with vascular tissue antigens. Immunological and immune electron microscopic studies.

Abstract

Human vascular tissue antigens were administered to guinea pigs for the study of humoral immune responses and of the microscopic and ultrastructural features of the changes produced in the aorta and liver. Immunization was followed by a definite humoral reaction. The passive haemagglutination test gave a cross reaction between the two antigenic effects. Histologic, immunofluorescent and electron microscopic studies revealed changes in the intima and the liver structure. IgG-containing immunocomplexes were demonstrable by means of ferritin-labelled monospecific antiserum in the aortic endothelium and hepatocytes.