Acta medica Academiae Scientiarum Hungaricae最新文献_第8页

Platelet turnover and megakaryocytopoiesis in ITP. ITP的血小板周转和巨核细胞生成。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

T Burger, J Schnell, M Schmelczer

引用次数: 0

Diagnostic and therapeutic aspects of splenectomy in syndromes associated with hypersplenia. 脾切除术对脾功能亢进综合征的诊断和治疗。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

A Patakfalvi

引用次数: 0

Significance of premature contractions of WPW type in the acute phase of myocardial infarction. 心肌梗死急性期WPW型早缩的意义。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

L Regös, Z Antalóczy

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A comparative molecular--pharmacological study of drugs inhibiting Na+--K+-dependent ATPase separated from human gastric fundic mucosa. (One receptor system and more drugs). 抑制人胃底黏膜Na+- K+依赖性atp酶药物的分子药理学比较研究。(一个受体系统和更多的药物)。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

G Mózsik, J Kutas, L Nagy, F Tárnok

{"title":"A comparative molecular--pharmacological study of drugs inhibiting Na+--K+-dependent ATPase separated from human gastric fundic mucosa. (One receptor system and more drugs).","authors":"G Mózsik, J Kutas, L Nagy, F Tárnok","doi":"","DOIUrl":"","url":null,"abstract":"The inhibitory effects of atropine, epinephrine, cyclic 3', 5'-AMP (cAMP), the prostaglandins E1 (PGE1) and E2 (PGE2) pentagastrin, histamine and ouabain have been studied on the activity of Na+--K+-dependent ATPase obtained from human gastric fundic mucosa. This study compares the sensitivity of the enzyme to a variety of drugs, applying the law of one receptor and more drugs. It was found that (1) the doses of drugs necessary to produce 50% inhibition to Na+--K+-dependent ATPase activity (affinity, pD2 value) significantly differ from each other C (atropine, 9.50; epinephrine, 8.60; cAMP: 11.30; PGE1, 9.30; PGE2, 9.45; pentagastrin, 9.45; histamine, 9.70 and ouabain, 9.50); (2) the intrinsic activities of drugs to Na+--K+-dependent, ATPase in comparison with ouabain (alpha=1.00) differ: atropine, PGE1, PGE2 and histamine, 1.00; pentagastrin, 0.87; cAMP, 0.48 and epinephrine, 0.41; (3) the inhibitory effects of different drugs, on Na+--K+-dependent ATPase system, depend on the magnitude of enzyme activity from human gastric fundic mucosa. It has been concluded that (1) the sensitivity of these drugs to the Na+--K+-dependent ATPase system and to the adenylate cyclase system, both obtained from human gastric mucosa, significantly differs from each other; (2) the main effect of pentagastrin and histamine on human gastric secretory function differs from the function of Na+--K+-dependent ATPase system; (3) the role of Na+--K+-dependent ATPase system and of adenylate cyclase can be separated pharmacologically from the point of view of human gastric H+ secretion.","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":"36 4","pages":"459-66"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11448127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical and energetic gradients in the mucosa of stomach and duodenum of patients with antral ulcer. 胃窦溃疡患者胃、十二指肠黏膜的生化和能量梯度。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

G Mózsik, J Kutas, L Nagy, F Tárnok

{"title":"Biochemical and energetic gradients in the mucosa of stomach and duodenum of patients with antral ulcer.","authors":"G Mózsik, J Kutas, L Nagy, F Tárnok","doi":"","DOIUrl":"","url":null,"abstract":"Separation and measurement of adenine-adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), lipid phosphates, RNA and DNA, further, separation and measurement of Mg2+-dependent, total (Mg2+-dependent plus Na+--K+-dependent, Mg2+-Na+-K-dependent) and Na+-K+-dependent ATPases were carried out in the mucosa and muscles of the corpus, antrum and duodenum of 68 patients with antral ulcer. It was found that (1) the substrate levels of adenosine nucleotides, lipid phosphates and RNA were significantly higher in the corpus mucosa than those in the mucosa of the antrum and duodenum (calculated for 1.0 mg DNA content); (2) the amounts of adenosine nucleotides and the sum of ATP + ADP + AMP did not alter significantly in the muscles of the corpus, antrum and duodenum; (3) the levels of adenosine nucleotides, sum of ATP + ADP + AMP, lipid phosphates and RNA, further the activities of Mg2+-dependent , total (Mg2/-dependent plus Na+-K+-dependent) and Na+-K+-dependent ATPases were significantly higher in the corpus mucosa than those in the corpus muscles. It was concluded that (1) energetic and biochemical gradients are present between the substrate levels in the mucosa of the corpus, antrum and duodenum; (2) the neural and/or humoral regulatory mechanisms differ in the mucosa and muscles of the corpus, in order to their biochemistry.","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":"36 4","pages":"449-57"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11316110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levamisole in the treatment of Hodgkin's disease. 左旋咪唑治疗何杰金氏病

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

E Berényi, M Kávai, M Szabolcsi, G Szegedi

{"title":"Levamisole in the treatment of Hodgkin's disease.","authors":"E Berényi, M Kávai, M Szabolcsi, G Szegedi","doi":"","DOIUrl":"","url":null,"abstract":"In vitro and in vivo action of levamisole has been studied in patients with Hodgkin's disease. In vitro levamisole significantly increased the active T cell count of 35 untreated active patients, of those being in complete remission after treatment and of 19 healthy controls; it significantly raised the total T cell count of patients. However, levamisole could not further improve the considerably increased active and total spontaneous rosette formation resulting from in vivo levamisole treatment. Twenty patients with Hodgkin's disease, being in complete remission, were given levamisole for 3 or 6 months, according to 2 different schedules. Levamisole (150 mg) given on 3 consecutive days of every second week for 3 months considerably increased the number of positive skin tests (from 8/60 to 29/60), the numbers of active and total T cells with unchanged absolute lymphocyte count, and decreased the quantity of circulating immune complex. Continuation of treatment for another 3 months resulted in slight, but consistent, decline in all the above parameters; the ratio of active T cells significantly decreased. This decline was even more pronounced if a raised larger dosage of levamisole was administered for 6 months. In the course of the treatment no side-effect or complication was observed. Levamisole is able to improve the weak cellular immune reactivity of patients with Hodgkin's disease, it can, however, result in undesired suppression in the case of too long treatment with high dose.","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":"36 2","pages":"177-85"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11531063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood coagulation abnormalities in the Schönlein-Henoch syndrome in adults. 成人Schönlein-Henoch综合征的凝血功能异常。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

G Boros, L Gofman, J Sámsik, J Nagy, A Hámori, G Deák

{"title":"Blood coagulation abnormalities in the Schönlein-Henoch syndrome in adults.","authors":"G Boros, L Gofman, J Sámsik, J Nagy, A Hámori, G Deák","doi":"","DOIUrl":"","url":null,"abstract":"23 adult patients with Schönlein-Henoch's syndrome were observed between 1965 and 1976. Nephropathy was noted in 18, gastrointestinal bleedings in 13, thrombosis of legs in 4, cases. Haemostasis was studied in the successive phases of the process on 185 occasions altogether. The studies included four different capillary tests, thromboelastography, the Gerendás coagulogram, determination of partial thromboplastin time and two platelet-function tests. Additional renal biopsy was performed in 10 cases, mesocolon and skin biopsy in one case each. The results of at least one of the capillary tests were found positive in each of the patients in some stage of the process. The coagulation status was marked by hyperocagulability either in itself or combined with laboratory signs of hypocoagulability. Immunohistological study of the biopsy specimens revealed glomerular fibrin deposits in 7 cases. On the evidence of the follow-up studies the laboratory tests may be used for the assessment of the activity of the process. The alternatives of local intravascular coagulation (LIC) or of compensated diffuse intravascular coagulation (DIC) are offered for the interpretation of hypercoagulability.","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":"36 2","pages":"151-66"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11606174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IXth Hungarian Endocrinological Congress, Szeged, July 2--4, 1979. Abstracts. 第8届匈牙利内分泌学大会，塞格德，1979年7月2- 4日。摘要。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

引用次数: 0

Correlation between hepatic transport of cholephilic organic anions and their effect on hepatic mitochondrial respiration. 亲胆性有机阴离子的肝脏转运及其对肝脏线粒体呼吸的影响。

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

Z Gregus, E Fischer, F Varga

引用次数: 0

Effect of ACTH-stimulated glucocorticoid hypersecretion on the serum concentrations of thyroxine-binding globulin, thyroxine, triiodothyronine, reverse triiodothyronine and on the TSH-response to TRH. 促肾上腺皮质激素刺激下糖皮质激素高分泌对血清甲状腺素结合球蛋白、甲状腺素、三碘甲状腺原氨酸、反三碘甲状腺原氨酸浓度及TRH对tsh反应的影响

Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01

C Bános, J Takó, F Salamon, S Györgyi, R Czikkely

{"title":"Effect of ACTH-stimulated glucocorticoid hypersecretion on the serum concentrations of thyroxine-binding globulin, thyroxine, triiodothyronine, reverse triiodothyronine and on the TSH-response to TRH.","authors":"C Bános, J Takó, F Salamon, S Györgyi, R Czikkely","doi":"","DOIUrl":"","url":null,"abstract":"The responses of serum concentrations of TSH, thyroxine (T4), triiodothyronine (T3) and of reverse triiodothyronine (rT3) to i. v. administration of 0.4 mg THR were examined prior to (and after) i. m. administration of ACTH (2 mg Synacthen Depot) in 7 euthyroid women using estrogen-containing oral contraceptives and in 8 controls, with the following results: (1) an increase in endogenous glucocorticoid secretion is associated with a depression of the TSH response to TRH; (2) TSH formed in decreased amounts is still capable of stimulating thyroid secretion; (3) the increased serum corticoid levels fail to affect the secretory response of the thyroid to TSH; (4) control of the pituitary-thyroid axis remains normal in the presence of increased serum thyroxine-binding globulin (TBG) levels. In a further series the serum levels of TBG, T4, T3, rT3 and cortisol under the effect of ACTH-induced endogenous glucocorticoid hypersecretion were studied in 6 normal untreated controls, in 6 normal women using oral contraceptives and in 10 untreated hyperthyroid patients. During four days subsequent to treatment the serum TBG levels decreased, maximum decrease being found in the users of oral contraceptives, minimum decrease in the controls. Serum T4 was found to decrease during 2 to 4 days, serum T3 parallel with an increase in serum rT3, for 1 to 2 days, subsequent for ACTH loading. In the euthyroid cases also the serum TSH levels showed a transitory decline. It is concluded that in case of endogenous hyperproduction of glucocorticoids (1) T4 leads to T3 monodeiodination decreases and T4 leads to rT3 conversion increases parallel with the changes in the serum cortisol levels; (2) TBG synthesis is inhibited by endogenous glucocorticoids; (3) the changes in serum TBG levels are accompanied by a decrease in the serum T4 concentrations.","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":"36 4","pages":"381-94"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11448125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0