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Bromocryptine therapy in luteal insufficiency. 溴隐亭治疗黄体功能不全。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
G Godó, M Sas, G Falkay
{"title":"Bromocryptine therapy in luteal insufficiency.","authors":"G Godó,&nbsp;M Sas,&nbsp;G Falkay","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifteen cases of female infertility, probably connected with luteal insufficiency, are reported. This abnormality was found to be fairly common in hyperprolactinaemic and clomiphene-treated normoprolactinaemic women with galactorrhoea. Bromocryptine reduces the prolactin-level, prolongs the luteal phase and increases the secretion of progesterone. According to the observations thus far reported, some optimum prolactin concentration seems to be desirable for an adequate luteal function. In the case of luteal insufficiency, estimation of the prolactin and progesterone level in the luteal phase is advocated. The basal temperature curve the hyperthermic phase to be followed up before and after treatment allows.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18207925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lectin-induced suppression of antibody-dependent cellular cytotoxicity (ADCC) of human peripheral blood mononuclear cells. 凝集素诱导的人外周血单个核细胞抗体依赖性细胞毒性(ADCC)抑制。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
P Gergely, I Láng, L Kalmár, R González-Cabello
{"title":"Lectin-induced suppression of antibody-dependent cellular cytotoxicity (ADCC) of human peripheral blood mononuclear cells.","authors":"P Gergely,&nbsp;I Láng,&nbsp;L Kalmár,&nbsp;R González-Cabello","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Incubation of human peripheral blood mononuclear cells in the presence of 25 mg/l concanavalin A (Con A) or 2 mg/l phytohaemagglutinin (PHA) suppressed their ADCC activity. Thirty-minute incubation with the mitogens resulted in a significant decrease in ADCC activity. The effect was more striking with longer (24 and 48 h) incubation. The suppressive effect of PHA was abolished after 6 days incubation, while no such phenomenon was observed with Con A. Macrophages participating in the ADCC reaction were not influenced by the lectin treatment, though their removal increased the suppressive effect. The lectin-induced suppression of ADCC activity did not correlate with the suppression of Con A-induced blastogenesis. The suppressive effect of lectins on ADCC is not mediated through suppressor cells, but rather represents a direct action of ligands on the (killer) lymphocyte membranes, resulting probably in an altered metabolism, or inhibition of membrane mobility or lymphocyte locomotion.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18248493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qualitative differences in the hepatobiliary transport of sulfobromophthalein (BSP) and its glutathione conjugate (BSP-GSH). 硫代溴代眼啡(BSP)及其谷胱甘肽偶联物(BSP- gsh)肝胆运输的质的差异。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
Z Gregus, E Fischer
{"title":"Qualitative differences in the hepatobiliary transport of sulfobromophthalein (BSP) and its glutathione conjugate (BSP-GSH).","authors":"Z Gregus,&nbsp;E Fischer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of phenobarbital pretreatment (PB; 75 mg/kg i.p. once daily for 5 days) and the simultaneous administration of taurocholate (TC; 200 mumol/kg i.v.), eosin(EO; 40-160 mumol/kg i.v.) and iodoxamic acid (IA; 125--500 mumol/kg i.v.) on the hepatic uptake and biliary excretion of BSP (30--120 mumol/kg i.v.) and BSP--GSH (40--160 mumol/kg i.v.) was investigated on diethyl maleate (DEM)-pretreated rats. The biliary excretion of BSP was not influenced by PB and EO, while it was increased by TC and decreased by IA. In contrast, the excretion of BSP--GSH was not influenced by TC or IA, it was stimulated by PB and inhibited by EO. In the different experimental conditions the hepatic uptake of BSP and BSP--GSH changed similarly: PB did not influence, TC, EO and IA decreased the accumulation of BSP and BSP--GSH in the liver. These results indicate that qualitative differences exist in the hepatobiliary transport of BSP and BSP--GSH, which manifest themselves following their hepatic uptake.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17226983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The alpha-1-antitrypsin--trypsin complex in acute pancreatitis. 急性胰腺炎中的-1-抗胰蛋白酶-胰蛋白酶复合物。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
G Domján, E Tassonyi
{"title":"The alpha-1-antitrypsin--trypsin complex in acute pancreatitis.","authors":"G Domján,&nbsp;E Tassonyi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Production in acute pancreatitis of the trypsin-alpha-1-antitrypsin complex was studied by means of two-dimensional immunoelectrophoresis. The complex was found to appear a few hours after the first clinical manifestations and to be demonstrable for 3 to 4 weeks. The diagnostic possibilities of the method are discussed.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18019331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levamisole treatment of acute viral hepatitis and HBsAG-positive chronic active hepatitis. 左旋咪唑治疗急性病毒性肝炎和hbsag阳性慢性活动性肝炎。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
A Pár, K Barna, G Bajtai, I Hollós, M Ambrus, M Kovács, T Jávor
{"title":"Levamisole treatment of acute viral hepatitis and HBsAG-positive chronic active hepatitis.","authors":"A Pár,&nbsp;K Barna,&nbsp;G Bajtai,&nbsp;I Hollós,&nbsp;M Ambrus,&nbsp;M Kovács,&nbsp;T Jávor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A fundamental role is attributed to the pathological immune response in the development of chronic hepatitis B. By virtue of its non-specific immune modulatory effect, levamisole is capable of improving impaired T-cell function. Hence, studies with treated and control groups were performed in determine the effect of levamisole in acute viral hepatitis and chronic active hepatitis B. In acute hepatitis B, levamisole promoted the normalization of GPT, the elimination of HBsAg; this improvement was preceded by higher GPT values and increased titres of IgG, IgA, and of anti-HBcore. In chronic active hepatitis in the first few months of treatment a moderate increase of the GPT and HBsAg levels occurred, followed later by a decrease of these values. At the same time the phytohaemagglutinin reactivity of lymphocytes increased, and so did the ratio of circulating active T-cells.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18467833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time course of the effects of phenobarbital on biliary flow and on the biliary excretion of bromcresol green in rats. 苯巴比妥对大鼠胆道流量及溴甲酚绿胆排泄影响的时间过程。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
E Fischer, Z Gregus
{"title":"Time course of the effects of phenobarbital on biliary flow and on the biliary excretion of bromcresol green in rats.","authors":"E Fischer,&nbsp;Z Gregus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Biliary flow and the biliary excretion of bromcresol green were measured in rats injected i.p. with a single dose of phenobarbital, 75 mg/kg. Biliary flow began to increase 6 h after the injection, it reached a peak at 36 h and returned to the control level at 72 h. In the same rats, the enhanced biliary excretion of bromcresol green was first observed at 12 h, it reached a peak at 24 h and returned to the control level at 72 h. Other groups of rats received 75 mg/kg phenobarbital as daily i.p. dose over 5 days. In these groups, the increase in biliary flow did not exceed that measured in the rats given the single dose, however, the biliary excretion of bromcresol green reached its peak after a 4-day phenobarbital treatment. After the 5th day of treatment the biliary flow and the biliary excretion of bromcresol green remained significantly stimulated for 4 days and the changes in these parameters regressed on the fifth day following the last injection of phenobarbital. The changes in liver weight appeared not to run closely parallel either with the increase in biliary flow or with the enhancement of biliary excretion of bromcresol green. It is suggested that the changes in biliary flow and in the biliary excretion of bromcresol green take place by different mechanisms after phenobarbital administration.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18467836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of calcitonin on basal and pentagastrin- and calcium-stimulated gastric acid secretion in patients with duodenal ulcer. 降钙素对十二指肠溃疡患者基础胃酸分泌、胃泌素和钙刺激胃酸分泌的影响。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
I Kisfalvi, P Földvári, K Szücs
{"title":"Effect of calcitonin on basal and pentagastrin- and calcium-stimulated gastric acid secretion in patients with duodenal ulcer.","authors":"I Kisfalvi,&nbsp;P Földvári,&nbsp;K Szücs","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Synthetic salmon calcitonin infused intravenously in a pharmacological dose of 2 MRCU/kg/hour resulted in an abrupt and profound inhibition of basal and pentagastrin and calcium induced gastric acid secretion in patients with duodenal ulcer. The inhibition in the sixth 15-minute period of the intravenous infusion of calcitonin amounted to 98.7% (basal acid secretion), 51.8% (pentagastrin-stimulated acid secretion) and 80.9% (calcium-induced acid secretion). There were no significant alterations in the serum calcium and gastrin levels during the intravenous infusion of calcitonin. The slight decrease in serum gastrin concentration in the first 30 minutes of calcitonin infusion cannot explain the strong inhibition of gastric acid secretion produced by calcitonin. It is assumed that calcitonin inhibits directly the parietal cells.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18466923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal absorption in the aged. 老年人肠道吸收。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
L Pénzes
{"title":"Intestinal absorption in the aged.","authors":"L Pénzes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The difficulties of differentiating functional disorders from organic diseases of the intestinal tract in old age are well known. It is also known that the age-related structural changes of the digestive tract are inconclusive of any functional disorder. This has raised the question whether the process of aging is bound to affect the absorption of d-glucose and the amino acids (gly, ala, val, thr, leu, phe, try, pro, his, lys and arg). The results of the present rat experiments, which have been undertaken under a kinetic approach, indicate that the intestinal carrier affinity to the molecules available for transport declines with aging. This implicates that in the young animal the transport of the absorbed molecules from the intestinal lumen at low (initial) concentrations proceeds at a higher rate than it does in the old animal. The reverse was found to be the case for the basic amino acids.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18466932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of atropine on different phases of pancreatic secretion in conscious rats. 阿托品对清醒大鼠不同时期胰腺分泌的影响。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
A Pap, H Sarles
{"title":"Effect of atropine on different phases of pancreatic secretion in conscious rats.","authors":"A Pap,&nbsp;H Sarles","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of submaximal doses of intravenous atropine and their combination with topical anaesthesia of the intestine by oxethazaine-HCl was investigated in conscious rats. I. Basal water, bicarbonate and protein secretion were significantly augmented after diversion of pancreatic juice. On the basis of the protein secretory pattern of basal secretion, 2 stable stages have been recognized: 1. The most physiological basal stage during return of pancreatic juice. 2. The first, highly elevated plateau from the 4th to the 7th 30 min period after diversion. 3. The second delayed and less elevated plateau after 240 min diversion. II. Atropine greatly suppressed protein secretion during recirculation but only moderately after diversion of juice, and during the first plateau an atropine resistant peak appeared. Inhibition of water secretion was equal during all the stages. Atropine infusion resulted in a further decrease in pancreatic secretion also after topical anaesthesia of the intestine. It was concluded that atropine had a complex effect on pancreatic secretion: it possibly decreased the CCK release in the first period after diversion but not later, and decreased the duodenopancreatic reflexes and other factors of the cholinergic tone.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17942432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemotactic response of polymorphonuclear leukocytes to corneal tissue extracts. 多形核白细胞对角膜组织提取物的趋化反应。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1980-01-01
I Hatvani, L Bordán, C Balázs, A Leövey
{"title":"Chemotactic response of polymorphonuclear leukocytes to corneal tissue extracts.","authors":"I Hatvani,&nbsp;L Bordán,&nbsp;C Balázs,&nbsp;A Leövey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The chemotactic response of polymorphonuclear leukocytes of normal subject, to corneal extracts of 0.2 and 0.4 mg/dl protein concentration were studied in blind-well type chemotactic chambers. E. coli endotoxin served for the positive, Rindex-5 fluid for the negative controls. The chemotactic response to corneal tissue extracts, as compared to random migration in the Rindex-5 medium, proved significant. It is suggested that chemotactic factors may be released from corneal grafts in vivo too, in consequence of diverse noxae. These factors are supposed to elicit a granulocytic invasion and to lead to an opacification of the graft as a result of a cellular reaction.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18053352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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