阿托品对大鼠胃粘膜细胞保护作用的实验证据。

G Mózsik, L Lovász, G Kutor, L Nagy, F Tárnok
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引用次数: 0

摘要

在大鼠实验中,研究了阿托品对外用阿司匹林引起的胃粘膜损伤的抑制作用,以及在有和没有160 mmol /l盐酸的情况下。胃粘膜损伤是由阿司匹林以192 mg/kg剂量灌胃引起的。局部应用单独或存在160摩尔/升HCl。在4 h内观察溃疡发生率、胃黏膜损伤的数量和大小。阿司匹林溶液分别与阿托品(4和10 mg/kg)合用或不合用。服用阿司匹林后立即加入阿托品。结果如下:1。在两组动物中,当阿司匹林单独或与160 mmol /l HCl一起给药时,阿托品对溃疡发生率、胃粘膜损伤数量和大小均产生剂量依赖性抑制;2. 阿斯匹林加160 mmol /l盐酸组阿托品的抑制作用明显弱于阿斯匹林组。认为阿托品的预防溃疡作用部分是通过抑制胃H+分泌,部分是通过某种“细胞保护作用”;阿托品的“细胞保护作用”约为胃H+分泌的一半。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experimental evidence for cytoprotective effect of atropine on the rat gastric mucosa.

The inhibitory effect of atropine on the gastric mucosal damage produced by topical aspirin has been studied in the rat, in the presence and in the absence of intragastrically applied 160 mmole/l HCl. The gastric mucosal damage was produced by aspirin given intragastrically in doses of 192 mg/kg. The topical application was done alone or in the presence of 160 mmole/l HCl. The ulcer incidence, the number and size of gastric mucosal damage were studied during 4 h. The aspirin solutions were administered with or without atropine (in doses of 4 and 10 mg/kg). The atropine was added immediately after the administration of aspirin. The results were as follows 1. A dose-dependent inhibition of ulcer incidence, number and size of gastric mucosal damage was produced by atropine in both groups of animals, when the aspirin was given alone or together with 160 mmole/l HCl; 2. The inhibitory effect of atropine was significantly weaker in the group treated with aspirin plus 160 mmole/l HCl than in th aspirin-treated group. It has been concluded the ulcer-preventing effect of atropine is mediated partly through the inhibition of gastric H+ secretion, and partly some "cytoprotective effect"; the extent of the "cytoprotective effect" of atropine was about half that on gastric H+ secretion.

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