Levamisole treatment of acute viral hepatitis and HBsAG-positive chronic active hepatitis.

A Pár, K Barna, G Bajtai, I Hollós, M Ambrus, M Kovács, T Jávor
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Abstract

A fundamental role is attributed to the pathological immune response in the development of chronic hepatitis B. By virtue of its non-specific immune modulatory effect, levamisole is capable of improving impaired T-cell function. Hence, studies with treated and control groups were performed in determine the effect of levamisole in acute viral hepatitis and chronic active hepatitis B. In acute hepatitis B, levamisole promoted the normalization of GPT, the elimination of HBsAg; this improvement was preceded by higher GPT values and increased titres of IgG, IgA, and of anti-HBcore. In chronic active hepatitis in the first few months of treatment a moderate increase of the GPT and HBsAg levels occurred, followed later by a decrease of these values. At the same time the phytohaemagglutinin reactivity of lymphocytes increased, and so did the ratio of circulating active T-cells.

左旋咪唑治疗急性病毒性肝炎和hbsag阳性慢性活动性肝炎。
病理免疫反应在慢性乙型肝炎的发展中起着重要作用。通过其非特异性免疫调节作用,左旋咪唑能够改善受损的t细胞功能。因此,对治疗组和对照组进行研究,以确定左旋咪唑在急性病毒性肝炎和慢性活动性乙型肝炎中的作用。在急性乙型肝炎中,左旋咪唑促进GPT正常化,消除HBsAg;在此改善之前,GPT值升高,IgG、IgA和anti-HBcore的滴度增加。在慢性活动性肝炎治疗的最初几个月,GPT和HBsAg水平出现中度升高,随后这些值又下降。与此同时,淋巴细胞的植物血凝素反应性增加,循环活性t细胞的比例也增加了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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