Time course of the effects of phenobarbital on biliary flow and on the biliary excretion of bromcresol green in rats.

E Fischer, Z Gregus
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Abstract

Biliary flow and the biliary excretion of bromcresol green were measured in rats injected i.p. with a single dose of phenobarbital, 75 mg/kg. Biliary flow began to increase 6 h after the injection, it reached a peak at 36 h and returned to the control level at 72 h. In the same rats, the enhanced biliary excretion of bromcresol green was first observed at 12 h, it reached a peak at 24 h and returned to the control level at 72 h. Other groups of rats received 75 mg/kg phenobarbital as daily i.p. dose over 5 days. In these groups, the increase in biliary flow did not exceed that measured in the rats given the single dose, however, the biliary excretion of bromcresol green reached its peak after a 4-day phenobarbital treatment. After the 5th day of treatment the biliary flow and the biliary excretion of bromcresol green remained significantly stimulated for 4 days and the changes in these parameters regressed on the fifth day following the last injection of phenobarbital. The changes in liver weight appeared not to run closely parallel either with the increase in biliary flow or with the enhancement of biliary excretion of bromcresol green. It is suggested that the changes in biliary flow and in the biliary excretion of bromcresol green take place by different mechanisms after phenobarbital administration.

苯巴比妥对大鼠胆道流量及溴甲酚绿胆排泄影响的时间过程。
用单剂量苯巴比妥75 mg/kg腹腔注射大鼠,测定胆道流量和溴甲酚绿的胆道排泄。注射后6 h胆道流量开始增加,36 h达到峰值,72 h恢复到对照水平。同一大鼠胆道中溴甲酚绿的排泄量在12 h首次增加,24 h达到峰值,72 h恢复到对照水平。其他各组大鼠给予苯巴比妥75 mg/kg的每日ig剂量,持续5天。在这些组中,胆道流量的增加没有超过单剂量大鼠,但溴甲酚绿的胆道排泄在苯巴比妥治疗4天后达到峰值。治疗第5天后,胆道流量和溴甲酚绿的胆道排泄仍受到显著刺激,持续4天,到最后一次注射苯巴比妥后第5天,这些参数的变化有所回归。肝脏重量的变化似乎与胆道流量的增加或溴甲酚绿胆道排泄的增加并不密切平行。提示苯巴比妥给药后胆道流量和溴甲酚绿排泄的改变可能通过不同的机制发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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