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Acta medica Academiae Scientiarum Hungaricae最新文献

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Comparison of two mathematical descriptions of the cumulative caries prevalence. 累积龋病流行率两种数学描述的比较。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
P Adler, Z Szabó
{"title":"Comparison of two mathematical descriptions of the cumulative caries prevalence.","authors":"P Adler, Z Szabó","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11750490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet and atherogenesis. 饮食和动脉粥样硬化。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
S Seely
{"title":"Diet and atherogenesis.","authors":"S Seely","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11750492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme induction in man: a study of the inducible systems of drug elimination. 人体内的酶诱导:药物消除诱导系统的研究。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
T Horváth, A Gógl, K Simon
{"title":"Enzyme induction in man: a study of the inducible systems of drug elimination.","authors":"T Horváth,&nbsp;A Gógl,&nbsp;K Simon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The individual enzyme inducibility was studied with methods of menthol loading and sulphobromophthalein in groups of patients with low and average metabolism. Both methods are suitable for testing inducible conjugation systems by providing indirect information on the rate of drug elimination. In the low-metabolism groups the response in per cent correlated inversely with the initial value, and the changes were significant not only in the low but also in the average-metabolism group at the end of 30 days of phenobarbital treatment. The results are discussed with regard to the avoidability of undesired drug effects.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11729343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme-inductive effect of a hypolipidemic compound N-bis-(p-chlorophenoxy)-acetyl-urea in man and rat. 降血脂化合物n -双-(对氯苯氧基)-乙酰脲在人和大鼠体内的酶诱导作用。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
A Gógl, K Simon, D Müller, W Klinger, C Ruzsa, Z Vezekényi
{"title":"Enzyme-inductive effect of a hypolipidemic compound N-bis-(p-chlorophenoxy)-acetyl-urea in man and rat.","authors":"A Gógl,&nbsp;K Simon,&nbsp;D Müller,&nbsp;W Klinger,&nbsp;C Ruzsa,&nbsp;Z Vezekényi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Besides its antilipidaemic effect, the new clofibric acid derivative (N-bis-(p-chlorohenoxy)-acetyl-urea) has an enzyme-inductive effect. The drug was administered (100 mg/kg orally) to male, Wistar rats for three days. The treatment raised the weight of the liver, the content of liver microsomal protein and cytochrome p-450 and shortened the hexobarbital sleeping time. The increase of cytochrome p-450 dependent biotransformation was found by in vitro methods in 9000-g supernatant of liver homogenate. There was a growth in biotransformation of substrates of type I (ethylmorphine, aminopyrine) and an extreme increase in reduction of nitrobenzene. We did not find any change in biotransformation of the type-II substrate aniline. In 16 patients suffering from Gilbert's syndrome, there was a decrease in the level of serum bilirubin, and increase of D-glucuric-acid output in urine and bromsulphophthalein transport maximum following the treatment of this drug given in 150 mg/day orally for three weeks. After this treatment, the level of gamma-glutamyl-transpeptides did not change. The authors highly recommend the serious consideration of metabolic interaction during the clinical application.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11729344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measurement of blood loss by total-body counting on the basis of calculated and predicted blood volumes. 在计算和预测血容量的基础上，通过全身计数测量失血量。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
B Keszthelyi, S Lakatos-Novotny, A Tóth
{"title":"Measurement of blood loss by total-body counting on the basis of calculated and predicted blood volumes.","authors":"B Keszthelyi,&nbsp;S Lakatos-Novotny,&nbsp;A Tóth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Blood loss was measured by total-body counting in conformity with the fall in activity, the calculated or predicted blood volumes being known. On the ground of the predicted and calculated blood volumes it was the Nadler formula which gave the best approximation. The method was employed for the measurement of blood loss in users of intrauterine contraceptive spirals. It was found suitable for the measurement of a sudden blood loss of major intensity.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11729347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of His bundle recording in different rhythm disturbances of the heart. 他束记录在不同心律失常中的应用。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
L Szatmáry, J Borbola, G Veress, L Bendig
{"title":"Application of His bundle recording in different rhythm disturbances of the heart.","authors":"L Szatmáry,&nbsp;J Borbola,&nbsp;G Veress,&nbsp;L Bendig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The new intracardiac electrophysiological method: His bundle electrocardiography, combined with the electrophysiological examination used in routine clinical practice, has considerably improved our knowledge of the cardiac dysrhythmias. It helps to localize the focus of the atypical junctional and other supraventricular premature beats complicated with either organic or functional intraventricular conduction disturbance. The various forms of paroxysmal tachycardias can be differentiated more exactly from each other. In pre-excitation syndrome, it has become possible to detect the abnormal pathway and to screen the patients susceptible to life-threatening arrhythmias. By means of this the diagnosis of sick sinus syndrome and estimation of its severity can be made more exactly. In addition to the diagnosis, the electrophysiological examinations connected with pharmacological tests give valuable information whether medical or pacemaker therapy should be applied. Six cases of various forms of cardiac dysrhythmias are presented to demonstrate the superiority of this method.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11757186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of the minimal amount of IgG synthesized within the central nervous system in different neurological diseases. 不同神经系统疾病中中枢神经系统合成IgG最低量的测定。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
L Kerényi, M Koltai, G Pálffy
{"title":"Determination of the minimal amount of IgG synthesized within the central nervous system in different neurological diseases.","authors":"L Kerényi,&nbsp;M Koltai,&nbsp;G Pálffy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The albumin and the IgG were determined in cerebrospinal fluid (CSF) and serum samples from 312 patients by radial immunodiffusion. The correlation between the CSF/serum ratio of IgG and the CSF/serum ratio of albumin was determined by regression analysis in three groups of patients with no signs of IgG synthesis within the central nervous system. The patients were selected on the basis of the state of the blood-CSF barrier, as indicated by the ratio of serum/CSF of albumin. Using the +2 S.D. regression borderlines, the maximal amount of IgG derived from the blood and the minimal amount of IgG synthesized within the central nervous system can be calculated in CSF samples of patients with acute infections and chronic inflammatory diseases.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11341801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the ATP--adenylate cyclase--cAMP system and its pharmacological regulation in the development of gastric hypersecretion and ulceration. ATP-腺苷酸环化酶-cAMP系统及其药理调控在胃高分泌和溃疡发生中的作用。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
G Mózsik, M Fiegler, P Lörincz, L Nagy, F Tárnok
{"title":"The role of the ATP--adenylate cyclase--cAMP system and its pharmacological regulation in the development of gastric hypersecretion and ulceration.","authors":"G Mózsik,&nbsp;M Fiegler,&nbsp;P Lörincz,&nbsp;L Nagy,&nbsp;F Tárnok","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role and pharmacological regulation of the ATP-adenylate-cyclase--cAMP system were studied in the mucosa of the gastric fundus, and in the forestomach, of pylorus-ligated rats to elucidate the development of gastric hypersecretion and ulceration. (1) cAMP content of the tissue of the fundus mucosa and of the forestomach decreased before the significant increase of gastric H+ output and ulcer development; (2) the gastric H+ outputs depended on the breakdown of ATP in the fundus mucosa; (3) the gastric H+ secretion was inhibited in a dose-dependent way by theophylline, epinephrine and cimetidine; (4) the inhibition of gastric H+ secretion by epinephrine , theophylline or epinephrine plus theophylline associated with a significant increase in the mucosal cAMP of the gastric fundus (5) the significant increase in gastric H+ secretion due to histamine associated with a significant decrease in fundic mucosal cAMP; (6) the gastric H+ secretion could be inhibited dose-dependently by ADP, AMP, cyclic 2', 3'-AMP and cAMP; (7) the inhibition of gastric H+ secretion by cimetidine developed without and with histamine application in pylorus-ligated rats; (8) the histamine on gastric H+ secretion could not be stimulated further with theophylline (9) no significant correlation was found between the mucosal cAMP level and the gastric H+ secretion and/or between the decrease of mucosal cAMP content and gastric H+ secretion. It has been concluded that in pylorus-ligated rats (1) the gastric H+ secretion is an ATP-dependent process; (2) the cAMP system has an inhibitory effect as regards the development of gastric hypersecretion and of ulceration; (3) histamine and cimetidine show no close correlation with the cAMP system; (4) an extracellular and intracellular feed-back mechanism system exists between th ATP-membrane-bound ATPase-ADP and the ATP--adenylate cyclase--cAMP systems in the background of the development of gastric hypersecretion and ulceration.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11448126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nepresol in the treatment of hypertension of major severity. Nepresol在重度高血压治疗中的应用。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
M Németh, I Tényi, A Pár
{"title":"Nepresol in the treatment of hypertension of major severity.","authors":"M Németh,&nbsp;I Tényi,&nbsp;A Pár","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifty patients with arterial hypertension of various causes were treated with a combination consisting of Nepresol, a beta-adrenergic receptor-blocking agent and a diuretic. Duration of treatment ranged between 3 months and 5 years. A significant reduction of blood pressure was attained in all of the cases, with a return of the values to the normal range in a high proportion of the patients. The renal function did not deteriorate during therapy, but owing to potassium loss regular potassium replacement was required in the majority of the cases. Allergic reactions appeared in two cases. Neither SLE nor rheumatoid arthritis was encountered. Positive ANF reaction and a significant elevation of the Rose-Waaler titre were demonstrated in a number of cases. The benefits as well as the hazards of the therapeutic use of hydrazine derivatives are pointed out.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11600770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet turnover and megakaryocytopoiesis in ITP. ITP的血小板周转和巨核细胞生成。
Acta medica Academiae Scientiarum Hungaricae Pub Date : 1979-01-01
T Burger, J Schnell, M Schmelczer
{"title":"Platelet turnover and megakaryocytopoiesis in ITP.","authors":"T Burger,&nbsp;J Schnell,&nbsp;M Schmelczer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Among patients with ITP, a group of 9 subjects displayed a reduced platelet turnover. In their bone marrow the megakaryocyte mass was measured by 59Fe, and the results were referred to those of 6 patients with a moderately increased and of 6 with a considerably increased platelet turnover. In the low-turnover group the megakaryocyte nuclear lobe number was subnormal cells with basophil cytoplasm were in the majority and the number of megakaryocytes was increased, whereas in the other two groups of megakaryocite population showed a shift to the right, and increased nuclear lobe number, and the number of megakaryocytes, related to the erythroid cells, was increased. It is therefore assumed that in the case of a reduced platelet turnover, the megakaryocytes are damaged, primarily their maturation in the bone marrow. The three groups showed, however, no clinical differences.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11777676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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