阿托品对清醒大鼠不同时期胰腺分泌的影响。

A Pap, H Sarles
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引用次数: 0

摘要

用清醒大鼠观察了亚最大剂量阿托品静脉注射及其联合盐酸奥西扎嗪小肠局部麻醉的效果。胰液分流后,基础水、碳酸氢盐和蛋白质分泌明显增加。在基础分泌蛋白分泌模式的基础上,确定了2个稳定阶段:胰液回流过程中最生理的基础阶段。2. 第一次,高海拔高原从第4至第7调水后30分钟。3.改道240 min后,第二次高原延迟,高原高度降低。2在循环过程中,阿托品对蛋白质分泌有很大的抑制作用,但在果汁分流后,抑制作用较弱,在第一个高原期出现了阿托品抗性高峰。各阶段对水分分泌的抑制作用相同。肠道局部麻醉后,阿托品输注导致胰腺分泌进一步减少。由此可见,阿托品对胰腺分泌具有复杂的影响,可能在分流后第一阶段降低CCK释放,但不降低后期,降低胆碱能张力的十二指肠胰反射等因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of atropine on different phases of pancreatic secretion in conscious rats.

The effect of submaximal doses of intravenous atropine and their combination with topical anaesthesia of the intestine by oxethazaine-HCl was investigated in conscious rats. I. Basal water, bicarbonate and protein secretion were significantly augmented after diversion of pancreatic juice. On the basis of the protein secretory pattern of basal secretion, 2 stable stages have been recognized: 1. The most physiological basal stage during return of pancreatic juice. 2. The first, highly elevated plateau from the 4th to the 7th 30 min period after diversion. 3. The second delayed and less elevated plateau after 240 min diversion. II. Atropine greatly suppressed protein secretion during recirculation but only moderately after diversion of juice, and during the first plateau an atropine resistant peak appeared. Inhibition of water secretion was equal during all the stages. Atropine infusion resulted in a further decrease in pancreatic secretion also after topical anaesthesia of the intestine. It was concluded that atropine had a complex effect on pancreatic secretion: it possibly decreased the CCK release in the first period after diversion but not later, and decreased the duodenopancreatic reflexes and other factors of the cholinergic tone.

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