偶极矩与药物吸收率的关系。

T Past, Z Tapsonyi, I Hortobágyi
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引用次数: 0

摘要

测定了10种药物的口腔吸收率,并考察了吸收速率常数与分子理化参数之间的关系。根据这些结果,分子偶极矩似乎比水脂分配系数或扩散常数提供了口腔吸收速率常数更可靠的信息。在一些病例中,还对离体肠道进行了额外的灌注研究。建立了一个数学模型,用于计算系统pH值随时间对数线性变化的速率常数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between the dipole moment and rate of absorption of drugs.

Ten drugs were measured for the rate of buccal absorption and examined for the relationships between the rate constant for absorption and molecular physicochemical parameters. On the ground of the results the molecular dipole moment seems to provide more reliable information on the rate constant of buccal absorption than does the water-lipid partition coefficient or the diffusion constant. Additional perfusion studies on isolated gut were also performed in some cases. A mathematical model was developed for the calculation of the rate constants for those cases in which pH of the system changes linearly with the logarithm of time.

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