{"title":"Design of Experiments for Optimizing Silver–Graphene Composite as a Conductive Paste","authors":"Sangmin Lee, Kye Sang Yoo","doi":"10.1007/s11814-025-00497-y","DOIUrl":"10.1007/s11814-025-00497-y","url":null,"abstract":"<div><p>This study presents a systematic optimization of a silver–graphene-based conductive paste by integrating multiple design of experiments methodologies across its three core components: particle synthesis, binder formulation, and final paste compounding. Four key synthesis variables—solvent ratio (BCA/EtOH), ultrasonic power, reaction temperature, and synthesis time—were evaluated using a full factorial design to control the thickness of the carbon layer on Ag–graphene particles. Statistical analysis, including ANOVA and Pareto charts, identified solvent ratio, ultrasonic power, and temperature as significant factors affecting carbon thickness, with time being negligible. Response optimization revealed optimal synthesis conditions that minimize thickness while ensuring uniform dispersion. For binder development, a mixture design approach was employed to determine the ideal proportions of epoxy resin, hardener, and additives. The optimal binder formulation was identified at a ratio of 0.90:0.01:0.09 (Resin:Hardener:Additive), ensuring stability and processability. Finally, Central Composite Design was applied to optimize the conductive paste by evaluating the effects of binder ratio and synthesis temperature on electrical conductivity and shear strength. A total of nine experimental conditions enabled the construction of second-order polynomial models. Statistical analysis confirmed high model significance (<i>P</i> < 0.01) with <i>R</i><sup>2</sup> values exceeding 0.95 for conductivity and 0.99 for shear strength. Contour plots revealed that reduced binder content improved conductivity, while both higher binder ratio and temperature enhanced mechanical strength. The optimized conditions achieved a balance between electrical performance and structural integrity, demonstrating the efficacy of the CCD approach for multivariable paste optimization.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 12","pages":"2997 - 3008"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced Interfacial Properties of Nafion-Coated Mg/TiO2 with (101) Anatase Facet for Photocatalytic CO2 Reduction","authors":"Nurul Afiqah Mokri, Pei Ching Oh","doi":"10.1007/s11814-025-00484-3","DOIUrl":"10.1007/s11814-025-00484-3","url":null,"abstract":"<div><p>Addressing the continual rise in atmospheric CO₂ levels is a pressing challenge. Developing sustainable methods to convert CO<sub>2</sub> into valuable products is crucial for mitigating global warming and meeting long-term energy demands. The development of novel photocatalysts and the use of solar energy via photocatalysis are key to achieving CO<sub>2</sub>-to-CH<sub>3</sub>OH conversion. Among these, TiO<sub>2</sub> anatase has shown significant results for photocatalytic CO<sub>2</sub> reduction; however, its high bandgap energy restricts its efficiency in utilizing visible wavelengths, highlighting the need for further optimization. By doping strategy with alkaline earth metal like Mg, it modified the electronic properties of anatase TiO<sub>2</sub> and introduced more Lewis basic sites. Furthermore, Nafion coating facilitates proton-coupled electron transfer (PCET), stabilizes intermediates, and prevents methanol back-oxidation. Under UV–Vis irradiation for 8 h, the CH<sub>3</sub>OH yield from the photocatalytic CO<sub>2</sub>-to-CH<sub>3</sub>OH by Nafion/Mg–TiO₂ is 1559.82 μmol<sup>−1</sup> g<sup>−1</sup> h<sup>−1</sup>, outperforming Mg–TiO<sub>2</sub> (1350.20 μmol<sup>−1</sup> g<sup>−1</sup> h<sup>−1</sup>) and pristine TiO₂ (930.96 μmol<sup>−1</sup> g<sup>−1</sup> h<sup>−1</sup>). Langmuir–Hinshelwood (L–H) kinetic model reveals that CO is an intermediate product in this process, where its subsequent reaction with oxygen produces CH<sub>3</sub>OH, marking the rate-determining step. The synergistic effect of Nafion and Mg doping in TiO₂ optimizes acid–base interfaces contributed by Lewis’s base and acidic protonated Nafion, enabling efficient charge separation and enhanced photocatalytic activity. Nafion/Mg–TiO₂ is a promising platform for designing advanced photocatalysts for CO₂ reduction to methanol.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 11","pages":"2523 - 2542"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanfen Niu, Yuwei Song, Aaron Albert Aryee, Rong Wang, Runping Han
{"title":"Adsorption of Diclofenac Sodium and 2, 4-Dichlorophenoxyacetic on Magnetic MIL-100(Fe) Composite Obtained at Room Temperature","authors":"Yanfen Niu, Yuwei Song, Aaron Albert Aryee, Rong Wang, Runping Han","doi":"10.1007/s11814-025-00487-0","DOIUrl":"10.1007/s11814-025-00487-0","url":null,"abstract":"<div><p>Metal–organic frameworks (MOFs) have found a wide range of applications in the field of water treatment owing to their large specific surface area, well-developed cavities and abundant active centers. In this study, a magnetic MOF composite (Fe<sub>3</sub>O<sub>4</sub>/MIL-100(Fe)) was synthesized via a one-pot synthesis at room temperature, and its adsorption capacities towards diclofenac sodium (DS) and 2,4-dichlorophenoxyacetic acid (2, 4-D) were assessed. The maximum adsorption capacity of Fe<sub>3</sub>O<sub>4</sub>/MIL-100(Fe) was 249 mg·g<sup>–1</sup> for DS (pH 6.8, 313 K), whereas it was found to be 163 mg·g<sup>–1</sup> for 2, 4-D (pH 3.0, 293 K). Results from fitting isotherm models with the equilibrium data suggested that both the Langmuir and Koble–Corrigan models be suitable for describing the adsorption equilibrium data. Results from kinetic model analysis suggested that both the pseudo-second-order and double-constant model could describe the uptake of DS and 2, 4-D onto Fe<sub>3</sub>O<sub>4</sub>/MIL-100(Fe) well, respectively. The adsorption processes include both homogeneous physical and chemical adsorptions, such as electrostatic interaction, hydrogen bonding, and π–π interaction. Furthermore, Fe<sub>3</sub>O<sub>4</sub>/MIL-100(Fe) showed good regeneration and reusability, indicating that the synthesized adsorbent is highly efficient, relatively cost-effective, and stable.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 11","pages":"2763 - 2776"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pho Thi Le, Khanh Quang Nguyen, Tin Chanh Duc Doan, Viet Van Pham
{"title":"2D/1D Heterojunction of g‐C3N4/TiO2 as an Efficient Photocatalyst for NOx Removal","authors":"Pho Thi Le, Khanh Quang Nguyen, Tin Chanh Duc Doan, Viet Van Pham","doi":"10.1007/s11814-025-00494-1","DOIUrl":"10.1007/s11814-025-00494-1","url":null,"abstract":"<div><p>A novel S-scheme heterojunction photocatalyst based on 2D g-C<sub>3</sub>N<sub>4</sub> nanosheets modified by 1D TiO<sub>2</sub> nanotubes (TNTs) has been successfully prepared. The successful fabrication of 2D/1D g-C<sub>3</sub>N<sub>4</sub>/TNTs S-scheme photocatalysts by hydrothermal method and thermolysis processes was confirmed through a variety of characterization methods (HR-TEM, XRD, and FTIR). The g-C<sub>3</sub>N<sub>4</sub>/TNTs S-scheme heterojunction expressed advances in the degradation of nitrogen oxide (NO), a harmful environmental pollutant. In detail, 2D/1D g-C<sub>3</sub>N<sub>4</sub>/TNTs heterojunctions demonstrated the most effective decomposition of NO and their ability to remain stable under visible-light conditions, achieving the removal of over 66.44% of NO at 550 ppb during the entirety of the experiment.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 10","pages":"2217 - 2229"},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing Force Field Accuracy: The Essential Role of Bond Length in Vapor–Liquid Equilibria Simulations for n-Alkanes and Ethers","authors":"Sunghyun Jang, Dongjin Kim, Yongjin Lee","doi":"10.1007/s11814-025-00495-0","DOIUrl":"10.1007/s11814-025-00495-0","url":null,"abstract":"<div><p>A new series of united atom force fields named optimized potentials for phase equilibria simulation (OPPES) are presented. Many classical force fields have been proposed for predicting various physicochemical properties. The OPPES aims to improve the accuracy of direct-phase equilibrium simulations, particularly for vapor–liquid equilibria. The main feature of OPPES is the use of a new bond length of carbon pseudo-atoms involving methyl groups, which differs from the typical value of 1.54 Å in previous united atom force fields. Some of the bonded interaction constants for CH<sub>2</sub>, CH<sub>3</sub> pseudo-atoms, and ether oxygen were determined using the density functional theory calculations, while others were taken from the TraPPE-UA, NERD, OPLS-UA, and AMBER models. The interatomic parameters of united atom potentials for linear alkanes and ethers were optimized by fitting to the selected properties such as vapor pressure and saturated liquid density, followed by a Gibbs ensemble Monte Carlo simulation to evaluate the performance of the newly determined potential parameters. The simulation results were compared to those obtained using the TraPPE-UA model, currently the best united atom force field for phase equilibria simulation. The OPPES model showed significant improvements for ethers while providing accurate phase equilibria description for short-chain n-alkanes comparable to the TraPPE-UA model.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 11","pages":"2729 - 2743"},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exergy and Economic Analysis of Water-to-Grid Supply Chain of Hydrogen Using the Physical and Chemical Storage System","authors":"Seon Hwa Baek, Jeong Won Kang","doi":"10.1007/s11814-025-00492-3","DOIUrl":"10.1007/s11814-025-00492-3","url":null,"abstract":"<div><p>A sustainable hydrogen economy requires effective storage and transportation strategies, alongside advanced production technologies. The traditional physical hydrogen storage often incurs significant losses and additional equipment costs, while material-based methods need additional supply of energy for dehydrogenation reactions. This study evaluates the exergy and economic performance of both approaches within a defined supply chain. High-pressure hydrogen storage is relatively simple but suffers considerable exergy losses during compression. In contrast, the liquid organic hydrogen carrier (LOHC) system offers advantages in both efficiency and economic feasibility. By thermally integrating LOHC dehydrogenation with fuel cell reactions, the overall system efficiency increases by about 6%, achieving 2% higher exergy efficiency compared to high-pressure storage. Moreover, the LOHC materials share properties with conventional fuels, providing economic benefits for long-distance transport and allowing the use of existing oil infrastructure. These findings suggest that LOHC-based storage is a viable option for large-scale hydrogen supply systems.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 11","pages":"2553 - 2567"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Rasidul Islam Rocky, Venugopal Nulu, Keun Yong Sohn
{"title":"Electrochemical Performance of N-Doped Graphite @Carbon/ Red Phosphorous Composite for Lithium-Ion Secondary Batteries","authors":"Md Rasidul Islam Rocky, Venugopal Nulu, Keun Yong Sohn","doi":"10.1007/s11814-025-00481-6","DOIUrl":"10.1007/s11814-025-00481-6","url":null,"abstract":"<div><p>Lithium-ion batteries (LIBs) are well-known for having three key features: lightweight, extended cycle life, and high energy density. This makes them perfect for various uses like electric cars and portable electronics. Red phosphorus (P) is low-cost, easily available, and possesses an excellent theoretical specific capacity (2596 mAh g<sup>−1</sup>) for use as the anode material in high-energy–density lithium-ion batteries (LIBs). However, P has poor conductivity (10<sup>–12</sup> Sm<sup>−1</sup>), and colossal volume expansion during charging-discharging hinders its application in LIBs. Conversely, despite various reported anode materials, graphite remains the commercial choice for lithium-ion batteries. This study presents a nitrogen-doped graphite@carbon anode material composite with P that was designed and fabricated through a simple and scalable process. The nitrogen-doped graphite composite with carbon, NGC, effectively reduces harmful reactions between the electrolyte and graphite, ensuring stable electrode performance during charging and discharging. By incorporating optimized content of high-capacity phosphorus (P), NGC’s capacity and electronic conductivity improve, minimizing volume changes of raw red phosphorus through hybridization with the conductive carbon framework. The best optimized NGC/P2 composite shows a high initial discharge capacity of 1486 mAh g<sup>−1</sup> and a reversible capacity of 530 mAh g<sup>−1</sup> at a current density of 100 mA g<sup>−1</sup> after 100 cycles, outperforming conventional graphite. This highlights innovative strategies for sustainable and efficient energy storage solutions.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 8","pages":"1693 - 1704"},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficient Removal of Perfluorooctane Sulfonic Acid (PFOS) from Aquatic Environment Using Carbon Black/Chitosan Beads Composite","authors":"Zeinab Salimi Torkamani, Wooriya Tarokh, Majid Baghdadi","doi":"10.1007/s11814-025-00479-0","DOIUrl":"10.1007/s11814-025-00479-0","url":null,"abstract":"<div><p>Perfluorooctane sulfonic acid (PFOS) is a persistent environmental pollutant, putting human health at risk. Therefore, in this article, a novel composite was prepared by incorporating carbon black into chitosan and used as an adsorbent to efficiently remove PFOS from aqueous environments. The incorporation of carbon black into chitosan showed great modification on the structure of chitosan, which resulted in more porosity and higher surface area, resulting in better adsorption capacity. The best carbon black/chitosan mass ratio under both acidic and neutral conditions was found to be 0.5, and the optimum removal efficiency under the optimum conditions (pH: 2, 0.3 g adsorbent dosage, 5 mg L<sup>−1</sup> PFOS concentration, and 5 h contact time) was found to be 92%. The FESEM and BET analysis resulted in greater porosity and more hollow structure as well as enhanced specific surface area of the carbon black/chitosan beads (CBCHB) adsorbent in comparison to chitosan beads (CHB). Freundlich isotherm model fits the equilibrium adsorption isotherm data better than the Langmuir model. The maximum adsorption capacity (<i>q</i><sub>m</sub>) under acidic conditions (pH: 2) was 359.38 mg g<sup>−1</sup>. Furthermore, the CBCHB adsorbent was capable of being reused after being washed 5 times and exhibiting a slight decline in removal efficiency.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 8","pages":"1745 - 1756"},"PeriodicalIF":3.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hojoon Yoon, Baekmin Q. Kim, SeoYoung Choi, EunSuk Lee, Jongmin Q. Kim, KyuHan Kim
{"title":"Formation of Asymmetric Colloidal Multilayers via Subduction of Laterally Segregated Domains at the Air/Water Interface","authors":"Hojoon Yoon, Baekmin Q. Kim, SeoYoung Choi, EunSuk Lee, Jongmin Q. Kim, KyuHan Kim","doi":"10.1007/s11814-025-00477-2","DOIUrl":"10.1007/s11814-025-00477-2","url":null,"abstract":"<div><p>We present an interfacial assembly strategy for constructing asymmetric multilayered colloidal films through lateral compression of laterally segregated particle microdomains at the air–water interface. These microdomains—composed of polystyrene (PS) and silica (SiO<sub>2</sub>) particles—serve as lateral templates that direct vertical rearrangement during monolayer collapse. Utilizing hydrophilic PS and SiO<sub>2</sub> particles with distinct interfacial adsorption affinities, we demonstrate that depletion interactions and compression-induced instabilities induce domain-selective subduction, a process in which one type of particle domain is driven beneath another. Specifically, more hydrophilic silica domains preferentially collapse and subduct beneath less hydrophilic PS domains, resulting in pronounced vertical asymmetry concentrated at the domain boundaries. Langmuir isotherm analysis and SEM imaging reveal that both the lateral extent of domain segregation and the vertical thickness of the resulting multilayers can be tuned by varying the compression distance and depletant concentration. Lower depletant concentrations reduce depletion pressure, facilitating enhanced particle desorption and enabling the formation of broader and more asymmetric multilayer structures. Importantly, this assembly framework remains effective even when the relative wettability of the particle types is reversed. By introducing sulfonic acid functional groups onto PS, we transform it into a highly hydrophilic species. Adjusting subphase pH to suppress SO<sub>3</sub>H dissociation allows both particle types to adsorb at the interface. Under acidic conditions, the PS–SO<sub>3</sub>H particles collapse first and subduct beneath silica domains, producing inverted stratification. This inversion confirms that the subduction-driven assembly is not limited to specific wettability pairings, but instead governed by dynamic interfacial energetics and domain interactions.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 11","pages":"2661 - 2672"},"PeriodicalIF":3.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sathianarayanan Sankaran, Avinash Shivdas, Jose Asha, Mahendra Gowdru Srinivasa, Rekha Thiruvengadam, Shine Kadaikunnan, Naiyf S. Alharbi, Rekha Arcot, Muthu Thiruvengadam
{"title":"Synthesis of Cefixime–Gelatin Chemical Conjugated Microparticles and Their Antibacterial Activity Against Escherichia coli","authors":"Sathianarayanan Sankaran, Avinash Shivdas, Jose Asha, Mahendra Gowdru Srinivasa, Rekha Thiruvengadam, Shine Kadaikunnan, Naiyf S. Alharbi, Rekha Arcot, Muthu Thiruvengadam","doi":"10.1007/s11814-025-00469-2","DOIUrl":"10.1007/s11814-025-00469-2","url":null,"abstract":"<div><p><i>Escherichia coli</i> (<i>E. coli</i>) is a Gram-negative bacillus found in the intestine, which can also cause intestinal and extraintestinal illnesses in humans. Several hundred <i>E. coli</i> strains have been identified to cause diseases ranging from mild, self-limiting gastroenteritis to renal failure and septic shock. Its virulence allows <i>E. coli</i> to evade host defenses and develop resistance to common antibiotics. The aim of our study was to develop an aqueous-soluble cefixime conjugate for the treatment of <i>E. coli</i> infections. Cefixime shows excellent activity against <i>E. coli</i> strains. However, it has poor aqueous solubility. Thus, it was conjugated with gelatin using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) to produce a Cefixime–gelatin chemical conjugate (CGcc) with a significantly higher solubility than that of the pure drug, which may produce a better therapeutic effect. The conjugate was characterized using spectral data. The conjugate was determined to be non-hemolytic and non-toxic to L929 cells. The antibacterial activity of CGcc against <i>E. coli</i> was evaluated in vitro using the disc-diffusion method. The results showed that CGcc was slightly soluble in methanol, but very soluble in water and PBS, and its melting point was found to be 224–230 °C. The SEM images revealed that the CGcc exhibited a spherical morphology. All spectral data support the chemical conjugation of gelatin. The conjugation efficiency of CGcc was 74.54 ± 3.358%. In addition to its hemocompatibility and biocompatibility, CGcc exhibited enhanced solubility. The antibacterial effects revealed that CGcc exhibited good antibacterial activity against <i>E. coli</i>. CGcc showed a clear zone of inhibition and it was found to be 11.74 mm for 0.5 µg and 15.13 mm for 1 µg, respectively. Overall, the cefixime–gelatin chemical conjugate was effective in treating <i>E. coli</i> infections. This preliminary study may provide valuable insights into therapeutic effects during both preclinical and clinical trials. Detailed innovative methods are needed for the future alteration of gelatin and cefixime and integration of polymers into proper therapeutic applications.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 8","pages":"1813 - 1823"},"PeriodicalIF":3.2,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145168910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}