Korean Journal of Chemical Engineering最新文献

{"title":"Morphology-Dependent Uranium Adsorption on Zinc Oxide: Unraveling the Synergistic Role of Surface Area and Oxygen Vacancies","authors":"Xiaonan Zhang,&nbsp;Dongdong Deng,&nbsp;Congyu Du,&nbsp;Huiye Zhang,&nbsp;Xueze Wang,&nbsp;Yuanyuan Cheng,&nbsp;Jingjing Dong,&nbsp;Liyong Yuan","doi":"10.1007/s11814-026-00686-3","DOIUrl":"10.1007/s11814-026-00686-3","url":null,"abstract":"<div>\u0000 \u0000 <p>Zinc oxide (ZnO), a low-cost and environmentally benign semiconductor material, holds promise for uranium (U(VI)) adsorption due to its tunable morphology and hydroxyl-rich surface. However, the quantitative relationship between its morphology, surface properties, and adsorption performance remains unclear, hindering the rational design of high-performance adsorbents. To address this, four distinct ZnO morphologies were systematically synthesized and comparatively evaluated for U(VI) removal. The adsorption performance followed the order: spherical flower-like (ZnO-1) &gt; rod-like (ZnO-3) &gt; sheet-like (ZnO-2) &gt; hollow spheres (ZnO-4). Remarkably, ZnO-1 achieved a high removal efficiency of 96.33% within 100 min. The superior performance is attributed to its unique hierarchical structure, which synergistically maximizes both specific surface area and oxygen vacancy concentration, with the co-presence of both being essential for optimal performance. This work elucidates a critical structure–property relationship and provides a clear design principle for ZnO-based adsorbents: synergistic enhancement of both physical and chemical surface properties through targeted morphology control.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2371 - 2383"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Step Emulsification Enables High Loading of Hydrophobic Drugs, But Not Transdermal Delivery: Phase-Inversion-Driven Double and Single Emulsions Stabilized by Silica Nanoparticles","authors":"Jaehong Lee,&nbsp;Hyun Seo Shim,&nbsp;Seong-Bae Min,&nbsp;Chan-Yeong Heo,&nbsp;Siyoung Q. Choi","doi":"10.1007/s11814-026-00708-0","DOIUrl":"10.1007/s11814-026-00708-0","url":null,"abstract":"<div>\u0000 \u0000 <p>Efficient transdermal delivery of hydrophobic small-molecule drugs remains a persistent challenge in dermatological therapeutics due to the limited solubility of active materials, stability of formulation, and the physical barrier posed by the stratum corneum. Here, we report a one-step emulsification strategy that enables the formation of water-in-oil-in-water (W/O/W) double emulsions and water-in-oil (W/O) single emulsions using silica nanoparticles as the sole stabilizer. A hydrophobic usnic acid derivative active material, usnic acid-cinnamic acid (UA-CA), was solubilized in aqueous solvents by the precise control of the polarity by addition of organic solvents. The aqueous phase was then incorporated into emulsions through a vortexing step with oil phase without the use of surfactants or multi-step emulsification processes. By tuning the polarity and volume fraction, phase behavior was correlated with emulsion morphology, demonstrating phase-inversion-driven enclosure of the inner dispersed phase to form double emulsions. While stable double emulsions and single emulsions with high UA-CA concentrations were successfully fabricated, ex vivo porcine skin permeation experiments revealed negligible transdermal transport efficacy (<i>C</i>_permeate/<i>C</i>_feed &lt; 10^–5) of the drug. These results highlights trade-off relationship between the emulsion stability and skin permeability, providing design principles for next-generation topical formulations.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2491 - 2501"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11814-026-00708-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cu-Fe Oxide Nanozymes with Enhanced Peroxidase-like Activity for Sensitive H2O2 Colorimetric Detection","authors":"Pengfei Jiang,&nbsp;Yifan Hao,&nbsp;Mingxi Jia,&nbsp;Cun Liu","doi":"10.1007/s11814-026-00710-6","DOIUrl":"10.1007/s11814-026-00710-6","url":null,"abstract":"<div>\u0000 \u0000 <p>Hydrogen peroxide (H₂O₂) is a key reactive oxygen species involved in physiological regulation and pathological processes, and its accurate quantification is essential for bioanalysis and disease-related studies. Herein, we report the synthesis of a series of Cu-Fe oxide nanozymes via a simple antisolvent crystallization strategy and systematically investigate their peroxidase-like catalytic activity toward colorimetric H₂O₂ detection. By tuning the Cu/Fe molar ratio, the catalytic activity of the nanozymes can be effectively regulated, with Cu₂FeO_x exhibiting the highest peroxidase-like activity toward 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation in the presence of H₂O₂ under acidic conditions and enabling sensitive colorimetric detection of H₂O₂ over a linear range of 10–200 µM with a detection limit of 0.572 µM. Furthermore, the proposed sensing platform demonstrates satisfactory selectivity and reproducibility, and is successfully applied to the determination of H₂O₂ released into cell culture supernatants after chemical stimulation. This work highlights the potential of composition‑regulated Cu-Fe oxide nanozymes as robust artificial enzymes for colorimetric H₂O₂ sensing and provides insights into their application in bioanalytical systems.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2503 - 2513"},"PeriodicalIF":3.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucosamine-Assisted Functionalization of Carbon Nanotubes for Vanadium Flow Batteries","authors":"Jihye Shin,&nbsp;Yejin Lim,&nbsp;Mingyu Shin,&nbsp;Yongchai Kwon","doi":"10.1007/s11814-026-00702-6","DOIUrl":"10.1007/s11814-026-00702-6","url":null,"abstract":"<div>\u0000 \u0000 <p>Vanadium flow batteries (VFBs) are a promising candidate for large-scale energy storage systems. However, their commercialization is hindered by the sluggish redox kinetics of vanadium ions and high overpotentials occurring at high current densities. In this study, to enhance the electrochemical reactivity of vanadium ions, glucosamine chemically grafted onto carboxylic acid-functionalized carbon nanotubes (CACNTs) (GACNT) is developed as a catalyst for electrodes. Electrochemical analyses reveal that GACNT exhibits improved reversibility and significantly reduced charge transfer resistance for redox reactions of vanadium ions compared to CACNT. This improvement is attributed to the newly introduced functional groups, which provide active sites for vanadium ions and enhance wettability with the electrolyte. In VFB single-cell tests, the GACNT electrode demonstrates excellent voltage and energy efficiencies even at a high current density of 300 mA cm^− 2. Notably, during a long-term cycling test over 1,000 cycles performed at 300 mA cm^− 2, the VFB single-cells show exceptional durability by stably maintaining coulombic and voltage efficiencies of 97.7 and 74.6%. Taken together, this study proposes an eco-friendly and effective catalyst modification strategy utilizing biomass-derived materials, suggesting new possibilities for the exploration of high-power VFBs.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 6","pages":"1689 - 1700"},"PeriodicalIF":3.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147968197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Antitumor Effects of Paclitaxel Combined with PDE5 Inhibitor Avanafil on Glioma U373 Cells","authors":"Havva Aybek,&nbsp;Mahinur Kırıcı,&nbsp;Kubra Koc,&nbsp;Burak Tüzün,&nbsp;Ramazan Gündoğdu,&nbsp;Mehmet Kadir Erdoğan","doi":"10.1007/s11814-026-00704-4","DOIUrl":"10.1007/s11814-026-00704-4","url":null,"abstract":"<div><p>Paclitaxel is a well-known chemotherapeutic agent that induces cancer cell death by stabilising microtubules. Avanafil, a phosphodiesterase type 5 (PDE5) inhibitor typically used for erectile dysfunction, has recently been proposed to enhance blood-brain barrier permeability. This research focuses on, for the first time, the role of avanafil used together with paclitaxel to treat glioma. The cytotoxic effect of this combination on the U373 brain cancer cell was evaluated using MTT, colony survival analysis, and wound healing assay. Western blot analyses of the agents were conducted to investigate their effects on p53, Cas-3, Cas-9, Bax, Bcl-2, and c-PARP proteins. Additionally, Avanafil, Paclitaxel, and Avanafil+Paclitaxel combinations were calculated using the Gaussian package program at the B3LYP, HF, and M062x levels in the 6–31 g, 6–31++g, and 6–31++g(d, p) basis sets. The activities of the agents against brain tumour proteins (PDB ID: 2DME and 6YPE) were compared and their ADME/T properties were also investigated. MTT and colony survival analysis demonstrated that the combination significantly inhibited U373 cell viability and proliferation. Wound healing and Western blot assays indicated impaired migration and altered expression of apoptosis-related proteins. Molecular docking and DFT analyses supported the experimental findings, and ADME/T profiling suggested favourable pharmacokinetics. Our results indicate that avanafil enhances the cytotoxicity of paclitaxel via non-apoptotic mechanisms, highlighting its potential as an adjuvant in glioma therapy.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2455 - 2476"},"PeriodicalIF":3.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11814-026-00704-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vanadium-Doped NiCoP Nanosheets for Enhanced Hydrogen Evolution Reaction in Alkaline Media","authors":"Mani Ram Kandel,&nbsp;Purna Prasad Dhakal,&nbsp;Chandan Chandru Gudal,&nbsp;Jay Ram Thapa,&nbsp;Keshav Raj Chapagain,&nbsp;Indra Bahadur Bhandari,&nbsp;Kisan Chhetri,&nbsp;Chan-Hwa Chung","doi":"10.1007/s11814-026-00692-5","DOIUrl":"10.1007/s11814-026-00692-5","url":null,"abstract":"<div>\u0000 \u0000 <p>Modifying the intrinsic activity and conductivity of electrocatalysts represents a pivotal approach for achieving outstanding performance in the hydrogen evolution reaction (HER). In this study, we focused on the rational fabrication of vanadium (V)-doped nickel cobalt phosphide on Ni foam (VNiCoP/NF) employing a wet chemical synthesis followed by a controlled NaH₂PO₂-assisted solid-gas phosphidation process. Electrochemical measurements conducted in an alkaline electrolyte demonstrated the significantly enhanced electrocatalytic activity of the synthesized VNiCoP/NF nanoparticles for HER, achieving overpotentials of 141, 137, and 79 mV at current densities of 200, 100, and 10 mA cm^− 2, respectively. The exceptional electrocatalytic performance of the VNiCoP/NF catalyst can be ascribed to the enhanced intrinsic activity and conductivity resulting from the phosphating process and the incorporation of vanadium, as well as the synergism between the V and NiCoP active sites. Prominently, the VNiCoP/NF catalyst demonstrated remarkable long-term stability for 50 h at 100 mA cm^− 2. Consequently, the introduction of metal doping into phosphides based on transition metals represents a highly promising strategy for developing exceptionally efficient HER electrocatalysts for green hydrogen production.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2443 - 2454"},"PeriodicalIF":3.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remarkable 4 Nitrophenol Degradation and Mineralization Performance Using Simple-Fabricated Oxygen Vacancy-Rich Copper Oxide/Peroxymonosulfate Photocatalytic System","authors":"Muhammad Hanif Ainun Azhar,&nbsp;Salh Alhammadi,&nbsp;Dohyung Kang,&nbsp;Woo Kyoung Kim","doi":"10.1007/s11814-026-00705-3","DOIUrl":"10.1007/s11814-026-00705-3","url":null,"abstract":"<div>\u0000 \u0000 <p>Inducing intrinsic oxygen vacancies (V_O) through structural engineering, rather than relying on complex doping or heterostructure formation, represents a novel and simplified strategy in developing high-efficiency catalyst. In this work, we report a facile and scalable chemical precipitation route to synthesize copper (II) oxide (CuO) nanorods (NRs) characterized by an unprecedented density of V_O defects. These NRs serve as an extraordinary activator for peroxymonosulfate (PMS) in a sulfate (<span>({text{S}text{O}}_{4}^{{bullet}-})</span>) radical-based advanced oxidation process (AOP). The CuO-PMS synergy achieved significant degradation of 10 ppm of 4-nitrophenol (4NP), reaching 84.47% degradation and 88.11% total organic carbon (TOC) mineralization within 5 min. With only small doses of 0.1 g/L CuO and 0.65 mM PMS, the system further achieved 95.36% degradation and 91.39% mineralization of the same sample. This high performance is attributed to the synergy of lower crystallinity, higher surface area, and greater V_O defects presence in the NRs compared to bulk CuO. The system operated effectively under normal to low-alkaline pH conditions, exhibiting a high capacity to oxidize higher 4NP doses, demonstrating excellent reusability, and a wide applicability range for various pollutants. Singlet oxygen (<span>({}_{}{}^{1}{text{O}}_{2}^{})</span>) has been identified as the main driver of the oxidation process, as confirmed by scavenger tests. This study provides a pivotal blueprint for the design of defect-rich binary metal oxides, offering a pragmatic yet powerful solution for high-performance wastewater remediation.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 on","pages":"2027 - 2044"},"PeriodicalIF":3.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of an Intelligent Optimization Method Based on Aspen Adsorption in the Purification Process of Helium Via Pressure Swing Adsorption","authors":"Hong-nan Lin,&nbsp;Zheng Fan,&nbsp;Gen-hui Jing,&nbsp;Han-lei Zhao,&nbsp;Yi-han Li","doi":"10.1007/s11814-026-00669-4","DOIUrl":"10.1007/s11814-026-00669-4","url":null,"abstract":"<div><p>Helium, a non-renewable strategic resource, demands efficient purification technologies to safeguard national resource security. To address the technical challenges of helium extraction from liquefied natural gas boil-off gas (BOG), this study developed a novel pressure swing adsorption (PSA) process using Aspen Adsorption software. Through systematic adsorbent screening, the CMS-5000-A carbon molecular sieves (CMS) with a pore size range^z,2 of 0.5 ~ 0.7 nm was selected, whose surface oxygen-containing polar functional groups enhanced interactions with the quadrupole moment of N₂, achieving an exceptional N₂/He adsorption selectivity of 87.5:1. A multi-scale coupled model integrating mass, energy, and momentum conservation equations was established to systematically investigate the effects of operational parameters on separation performance. An extended two-column PSA scheme incorporating pressure equalization and vacuum desorption steps was proposed. For the first time, Bayesian algorithm-enabled multi-parameter co-optimization of six key operational parameters (feed flow rate, pressure, bed height, porosity, packing density, temperature) was realized, overcoming the limitations of traditional single-factor optimization in handling parameter coupling effects. Bayesian algorithm-enabled multi-parameter optimization revealed that an adsorption pressure of 0.3 ~ 0.4 MPa increased helium recovery by 15%, while a 1.0 ~ 1.1 m adsorption bed height ensured product purity ≥ 99.999% with energy consumption maintained at 0.36 kWh/m³. Compared to the single-column system, the two-column configuration improved helium recovery by 5.06%. Notably, the novel PSA process reduces energy consumption by up to 60% compared to conventional methods, providing a data-driven and quantifiable design paradigm for lean helium purification and presenting an efficient and energy-saving technical solution for industrial-scale helium purification.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2329 - 2342"},"PeriodicalIF":3.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust NH₂-UiO-66 for Efficient Cr(VI) Sequestration from Water","authors":"Ruiming Zhao,&nbsp;Lingling Li,&nbsp;Yongqing Wang","doi":"10.1007/s11814-026-00673-8","DOIUrl":"10.1007/s11814-026-00673-8","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of robust adsorbents for the efficient removal of toxic hexavalent chromium (Cr(VI)) from wastewater remains a critical challenge. Herein, an amino-functionalized metal-organic framework (NH₂-UiO-66) was synthesized via a solvothermal method and evaluated for the sequestration of Cr(VI). The synthesized NH₂-UiO-66 exhibited a hierarchical micro-mesoporous structure, originating from defects created during synthesis, a high specific surface area of 782.58 m²·g⁻¹, and exceptional thermal stability. Adsorbent exhibited a maximum Langmuir adsorption capacity of 30.73 mg·g⁻¹ for Cr(VI) at pH 6.0. The adsorption kinetics and isotherms were well-described by the pseudo-second-order (<i>R</i>² = 0.9952) and Langmuir models (<i>R</i>² = 0.9948), respectively, indicating a chemisorption-driven, monolayer process. Thermodynamic analysis revealed the adsorption to be endothermic and spontaneous. Notably, the adsorbent retained approximately 80% removal efficiency after five consecutive adsorption-desorption cycles, demonstrating excellent reusability. Importantly, PXRD pattern of the recycled material confirms its robust structural stability. FT-IR analysis confirmed that enhanced adsorption was primarily driven by strengthened electrostatic attraction between protonated amino groups and Cr(VI) anions, facilitated by defect-generated mesopores. Thus, NH₂-UiO-66 emerges as a highly promising and sustainable adsorbent for wastewater remediation.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2343 - 2355"},"PeriodicalIF":3.4,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold Nanocluster-Conjugated Magnetic Immunocomplexes for Quantitative Detection of C-Reactive Protein","authors":"Bong-Geun Kim,&nbsp;Yusung Choi,&nbsp;Sehee Ryu,&nbsp;Songyi Lee,&nbsp;Myeongkee Park,&nbsp;Hyon Bin Na","doi":"10.1007/s11814-026-00690-7","DOIUrl":"10.1007/s11814-026-00690-7","url":null,"abstract":"<div>\u0000 \u0000 <p>In extinction-based immunosorbent assays, enzymes are commonly used as signal transducers; however, their intrinsic instability has prompted the search for more stable alternatives, such as inorganic nanomaterials. In this study, we developed a robust signal transduction strategy utilizing the localized surface plasmon resonance (LSPR) of gold nanoclusters (AuNCs) to generate distinct and easily interpretable extinction signals, which were applied to C-reactive protein (CRP) quantification. To implement this, AuNCs and anti-CRP antibodies were co-immobilized on magnetic nanoparticles (MNPs), preparing “MagANC immunocomplexes” that can be rapidly purified via magnetic separation. By exploiting the seed-mediated growth of AuNCs, these immunocomplexes generated CRP-dependent extinction signals, enabling sensitive quantification. This approach effectively eliminates the need for unstable enzymes while leveraging the superparamagnetic properties of MNPs to simplify the purification process. The assay demonstrated a wide dynamic range of 0.001–1 µg/mL with two complementary readouts: maximum LSPR wavelength (0.03–1 µg/mL) and the absorbance at 600 nm (0.001–0.03 µg/mL). The limit of detection (LOD) was 1.58 ng/mL. Furthermore, the method showed excellent reliability in CRP-spiked serum, with a mean recovery of 100.47% and a coefficient of variation of 4.79%. Overall, the proposed MagANC strategy offers a practical, enzyme-free alternative for clinical CRP diagnostics, delivering a wide dynamic range and competitive sensitivity with a simplified workflow.</p>\u0000 </div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"43 9","pages":"2385 - 2394"},"PeriodicalIF":3.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}