Yi-Sin Chen, C. Lai, Chen-Wei Fan, Chihchen Chen, Gwo-Bin Lee
{"title":"Rapid Enrichment of Extracellular Vesicles via Optically-induced Dielectrophoresis and Microfluidics","authors":"Yi-Sin Chen, C. Lai, Chen-Wei Fan, Chihchen Chen, Gwo-Bin Lee","doi":"10.1109/NEMS50311.2020.9265578","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265578","url":null,"abstract":"This study demonstrates a novel method to enrich and recover extracellular vesicles (EVs) by using an integrated microfluidic system and optically-induced dielectrophoresis (ODEP) technique. It is the first time that label-free and contact-free enrichment and recovery of EVs via ODEP with minimal intervention has been achieved. The optimal driving frequency (20 kHz) was found for EV manipulation via ODEP. The rapid and automatic procedure could be performed to enrich and recover 20 μL of the EV sample with a recovery rate of 27.8% within 3 min by using an integrated microfluidic optically-induced EV sorting chip and a home-made control system, showing great potential for further EV-associated applications.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"26 1","pages":"390-393"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84410729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaisheng Zhang, W. Luo, Tao Wang, Jing Yang, Yupeng Yuan, Zuwei Zhang, Y. Shuai, Chuangui Wu, Wanli Zhang
{"title":"Gas chamber and thermal isolation structure simulation for an integrated NDIR gas sensor","authors":"Kaisheng Zhang, W. Luo, Tao Wang, Jing Yang, Yupeng Yuan, Zuwei Zhang, Y. Shuai, Chuangui Wu, Wanli Zhang","doi":"10.1109/NEMS50311.2020.9265577","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265577","url":null,"abstract":"The application of non-dispersive infrared (NDIR) gas sensors, which is one of the best gas sensing technology in many aspects, has been hampered by its large volume. A device structure integrated with Si gas chamber was proposed and simulated to realize an ultra-small NDIR gas sensor in this paper. 19.75 mm light transport length with 29% efficiency is achieved in a 10 × 10 × 1 mm3 Si gas chamber according to TracePro simulation. Furthermore, thermal isolation structures on silicon interposer have also been simulated and optimized to increase signal to noise ratio of the gas sensor. Finally, a 10 × 10 × 2 mm3 NDIR sensor show high SNR value (162.5) has been designed, which show promising application in mobile phones, internet of things technology, and house air pollution monitoring.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"18 1","pages":"338-341"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91024795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrical and Optoelectronic Properties Analysis in Two-dimensional Multilayer WSe2 Phototransistor for High Speed Device Applications","authors":"A. S. Bandyopadhyay, K. Jayanand, A. Kaul","doi":"10.1109/NEMS50311.2020.9265572","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265572","url":null,"abstract":"In this work, we fabricated back gated multilayer WSe2 phototransistor with Au/Ti as electrodes whose electrical properties were investigated over a wide range of temperature T from T = 5.4 to T = 350 K from which several electrical parameters including mobility μ and barrier height ϕms were extracted to analyze their T-dependencies. For example, the T-dependent mobility μ was characterized by a peak at ~ 250 K after which point μ decreased according to μ ~ T-0.71, attributed to phonon scattering. Additionally, ϕms was found to be 29 meV at VG = 0 V which decreased as VG increased in alignment with barrier modulation theory. Finally, optoelectronic properties of our Au/Ti/WSe2 field effect transistors (FETs) were investigated by exposing the device to a tunable laser, where the photoresponsivity R was calculated to be ~ 43 A/W at an optical power of 0.786 nW. The phototransistor also showed very short response time with τrise = 10 ms, and Tfall = 3 ms. Our work demonstrates excellent potential of WSe2 as a promising 2D semiconductor for high speed electronics and opto-electronics.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"1 1","pages":"18-21"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90630364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fangchi Shao, K. Hsieh, Pengfei Zhang, Aniruddha M. Kaushik, Tza-Huei Wang
{"title":"A Programmable Nanodroplet Device with Direct Sample-to-Droplet Interface toward High-Throughput Screening","authors":"Fangchi Shao, K. Hsieh, Pengfei Zhang, Aniruddha M. Kaushik, Tza-Huei Wang","doi":"10.1109/NEMS50311.2020.9265519","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265519","url":null,"abstract":"Droplet microfluidics offers a promising technology for high-throughput screening due to its potential for massive parallelization of nano- to picoliter-sized reactions. Fulfillment of this promise, however, has been impeded by ineffective \"sample-to-droplet\" interfaces with shortcomings ranging from significant waste of sample volume, limited scalability of the number of samples, to lengthy idle time due to sample injection and switch. In response, we have developed a programmable nanodroplet device with a \"direct\" sample-to-droplet interface that has low sample waste, high scalability, and minimal idle time. In our device, each sample (0.8 μL) is directly spotted onto an open-to-atmosphere device inlet. The sample-to-droplet interface of our device uses programmable microfluidic valves to regulate vacuum-assisted infusion of the sample from the open inlet into the device, as well as pressure-driven generation of nanodroplets (as small as ~5 nL) from the sample with minimal waste. Our device ensures high scalability, as series of samples are simply processed by the sample-to-droplet interface in succession. Parallelization of a pair of our sample-to-droplet interfaces and effective cleaning between successive samples help minimize idle time and cross-contamination. Finally, we have integrated nanodroplet assembly and on-chip incubation capabilities in our device and have coupled our device with an in-house laser-induced fluorescence detector to achieve in-line fluorescence detection of our nanodroplets. For demonstration, we perform a cytochrome P450-based drug screening assay in 50-nL nanodroplets - a 2000-fold reduction from 100-μL benchtop reactions - in our device and achieve excellent differentiation of no-drug controls from inhibitor controls (Z′ = 0.84).","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"3 1","pages":"255-260"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75073817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MEMS Based Triaxial Electrochemical Seismometer","authors":"Wenjie Qi, Chao Xu, Bowen Liu, Xichen Zheng, Tian Liang, Xu She, Jian Chen, Junbo Wang, Deyong Chen","doi":"10.1109/NEMS50311.2020.9265585","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265585","url":null,"abstract":"This paper presents a MEMS based triaxial electrochemical seismometer. The design, fabrication and characterization of the proposed device were included in this article. The MEMS based triaxial electrochemical seismometer has three axes, which are perpendicular and connected to each other, and each axis can independently detect vibrations in the corresponding direction. Compared with uniaxial electrochemical seismometer, the proposed device can directly measure vibrations in any direction, and has a much higher sensitivity.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"4 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79980407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ramachandran, Changhui Zhao, Zongxiang Xu, Fei Wang
{"title":"Construction Of NiCe-LDH Nanostructure From Ni-MOF As A Positive Electrode Material for High-Performance Asymmetric Supercapacitor Device","authors":"R. Ramachandran, Changhui Zhao, Zongxiang Xu, Fei Wang","doi":"10.1109/NEMS50311.2020.9265587","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265587","url":null,"abstract":"Metal-organic framework derivatives are potential candidates for supercapacitors electrodes because of their controllable structure and high surface area. In this study, we report, for the first time, the in-situ conversion of NiCe-LDH from Ni-MOF at different synthesis time and its electrochemical activities towards asymmetric supercapacitor. The flower-like NiCe-LDHs provide extra active sites for redox reactions and achieved a maximum specific capacitance of 1500.6 F g-1 for NiCe-LDH/10 electrode as a result of higher surface area and rich redox chemistry. The fabricated asymmetric supercapacitor device exhibited a maximum energy density of 13.86 Wh kg-1 with superior cyclic stability. This work proves the potential of MOF derived LDH materials for electrochemical supercapacitor applications.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"22 1","pages":"485-489"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91125489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Size of Gold Nanoparticles (GNP) on Intracellular Uptake and Cytotoxicity in Breast Cancer Cells","authors":"Yuwen Zhao, Rui Yang, Shue Wang","doi":"10.1109/NEMS50311.2020.9265576","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265576","url":null,"abstract":"We investigated the effects of intracellular uptake of different sizes of gold nanoparticles (GNP) ranging from 10 nm to 100 nm on breast cancer cells (MDA-MB-231). The experimental results showed the cell cytotoxicity is high dose-and dimension- dependent. We further investigated the effect of intracellular uptake of GNP on cell morphology, including cell area, perimeter, and aspect ratio. We showed GNP with a diameter of 20 nm enhanced cell proliferation with a low concentration of GNP (2 μg/mL, 4 μg/mL, and 10 μg/mL). To evaluate the specific sizes of GNP affection in wound healing, we investigated the cell migration ability after GNP uptake. Also, we detect the Dll4 expression when the GNP works as a probe, in which the 10 nm GNP-LNA complex reveals significant signal intensity.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"81 2 1","pages":"402-405"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77374199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of The Twist Rod Angles on An Inertial Rotary Electromagnetic Energy Harvester","authors":"Xiangtian Dai, Yifan Wang, Anxin Luo, Fei Wang","doi":"10.1109/NEMS50311.2020.9265526","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265526","url":null,"abstract":"This paper presents the effect of the twist rod angles on an inertial rotary electromagnetic energy harvester. Adopting a twist driving system and ratchet clutch system, the harvester can convert linear motion into inertial rotation. There is a remarkable increase of the output when the twist rod is designed with an angle of 50 degrees compared with that of 80 degrees. A power output of 6.2 mW is achieved on the 50 degrees harvester when the rod speed reaches 154.93 mm/s, while the power output is only 0.34 mW on the harvester of 80 degrees. Detailed study is made to investigate the rod speed, the rotor rotating speed, the output and force on the lid. Linearity is observed in the rod speed and the output. The curve related to the 50 degrees harvester has a largest slope among all harvesters.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"46 1","pages":"281-285"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85005104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Nonlinear One-Dimensional Model of Thermoresistive Micro Calorimetric Flow Sensor for Response Time Improving","authors":"Zongqin Ke, Xiaoyi Wang, Xuankai Xu, Xuanhao Cao, Izhar, W. Xu","doi":"10.1109/NEMS50311.2020.9265550","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265550","url":null,"abstract":"We developed a nonlinear one-dimensional (1-D) model to optimize the response time of the Thermoresistive Micro Calorimetric Flow (TMCF) sensor. The proposed sensor model was verified by the reported experimental data and it was further used for the efficient optimization of the TMCF sensor design with different key parameters: (1) the response time τc prediction, (2) the optimum distance D from microheater to thermal sensing element, (3) membrane thickness t, (4) the depth of bottom cavity h. After that, we designed and fabricated a TMCF sensor with CMOS compatible materials using MEMS technology. The measured response time of the TMCF sensors with the nitrogen flow from 0 m/s to 8 m/s was in reasonable agreement with the theoretical prediction. Therefore, this nonlinear model can be quite useful for the design and optimization of a new TMCF sensor. Moreover, the measured response time of the fabricated flow sensor (pair 1) is as good as less than 6 ms, which reveals that our developed TMCF sensor can be used for the monitoring of human respiration in the future.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"220 1","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89126524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Platinum Nanoparticles Decorated Multiwalled Carbon Nanotubes and Chemically Modified Graphene based Electrochemical Biosensor for Highly Sensitive and Selective Glucose Detection","authors":"Md. Faruk Hossain, Insoo Kim, G. Slaughter","doi":"10.1109/NEMS50311.2020.9265562","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265562","url":null,"abstract":"In this work, a novel enzymatic glucose sensor was developed on the platinum nanoparticles embedded chemically modified graphene (CG) and functionalized multiwalled carbon nanotubes (f@MWCNTs) composite. The CG/f@MWCNTs composite was embedded on gold electrode and platinum nanoparticle (PtNP) was electroplated on the CG/f@MWCNTs composite electrode. Glucose oxidase was covalently immobilized onto the nanoparticles on the surface of the electrode. The stability and selectivity of the biosensor was increased by nafion coating on the glucose oxidase modified surface. The as fabricated biosensor electrode demonstrated high electrocatalytic activities toward oxidation of glucose, with a wide linear response range from 0.005 to 13 mM, high sensitivity of 26.5 μΑ/mM cm2, a fast response time (5 s) and a low detection limit of 5 μΜ (signal to noise ratio is 3). It showed negligible interference effects and exhibited good stability. These results indicate that the nanostructured glucose sensor offers great promise for use in noninvasive glucose sensing applications.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"66 1","pages":"506-509"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72563286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}