2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)最新文献_第10页

A Highly Robust Silicon Nano-pillar Chip for Electroporation Chip for Delivering Molecules to HeLa Cells 一种用于向HeLa细胞输送分子的高鲁棒硅纳米柱电穿孔芯片

2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS) Pub Date : 2020-09-27 DOI: 10.1109/NEMS50311.2020.9265581

Xu Zhao, Haixiang Liu, Xiaoyi Wang, Cong Zhao, Izhar, Benzhong Tang, Yi-Kuen Lee

{"title":"A Highly Robust Silicon Nano-pillar Chip for Electroporation Chip for Delivering Molecules to HeLa Cells","authors":"Xu Zhao, Haixiang Liu, Xiaoyi Wang, Cong Zhao, Izhar, Benzhong Tang, Yi-Kuen Lee","doi":"10.1109/NEMS50311.2020.9265581","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265581","url":null,"abstract":"Electroporation (EP) is one of key bio-techniques for delivery of molecules to different types of cells, which uses the pulsed electric field to increase the permeability of cell membranes for drug delivery and DNA transfection because of its high cell viability and efficiency. Up to now, the researcher proposed micro/nanotechnology for electroporation (EP). The aluminum nano-spike EP (ANS-EP) chip has been fabricated for the small molecule delivery under a low applied voltage. However, the nano-spike on the chip is highly deformable and highly chemically reactive. We propose a novel gold-coated silicon nano-pillar electroporation (Au-SiNP-EP) chip to improve the mechanical strength of EP chips. COMSOL, electric field numerical simulations, indicated that the electric field enhancement, especially near the tips of Au-SiNP EP chip because of low-macroscopic-field emission (LMFE). Au-SiNP-EP chips were fabricated by projection photolithography, etching, and sputtering processes. The optimized protocol of Au-SiNP-EP chip using HeLa cells only requires the applied voltage of 3V using digital fluorescence microscopy with Acridine Orange (AO) and Propidium Iodide (PI) dyes. In summary, comparing to ANS-EP chips, the low-voltage Au-SiNP-EP chip with high mechanical strength is promising for large-scale high-throughput EP for molecular delivery to cells.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"15 1","pages":"230-233"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85936379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Organic Framework Derived CeO2 Based Two-Dimensional Layered Nanocomposites for Selective Electrochemical Dopamine Detection 金属-有机框架衍生的基于CeO2的二维层状纳米复合材料用于选择性电化学多巴胺检测

2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS) Pub Date : 2020-09-27 DOI: 10.1109/NEMS50311.2020.9265548

Chengjie Ge, R. Ramachandran, Fei Wang

{"title":"Metal-Organic Framework Derived CeO2 Based Two-Dimensional Layered Nanocomposites for Selective Electrochemical Dopamine Detection","authors":"Chengjie Ge, R. Ramachandran, Fei Wang","doi":"10.1109/NEMS50311.2020.9265548","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265548","url":null,"abstract":"In past decades, nanomaterials have received much attraction in numerous applications. Still now, making and finding a novel nanomaterial is primary and basic research to improve the performance of the existing materials. Recently, Metal-organic frameworks and their derivatives become the hot star for energy and environmental applications owing to controllable structure and large surface area. During this work, we present the preparation of a neoteric CeO2 nanomaterial with two materials siloxene and g-C3N4 from MOF as a sacrificial template by the thermolysis process. Furthermore, we optimize the pyrolysis conditions to obtain higher crystallization of the CeO2 nanomaterials towards the use in electrochemical dopamine detection. Here, we focus on the CeO2 nanomaterial formation with different conditions and optimized the synthesize temperature based on the characterization results. Compared to g-C3N4, siloxene with CeO2 enhances the redox reaction for dopamine detection. The modified CeO2-siloxene electrode showed a low detection limit of 0.292 μΜ and a linear range from 0 to 7.8 μΜ. Our work shows that the CeO2/siloxene electrodes are suitable for application of electrochemical dopamine sensor.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"89 1","pages":"512-517"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84362959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Numerical Simulation of a Microscale Dynamo Driven by Tethered, Magnetized Bacterial Cell 系留磁化细菌细胞驱动微型发电机的数值模拟

2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS) Pub Date : 2020-09-27 DOI: 10.1109/NEMS50311.2020.9265520

Jeremy Meyer, Jin-Woo Kim, S. Tung

引用次数: 0

TDDFT Studies on Sheet Size-Dependency of Optoelectronic Properties of 2D Silicon Doped with Alkali Metals 碱金属掺杂二维硅光电性能随片径变化的TDDFT研究

2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS) Pub Date : 2020-09-27 DOI: 10.1109/NEMS50311.2020.9265608

M. Alam, Muath Bani-Salim, Ganesh Alwarappan, A. Bhandari, S. Patil, S. Alfalah, M. Shibl, W. Hassan, R. Nekovei, A. Verma

{"title":"TDDFT Studies on Sheet Size-Dependency of Optoelectronic Properties of 2D Silicon Doped with Alkali Metals","authors":"M. Alam, Muath Bani-Salim, Ganesh Alwarappan, A. Bhandari, S. Patil, S. Alfalah, M. Shibl, W. Hassan, R. Nekovei, A. Verma","doi":"10.1109/NEMS50311.2020.9265608","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265608","url":null,"abstract":"This work investigates the effect of alkali metals (Li, Na, and K) doping on silicene sheets (2D silicon) by using Time-Dependent Density Functional Theory (TDDFT). This includes Si<inf>13</inf>H<inf>22</inf>, Si<inf>19</inf>H<inf>30</inf>, Si<inf>54</inf>H<inf>74</inf>, and Si<inf>104</inf>H<inf>134</inf> silicene sheets. The results show some variation in the IR and UV-Vis spectrums as the sheet size change, with the largest structure showing an onset of absorption in the visible spectrum. Also, the results show that excitation energy decreases significantly by 29% as the number of atoms increases from Si<inf>13</inf>H<inf>22</inf>to Si<inf>104</inf>H<inf>134</inf>. Also, this work investigates the doping effect of alkali metals (Li, Na, and K) on the silicene sheets. The doped structures showed a dipole moment as high as approximately 10 Debye. The doped structures show a significant increase in optical absorption in the visible spectrum, as well as the potential for high reactivity","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"1 1","pages":"518-521"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84330274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bending Properties of Materials for Peripheral Nerve Interfaces. 外周神经界面材料的弯曲特性研究。

2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS) Pub Date : 2020-09-01 Epub Date: 2020-11-27 DOI: 10.1109/nems50311.2020.9265629

Joshua E Woods, Elissa J Welle, Lei Chen, Julianna M Richie, Paras R Patel, Cynthia A Chestek

{"title":"Bending Properties of Materials for Peripheral Nerve Interfaces.","authors":"Joshua E Woods, Elissa J Welle, Lei Chen, Julianna M Richie, Paras R Patel, Cynthia A Chestek","doi":"10.1109/nems50311.2020.9265629","DOIUrl":"10.1109/nems50311.2020.9265629","url":null,"abstract":"Intrafascicular peripheral nerve interfaces (PNIs) with penetrating electrodes have the potential to chronically record from nerves on the scale of single axons. The small size and dynamic environment of peripheral nerves makes material selection important for these devices. In this work, we describe how the bending properties of common PNI electrode materials contribute to their effectiveness as self-inserting PNIs. First, tungsten, platinum-iridium, and carbon fiber wires are tested to assess their ability to survive repeated bending stresses when embedded in silicone. Next, carbon fiber wires are attached to a flexible circuit board encased in silicone to characterize how they survive stresses in prototype PNI devices. Finally, in order to validate experimental results, we use COMSOL to investigate the optimal thickness of the embedded silicone layer by simulating the stress distribution in carbon fiber wires on a flexible circuit board. Carbon fiber wires were shown to survive bending stresses better than tungsten and platinum-iridium wires. Physical testing and COMSOL modeling of carbon fiber prototype devices showed an optimal silicone thickness of 200 μm that prevents carbon fiber breakage but minimizes PNI device size. Overall, these results serve as a guide for selection of self-inserting PNI materials and development of carbon fiber PNIs.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"28 1","pages":"407-412"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78133857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0