Platinum Nanoparticles Decorated Multiwalled Carbon Nanotubes and Chemically Modified Graphene based Electrochemical Biosensor for Highly Sensitive and Selective Glucose Detection

Abstract

In this work, a novel enzymatic glucose sensor was developed on the platinum nanoparticles embedded chemically modified graphene (CG) and functionalized multiwalled carbon nanotubes (f@MWCNTs) composite. The CG/f@MWCNTs composite was embedded on gold electrode and platinum nanoparticle (PtNP) was electroplated on the CG/f@MWCNTs composite electrode. Glucose oxidase was covalently immobilized onto the nanoparticles on the surface of the electrode. The stability and selectivity of the biosensor was increased by nafion coating on the glucose oxidase modified surface. The as fabricated biosensor electrode demonstrated high electrocatalytic activities toward oxidation of glucose, with a wide linear response range from 0.005 to 13 mM, high sensitivity of 26.5 μΑ/mM cm2, a fast response time (5 s) and a low detection limit of 5 μΜ (signal to noise ratio is 3). It showed negligible interference effects and exhibited good stability. These results indicate that the nanostructured glucose sensor offers great promise for use in noninvasive glucose sensing applications.