{"title":"A Highly Sensitive Non-Enzymatic Hydrogen Peroxide Sensor based on Palladium-Gold Nanoparticles","authors":"Saikat Banerjee, Md. Faruk Hossain, G. Slaughter","doi":"10.1109/NEMS50311.2020.9265596","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265596","url":null,"abstract":"Here a simple strategy was employed to fabricate a hydrogen peroxide (H2O2) sensor based on gold nanoparticles and palladium nanoparticles onto a tungsten wire. The electrochemical activities of the bimetallic nanoparticles decorated electrode were characterized by the voltammetry and amperometry. The decorated electrode showed excellent catalytic activity towards the H2O2 reduction. The fabricated electrode demonstrated a good linear range, fast response time, good reproducibility, and a sensitivity of 0.317 mA mM-1 cm-2 for H2O2 detection. In addition, it also showed good antiinterference capability towards common interfering analytes. Thereby, the fabricated sensor has the potential to be used as a simple, rapid, and cost-effective non-enzymatic sensor.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"10 1","pages":"286-289"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84361449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Duhem Hysteresis Modeling of Magnetic Shape Memory Alloy Actuator via Takagi-Sugeno Fuzzy Neural Network","authors":"Chen Zhang, Yewei Yu, Jingwen Xu, Zhiwu Han, Miaolei Zhou","doi":"10.1109/NEMS50311.2020.9265582","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265582","url":null,"abstract":"The magnetic shape memory alloy (MSMA)-based actuator is a promising candidate in the micro positioning field by virtues of its large stroke and small volume. However, the inherent hysteresis nonlinearity between the input current and the output displacement seriously limited the application of the MSMA-based actuator. In this paper, the hysteresis, which is related to the input frequency and working condition (such as load), is analyzed. Then a mathematical modeling method using Duhem model (DM) and Takagi-Sugeno fuzzy neural network (TSFNN) is introduced to describe the hysteresis behavior. The mathematical expression of the DM is explicit and simple; and the TSFNN, which has the advantages of both fuzzy system and NN structure, is used to identify the DM parameter. Hence, the proposed TSFNN-DM method has the merits of self adjustment and clear expression. To certify the validity of the developed model, comparative experiments with the modeling methods in other literatures are executed. Experimental results confirm that the TSFNN-DM has the better modeling performance to depict the hysteresis under the different input frequencies and loads than other modeling methods in previous studies.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"10 1","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89156104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scaling Effect Induced Rapid Quenching Improves the Performance of Microfabricated Electrostatic Micromirrors","authors":"Hao Ren, Weimin Wang, Haichao Cao, Sitao Fei, Yunping Niu, Zhihao Li","doi":"10.1109/NEMS50311.2020.9265626","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265626","url":null,"abstract":"In this paper we study the scaling effect on the heat transfer of microfabricated electrostatic micromirrors with polysilicon and gold bimorph structure. Based on scaling effect study, it is found that as the characteristic length of micromirror reduces, rapid cooling occurs, and we implemented the scaling effect to perform thermal processing to cause rapid quenching and plastic deformation on microfabricated micromirrors to improve its performance, including the maximum out-of-plane displacement and bandwidth. Electrostatic micromirrors were fabricated by a two-layer polysilicon microfabrication process. Measurement results demonstrated that after the thermal processing, the maximum out-of-plane displacement increased by 60.8%, from 1.25 μm to 2.01 μm, and the 3dB bandwidth was increased by 40.7%, from 1.35 kHz to 1.90 kHz.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"38 1","pages":"545-548"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89703361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pallavi Shinde, Kavitha Illath, Srabani Kar, T. Santra
{"title":"Nanosecond Pulsed Laser Activated Massively Parallel Single-cell Intracellular Delivery Using Ti Micro-Dish","authors":"Pallavi Shinde, Kavitha Illath, Srabani Kar, T. Santra","doi":"10.1109/NEMS50311.2020.9265624","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265624","url":null,"abstract":"Single-cell intracellular delivery is a booming field of interest with the various challenges faced due to the impermeability of cargo to the cell membrane barrier. The idea is to locally disrupt cell membrane for allowing cargo passage into the cytosol such as to create its therapeutic effect. Till to date, most of the intracellular delivery is performed in bulk approaches, which provides an average ensemble data, losing low-frequency rare information. Besides, reliable results require huge data from multiple cells. Hence, to ensure huge data on individual cells it becomes necessary to carry out delivery experiments on a large number of single-cells simultaneously. This ensures the same experimental conditions conserving heterogeneity in the cell population. The collection of data from individual cells provides information about rare low-frequency alleles in the cell population. Massively parallel delivery ensures such uniform experimental conditions with uniform cargo delivery to a large number of individual cells. The proposed device platform is an array of photothermal Micro-dish patterned with fibronectin protein to obtain specific Single-cell attachment. The device can deliver 10,000 individual cells with 97% efficiency and 95% cell viability simultaneously.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"16 1","pages":"320-324"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90433705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan Gong, Matthew Harris Brauer, Kristine Zheng, Wen Li
{"title":"Accelerated, Reactive Aging Tests of Parylene C, SiO2, and Si3N4 Packages for Chronic Neural Implants","authors":"Yan Gong, Matthew Harris Brauer, Kristine Zheng, Wen Li","doi":"10.1109/NEMS50311.2020.9265554","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265554","url":null,"abstract":"Reliable packaging for implantable neural prosthetic devices in body fluids is a long-standing challenge for device’s chronic applications. This work studied the stability of Parylene C (PA), SiO2, and Si3N4 packages on tungsten wires using accelerated, reactive aging tests in three solutions: pH 7.4 phosphate-buffered saline (PBS), PBS+30 mM H2O2, and PBS+150 mM H2O2. Different combinations of coating thicknesses and deposition methods were studied at 67 °C. Analysis of the preliminary data shows that the pinholes/defects, cracks, and interface delamination are the main attributes of metal erosion and degradation in reactive aging solutions. Failure at the interface of package and metal is the dominating factor in the wire samples with open tips.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"2013 1","pages":"394-397"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86459705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microfluidic Enzymatic Glucose Biofuel Cell with MWCNT patterned Printed Circuit Board Electrodes","authors":"Prakash Rewatkar, S. Goel","doi":"10.1109/NEMS50311.2020.9265600","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265600","url":null,"abstract":"Enzymatic biofuel cells (EBFCs) have gained a substantial attention due to their ability to be produce clean, economical and qualitative self-sustainable power. In this regards, a variety of methodologies have been reported in the field of device and electrode manufacturing, and dedicated enzyme immobilization chemistry. However, the lower power output, shorter enzyme life, and high operating and maintenance overheads are key barriers to the commercialization of EBFCs. Here, easily fabricated and cost-efficient printed circuit board (PCB) electrodes, patterned with multi-walled carbon nanotubes (MWCNT), have been presented. These bioelectrodes were further positioned over a Y-shaped PDMS microchannel and tested under microfluidic environment. The electrodes were further immobilized with GOx and laccase enzymes, to behave as anode and cathode respectively, and voltammetric electrochemical performance was established with respective electrolytes (glucose and oxygen). Finally the polarization studies of fully integrated EBFC were evaluated, where the maximum peak power density of 2.29 μW.cm-2 was observed at maximum current density of 32 μA.cm-2 with open circuit potential of 0.257 V.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"3 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84234962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi-Sin Chen, C. Lai, Chen-Wei Fan, Chihchen Chen, Gwo-Bin Lee
{"title":"Rapid Enrichment of Extracellular Vesicles via Optically-induced Dielectrophoresis and Microfluidics","authors":"Yi-Sin Chen, C. Lai, Chen-Wei Fan, Chihchen Chen, Gwo-Bin Lee","doi":"10.1109/NEMS50311.2020.9265578","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265578","url":null,"abstract":"This study demonstrates a novel method to enrich and recover extracellular vesicles (EVs) by using an integrated microfluidic system and optically-induced dielectrophoresis (ODEP) technique. It is the first time that label-free and contact-free enrichment and recovery of EVs via ODEP with minimal intervention has been achieved. The optimal driving frequency (20 kHz) was found for EV manipulation via ODEP. The rapid and automatic procedure could be performed to enrich and recover 20 μL of the EV sample with a recovery rate of 27.8% within 3 min by using an integrated microfluidic optically-induced EV sorting chip and a home-made control system, showing great potential for further EV-associated applications.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"26 1","pages":"390-393"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84410729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Flexible Electrochemical Lactate Biosensor","authors":"Peyton Miesse, G. Slaughter","doi":"10.1109/NEMS50311.2020.9265579","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265579","url":null,"abstract":"Lactic acid is a key indicator for trauma and exercise intolerance. It is the primary metabolically produced acid responsible for tissue acidosis that can lead to muscle fatigue. During intensive exercise, the muscles go through anerobic metabolism to produce energy. This leads to decreases in the blood flow of nutrients and oxygen to the muscles and increases in lactate production, which in turn cause lactic acidosis. Currently, changes in blood lactate concentrations are monitored by sensors that can be invasive via blood or wearable based sensors that use the enzyme lactate oxidase. Lactate oxidase produces hydrogen peroxide, which is a toxic byproduct and can foul the surface of the sensor. Here we present the development of a noninvasive wearable electrochemical lactate biosensor for the detection of lactic acid. This work presents the development of non- invasive wearable electrochemical lactate biosensor for detection of lactic acid. The bioelectrode comprised D-Lactate dehydrogenase (D-LDH) immobilized on multi-walled carbon nanotubes (MWCNTs) using polydimethylsiloxane (PDMS) as a flexible substrate platform. The lactate biosensor exhibited a dynamic linear range of 2 mM to 44 mM lactic acid with a good sensitivity of 189.89 μA/mM cm2. This electrochemical biosensor has the potential to be used for the real-time detection of lactate in the clinical, biological and sports medicine fields.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"7 1","pages":"580-583"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82484974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Many-body Interactions in Halide-assisted CVD Grown WSe2 for High Performance Photodetectors","authors":"A. S. Bandyopadhyay, K. Jayanand, A. Kaul","doi":"10.1109/NEMS50311.2020.9265522","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265522","url":null,"abstract":"Practical device applications of semiconducting two-dimensional (2D) materials based devices rely on their large area growth using Chemical Vapor Deposition (CVD) method. Controlled CVD growth of tungsten diselenide (WSe<inf>2</inf>) is often challenging because of the high sublimation point of tungsten. In this work, we used NaCl with tungsten oxide to allow the growth of monolayer (1L) WSe<inf>2</inf> at a temperature (T) of ~ 750°C. Additionally, we utilized T-dependent PL spectroscopy to analyse the dynamics of excitons, trions and localized excitons states in 1L WSe<inf>2</inf>. Moreover, we fabricated Al/WSe<inf>2</inf> based photodetector (PD) which show a high responsivity of ~ 502 A/W. The frequency-dependent capacitance response of the PD was also analyzed from which an interface trap density D<inf>it</inf> was computed to be ~ 3.45 × 10<sup>12</sup> cm<sup>-2</sup> eV<sup>-1</sup>; this is the lowest D<inf>it</inf> value reported for WSe<inf>2</inf>-based devices to date. The results obtained in this work reveals great potential of WSe<inf>2</inf> for electronic, opto-electronic device applications.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"37 1","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88946629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaisheng Zhang, W. Luo, Tao Wang, Jing Yang, Yupeng Yuan, Zuwei Zhang, Y. Shuai, Chuangui Wu, Wanli Zhang
{"title":"Gas chamber and thermal isolation structure simulation for an integrated NDIR gas sensor","authors":"Kaisheng Zhang, W. Luo, Tao Wang, Jing Yang, Yupeng Yuan, Zuwei Zhang, Y. Shuai, Chuangui Wu, Wanli Zhang","doi":"10.1109/NEMS50311.2020.9265577","DOIUrl":"https://doi.org/10.1109/NEMS50311.2020.9265577","url":null,"abstract":"The application of non-dispersive infrared (NDIR) gas sensors, which is one of the best gas sensing technology in many aspects, has been hampered by its large volume. A device structure integrated with Si gas chamber was proposed and simulated to realize an ultra-small NDIR gas sensor in this paper. 19.75 mm light transport length with 29% efficiency is achieved in a 10 × 10 × 1 mm3 Si gas chamber according to TracePro simulation. Furthermore, thermal isolation structures on silicon interposer have also been simulated and optimized to increase signal to noise ratio of the gas sensor. Finally, a 10 × 10 × 2 mm3 NDIR sensor show high SNR value (162.5) has been designed, which show promising application in mobile phones, internet of things technology, and house air pollution monitoring.","PeriodicalId":6787,"journal":{"name":"2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS)","volume":"18 1","pages":"338-341"},"PeriodicalIF":0.0,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91024795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}