Journal of Materials Science: Materials in Medicine最新文献

{"title":"An innovative hierarchical porous oxide surface with enhanced surface area for promoting early-stage bone regeneration potential","authors":"Chia-Ling Shen,&nbsp;Kuo-Sheng Hung,&nbsp;Hsieh-Tsung Shen,&nbsp;Yu-Sin Jennifer Ou,&nbsp;Jungshan Chang,&nbsp;Chi-Hsun Tsai,&nbsp;Takashi Saito,&nbsp;Yi-Ren Pao,&nbsp;Keng-Liang Ou,&nbsp;Chih-Ming Tsai,&nbsp;Xiaoxia Wei","doi":"10.1007/s10856-026-07018-1","DOIUrl":"10.1007/s10856-026-07018-1","url":null,"abstract":"<div><p>In this study, an innovative hierarchical porous oxide surface (HPOS) with an increased surface area was developed on biomedical 316L stainless steel (SS) implants to promote early bone and implant integration. The surface features and in vivo performance of the HPOS implant were examined using field-emission scanning electron microscopy, nanoindenter, roughness measurement instrument, contact angle goniometer, micro-computed tomography, and histological analysis. Results showed that the HPOS consisted of a hybrid micro-nano-pores structure and had a relatively low elastic modulus (150.6 ± 7.8 GPa, *<i>p</i> &lt; 0.05), high roughness (8.6 ± 1.2 μm, **<i>p</i> &lt; 0.01), and a low contact angle (15.6 ± 1.8°, ***<i>p</i> &lt; 0.001). Additionally, rapid new bone formation was observed on the HPOS of the 316L SS implant modified at 5 V for 5 min, producing pore sizes from approximately 300 nm to 13.5 μm, with bone contact interfaces exceeding 64% at 12 weeks. The HPOS maintained mechanical interlocking ability at the microscale, which positively influenced osseointegration. Moreover, the difference in new bone formation thickness between the unmodified control group (0.45 ± 0.11 mm) and the modified 316L SS implant with HPOS (0.66 ± 0.13 mm) was statistically significant at 12 weeks post-implantation (*<i>p</i> &lt; 0.05). These findings suggest that forming an innovative HPOS on a 316L SS implant could offer a potential solution to enhance early-stage osseointegration in clinical applications.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07018-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of soft tissue-mimicking materials for ultrasound training phantoms","authors":"Marta Mencarelli,&nbsp;Luca Puggelli,&nbsp;Antonio Virga,&nbsp;Rocco Furferi,&nbsp;Yary Volpe","doi":"10.1007/s10856-026-07020-7","DOIUrl":"10.1007/s10856-026-07020-7","url":null,"abstract":"<div><p>Tissue-mimicking materials are essential for developing realistic ultrasound phantoms in medical training and device calibration. This study systematically evaluates the acoustic and physical properties of 15 materials, including gelatin-based formulations, synthetic gels, and rubbers, to assess their suitability for simulating human soft tissues. The investigation focused on ultrasound propagation speed, attenuation coefficients, and temporal stability, with measurements conducted under controlled conditions to ensure consistency. Results revealed that organic gelatins exhibited propagation speeds (1508–1626 m/s) and attenuation coefficients (0.21–1.10 dB/cm) closely aligned with soft tissue benchmarks (1540 m/s and 0.54 dB/cm MHz, respectively), with minimal variations (&lt;5%) over 15 days. However, their susceptibility to dehydration and mold growth necessitates protective measures. Synthetic gels, such as ballistic gel and PVC-Plastisol, demonstrated superior long-term stability but required more complex fabrication processes. Rubbers, while durable, exhibited acoustic properties that deviated significantly from tissue standards, limiting their utility. The study quantitatively highlights trade-offs between material categories: gelatins offer cost-effectiveness and acoustic fidelity for short-term use, whereas synthetic gels provide durability for repeated applications. These findings provide a comprehensive framework for selecting materials tailored to specific phantom requirements, balancing acoustic accuracy, stability, and manufacturability. The work advances the development of high-fidelity, cost-effective phantoms, with implications for improving ultrasound training and diagnostic tool validation. Future research should explore hybrid materials and extended stability assessments to further optimize phantom performance.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07020-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable development of ZnO nanoparticles and nanocellulose-modified CPE for electrochemical sensing of tinidazole","authors":"Mohamed Abd-Elsabour,&nbsp;Mortaga M. Abou-Krisha,&nbsp;Abdulrahman G. Alhamzani,&nbsp;Ehab A. Abdelrahman","doi":"10.1007/s10856-026-07010-9","DOIUrl":"10.1007/s10856-026-07010-9","url":null,"abstract":"<div><p>The detection of tinidazole (TIZ) in environmental and pharmaceutical samples remains constrained by conventional electrochemical sensors, which often rely on energy-intensive synthesis routes and toxic modifiers, undermining their sustainability. To bridge this gap, this study introduces a green synthesis approach for sensor fabrication, leveraging the concept of waste-to-value by converting banana peel into nanocellulose (PNC) and using it as a sustainable scaffold for zinc oxide nanoparticles (ZnO NPs). The enhanced performance of the PNC-ZnO/CPE sensor originates from a synergistic interplay between the high surface area and conductivity of ZnO NPs and the dispersive and stabilizing properties of PNC, which collectively facilitate the electron transfer kinetics for TIZ reduction. The prepared samples were analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDX). The sensor demonstrated a linear response to TIZ concentrations ranging from 9.0 ×10⁻⁹ M to 25.0 ×10⁻⁶ M, with a detection limit of 2.1 nM under optimized conditions. Furthermore, selectivity was quantitatively demonstrated, with the sensor maintaining a stable signal (&lt;5% deviation) in the presence of common interferents. The combination of performance metrics derived from agricultural waste not only validates the sensor’s efficacy but also provides a cost-effective and environmentally benign alternative, advancing the principles of green chemistry in electroanalysis. This work establishes a platform for the future development of sustainable, waste-derived nanocomposites for a broader range of electrochemical sensing applications.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07010-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of niosome formation with chitosan coating on the stability and absorption of orally administered vesicular ursolic acid","authors":"Devy Maulidya Cahyani,&nbsp;Paskalis Yosna Piyambudi,&nbsp;Retno Sari,&nbsp;Asri Darmawati,&nbsp;Berlian Sarasitha Hariawan,&nbsp;Qonita Kurnia Anjani,&nbsp;Ram Kumar Sahu,&nbsp;Esti Hendradi,&nbsp;Andang Miatmoko","doi":"10.1007/s10856-026-07021-6","DOIUrl":"10.1007/s10856-026-07021-6","url":null,"abstract":"<div><p>Niosomes are known to improve the bioavailability of drugs. However, niosomes have drawbacks related to stability and absorption in the gastrointestinal tract. Chitosan coating on niosomes can increase their stability in gastrointestinal fluid and absorption after oral administration. This study aimed to evaluate the biopharmaceutical stability and oral absorption of chitosan-coated Ursolic acid niosomes in vivo. Niosomes Ursolic Acid (Nio-UA) were prepared using a thin-layer hydration method, and chitosan was added to produce Niosomes Ursolic Acid with chitosan coating (Nio-UA-CS). The stability of niosomes was evaluated by exposing them to simulated gastrointestinal fluid. The oral absorption and biodistribution were determined in vivo. The results showed that niosome formation increased UA solubility from 1.02 × 10^–4mg/mL to 23.49 × 10^–3mg/mL for Nio-UA and 22.34 × 10^–3mg/mL for Nio-UA-CS and decreased the LogP value of UA from 5.18 ± 0.05 to 1.70 ± 0.22 for Nio-UA and 1.74 ± 0.30 for Nio-UA-CS. Adding chitosan layers increased the stability of the niosome, resulting in the lowest %cumulative calcein release of 7.05 ± 1.77% in Nio-UA-CS after exposure to simulated gastric fluid and 31.53 ± 8.80% after exposure to simulated intestinal fluid. Chitosan-coated niosomes exhibited higher absorption in the duodenum. Moreover, photomicrographs revealed that UA niosomes with a chitosan layer were highly accumulated in the liver 4 h after oral administration. A biodistribution study revealed that chitosan coating increased the plasma concentration of UA and selective hepatic accumulation. Thus, the chitosan layer successfully improved the oral absorption of UA niosomes, providing potential uses of nanoparticles for improving drugs’ bioavailability.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07021-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of PLCL as a biodegradable polymer in biomedical engineering","authors":"Yonggang Zhao,&nbsp;Honglei Liu","doi":"10.1007/s10856-026-07016-3","DOIUrl":"10.1007/s10856-026-07016-3","url":null,"abstract":"<div><p>Poly (L-lactide-co-ε-caprolactone) (PLCL) is a novel polymer that has attracted considerable attention in the biomedical field due to its exceptional biocompatibility. However, a comprehensive and systematic summary of its diverse applications remains lacking. To address this gap, the present review outlines the physicochemical properties of PLCL and the factors that influence them. Additionally, it consolidates the most commonly employed processing and preparation methods for PLCL in biomedical applications. The review further provides a systematic overview of current applications of PLCL in various biomedical fields, including wound healing, cardiovascular stents, nerve repair, osteochondral tissue engineering, drug delivery, and screening. It also examines modification strategies aimed at enhancing PLCL performance. Ultimately, this review seeks to provide valuable insights for future research and development of PLCL in biomedical contexts.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07016-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pH-responsive mesoporous Zn-MOF nanocarrier for efficient cisplatin delivery and inhibition of A549 cancer cells","authors":"Xiaomei Ye,&nbsp;Shuzhen Lu,&nbsp;Hao Peng,&nbsp;Zhirong Huang,&nbsp;Chunyu Pan,&nbsp;Yayan Huang,&nbsp;Kangrui Yuan,&nbsp;Youfa Qin","doi":"10.1007/s10856-026-07022-5","DOIUrl":"10.1007/s10856-026-07022-5","url":null,"abstract":"<div><p>Mesoporous metal-organic frameworks (MOFs) have the advantages of high specific surface area, tunable pore size, and favorable biocompatibility, making them promising candidates for drug delivery in cancer therapy. In this study, a series of mesoporous zinc-based MOF, constructed using cyclopentane dicarboxylic acid as the organic linker, was successfully synthesized via a surfactant-assisted solvothermal method. Surface characterization revealed that MOF-2 exhibited high surface area (1325 m²/g), pore volume (0.273 cm³/g), and average pore diameter (5.69 nm). UV-Vis analysis showed that MOF-2 demonstrated improved drug loading (18% w/w), encapsulation efficiency (86%), and cumulative release (96%), along with both pH-responsive degradation and drug release properties. Furthermore, cisplatin-loaded MOF-2 exhibited potent antitumor activity against A549 cells and effectively inhibited cell migration and invasion, while maintaining minimal cytotoxicity toward LO2 normal hepatic cells. These findings suggest MOF-2 as a promising nanocarrier for pH-responsive anticancer drug delivery.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07022-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation and development of bilayer scaffolds: ZnONPs-loaded poly (vinyl alcohol) incorporated with Platostoma palustre aqueous extract and sponge collagen derived from fish skin","authors":"Ngoc Minh Thu Nguyen,&nbsp;Hoang Van Huy Dai,&nbsp;Anh Hue Luong,&nbsp;Wei-Chih Lin","doi":"10.1007/s10856-026-07015-4","DOIUrl":"10.1007/s10856-026-07015-4","url":null,"abstract":"<div><p>This study introduces the design of two bilayer scaffolds that offer safety and show potential for biomedical applications, especially for wound healing in the skin or oral cavity. Each scaffold is composed of a collagen sponge layer derived from warm-water fish skin (seabass and tilapia) and a PVA layer incorporated with Hsiantsao extract and biosynthesized ZnONPs. Both extracted collagens were identified as type I, with their purity and triple-helical structure confirmed by electrophoresis, FT-IR, UV-Vis, and EDX analyses. TEM characterization revealed that the ZnONPs were small (7.95 ± 1.45 nm) and spherical. The bilayer scaffolds utilize the unique functions of each layer: the denser PVA layer, integrated with nanoparticles, acts as a barrier against dust and bacteria and releases bioactive compounds from the Hsiantsao extract, while the sponge collagen layer supports cell proliferation. Mechanically, the scaffolds showed high flexibility, with a tensile strength of about 4 MPa and an elongation at break of around 300%. They also absorbed fluids rapidly and maintained a slightly acidic pH (6.5–6.8). Additionally, the scaffolds exhibited excellent biocompatibility (cell viability &gt; 115% after 48 h and a hemolytic percentage &lt; 1.5%), strong antioxidant activity (69–70% DPPH and 80% ABTS scavenging), and antimicrobial properties against both Gram-positive and Gram-negative bacteria. These findings suggest that the Hsiantsao/ZnONPs-loaded PVA/Seabass and Hsiantsao/ZnONPs-loaded PVA/Tilapia scaffolds are promising candidates for medical treatments.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07015-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-healing hydrogel based on modified chitosan and sodium alginate oxide reinforced with hydrophilic nanomaterials for wound dressing applications","authors":"Mahla Shahabi Shalghouni,&nbsp;Saied Nouri Khorasani,&nbsp;Shahla Khalili,&nbsp;Mahshid Hafezi,&nbsp;Mehdi Sattari-Najafabadi,&nbsp;Rasoul Esmaeely Neisiany","doi":"10.1007/s10856-026-07019-0","DOIUrl":"10.1007/s10856-026-07019-0","url":null,"abstract":"<div><p>N-carboxyethyl chitosan (CECS) and sodium alginate oxide (SAO) are two biomaterials extensively used in tissue engineering, particularly in wound dressing (WD) applications. Nonetheless, these materials exhibit certain limitations such as inadequate physicomechanical properties, limited antibacterial activity in non-acidic environments, and insolubilityunder physiological condition. This study introduces an injectable self-healing hydrogel composed of CECS and SAO, improved with hydrophilic nanomaterials, i.e., cellulose nanofibers (CNFs) and copper oxide (CuO) nanoparticles, to address the inherent drawbacks of these hydrogels. The CECS/SAO/CNFs/CuO hydrogels were analyzed by varying the CNFs concentration (0, 0.05, 0.10, and 0.15 wt.%) and CuO nanoparticles content (0, 0.008, 0.020, 0.032 wt.%). Physicomechanical properties (compressive modulus and strength, % degradation, swelling, and pore size), rheological characteristics, and biological performance (assessed by fibroblast cell growth, adhesion, and live-dead tests) of the hydrogels were evaluated. The findings indicated that the CECS/SAO hydrogel containing 0.10% CNFs and 0.032% CuO nanoparticles exhibited appropriate physical properties (2259% swelling after 1 h, 22.3% degradation after 6 days, and 151 µm pore size), compressive modulus (22.31 kPa), shear thinning behavior, and biological viability (more than 90% after 3 days), while ensuring adequate injectability and proper self-healing. The antibacterial property of the hydrogel against <i>Staphylococcus aureus and Escherichia coli</i> was observed to be higher than 99.5%. These results highlight the significant potential of the CCH/SAO/CNFs/CuO hydrogel for wound dressing applications.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07019-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M1 macrophage membrane-engineered PLGA nanoparticles reprogram M2 tumor-associated macrophages to enhance anti-tumor immunity in breast cancer","authors":"Asal Katebi,&nbsp;Farhad Riazi-Rad,&nbsp;Fatemeh Ahangari,&nbsp;Soheila Ajdary","doi":"10.1007/s10856-026-07017-2","DOIUrl":"10.1007/s10856-026-07017-2","url":null,"abstract":"<div><p>Nanoparticles (NPs) are used as a suitable delivery system in cancer immunotherapy. Coating NPs with cell membranes can improve their therapeutic efficacy. Tumor-associated macrophages (TAMs) with a dominant phenotype of M2 and anti-inflammatory properties are found within the tumor microenvironment and contribute to tumor progression. Reprogramming TAMs toward a pro-inflammatory M1 phenotype can be a suitable approach to alter the tumor microenvironment and improve treatment outcomes. In this study, we synthesized poly(lactic-co-glycolic acid) (PLGA) NPs loaded with a TLR7/8 agonist (R848) and coated with M1 macrophage cell membranes (CM1), along with a cyclic dinucleotide (CDN) agonist (PLGA-CM1-CDN-R848 NPs), and their ability to reprogram M2-like macrophages was investigated using an in vitro model. PLGA-CM1-CDN-R848 NPs were preferentially taken up by M2-like macrophages and efficiently stimulated the pro-inflammatory cytokines (IL-6, TNF-α, and iNOS) as well as the STING pathway (IFN-β). The reprogrammed macrophages induced apoptosis and cell cycle arrest (G0/G1 and G2/M phases) in 4T1 breast cancer cells. In conclusion, the PLGA-CM1-CDN-R848 NPs formulation represents a promising strategy for breast cancer immunotherapy by targeting M2 TAMs within the TME and reprogramming them toward the M1 phenotype.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of thin porous ceramic coatings on implant stability: a comparative study of GB14 and β-TCP with and without Cu","authors":"Mihail Genchev,&nbsp;Coralie Nagels,&nbsp;Hagen Schmal,&nbsp;Eva Johanna Kubosch,&nbsp;Maria Carolina Lanzino,&nbsp;Andreas Killinger,&nbsp;Sofia Dembski,&nbsp;Anika Höppel,&nbsp;Jakob Neubauer,&nbsp;Michael Seidenstuecker","doi":"10.1007/s10856-026-07013-6","DOIUrl":"10.1007/s10856-026-07013-6","url":null,"abstract":"<div><p>The present study investigates the effect of thin porous ceramic coatings on implant stability, focusing on two materials: a calcium alkali orthophosphate (GB14, Ca₂KNa(PO₄)₂) and β-tricalcium phosphate (β-TCP), with and without copper (Cu) incorporation. The coatings were applied to titanium implant surfaces (CP Ti, grade 2) and characterized for porosity and microstructure. The in vivo performance of the material is assessed in a New Zealand White rabbit model. Following defined healing periods, biomechanical push-out testing were performed. The results of β-TCP/Cu for cancellous bone show that Cu-doped coatings exhibit significantly improved bone integration compared to their Cu-free counterparts. The enhanced fixation is attributed to the bioactive and potential antibacterial properties of copper, which may stimulate osteogenesis and the presence of supraparticles in the Cu samples. Furthermore, the incorporation of β -TCP supraparticles into the ceramic matrix increases overall coating porosity, facilitating deeper bone ingrowth and improved mechanical interlocking. This structural change results in improved osseointegration compared to less porous coatings. This structural change results in improved osseointegration compared to less porous coatings. The results of this study demonstrate that combining copper incorporation with enhanced porosity through supraparticles can improve implant stability by shortening the time required for the transition from primary to secondary stability. This approach offers a promising strategy for optimizing surface design in orthopedic and dental implants.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}