Journal of Materials Science: Materials in Medicine最新文献

{"title":"Gelatin methacryloyl/hyaluronic acid hydrogel for localized ropivacaine delivery alleviates neuropathic pain and supports functional recovery after spinal cord injury","authors":"Xuqi Yu,&nbsp;Liwen Du,&nbsp;Qiong Hu,&nbsp;Dan Xia,&nbsp;Fen Wang,&nbsp;Binnan Hu","doi":"10.1007/s10856-026-07064-9","DOIUrl":"10.1007/s10856-026-07064-9","url":null,"abstract":"<div><p>Neuropathic pain caused by spinal cord injury severely compromises patients’ quality of life. The clinical application of ropivacaine is limited by its short duration of action and the significant side effects associated with repeated administration. In this study, we developed a Gelatin methacryloyl/hyaluronic acid-based hydrogel (Ropi-GelMA/HA) to enable localized and controlled delivery of ropivacaine by photo-crosslinking. In a rat model of spinal cord contusion, Ropi-GelMA/HA was associated with lower Nav1.3 and TNF-α expression and higher NGF and BDNF expression, together with improved motor recovery in rats with SCI. In vitro studies further supported the hydrogel’s favorable biocompatibility and controlled release behavior during the early phase after administration. Under the tested dosing regimens, Ropi-GelMA/HA was associated with reduced hepatorenal toxicity and more durable analgesic efficacy compared with free ropivacaine, resulting in prolonged analgesic effects and improved functional outcomes under localized controlled delivery conditions. These findings highlight the potential clinical utility of Ropi-GelMA/HA in the treatment of neuropathic pain following spinal cord injury.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic potential of a novel magnesium-containing calcium silicate-based bioactive glass-ceramic scaffold in critical bone defect.","authors":"George Gonçalves Dos Santos, Carmen Sara Rodrigo-Vázquez, Iorrana Índira Dos Anjos Ribeiro, Izamir Resende Júnior Borges Miguel, Aryon de Almeida Barbosa Júnior, Miguel A Rodríguez, Antonio H de Aza, Fabiana Paim Rosa, Fúlvio Borges Miguel","doi":"10.1007/s10856-026-07051-0","DOIUrl":"https://doi.org/10.1007/s10856-026-07051-0","url":null,"abstract":"<p><p>This study aimed to evaluate the osteogenic potential of a novel magnesium (Mg)-containing calcium silicate (CS)-based glass-ceramic scaffold. For this purpose, twenty-four male Wistar rats were randomly assigned to two experimental groups: Glass-ceramic scaffold developed and sintered at 900 °C/1 h (GCS9) and 1250 °C/8 h (GCS1). The scaffolds were implanted in 8 mm critical bone defects and evaluated at biological points of 15 and 45 days. Histomorphological analysis revealed that the scaffolds completely filled the bone defect, demonstrated biocompatibility, and promoted bone neoformation beyond the defect margins in direct contact with the biomaterial surface. Bone formation was observed throughout the entire defect and within the fragmented scaffolds in its central regions. Both groups exhibited mild chronic granulomatous inflammation in the interstitial tissue formed between the biomaterial fragments. Histomorphometric analysis revealed a greater bone neoformation area in the GCS1 group (44%) at 45 days, with a statistically significant difference between the biological points in this group (ANOVA p = 0.048). Therefore, this study demonstrated that Mg-containing CS-based glass-ceramic scaffolds, particularly GCS1, were notably bioactive and osteoconductive, exhibiting significant osteogenic potential for critical bone defect repair and showing promise for future clinical applications.</p>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of ceria nanoclusters against delayed paraplegia after spinal cord ischemia","authors":"Wang Yang,&nbsp;Ling Zou,&nbsp;Qianqian Wu,&nbsp;Lu Yang,&nbsp;Yonghui Wu,&nbsp;Qingshan Liu,&nbsp;Guangyou Shi,&nbsp;Renqing Jiang,&nbsp;Ying Xia,&nbsp;Jian Sun,&nbsp;Xiaochao Yang","doi":"10.1007/s10856-026-07062-x","DOIUrl":"10.1007/s10856-026-07062-x","url":null,"abstract":"<div><p>Spinal cord ischemia reperfusion injury (SCIRI) induced delayed paraplegia is a complex complication of thoracoabdominal aortic surgery. Reactive oxygen species (ROS) play a critical role in the pathogenesis of delayed paraplegia, suggesting that antioxidants could be a promising therapeutic strategy. Ceria nanomaterials have demonstrated potent antioxidant properties and therapeutic potential in various central nervous system disorders. Herein, the preventive effects of ceria nanoclusters (NCs) against delayed paraplegia were investigated. NCs were synthesized using a facile and green method, incubated with albumin, and exhibited excellent biocompatibility and ROS scavenging activity in vitro, providing neuroprotective effects on neuronal cells. To explore the protective effects against delayed paraplegia in vivo, NCs were intravenously injected into SCIRI rabbits both before ischemia and after reperfusion. Post-reperfusion NCs treatment significantly preserved hindlimb motor function and reduced the incidence of delayed paraplegia. Histopathological and biochemical analyses revealed that NCs protected motor neurons, mitigated oxidative stress, and reduced apoptosis and inflammation in the ischemic spinal cord. These results showed that NCs successfully prevented the development of delayed paraplegia by eliminating excessive ROS.</p><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07062-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Temporary skin grafts based on hybrid graphene oxide-natural biopolymer nanofibers as effective wound healing substitutes: pre-clinical and pathological studies in animal models","authors":"N. Mahmoudi,&nbsp;N. Eslahi,&nbsp;A. Mehdipour,&nbsp;M. Mohammadi,&nbsp;M. Akbari,&nbsp;A. Samadikuchaksaraei,&nbsp;A. Simchi","doi":"10.1007/s10856-025-06892-5","DOIUrl":"10.1007/s10856-025-06892-5","url":null,"abstract":"","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06892-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled drug release and electroconductive performance of 3D printed scaffolds for neural tissue regeneration","authors":"Busra Oktay,&nbsp;Fatih Ciftci,&nbsp;Israa F. Abdulazez,&nbsp;Ayse Betul Bingol,&nbsp;Alpay Kose,&nbsp;Azime Erarslan,&nbsp;Cem Bulent Ustundag","doi":"10.1007/s10856-026-07043-0","DOIUrl":"10.1007/s10856-026-07043-0","url":null,"abstract":"<div><p>Nerve cell repair is a complex process influenced by genetic factors, damage severity, and treatment type. Although nerve tissue engineering has advanced, many scaffolds still fail to mimic the natural electrical properties of nerve tissue or deliver drugs effectively. To address these issues, this study presents a multifunctional scaffold designed to support nerve regeneration while reducing inflammation and pain. The scaffold was fabricated using 3D microextrusion printing, allowing precise control over geometry and composition. Polyvinyl alcohol (PVA) and collagen (Col) provided biocompatibility and biodegradability, while reduced graphene oxide (rGO) enhanced electrical conductivity. Amoxicillin (Amox) and ibuprofen (Ibu) were incorporated for antibacterial and anti-inflammatory effects. The scaffold exhibited a conductivity of (5.83 ± 0.65) × 10⁻³ S/m, and sustained drug release, with amoxicillin reaching ~0.6 mg/L and ibuprofen ~0.12 mg/L after 480 min. It showed strong antibacterial activity, with inhibition zones of 28.3 ± 3.32 mm (<i>E. coli</i>) and 18.34 ± 2.83 mm (<i>S. aureus</i>). Mechanically, it withstood ~5.5 MPa of stress and over 150% tensile strain. Cell viability exceeded 120%, indicating excellent biocompatibility. These results suggest the scaffold effectively integrates conductivity, structural strength, and therapeutic delivery to promote nerve regeneration.</p><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07043-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term disinfection of 3D-printed denture resin: physical and biological in vitro assessments","authors":"Amanda C. Ferro,&nbsp;Caroline C. de Oliveira,&nbsp;Bárbara L. Morais,&nbsp;Jonatas S. de Oliveira,&nbsp;Rodolfo D. Piazza,&nbsp;Rodrigo F. C. Marques,&nbsp;Carlos Mota,&nbsp;Matthew B. Baker,&nbsp;Janaina H. Jorge","doi":"10.1007/s10856-026-07049-8","DOIUrl":"10.1007/s10856-026-07049-8","url":null,"abstract":"<div><p>This study evaluated the effects of prolonged overnight immersion in disinfectant solutions on the physical and biological properties of 3D-printed and heat-polymerized polymethyl methacrylate (PMMA) denture base materials. Four solutions were tested: distilled water (control), 1% sodium hypochlorite, 2% chlorhexidine digluconate, and a disinfectant soap (Lifebuoy®). Daily cycles of 8 h in disinfectant solutions and 16 h in distilled water were performed for up to 6 months to represent overnight disinfection and daily use. The evaluated parameters included color change, water contact angle, Vickers hardness, surface roughness and topography, residual antimicrobial activity against <i>Candida albicans</i> biofilm, and cytotoxicity in L-929 cells. Color change remained within clinically acceptable thresholds for all groups, with Lifebuoy® showing values comparable to the control. Water contact angles decreased after immersion, while surface roughness was stable up to 3 months and decreased at 6 months, particularly in PMMA. Hardness increased in heat-polymerized specimens, whereas 3D-printed materials showed greater stability over time. 3D-printed resins exhibited higher <i>C. albicans</i> biofilm formation than PMMA. Chlorhexidine digluconate resulted in the greatest reduction in fungal growth and metabolic activity, followed by sodium hypochlorite and Lifebuoy®. Most groups showed no cytotoxic effects, except for moderate cytotoxicity of chlorhexidine at 3 months. In conclusion, 3D-printed resin showed superior physical performance, while PMMA demonstrated lower <i>Candida</i> colonization. Chlorhexidine was the most effective antibiofilm agent despite time-dependent cytotoxicity, while Lifebuoy® served as a non-cytotoxic alternative.</p><div><figure><div><div><picture><img></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07049-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed PCL scaffolds: optimising material selection for specific bone regeneration applications","authors":"Izabella Rajzer,&nbsp;Renata Novotna,&nbsp;Anna Kurowska,&nbsp;Jarosław Janusz,&nbsp;Janusz Fabia,&nbsp;Adam Jabłoński,&nbsp;Wojciech Piekarczyk,&nbsp;Oscar Castano,&nbsp;Magdalena Ziąbka,&nbsp;Jana Frankova","doi":"10.1007/s10856-026-07047-w","DOIUrl":"10.1007/s10856-026-07047-w","url":null,"abstract":"<div><p>Significant clinical challenges are posed by large bone defects, necessitating the use of scaffolds that combine mechanical stability with osteoinductive properties. While polycaprolactone (PCL) lends itself well to 3D printing, its limited bioactivity means it needs to be modified with bioactive additives. Various additives have been proposed to enhance PCL scaffolds, but a systematic comparative evaluation of their mechanical and biological effects is lacking. This hinders the optimal selection of materials for specific applications. In this study, we compared the effects of four additives—silver nanoparticles (AgNPs), osteogenon (OST), zinc oxide (ZnO) and vitroceramic calcium phosphate (CaPNPs)—when incorporated at a concentration of 0.5 wt% into 3D-printed PCL scaffolds. We comprehensively evaluated the mechanical properties, thermal characteristics, and osteoblast biocompatibility using tensile testing, differential scanning calorimetry, and SaOS-2 cell culture assays (MTT test, activity of alkaline phosphatase, production of collagen I and fluorescent staining with acridine orange or phalloidin). ZnO modification significantly enhanced the mechanical properties (834% strain at break versus 658% for pure PCL and an increased Young’s modulus), as well as supporting cell viability (87 and 85%). Meanwhile, CaPNPs demonstrated the highest level of early-stage cell viability (103% after 24 h), although this was not statistically significant. All additives exhibited non-cytotoxic profiles with &gt;80% cell viability and demonstrated time-dependent increases in alkaline phosphatase activity, but further evaluation for clinical application is essential. These findings provide evidence-based guidance for selecting PCL scaffold additives based on specific application requirements: ZnO is optimal for mechanically demanding applications, while CaPNPs could be optimal for facilitating rapid cell integration.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07047-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Montmorillonite in next-generation drug delivery: patent trends, safety insights, and industrial advancements","authors":"Afzal Haq Asif,&nbsp;B. R. Asha,&nbsp;Samathoti Prasanthi,&nbsp;Prakash Goudanavar,&nbsp;Kalappa Prashantha,&nbsp;K. S. Srikruthi,&nbsp;N. Raghavendra Naveen,&nbsp;Girish Meravanige,&nbsp;Predeepkumar Narayanappa Shiroorka,&nbsp;Krishna Swaroop,&nbsp;Pavan Kumar Pavagada Sreenivasalu,&nbsp;Nagaraja Sreeharsha","doi":"10.1007/s10856-026-07031-4","DOIUrl":"10.1007/s10856-026-07031-4","url":null,"abstract":"<div><p>Montmorillonite (MMT) is a natural clay mineral and the major component of bentonite, and it possesses an exceptional swelling capacity, a high potential for adsorption, and excellent biocompatibility. Therefore, MMT has been identified as an attractive candidate for pharmaceutical applications in drug nano delivery systems. In recent years, research on MMT has also gained momentum because of its ability to improve the solubility, rate of dissolution, and bioavailability of poor-water-soluble drugs in polymeric nanocomposites. Although much research has been done on the formulation advantages of MMT, critical analysis of their translational progress and industrial uptake remains inadequate. This reviews an in-depth study of the role of MMT as a pharmaceutical excipient in nano drug delivery through a synergy of published work and patent landscape analysis. Patents on MMT-based formulations are sequenced and scrutinized to identify significant players in the industry, therapeutic applications, and emerging patterns of technology. In the comparative assessment of research publications vis-a-vis patents in the decade under review, evolving innovation patterns have of late drawn attention to scalable, multifunctional, clinically relevant MMT nanocomposites. Overall, the review indicates how MMT is gaining importance in pharmaceutical development and what it will provide for the future concerning rational design, regulatory convergence, and commercialization of MMT-embedded polymeric nano drug delivery systems.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07031-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Isoxazole-Hydroxyapatite composites as antimicrobial agents: integrated in silico and in vitro investigation","authors":"Aziz Arzine,&nbsp;Khalil Azzaoui,&nbsp;Khaoula Faiz,&nbsp;Yousra Kachbou,&nbsp;Asmae Nakkabi,&nbsp;Bouchra Louasté,&nbsp;Joel T. Mague,&nbsp;Belkheir Hammouti,&nbsp;Mohammed Merzouki,&nbsp;Ghanem Hamdoun,&nbsp;Adam Duong,&nbsp;Shehdeh Jodeh,&nbsp;Mohamed El Yazidi","doi":"10.1007/s10856-026-07052-z","DOIUrl":"10.1007/s10856-026-07052-z","url":null,"abstract":"<div><p>In this study, an innovative methodology was implemented to combine an isoxazole derivative (ARZ) with hydroxyapatite (HAp), varying several parameters to obtain three distinct composites (ARZ-Hap-1, ARZ-Hap-2 and ARZ-Hap-3). These composites (ARZ-Hap) were synthesized by a dissolution-recrystallization process, thereby facilitating enhanced interaction between ARZ and HAp. This approach promoted homogeneous dispersion of ARZ within the HAp matrix, consequently enhancing the stability and functionality of the resulting materials. The structural characterization of these composites was determined by FT-IR, XRD, BET, TGA, and NMR (¹³C, ³¹P) methods. Subsequently, the composites were subjected to a rigorous evaluation process to ascertain their antibacterial and antifungal activities. Among them, ARZ-HAp-3 exhibited noticeable antimicrobial activity against <i>E. coli</i>, <i>S. aureus</i>, and <i>B. subtilis</i>, demonstrating a measurable inhibitory effect on bacterial growth. In terms of antifungal activity, this composite demonstrated the best results, particularly against <i>C. albicans</i> and <i>F. oxysporum</i>, with minimal MIC and MFC values comparable to those of fluconazole. These results indicate the potential of the ARZ-HAp-3 composite as a promising bioactive material, demonstrating a combination of structural efficiency and targeted biological activity. The release of ARZ from the composites was monitored by UV-Visible spectroscopy, revealing a gradual and controlled profile. The quantity of the substance released is proportional to the initial content of ARZ, with a maximum observed for ARZ-Hap-3 (~900 mg/L). This mechanism, based on slow diffusion, confirms the potential of these materials for sustained release of active ingredients. Furthermore, a molecular docking analysis was conducted to explore potential interactions between ARZ and biological targets associated with the pathogens studied. The results of the study indicated a high binding affinity of ARZ with certain enzymes that are essential for bacterial and fungal survival. This finding corroborates the experimental observations made in the study, thereby providing a scientific rationale for the observed effects.</p><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07052-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microstructural and functional evaluation of bioactive glass–ferrite hybrid coatings deposited on pure titanium using an electric-field-assisted technique","authors":"Zahra Sohani,&nbsp;Hamed Jamshidi Aval,&nbsp;Sayed Mahmood Rabiee","doi":"10.1007/s10856-026-07028-z","DOIUrl":"10.1007/s10856-026-07028-z","url":null,"abstract":"<div><p>In this study, bioactive glass–ferrite (Fe₃O₄) hybrid coatings were deposited on commercially pure titanium using an electric-field-assisted electrophoretic deposition (EPD) technique, and their microstructural and functional properties were quantitatively evaluated. Bioactive glass co-deposited with 5 wt.% Fe₃O₄ particles at a constant applied voltage of 25 V, while the deposition time was systematically varied between 6- and 24-min. Microstructural observations revealed that short deposition times (6–12 min) resulted in discontinuous and non-uniform coatings, whereas prolonged deposition (18–24 min) produced dense, continuous, and well-adhered layers. Wettability measurements showed a pronounced enhancement in surface hydrophilicity, with water contact angles decreasing from 57.6 ± 1.22° for the bare substrate to 35.4 ± 1.35° and 18.9 ± 1.18° for coatings deposited for 12 and 24 min, respectively. Electrochemical tests in phosphate-buffered saline at 37 °C demonstrated that increasing deposition time improved the barrier performance of the coatings, as evidenced by a reduction in corrosion current density from 8.16 × 10⁻⁷ A/cm² at 18 min to 2.95 × 10⁻⁷ A/cm² at 24 min, alongside an increase in charge transfer resistance from 1.35 × 10⁴ to 4.58 × 10⁴ Ω·cm². Although the uncoated titanium exhibited the highest intrinsic corrosion resistance due to its stable passive oxide layer, the optimized hybrid coating deposited at 25 V for 24 min offered the best compromise between enhanced surface roughness, superior wettability, and improved electrochemical performance among the coated samples.</p><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"37 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-026-07028-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}