中国临床实用医学最新文献

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The clinical research of surgical treatment in off-pump coronary artery bypass 非体外循环冠状动脉搭桥手术治疗的临床研究
中国临床实用医学 Pub Date : 2016-10-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.05.003
Ying Lv, Zhejun V. Zhang, Wensi Wang, Huijun Zhang, Junyan Feng, D. Li
{"title":"The clinical research of surgical treatment in off-pump coronary artery bypass","authors":"Ying Lv, Zhejun V. Zhang, Wensi Wang, Huijun Zhang, Junyan Feng, D. Li","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.05.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.05.003","url":null,"abstract":"Objective \u0000To summarize clinical effect and experience for surgical treatment in off-pump coronary artery bypass in 128 patients. \u0000 \u0000 \u0000Methods \u0000128 cases of age older than 60 years with Coronary heart disease (CHD) undergoing surgical repair in off-pump coronary artery bypass from October 2013 to June 2016 were analyzed retrospectively in our department. All the patients received surgical repair in off-pump coronary artery bypass under general anesthesia by the sternum midline incision line. Summary the complications following surgery. \u0000 \u0000 \u0000Results \u0000Surgical operations were performed in all patients and no death occurred during surgery.The perioperative complications after surgery: low cardiac syndrome (3 cases), arrhythmia(7 cases),including supraventricular tachicardia(2cases),complete atrioventricular block (1 cases), atrial fibrillation(4 cases); pulmonary infection with hypoxemia(5 cases).Secondary endotracheal intubation (2 cases),pleural effusion(3 case),atelectasis (2 cases), kidney injury(1 case),brain injury(1 case). The average drainage of chest was 350 ml, the time for making use of respirometer was (10.12±3.46) h, the length of hospital stay was (10±6) d. All patients were followed up from 3 months to 3 years.As a result,postoperative cardiac function improved significantly. \u0000 \u0000 \u0000Conclusions \u0000Surgical repair in off-pump coronary artery bypass for older patients with Coronary heart disease is safe and effective, surgical technical experience accumulation and the improvement of postoperative care can help to further reduce the incidence of complications. \u0000 \u0000 \u0000Key words: \u0000Off-pump coronary artery bypass; Coronary heart disease; Cardiac surgical treatment","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"2016-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69974024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curative effect analysis of laparoscopic radical operation and conventional open surgery in the treatment of early gastric cancer 腹腔镜根治术与常规开放手术治疗早期胃癌的疗效分析
中国临床实用医学 Pub Date : 2016-06-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.03.004
Jiepeng Jia, Q. Shao
{"title":"Curative effect analysis of laparoscopic radical operation and conventional open surgery in the treatment of early gastric cancer","authors":"Jiepeng Jia, Q. Shao","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.03.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.03.004","url":null,"abstract":"Objective \u0000To explore the conventional laparotomy and laparoscopic radical prostatectomy clinical effect for the treatment of early gastric cancer. \u0000 \u0000 \u0000Methods \u0000From January 2012 - January 2013 treated 74 cases of early gastric cancer patients as the research object in the General Hospital of Tisco Affiliated to Shanxi Medical University, and randomly divided into two groups, the control group conventional laparotomy, while the observation group line of laparoscopic radical prostatectomy, compared two groups of therapeutic effect. \u0000 \u0000 \u0000Results \u0000The incidence of complications of observation group was 2.70%, significantly lower than the control group 16.22%, comparing differences between group significantly (P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Compared with the conventional laparotomy, laparoscopic radical treatment of early gastric cancer has small trauma, rapid recovery, fewer complications, and many other advantages, is a kind of safe and effective operation. \u0000 \u0000 \u0000Key words: \u0000Gastric cancer; Conventional open surgery; Laparoscopic radical operation","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69974223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of LOX-1 in predicting the prognosis of acute stroke LOX-1在预测急性脑卒中预后中的作用
中国临床实用医学 Pub Date : 2016-06-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.03.007
Su Pu, Hui Zheng, Hui Wang, Fang Wang, Shunjun Li, Yueyu Tang
{"title":"The effect of LOX-1 in predicting the prognosis of acute stroke","authors":"Su Pu, Hui Zheng, Hui Wang, Fang Wang, Shunjun Li, Yueyu Tang","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.03.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.03.007","url":null,"abstract":"Objective \u0000The aim of this study is to inquire awareness of predictive value of LOX-1 to acute stroke patients. \u0000 \u0000 \u0000Methods \u000060 cases of acute stroke patients, including 49 patients with Ischemic stroke and 11 patients with hemorrhagic apoplexy, 30 healthy persons were selected as control group. Respectively, in patients with the third day, the 14th day, the 90th day, collecting blood of elbow vein, measuring the serum levels of LOX-1 by enzyme-linked immunosorbent assay, marking NIHSS score simultaneously. We analysed the relationship between LOX-1 level and NIHSS score , the size of this relationship. \u0000 \u0000 \u0000Results \u0000Serum LOX-1 concentrations of third day, 14th day and 90th day in the case group were compared with the control group. The result is that serum LOX-1 level in the case group were apparently higher than that of the control group, the difference was statistically significant(P<0.05); The D-value of 14th days and third days NIHSS score was positively correlated with the change of LOX-1 concentration(γ=0.780, P=0.000), the D-value of 90th days and third days NIHSS score was positively correlated with the change of LOX-1 concentration(γ=0.378, P=0.003). \u0000 \u0000 \u0000Conclusion \u0000LOX-1 is a biochemical indicator which can predict the prognosis of patients with acute stroke. \u0000 \u0000 \u0000Key words: \u0000LOX-1; Stroke; Prognosis","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"20-23"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The application value of aEEG and NBNA in the early evaluation on brain damage for full-term neonates with hyperbilirubinemia aEEG与NBNA在高胆红素血症足月新生儿脑损伤早期评估中的应用价值
中国临床实用医学 Pub Date : 2016-06-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.03.011
Liting Chen, Yuxiu Guo, Yuan Lyu, Q. Liang, Yanlin Liu, Lingling Zhu
{"title":"The application value of aEEG and NBNA in the early evaluation on brain damage for full-term neonates with hyperbilirubinemia","authors":"Liting Chen, Yuxiu Guo, Yuan Lyu, Q. Liang, Yanlin Liu, Lingling Zhu","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.03.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.03.011","url":null,"abstract":"Objective \u0000To investigate the application value of amplitude integrated electroencephalogram (aEEG) and neonatal behavioral neurological assessment(NBNA) in the early evaluation on brain damage for full-term neonates with hyperbilirubinemia. \u0000 \u0000 \u0000Methods \u0000From August 2015 to February 2016, 42 full-term neonates with hyperbilirubinemia were divided into two groups:subclinical bilirubin encephalopathy group and hyperbilirubinemia control group according to the results of magnetic resonance imaging(MRI), while 20 normal healthy full-term infants born in our hospital at the same time were chosen as normal control group. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Clinic Medical College of Yangzhou University. Informed consent was obtained from each parents.The serum level of total bilirubin(TB), the score of NBNA, the abnormality rate for brainstem auditory evoked potential (BAEP) and aEEG were compared among three groups,meanwhile the correlation for these parameters were assayed. \u0000 \u0000 \u0000Results \u0000(1)There were significant differences in the level of UCB ,the score of NBNA, the abnormality rate of BAEP and aEEG among different groups (F=20.16, 7.12,χ2=15.18,12.23,P 0.05). (2)Of the 7 mildly abnormal aEEG cases in the subclinical bilirubin encephalopathy group, 6 mildly abnormal and 1 moderately abnormal were found in BAEP test. All of the 9 severely abnormal aEEG cases in the subclinical bilirubin encephalopathy group were found 1 moderately abnormal and 8 severely/very severely abnormal of BAEP. By linear correlation analysis,the abnormality degree of aEEG was positively correlation with BAEP (γ=0.806,P=0.032). (3)22 cases of subclinical bilirubin encephalopathy group inclued 16 abnormal aEEG cases (72.73%) and 21abnormal aEEG with NBNA cases (95.45%) respectively,there were statistically significant differences (χ2=4.08,P<0.05). \u0000 \u0000 \u0000Conclusion \u0000aEEG combining with NBNA may be an reference indicator for early evaluation on brain damage in full-term neonates with hyperbilirubinemia. It has great clinical important value and can be worth popularizing. \u0000 \u0000 \u0000Key words: \u0000aEEG; NBNA; Neonate; Hyperbilirubinemia; Brain damage","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and treatment of gastrointestinal stromal tumors(GIST) :an analysis of 86 cases 胃肠道间质瘤86例诊治分析
中国临床实用医学 Pub Date : 2016-06-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.03.003
J. Hou, Yuankui Wang, Liang Gao, Zhen-Lue Li
{"title":"Diagnosis and treatment of gastrointestinal stromal tumors(GIST) :an analysis of 86 cases","authors":"J. Hou, Yuankui Wang, Liang Gao, Zhen-Lue Li","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.03.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.03.003","url":null,"abstract":"Objective \u0000To analyze the clinical characteristics and treatment of gastrointestinal stromal tumors(GIST). \u0000 \u0000 \u0000Methods \u0000The Clinical data of 86 patients of GIST proved pathologically admitted from July 2000 to September 2015 at Department of surgery, the Second Traditional Medicine Hospital of Luoyang were analyzed retrospectively. \u0000 \u0000 \u0000Results \u0000The tumors originated respectively from the esophagus(n=2),stomach (n=43),duodenum(n=1),intestine(n=21),colon(n=5),rectum(n=2),pelvic cavity(n=6),peritoneum(n=6).Twenty-six cases of gastric and five cases of colon GIST were performed by laparoscopic lumpectomy.Fifty-five cases of GIST were performed by laparotomy.Six of them underwent palliative resection or biopsy because of extensive metastasis.Forty-nine cases were resected completely.There was no operative mortality.Sixty-three cases were followed-up.Recurrence and metastasis in ten patients,and eight of them were abdominal metastasis. \u0000 \u0000 \u0000Conclusion \u0000Surgical procedures is the first choice for treatment of GIST,imatinib mesylate targeted therapy can improve survival. \u0000 \u0000 \u0000Key words: \u0000Gastrointestinal stromal tumors; Surgical procedures; Imatinib mesylate","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"7-9"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69974177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical analysis of acute pulmonary embolism with type 2 diabetes mellitus 急性肺栓塞合并2型糖尿病临床分析
中国临床实用医学 Pub Date : 2016-06-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.03.009
Feng Chen, Xuefeng Han, Qingrong Nie, Lei Zhang
{"title":"Clinical analysis of acute pulmonary embolism with type 2 diabetes mellitus","authors":"Feng Chen, Xuefeng Han, Qingrong Nie, Lei Zhang","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.03.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.03.009","url":null,"abstract":"Objective \u0000To explore the clinical features and recurrence rates of acute pulmonary embolism (APE) with type 2 diabetes mellitus(DM2). \u0000 \u0000 \u0000Methods \u0000126 patients with acute pulmonary embolism were retrospectively analysed from January 2010 to December 2015. All patients were divided into two groups:observation group (APE with DM2,43 cases) and control group(APE without DM2,83 cases).The differences of clinical manifestations, complications,laboratory results,thrombus localizations,risk stratification and the recurrence rates of acute pulmonary embolism were analysed between the two groups. \u0000 \u0000 \u0000Results \u0000There were no significant differences in age,sex and clinical manifestations between the two groups. The combination of respiratory failure,coronary heart disease and pneumonia were more frequently seen in observation group(P<0.05). The level of creatine kinase, lactate dehydrogenase, fasting blood glucose,cTnI,NT-pro-BNP, CREA were obviously higher than control group(P<0.05). A higher risk stratification and recurrence rate were observed in the bservation group(P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Patients with acute pulmonary embolism and type 2 diabetes mellitus are more serious and more affected by complications and a higher recurrence rate,thus,we should give more attention to these patients and reduce the recurrence rate. \u0000 \u0000 \u0000Key words: \u0000Pulmonary embolism; Type 2 diabetes mellitus; Recurrence rate","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"28-30"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The renal function as assessed by 99mTc-DTPA renal dynamic imaging and Cockcroft-Gault formula: a comparison study 99mTc-DTPA肾动态显像与Cockcroft-Gault公式评价肾功能的比较研究
中国临床实用医学 Pub Date : 2016-06-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.03.012
Xiu-qin Liu, Yue Guo, Zhiguo Yu, S. Qin
{"title":"The renal function as assessed by 99mTc-DTPA renal dynamic imaging and Cockcroft-Gault formula: a comparison study","authors":"Xiu-qin Liu, Yue Guo, Zhiguo Yu, S. Qin","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.03.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.03.012","url":null,"abstract":"Objective \u0000To evaluate the difference of the glomerular filtration rate (GFR) estimated by99mTc-DTPA renal dynamic imaging (gGFR) and Cockcroft-Gault (C-G) formula(eGFR), and the consistency in the staging of the chronic kidney disease patients. \u0000 \u0000 \u0000Methods \u0000gGFR and eGFR were calculated from the data of 945 chronic kidney disease patients who underwent the dynamic renal imaging. Wilcoxon test was performed to determine the difference of the two and the Spearman test for the correlation. Kappa test was used to evaluate the consistency of the staging of the patients, according to the gGFR and eGFR respectively. \u0000 \u0000 \u0000Results \u0000(1) The global eGFR (median 51.8)was significantly higher than gGFR(median 44.6),Z=-12.53,P<0.001; (2) there was a strong correlation between gGFR and eGFR (r=0.719,P<0.001); (3) the patients were divided into 3 stages (compensatory stage, moderately decreased stage and severely decreased stage ) according to eGFR and gGFR respectively, the global coincidence rate was 63.3% (598/945) with moderate consistency (Kappa=0.405,P<0.001); (4) when the patients were divided into 5 stages according to the gGFR, the serum creatinine value showed significant difference between every two stages (P<0.001) except stage1 and 2 (Z=-1.844,P=0.065), and the creatinine value increased as the stage going up. \u0000 \u0000 \u0000Conclusion \u0000There was a strong correlation between the GFR value estimated by99mTc-DTPA renal dynamic imaging and C-G formula, and a moderate consistency in the staging of the chronic renal disease patients. The two methods are complementary with each other and should be comprehensively utilized to accurately assess the renal function. \u0000 \u0000 \u0000Key words: \u0000Glomerular filtration rate; Renal fuction; DTPA","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"38-40"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and clinical significance of I-TAC and its receptor CXCR3 in gastric hepatic metastases I-TAC及其受体CXCR3在胃肝转移瘤中的表达及临床意义
中国临床实用医学 Pub Date : 2016-06-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.03.002
Xianwen Dong, Hui Sun, K. Zhao, Xinfang Shan, Yanhai Li
{"title":"Expression and clinical significance of I-TAC and its receptor CXCR3 in gastric hepatic metastases","authors":"Xianwen Dong, Hui Sun, K. Zhao, Xinfang Shan, Yanhai Li","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.03.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.03.002","url":null,"abstract":"Objective \u0000To investigate the expression of I-TAC、CXCR3 in gastric cancer, and to reveal the role of I-TAC/CXCR3 in the metastasis of gastric carcinoma. \u0000 \u0000 \u0000Methods \u0000Two groups were selected, the research group (30 gastric cancer tissues with hepatic metastasis), and the control group (35 gastric cancer tissues without liver metastasis). Expression of I-TAC、CXCR3 in surgical specimens were determined by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. The expression of I-TAC and CXCR3 was detected by immunohistochemical staining in surgical specimens of gastric carcinoma with and without hepatic metastasis. Associations between the above two indicators and clinicopathological characteristics were finally analyzed. \u0000 \u0000 \u0000Results \u0000Compared with those without liver metastasis of gastric cancer tissue, the gene expression of I-TAC and CXCR3 in the gastric carcinoma tissues with hepatic metastasis were significantly higher. Positive expression rate of I-TAC in the gastric tissues with hepatic metastasis were 93.33%%, while positive expression rate of I-TAC in the gastric tissues without hepatic metastasis were 31.43%%, which were significantly lower than that of the group with hepatic metastasis. Positive expression rate of CXCR3 in the research group were 83.33%, while the positive expression rate of CXCR3 in the control group were 45.71%, which were significantly lower than that of the group with hepatic metastasis. Expression of CXCR3 in the tissue of gastric carcinoma were positively related to tissue histologic differentiation, lymph node metastasis. \u0000 \u0000 \u0000Conclusion \u0000Up-regulated expression of I-TAC and CXCR3 was associated with gastric cancer metastasis, I-TAC-CXCR3 signaling pathway may play a role in the process of gastric hepatic metastases. \u0000 \u0000 \u0000Key words: \u0000I-TAC; CXCR3; Chemokine; Gastric hepatic metastases","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"7 1","pages":"3-6"},"PeriodicalIF":0.0,"publicationDate":"2016-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69974162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of glucocorticoid in patients with tuberculous pleurifis and its influnce on the expression of inflammatory cytokines IL-6 and IL-8 糖皮质激素对结核性胸膜炎患者炎症因子IL-6、IL-8表达的影响
中国临床实用医学 Pub Date : 2016-04-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.02.008
Decui Wang, Junling Wang, Junying Wang
{"title":"Effects of glucocorticoid in patients with tuberculous pleurifis and its influnce on the expression of inflammatory cytokines IL-6 and IL-8","authors":"Decui Wang, Junling Wang, Junying Wang","doi":"10.3760/CMA.J.ISSN.1673-8799.2016.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2016.02.008","url":null,"abstract":"Objective \u0000To investigate the effects of glucocortieoid in patients with tuberculous pleuritis and its impact on the level of inflammatory cytokines IL-6 and IL-8. \u0000 \u0000 \u0000Methods \u0000From January 2012 to June 2015,193 patients with tuberculous pleuritis were divided into research group and control group by random digits table methodin the TB Prevention Hospital of Binzhou City. The patients in two groups were all given anti-TB medication, and the research group was also given chest injection of dexamethasone treatment on the basis of anti-TB medication treatment. The clinical efficacy and IL-6 and IL-8 level change was observed. \u0000 \u0000 \u0000Results \u000089 cases showed good effect, and 9 cases was invalid in research group and there were 74 and 21 cases in control group respectively, and there was significant difference between research group and control group (P 0.05). The levels of inflammatory cytokines IL-6 level after treatment of 3, 6 and 9 d in research group was lower than that in control group [(276.49±27.85) pg/ml vs (350.38±20.01) pg/ml,(195.32±14.35) pg/ml vs (312.51±14.82) pg/ml,(86.74±10.28) pg/ml vs (251.74±16.62) pg/ml, and there was significant difference(P<0.05).and IL-8 level[(576.51±19.79) pg/ml vs (850.64±27.70) pg/ml, (225.30±14.29) pg/ml vs (742.49±15.28) pg/ml, (127.68±11.23) pg/ml vs (443.47±12.63) pg/ml] \u0000 \u0000 \u0000Conclusions \u0000Intrapleural injection of glucocorticoid in the treatment of tuberculous pleurisy, can make the drug directly acts on the chest, better realize the control of inflammatory cytokines, encourage pleural effusion absorption, improve the clinical symptoms early. It is worthy of clinical apphcation. \u0000 \u0000 \u0000Key words: \u0000Ghcocorticoids; Tuberculous Pleurifis; Cell Inflammatory Cytokines","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"74 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2016-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the distribution width of red blood cells in patients with chronic heart failure 慢性心力衰竭患者红细胞分布宽度的研究
中国临床实用医学 Pub Date : 2016-04-25 DOI: 10.3760/CMA.J.ISSN.1673-8799.2016.02.012
Sen Liu, Yong Yu, Ping Wang
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