Diagnosis and treatment of gastrointestinal stromal tumors(GIST) :an analysis of 86 cases

中国临床实用医学 Pub Date : 2016-06-25 DOI:10.3760/CMA.J.ISSN.1673-8799.2016.03.003

J. Hou, Yuankui Wang, Liang Gao, Zhen-Lue Li

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Abstract

Objective To analyze the clinical characteristics and treatment of gastrointestinal stromal tumors(GIST). Methods The Clinical data of 86 patients of GIST proved pathologically admitted from July 2000 to September 2015 at Department of surgery, the Second Traditional Medicine Hospital of Luoyang were analyzed retrospectively. Results The tumors originated respectively from the esophagus(n=2),stomach (n=43),duodenum(n=1),intestine(n=21),colon(n=5),rectum(n=2),pelvic cavity(n=6),peritoneum(n=6).Twenty-six cases of gastric and five cases of colon GIST were performed by laparoscopic lumpectomy.Fifty-five cases of GIST were performed by laparotomy.Six of them underwent palliative resection or biopsy because of extensive metastasis.Forty-nine cases were resected completely.There was no operative mortality.Sixty-three cases were followed-up.Recurrence and metastasis in ten patients,and eight of them were abdominal metastasis. Conclusion Surgical procedures is the first choice for treatment of GIST,imatinib mesylate targeted therapy can improve survival. Key words: Gastrointestinal stromal tumors; Surgical procedures; Imatinib mesylate

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胃肠道间质瘤86例诊治分析

目的分析胃肠道间质瘤(GIST)的临床特点及治疗方法。方法回顾性分析2000年7月至2015年9月洛阳第二中医医院外科收治的经病理证实的86例GIST患者的临床资料。结果肿瘤分别起源于食道(2例)、胃(43例)、十二指肠(1例)、肠(21例)、结肠(5例)、直肠(2例)、盆腔(6例)、腹膜(6例)。腹腔镜下行胃间质瘤切除术26例，结肠间质瘤切除术5例。经剖腹手术治疗间质瘤55例。其中6例因广泛转移而行姑息性切除或活检。49例完全切除。无手术死亡率。对63例进行了随访。复发转移10例，其中腹部转移8例。结论手术是治疗GIST的首选方法，甲磺酸伊马替尼靶向治疗可提高生存率。关键词:胃肠道间质瘤;外科手术;甲磺酸伊马替尼

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中国临床实用医学

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