The effect of LOX-1 in predicting the prognosis of acute stroke

中国临床实用医学 Pub Date : 2016-06-25 DOI:10.3760/CMA.J.ISSN.1673-8799.2016.03.007

Su Pu, Hui Zheng, Hui Wang, Fang Wang, Shunjun Li, Yueyu Tang

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Abstract

Objective The aim of this study is to inquire awareness of predictive value of LOX-1 to acute stroke patients. Methods 60 cases of acute stroke patients, including 49 patients with Ischemic stroke and 11 patients with hemorrhagic apoplexy, 30 healthy persons were selected as control group. Respectively, in patients with the third day, the 14th day, the 90th day, collecting blood of elbow vein, measuring the serum levels of LOX-1 by enzyme-linked immunosorbent assay, marking NIHSS score simultaneously. We analysed the relationship between LOX-1 level and NIHSS score , the size of this relationship. Results Serum LOX-1 concentrations of third day, 14th day and 90th day in the case group were compared with the control group. The result is that serum LOX-1 level in the case group were apparently higher than that of the control group, the difference was statistically significant(P<0.05); The D-value of 14th days and third days NIHSS score was positively correlated with the change of LOX-1 concentration(γ=0.780, P=0.000), the D-value of 90th days and third days NIHSS score was positively correlated with the change of LOX-1 concentration(γ=0.378, P=0.003). Conclusion LOX-1 is a biochemical indicator which can predict the prognosis of patients with acute stroke. Key words: LOX-1; Stroke; Prognosis

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LOX-1在预测急性脑卒中预后中的作用

目的探讨LOX-1对急性脑卒中患者的预测价值。方法选取急性脑卒中患者60例，其中缺血性脑卒中49例，出血性脑卒中11例，健康人群30例作为对照组。分别于治疗第3天、第14天、第90天采血肘静脉，采用酶联免疫吸附法测定血清LOX-1水平，同时进行NIHSS评分。我们分析了LOX-1水平与NIHSS评分之间的关系，以及这种关系的大小。结果病例组第3天、第14天、第90天血清LOX-1浓度与对照组比较。结果:病例组血清LOX-1水平明显高于对照组，差异有统计学意义(P<0.05);第14天和第3天NIHSS评分的d值与LOX-1浓度变化呈正相关(γ=0.780, P=0.000)，第90天和第3天NIHSS评分的d值与LOX-1浓度变化呈正相关(γ=0.378, P=0.003)。结论LOX-1是预测急性脑卒中患者预后的生化指标。关键词:LOX-1;中风;预后

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中国临床实用医学

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